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ONTOLOGY REPORT - ANNOTATIONS


Term:VCP-NPL4-UFD1 AAA ATPase complex
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Accession:GO:0034098 term browser browse the term
Definition:A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry).
Synonyms:exact_synonym: p97-Ufd1-Npl4 complex
 narrow_synonym: Cdc48p-Npl4p-Ufd1p AAA ATPase complex


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VCP-NPL4-UFD1 AAA ATPase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Faf1 Fas associated factor 1 part_of IEA
ISO
GO_REF:0000107
(PMID:18775313)
Ensembl
RGD
PMID:18775313 GO_REF:0000107 NCBI chr 5:129,370,767...129,738,393
Ensembl chr 5:129,448,879...129,738,252
JBrowse link
G Faf2 Fas associated factor family member 2 part_of ISO
IEA
(PMID:18775313)
GO_REF:0000107
RGD
Ensembl
PMID:18775313 GO_REF:0000107 NCBI chr17:10,485,650...10,527,886
Ensembl chr17:10,485,642...10,527,864
JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor part_of IDA
IEA
NAS
ISO
PMID:17000876
GO_REF:0000107
PMID:10811609
PMID:12847084
PMID:18775313
(PMID:26471729)
Ensembl
RGD
PMID:26471729, PMID:17000876, PMID:10811609, PMID:12847084, PMID:18775313 GO_REF:0000107, RGD:10047192, RGD:633500, RGD:10047330, RGD:8554384 NCBI chr10:109,553,518...109,610,087
Ensembl chr10:109,552,649...109,610,030
JBrowse link
G Rnf125 ring finger protein 125 part_of IBA
ISO
PMID:21873635
(PMID:26471729)
RGD PMID:26471729, PMID:21873635 RGD:13792537 NCBI chr18:15,193,226...15,225,454
Ensembl chr18:15,192,962...15,225,427
JBrowse link
G Ubxn1 UBX domain protein 1 part_of ISO (PMID:18775313) RGD PMID:18775313 NCBI chr 1:225,067,953...225,071,944
Ensembl chr 1:225,068,009...225,071,945
JBrowse link
G Ubxn7 UBX domain protein 7 part_of ISO (PMID:18775313) RGD PMID:18775313 NCBI chr11:71,662,786...71,695,031 JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 part_of IBA
ISO
IDA
IPI
PMID:21873635
(MGI:5634894|PMID:10811609), (MGI:5640950|PMID:17000876)
(PMID:26471729)
PMID:12847084
RGD PMID:10811609 PMID:17000876 PMID:26471729, PMID:21873635, PMID:10811609, PMID:12847084 MGI:5634894 MGI:5640950, RGD:13792537, RGD:633500, RGD:10047330 NCBI chr11:86,304,836...86,328,478
Ensembl chr11:86,304,815...86,328,469
JBrowse link
G Vcp valosin-containing protein part_of IDA
ISO
IBA
PMID:10811609
UniProtKB:Q9ES53 (MGI:5634892|PMID:12847084), (MGI:5634894|PMID:10811609), (MGI:5640950|PMID:17000876)
PMID:21873635
RGD PMID:10811609 PMID:12847084 PMID:17000876, PMID:10811609, PMID:21873635 MGI:5634892 MGI:5634894 MGI:5640950, RGD:633500, RGD:13792537 NCBI chr 5:58,426,548...58,445,953
Ensembl chr 5:58,426,549...58,445,953
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20011
    protein-containing complex 6011
      endoplasmic reticulum protein-containing complex 139
        VCP-NPL4-UFD1 AAA ATPase complex 8
Path 2
Term Annotations click to browse term
  cellular_component 20011
    cellular anatomical entity 19715
      organelle 13098
        intracellular organelle 12747
          intracellular membrane-bounded organelle 11193
            endoplasmic reticulum 1757
              endoplasmic reticulum subcompartment 961
                endoplasmic reticulum membrane 951
                  VCP-NPL4-UFD1 AAA ATPase complex 8
paths to the root