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ONTOLOGY REPORT - ANNOTATIONS


Term:VCP-NPL4-UFD1 AAA ATPase complex
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Accession:GO:0034098 term browser browse the term
Definition:A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry).
Synonyms:exact_synonym: p97-Ufd1-Npl4 complex
 narrow_synonym: Cdc48p-Npl4p-Ufd1p AAA ATPase complex



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VCP-NPL4-UFD1 AAA ATPase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07034438.1 part_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 Ensembl chr11:68,398,182...68,460,080 JBrowse link
G Faf1 Fas associated factor 1 part_of ISO (PMID:18775313) RGD PMID:18775313 NCBI chr 5:124,426,032...124,790,014
Ensembl chr 5:124,426,062...124,789,977
JBrowse link
G Faf2 Fas associated factor family member 2 part_of ISO
IEA
(PMID:18775313)
GO_REF:0000107
RGD
Ensembl
PMID:18775313 GO_REF:0000107 NCBI chr17:9,947,216...9,989,474
Ensembl chr17:9,947,220...9,989,485
JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor part_of
located_in
IDA
ISO
NAS
IEA
IC
PMID:17000876
(PMID:26471729)
PMID:18775313
PMID:12847084
PMID:10811609
GO_REF:0000107
(PMID:20414249)
PMID:22232657
RGD
Ensembl
PMID:20414249 PMID:26471729 PMID:17000876 PMID:18775313 PMID:12847084 More... GO_REF:0000107, RGD:10047192, RGD:8554384, RGD:10047330, RGD:633500, RGD:13432281 NCBI chr10:105,654,395...105,709,958
Ensembl chr10:105,654,812...105,709,913
JBrowse link
G Rnf125 ring finger protein 125 part_of ISO (PMID:26471729) RGD PMID:26471729 NCBI chr18:12,254,066...12,275,719
Ensembl chr18:12,253,852...12,275,983
JBrowse link
G Ubxn1 UBX domain protein 1 part_of ISO (PMID:18775313) RGD PMID:18775313 NCBI chr 1:205,765,212...205,769,236
Ensembl chr 1:205,745,120...205,816,520
JBrowse link
G Ubxn7 UBX domain protein 7 part_of ISO (PMID:18775313) RGD PMID:18775313 NCBI chr11:68,427,896...68,460,100 JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 part_of
located_in
IBA
IPI
ISO
IDA
IC
PMID:21873635
PMID:12847084
(PMID:26471729)
PMID:10811609
(MGI:5634894|PMID:10811609), (MGI:5640950|PMID:17000876)
(PMID:20414249)
PMID:22232657
RGD PMID:10811609 PMID:17000876 PMID:20414249 PMID:26471729 PMID:21873635 More... MGI:5634894 MGI:5640950, RGD:13792537, RGD:10047330, RGD:633500, RGD:13432281 NCBI chr11:82,161,618...82,185,107
Ensembl chr11:82,161,619...82,185,087
JBrowse link
G Vcp valosin-containing protein part_of
located_in
IDA
ISO
IC
IBA
PMID:10811609
UniProtKB:Q9ES53 (MGI:5634892|PMID:12847084), (MGI:5634894|PMID:10811609), (MGI:5640950|PMID:17000876)
(PMID:20414249)
PMID:22232657
PMID:21873635
RGD PMID:10811609 PMID:12847084 PMID:17000876 PMID:20414249 PMID:10811609 More... MGI:5634892 MGI:5634894 MGI:5640950, RGD:633500, RGD:13432281, RGD:13792537 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20621
    protein-containing complex 6394
      endoplasmic reticulum protein-containing complex 141
        VCP-NPL4-UFD1 AAA ATPase complex 9
Path 2
Term Annotations click to browse term
  cellular_component 20621
    cellular anatomical entity 20375
      organelle 13559
        intracellular organelle 13173
          intracellular membrane-bounded organelle 11570
            endoplasmic reticulum 1814
              endoplasmic reticulum subcompartment 1008
                endoplasmic reticulum membrane 998
                  VCP-NPL4-UFD1 AAA ATPase complex 9
paths to the root