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ONTOLOGY REPORT - ANNOTATIONS

Term:deoxyhypusine synthase activity
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Accession:GO:0034038 term browser browse the term
Definition:Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+.
Comment:Note that this term is equivalent to the obsolete molecular function term 'deoxyhypusine synthase activity ; GO:0004171' and corresponds closely to the biological process term 'deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase ; GO:0050983'.
Synonyms:broad_synonym: (4-aminobutyl)lysine synthase;   spermidine dehydrogenase
 related_synonym: eIF-5A-deoxyhypusine synthase activity
 xref: EC:2.5.1.46;   MetaCyc:2.5.1.46-RXN;   RHEA:33299;   reactome:R-HSA-204617 "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A";   reactome:R-HSA-204647 "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine"


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deoxyhypusine synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhps deoxyhypusine synthase enables IDA
ISO
IBA		 (PMID:23525104), (PMID:30661771), (PMID:8549832)
GO_REF:0000033		 RGD
GO_Central		 PMID:8549832 PMID:23525104 PMID:30661771 PMID:7721768 GO_REF:0000033, RGD:2316236 NCBI chr19:23,082,454...23,086,544
Ensembl chr19:23,082,448...23,086,881 		JBrowse link
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  molecular_function 21010
    catalytic activity 6145
      transferase activity 2451
        transferase activity, transferring alkyl or aryl (other than methyl) groups 80
          deoxyhypusine synthase activity 1
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