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ONTOLOGY REPORT - ANNOTATIONS

Term:thyroxine 5-deiodinase activity
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Accession:GO:0033798 term browser browse the term
Definition:Catalysis of the reaction: 3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + acceptor-H2.
Synonyms:exact_synonym: inner ring-deiodinating pathway
 narrow_synonym: type III iodothyronine deiodinase activity
 broad_synonym: diiodothyronine 5'-deiodinase activity
 related_synonym: acceptor:3,3',5'-triiodo-L-thyronine oxidoreductase (iodinating) activity;   iodothyronine 5-deiodinase activity;   iodothyronine inner ring monodeiodinase activity
 xref: EC:1.21.99.3;   MetaCyc:1.97.1.11-RXN;   RHEA:18897


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thyroxine 5-deiodinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dio1 iodothyronine deiodinase 1 enables IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000116
GO_REF:0000024
(PMID:32718224)		 Ensembl
RHEA
UniProt
RGD		 PMID:32718224 GO_REF:0000024 GO_REF:0000107 GO_REF:0000116 NCBI chr 5:127,303,089...127,319,784
Ensembl chr 5:122,074,279...122,090,970 		JBrowse link
G Dio2 iodothyronine deiodinase 2 enables ISO
IEA		 (PMID:18566113)
GO_REF:0000107		 RGD
Ensembl		 PMID:18566113 GO_REF:0000107 NCBI chr 6:115,396,308...115,410,594
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Dio3 iodothyronine deiodinase 3 enables ISO
ISS
IEA		 (PMID:12586753), (PMID:20203194), (PMID:25002520)
GO_REF:0000024
(PMID:12746313), (PMID:18566113)
GO_REF:0000107
GO_REF:0000003
GO_REF:0000116		 RGD
UniProt
Ensembl
RHEA		 PMID:12586753 PMID:12746313 PMID:18566113 PMID:20203194 PMID:25002520 GO_REF:0000003 GO_REF:0000024 GO_REF:0000107 GO_REF:0000116 NCBI chr 6:135,107,072...135,108,933
Ensembl chr 6:129,285,749...129,286,660 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21100
    catalytic activity 6213
      oxidoreductase activity 868
        oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond 4
          thyroxine 5-deiodinase activity 3
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