cholesterol 24-hydroxylase activity - Ontology Report

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Term:	cholesterol 24-hydroxylase activity	go back to main search page
Accession:	GO:0033781	browse the term
Definition:	Catalysis of the reaction: cholesterol + H+ + NADPH + O2 = (24S)-24-hydroxycholesterol + H2O + NADP+.
Synonyms:	related_synonym:	CYP46; CYP46A1; cholesterol 24-monooxygenase activity; cholesterol 24S-hydroxylase activity; cholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating) activity; cytochrome P450 46A1
	xref:	EC:1.14.14.25; KEGG_REACTION:R07207; MetaCyc:1.14.13.98-RXN; RHEA:22716; reactome:R-HSA-192061 "CYP46A1 24-hydroxylates CHOL"

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Genes (1)

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CYP46A1

cytochrome P450 family 46 subfamily A member 1

enables

(PMID:14640697), (PMID:18621681), (PMID:25017465)

GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 Reactome:R-HSA-192061

NCBI chr14:99,684,298...99,727,301
Ensembl chr14:99,684,298...99,727,301

Term paths to the root

Path 1
Term	Annotations
molecular_function	19566
catalytic activity	5977
oxidoreductase activity	740
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	192
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	39
cholesterol 24-hydroxylase activity	1

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