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ONTOLOGY REPORT - ANNOTATIONS

Term:osteoblast proliferation
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Accession:GO:0033687 term browser browse the term
Definition:The multiplication or reproduction of osteoblasts, resulting in the expansion of an osteoblast cell population. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone.


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osteoblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fignl1 fidgetin-like 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4943395|PMID:17352653)		 UniProt
RGD		 PMID:17352653 GO_REF:0000024 MGI:4943395 NCBI chr14:86,368,670...86,381,728
Ensembl chr14:86,368,675...86,377,455 		JBrowse link
G Ift80 intraflagellar transport 80 acts_upstream_of_or_within ISO MGI:3689350|MGI:5818514 (MGI:5807019|PMID:26996322) RGD PMID:26996322 MGI:5807019 NCBI chr 2:153,144,707...153,240,024
Ensembl chr 2:153,145,795...153,240,024 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2176174|MGI:3036209 (MGI:3029146|PMID:14769860)		 Ensembl
RGD		 PMID:14769860 GO_REF:0000107 MGI:3029146 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Lrrc17 leucine rich repeat containing 17 NOT|involved_in ISO (MGI:3850892|PMID:19336404) RGD PMID:19336404 MGI:3850892 NCBI chr 4:13,501,428...13,531,845
Ensembl chr 4:13,501,436...13,531,845 		JBrowse link
G Mus81 MUS81 structure-specific endonuclease subunit involved_in ISO (PMID:26415217) RGD PMID:26415217 NCBI chr 1:202,790,295...202,796,008
Ensembl chr 1:202,790,466...202,795,843 		JBrowse link
G Osr2 odd-skipped related transciption factor 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3818159|PMID:17547533)		 UniProt
RGD		 PMID:17547533 GO_REF:0000024 MGI:3818159 NCBI chr 7:66,487,841...66,495,003
Ensembl chr 7:66,487,839...66,495,224 		JBrowse link
G Smo smoothened, frizzled class receptor IEP RGD PMID:19649528 RGD:2324984 NCBI chr 4:58,344,101...58,372,828
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
negative regulation of osteoblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor IEP RGD PMID:23529231 RGD:7244256 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Ahr aryl hydrocarbon receptor IDA RGD PMID:12193573 RGD:625678 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Atraid all-trans retinoic acid-induced differentiation factor involved_in ISO (PMID:21723284) RGD PMID:21723284 NCBI chr 6:25,315,236...25,319,804 JBrowse link
G Bcl2 BCL2, apoptosis regulator involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857430 (MGI:1307011|PMID:10193316)		 Ensembl
RGD		 PMID:10193316 GO_REF:0000107 MGI:1307011 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 involved_in ISO
IEA
ISS		 (PMID:16216244)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:16216244 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971 		JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist involved_in ISO (PMID:15539560) RGD PMID:15539560 NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082 		JBrowse link
G Mn1 MN1 proto-oncogene, transcriptional regulator involved_in ISO (PMID:15890672) RGD PMID:15890672 NCBI chr12:45,184,060...45,220,102
Ensembl chr12:45,183,085...45,221,651 		JBrowse link
G Nell1 neural EGFL like 1 involved_in ISO
IEA
ISS		 (PMID:21723284)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:21723284 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:99,709,305...100,573,872
Ensembl chr 1:99,709,793...100,573,860 		JBrowse link
G Plxnb1 plexin B1 involved_in ISO (MGI:5297297|PMID:22019888) RGD PMID:22019888 MGI:5297297 NCBI chr 8:109,743,470...109,769,153
Ensembl chr 8:109,744,697...109,769,027 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3045799 (MGI:3040721|PMID:14976225)
(PMID:19072540)		 Ensembl
RGD		 PMID:14976225 PMID:19072540 GO_REF:0000107 MGI:3040721 NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286 		JBrowse link
G Smad3 SMAD family member 3 involved_in ISO (MGI:5285145|PMID:21035443) RGD PMID:21035443 MGI:5285145 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Tnn tenascin N involved_in ISO (MGI:3710297|PMID:17395156) RGD PMID:17395156 MGI:3710297 NCBI chr13:72,319,160...72,386,362
Ensembl chr13:72,319,155...72,408,156 		JBrowse link
positive regulation of osteoblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:2153718 (MGI:5449665|PMID:22729085) RGD PMID:22729085 MGI:5449665 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Bmp2 bone morphogenetic protein 2 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5009350|PMID:20675382)		 Ensembl
RGD		 PMID:20675382 GO_REF:0000107 MGI:5009350 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Ccn1 cellular communication network factor 1 involved_in ISO
IEA		 (PMID:20675382)
GO_REF:0000107		 RGD
Ensembl		 PMID:20675382 GO_REF:0000107 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Cthrc1 collagen triple helix repeat containing 1 acts_upstream_of_or_within ISO MGI:3830252 (MGI:3829514|PMID:18779865) RGD PMID:18779865 MGI:3829514 NCBI chr 7:70,122,474...70,132,756
Ensembl chr 7:70,122,474...70,132,756 		JBrowse link
G Fbln5 fibulin 5 involved_in ISO (MGI:5780490|PMID:26399686) RGD PMID:26399686 MGI:5780490 NCBI chr 6:120,899,219...120,977,829
Ensembl chr 6:120,899,224...120,977,755 		JBrowse link
G Gata1 GATA binding protein 1 acts_upstream_of_or_within ISO MGI:2177586 (MGI:3653541|PMID:15005853) RGD PMID:15005853 MGI:3653541 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IMP RGD PMID:26722385 RGD:11555176 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hpse heparanase involved_in IEA
ISO		 GO_REF:0000107
(MGI:5284762|PMID:18589009)
(PMID:20309870)		 Ensembl
RGD		 PMID:18589009 PMID:20309870 GO_REF:0000107 MGI:5284762 NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor IMP RGD PMID:15110779 RGD:10045881 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Itgav integrin subunit alpha V involved_in ISO (MGI:5009350|PMID:20675382) RGD PMID:20675382 MGI:5009350 NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Itgb3 integrin subunit beta 3 involved_in ISO (MGI:5009350|PMID:20675382) RGD PMID:20675382 MGI:5009350 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Lrp5 LDL receptor related protein 5 acts_upstream_of_or_within ISO MGI:2183279 (MGI:2178168|PMID:11956231) RGD PMID:11956231 MGI:2178168 NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581 		JBrowse link
G Ltf lactotransferrin involved_in ISO (PMID:15166119) RGD PMID:15166119 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795 		JBrowse link
G Sox8 SRY-box transcription factor 8 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:2154329 (MGI:3577129|PMID:15753123)		 UniProt
RGD		 PMID:15753123 GO_REF:0000024 MGI:3577129 NCBI chr10:14,584,829...14,589,818
Ensembl chr10:14,584,829...14,589,818 		JBrowse link
G Tmem119 transmembrane protein 119 involved_in ISO
IBA		 (PMID:20025746)
(MGI:4418582|PMID:20025746)
PMID:21873635		 RGD PMID:20025746 PMID:21873635 MGI:4418582, RGD:13792537 NCBI chr12:42,828,621...42,835,678
Ensembl chr12:42,828,418...42,835,689 		JBrowse link
regulation of osteoblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Npr3 natriuretic peptide receptor 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:1339924|PMID:10377427)		 UniProt
RGD		 PMID:10377427 GO_REF:0000024 MGI:1339924 NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955 		JBrowse link
G Rhoa ras homolog family member A involved_in ISO (MGI:5297297|PMID:22019888) RGD PMID:22019888 MGI:5297297 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19390
    cellular process 18252
      cell population proliferation 2158
        osteoblast proliferation 36
          negative regulation of osteoblast proliferation 12
          positive regulation of osteoblast proliferation 15
          regulation of osteoblast proliferation + 29
paths to the root