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ONTOLOGY REPORT - ANNOTATIONS

Term:integrin activation
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Accession:GO:0033622 term browser browse the term
Definition:The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands.
Synonyms:exact_synonym: integrin complex activation;   integrin complex assembly


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integrin activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd24 CD24 molecule acts_upstream_of ISO MGI:2179996 (MGI:3757613|PMID:10601245) RGD PMID:10601245 MGI:3757613 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662 		JBrowse link
G Col16a1 collagen type XVI alpha 1 chain involved_in ISO (PMID:16754661) RGD PMID:16754661 NCBI chr 5:142,388,376...142,442,825
Ensembl chr 5:142,388,426...142,442,825 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 involved_in ISO
IEA
ISS		 (PMID:23125415)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:23125415 GO_REF:0000024 GO_REF:0000107 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 involved_in ISO (PMID:29301984) RGD PMID:29301984 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Fermt2 FERM domain containing kindlin 2 involved_in ISO (PMID:22030399)
(MGI:3789779|PMID:18483218)		 RGD PMID:18483218 PMID:22030399 MGI:3789779 NCBI chr15:18,682,927...18,751,959
Ensembl chr15:18,682,927...18,751,811 		JBrowse link
G Fermt3 FERM domain containing kindlin 3 involved_in ISO
IBA		 (PMID:19234460), (PMID:19234463)
(MGI:3783912|PMID:18278053), (MGI:3838441|PMID:19234461)
PMID:21873635		 RGD PMID:18278053 PMID:19234460 PMID:19234461 PMID:19234463 PMID:21873635 MGI:3783912 MGI:3838441, RGD:13792537 NCBI chr 1:204,189,483...204,207,683
Ensembl chr 1:204,189,484...204,207,587 		JBrowse link
G Fn1 fibronectin 1 involved_in ISO
IEA		 (PMID:24658351)
GO_REF:0000107		 RGD
Ensembl		 PMID:24658351 GO_REF:0000107 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 involved_in ISO (MGI:5486544|PMID:18227284)
(PMID:23317506)		 RGD PMID:18227284 PMID:23317506 MGI:5486544 NCBI chr 6:40,820,693...40,836,074
Ensembl chr 6:40,821,339...40,836,037 		JBrowse link
G Krit1 KRIT1, ankyrin repeat containing involved_in ISO (PMID:23317506) RGD PMID:23317506 NCBI chr 4:30,299,203...30,333,366
Ensembl chr 4:30,299,203...30,333,359 		JBrowse link
G Mzb1 marginal zone B and B1 cell-specific protein involved_in ISS
ISO		 GO_REF:0000024
(MGI:4866969|PMID:21093319)		 UniProt
RGD		 PMID:21093319 GO_REF:0000024 MGI:4866969 NCBI chr18:27,238,999...27,241,060
Ensembl chr18:27,239,001...27,241,094 		JBrowse link
G Tln1 talin 1 involved_in ISO (MGI:4439219|PMID:20150896) RGD PMID:20150896 MGI:4439219 NCBI chr 5:57,787,670...57,817,900
Ensembl chr 5:57,787,943...57,817,900 		JBrowse link
negative regulation of integrin activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jam3 junctional adhesion molecule 3 involved_in ISO (PMID:19461049) RGD PMID:19461049 NCBI chr 8:25,508,461...25,569,306
Ensembl chr 8:25,507,057...25,569,355 		JBrowse link
G Kif14 kinesin family member 14 acts_upstream_of_or_within ISO (PMID:23209302) RGD PMID:23209302 NCBI chr13:47,926,975...47,990,598
Ensembl chr13:47,927,044...47,989,164 		JBrowse link
G Ptger4 prostaglandin E receptor 4 involved_in ISO
IEA
ISS		 (PMID:21681739)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:21681739 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
positive regulation of integrin activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd24 CD24 molecule acts_upstream_of_or_within ISO MGI:2179996 (MGI:3757613|PMID:10601245), (MGI:3757620|PMID:7534304) RGD PMID:7534304 PMID:10601245 MGI:3757613 MGI:3757620 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662 		JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 involved_in ISO (MGI:3702377|PMID:15972452) RGD PMID:15972452 MGI:3702377 NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933 		JBrowse link
G Fermt1 FERM domain containing kindlin 1 involved_in ISO UniProtKB:Q96AC1 (PMID:21356350) RGD PMID:21356350 NCBI chr 3:120,171,301...120,213,555
Ensembl chr 3:120,171,561...120,213,555 		JBrowse link
G Fermt2 FERM domain containing kindlin 2 involved_in ISO UniProtKB:Q9BQL6 (PMID:21356350) RGD PMID:21356350 NCBI chr15:18,682,927...18,751,959
Ensembl chr15:18,682,927...18,751,811 		JBrowse link
G Izumo1 izumo sperm-oocyte fusion 1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 1:96,090,817...96,096,893 JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 IMP RGD PMID:14970114 RGD:11556214 NCBI chr 1:214,837,847...215,267,626
Ensembl chr 1:214,837,927...215,267,600 		JBrowse link
G Piezo1 piezo-type mechanosensitive ion channel component 1 involved_in ISO
ISS
IEA		 (PMID:20016066)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:20016066 GO_REF:0000024 GO_REF:0000107 NCBI chr19:50,544,580...50,606,812
Ensembl chr19:50,544,582...50,606,501 		JBrowse link
G Plek pleckstrin involved_in ISO
IEA		 (MGI:3844782|PMID:19190246)
GO_REF:0000107		 RGD
Ensembl		 PMID:19190246 GO_REF:0000107 MGI:3844782 NCBI chr14:91,397,015...91,429,693
Ensembl chr14:91,397,019...91,454,131 		JBrowse link
G Rap1b RAP1B, member of RAS oncogene family involved_in ISO (PMID:19461049) RGD PMID:19461049 NCBI chr 7:53,423,039...53,456,388
Ensembl chr 7:53,423,130...53,456,370 		JBrowse link
G Rasip1 Ras interacting protein 1 involved_in ISO (PMID:26780829) RGD PMID:26780829 NCBI chr 1:96,097,078...96,109,564
Ensembl chr 1:96,091,074...96,109,562 		JBrowse link
G Skap1 src kinase associated phosphoprotein 1 involved_in ISO (PMID:12652296) RGD PMID:12652296 NCBI chr10:81,425,472...81,732,651
Ensembl chr10:81,425,525...81,732,650 		JBrowse link
positive regulation of integrin activation by cell surface receptor linked signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh17 cadherin 17 involved_in ISO (PMID:25336636) RGD PMID:25336636 NCBI chr 5:25,262,820...25,314,884
Ensembl chr 5:25,262,758...25,314,884 		JBrowse link
G P2ry12 purinergic receptor P2Y12 involved_in IDA PMID:20091784 ARUK-UCL PMID:20091784 RGD:6480646 NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361 		JBrowse link
regulation of integrin activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Farp2 FERM, ARH/RhoGEF and pleckstrin domain protein 2 involved_in ISO (MGI:4844210|PMID:20702777) RGD PMID:20702777 MGI:4844210 NCBI chr 9:94,053,650...94,162,212
Ensembl chr 9:94,053,726...94,162,212 		JBrowse link
G Fblim1 filamin binding LIM protein 1 involved_in ISO (PMID:19074766) RGD PMID:19074766 NCBI chr 5:153,883,946...153,915,524
Ensembl chr 5:153,883,960...153,913,757 		JBrowse link
G Selp selectin P involved_in ISO
IEA		 (PMID:17632516)
GO_REF:0000107		 RGD
Ensembl		 PMID:17632516 GO_REF:0000107 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19748
    cellular process 18161
      cellular component organization or biogenesis 6791
        cellular component organization 6546
          cellular component assembly 3036
            protein-containing complex assembly 1596
              integrin activation 28
                negative regulation of integrin activation 3
                positive regulation of integrin activation + 13
                regulation of integrin activation + 19
paths to the root