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ONTOLOGY REPORT - ANNOTATIONS

Term:integrin activation
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Accession:GO:0033622 term browser browse the term
Definition:The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands.
Synonyms:exact_synonym: integrin complex activation;   integrin complex assembly


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integrin activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd24 CD24 molecule acts_upstream_of ISO MGI:2179996 (PMID:10601245) RGD PMID:10601245 NCBI chr20:48,655,549...48,661,786
Ensembl chr20:47,073,512...47,079,662 		JBrowse link
G Col16a1 collagen type XVI alpha 1 chain involved_in ISO
IEA		 (PMID:16754661)
GO_REF:0000107		 RGD
Ensembl		 PMID:16754661 GO_REF:0000107 NCBI chr 5:142,388,376...142,442,825
Ensembl chr 5:142,388,426...142,442,825 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:23125415)		 UniProt
Ensembl
RGD		 PMID:23125415 GO_REF:0000024 GO_REF:0000107 NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 involved_in ISO
IEA		 (PMID:29301984)
GO_REF:0000107		 RGD
Ensembl		 PMID:29301984 GO_REF:0000107 NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Fermt2 FERM domain containing kindlin 2 involved_in ISO
IEA		 (PMID:22030399)
GO_REF:0000107
(PMID:18483218)		 RGD
Ensembl		 PMID:18483218 PMID:22030399 GO_REF:0000107 NCBI chr15:21,162,603...21,257,995
Ensembl chr15:18,682,927...18,751,811 		JBrowse link
G Fermt3 FERM domain containing kindlin 3 involved_in ISO
IEA
IBA		 (PMID:19234460), (PMID:19234463)
GO_REF:0000107
(PMID:18278053), (PMID:19234461)
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:18278053 PMID:19234460 PMID:19234461 PMID:19234463 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:213,618,691...213,636,889
Ensembl chr 1:204,189,484...204,207,587 		JBrowse link
G Fn1 fibronectin 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:24658351)		 Ensembl
RGD		 PMID:24658351 GO_REF:0000107 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 involved_in ISO
IEA		 (PMID:23317506)
GO_REF:0000107
(PMID:18227284)		 RGD
Ensembl		 PMID:18227284 PMID:23317506 GO_REF:0000107 NCBI chr 6:46,549,994...46,564,735
Ensembl chr 6:40,821,339...40,836,037 		JBrowse link
G Krit1 KRIT1, ankyrin repeat containing involved_in ISO (PMID:23317506) RGD PMID:23317506 NCBI chr 4:31,253,918...31,288,066
Ensembl chr 4:30,299,203...30,333,359 		JBrowse link
G Lrp12 LDL receptor related protein 12 acts_upstream_of_or_within IEA
ISO		 GO_REF:0000107
(PMID:37330909)		 Ensembl
RGD		 PMID:37330909 GO_REF:0000107 NCBI chr 7:72,825,979...72,897,308
Ensembl chr 7:70,941,068...71,012,441 		JBrowse link
G Mzb1 marginal zone B and B1 cell-specific protein involved_in ISO
IEA
ISS		 (PMID:21093319)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:21093319 GO_REF:0000024 GO_REF:0000107 NCBI chr18:27,513,087...27,515,148
Ensembl chr18:27,239,001...27,241,094 		JBrowse link
G Tln1 talin 1 involved_in ISO
IEA		 (PMID:20150896)
GO_REF:0000107		 RGD
Ensembl		 PMID:20150896 GO_REF:0000107 NCBI chr 5:62,583,730...62,613,687
Ensembl chr 5:57,787,943...57,817,900 		JBrowse link
negative regulation of integrin activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jam3 junctional adhesion molecule 3 involved_in IEA
ISO		 GO_REF:0000107
(PMID:19461049)		 Ensembl
RGD		 PMID:19461049 GO_REF:0000107 NCBI chr 8:33,767,606...33,828,451
Ensembl chr 8:25,507,057...25,569,355 		JBrowse link
G Kif14 kinesin family member 14 acts_upstream_of_or_within ISO
IEA		 (PMID:23209302)
GO_REF:0000107		 RGD
Ensembl		 PMID:23209302 GO_REF:0000107 NCBI chr13:50,478,646...50,542,256
Ensembl chr13:47,927,044...47,989,164 		JBrowse link
G Ptger4 prostaglandin E receptor 4 involved_in ISS
ISO		 GO_REF:0000024
(PMID:21681739)		 UniProt
RGD		 PMID:21681739 GO_REF:0000024 NCBI chr 2:56,061,699...56,074,594
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
positive regulation of integrin activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd24 CD24 molecule acts_upstream_of_or_within ISO MGI:2179996 (PMID:10601245), (PMID:7534304) RGD PMID:7534304 PMID:10601245 NCBI chr20:48,655,549...48,661,786
Ensembl chr20:47,073,512...47,079,662 		JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 involved_in ISO (PMID:15972452) RGD PMID:15972452 NCBI chr14:13,912,858...13,917,920
Ensembl chr14:13,608,902...13,613,933 		JBrowse link
G Fermt1 FERM domain containing kindlin 1 involved_in ISO
IEA		 UniProtKB:Q96AC1 (PMID:21356350)
GO_REF:0000107		 RGD
Ensembl		 PMID:21356350 GO_REF:0000107 NCBI chr 3:140,624,434...140,666,419
Ensembl chr 3:120,171,561...120,213,555 		JBrowse link
G Fermt2 FERM domain containing kindlin 2 involved_in ISO
IEA		 UniProtKB:Q9BQL6 (PMID:21356350)
GO_REF:0000107		 RGD
Ensembl		 PMID:21356350 GO_REF:0000107 NCBI chr15:21,162,603...21,257,995
Ensembl chr15:18,682,927...18,751,811 		JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 IMP RGD PMID:14970114 RGD:11556214 NCBI chr 1:224,263,823...224,694,350
Ensembl chr 1:214,837,927...215,267,600 		JBrowse link
G Piezo1 piezo-type mechanosensitive ion channel component 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:20016066)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:20016066 GO_REF:0000024 GO_REF:0000107 NCBI chr19:67,453,120...67,515,347
Ensembl chr19:50,544,582...50,606,501 		JBrowse link
G Plek pleckstrin involved_in ISO
IEA		 (PMID:19190246)
GO_REF:0000107		 RGD
Ensembl		 PMID:19190246 GO_REF:0000107 NCBI chr14:95,598,650...95,631,326
Ensembl chr14:91,397,019...91,454,131 		JBrowse link
G Rap1b RAP1B, member of RAS oncogene family involved_in ISO (PMID:19461049) RGD PMID:19461049 NCBI chr 7:55,308,922...55,342,217
Ensembl chr 7:53,423,130...53,456,370 		JBrowse link
G Rasip1 Ras interacting protein 1 involved_in ISO
IEA		 (PMID:26780829)
GO_REF:0000107		 RGD
Ensembl		 PMID:26780829 GO_REF:0000107 NCBI chr 1:105,233,599...105,246,028
Ensembl chr 1:96,091,074...96,109,562 		JBrowse link
G Skap1 src kinase associated phosphoprotein 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:12652296)		 Ensembl
RGD		 PMID:12652296 GO_REF:0000107 NCBI chr10:81,921,961...82,229,106
Ensembl chr10:81,425,525...81,732,650 		JBrowse link
positive regulation of integrin activation by cell surface receptor linked signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh17 cadherin 17 involved_in ISO
IEA		 (PMID:25336636)
GO_REF:0000107		 RGD
Ensembl		 PMID:25336636 GO_REF:0000107 NCBI chr 5:30,024,544...30,112,226
Ensembl chr 5:25,262,758...25,314,884 		JBrowse link
G P2ry12 purinergic receptor P2Y12 involved_in IDA PMID:20091784 ARUK-UCL PMID:20091784 RGD:6480646 NCBI chr 2:145,631,487...145,673,194
Ensembl chr 2:143,481,430...143,523,361 		JBrowse link
regulation of integrin activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Farp2 FERM, ARH/RhoGEF and pleckstrin domain protein 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:20702777)		 Ensembl
RGD		 PMID:20702777 GO_REF:0000107 NCBI chr 9:101,501,061...101,609,092
Ensembl chr 9:94,053,726...94,162,212 		JBrowse link
G Fblim1 filamin binding LIM protein 1 involved_in ISO (PMID:19074766) RGD PMID:19074766 NCBI chr 5:159,167,004...159,198,578
Ensembl chr 5:153,883,960...153,913,757 		JBrowse link
G Selp selectin P involved_in IEA
ISO		 GO_REF:0000107
(PMID:17632516)		 Ensembl
RGD		 PMID:17632516 GO_REF:0000107 NCBI chr13:79,009,379...79,044,994
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      cellular component organization or biogenesis 7104
        cellular component organization 6817
          cellular component assembly 3214
            protein-containing complex assembly 1611
              integrin activation 28
                negative regulation of integrin activation 3
                positive regulation of integrin activation + 12
                regulation of integrin activation + 18
paths to the root