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ONTOLOGY REPORT - ANNOTATIONS


Term:membrane protein proteolysis
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Accession:GO:0033619 term browser browse the term
Definition:The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.


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membrane protein proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AFG3L2 AFG3 like matrix AAA peptidase subunit 2 ISO (PMID:22354088) UniProt PMID:22354088 NCBI chr 6:97,200,890...97,234,577 JBrowse link
G CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit IEA Ensembl GO_REF:0000107 NCBI chr 2:72,707,363...72,713,481
Ensembl chr 2:72,707,158...72,713,475
JBrowse link
G CTSH cathepsin H ISS UniProt GO_REF:0000024 NCBI chr 7:48,084,882...48,106,072
Ensembl chr 7:48,083,569...48,106,041
JBrowse link
G HM13 histocompatibility minor 13 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:35,248,575...35,288,431
Ensembl chr17:35,248,569...35,288,424
JBrowse link
G NAPSA napsin A aspartic peptidase IEA Ensembl GO_REF:0000107 NCBI chr 6:55,221,203...55,230,609
Ensembl chr 6:55,221,204...55,230,449
JBrowse link
G PARL presenilin associated rhomboid like ISO (PMID:22354088) UniProt PMID:22354088 NCBI chr13:121,758,734...121,813,679 JBrowse link
G RET ret proto-oncogene IEA Ensembl GO_REF:0000107 NCBI chr14:61,305,818...61,361,416
Ensembl chr14:61,305,841...61,361,415
JBrowse link
G RHBDD1 rhomboid domain containing 1 ISO (PMID:18953687), (PMID:22624035) UniProtKB PMID:18953687, PMID:22624035 NCBI chr15:128,346,315...128,499,151
Ensembl chr15:128,346,373...128,469,213
JBrowse link
G SPPL2A signal peptide peptidase like 2A IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:121,067,638...121,134,896
Ensembl chr 1:121,066,674...121,134,891
JBrowse link
G SPPL2B signal peptide peptidase like 2B IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:76,230,060...76,247,067
Ensembl chr 2:76,230,060...76,247,052
JBrowse link
G SPPL2C signal peptide peptidase like 2C IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:17,238,339...17,245,060
Ensembl chr12:17,240,736...17,242,823
JBrowse link
G SPPL3 signal peptide peptidase like 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:40,699,931...40,870,288
Ensembl chr14:40,699,936...40,822,761
JBrowse link
G TMPRSS6 transmembrane serine protease 6 IEA Ensembl GO_REF:0000107 NCBI chr 5:10,663,491...10,704,583
Ensembl chr 5:10,663,635...10,705,480
JBrowse link
constitutive protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM10 ADAM metallopeptidase domain 10 IEA Ensembl GO_REF:0000107 NCBI chr 1:113,289,480...113,407,940
Ensembl chr 1:113,289,197...113,413,569
JBrowse link
membrane protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM10 ADAM metallopeptidase domain 10 ISS
IBA
IEA
(PMID:21873635) UniProt
GO_Central
InterPro
PMID:21873635 GO_REF:0000002, GO_REF:0000024 NCBI chr 1:113,289,480...113,407,940
Ensembl chr 1:113,289,197...113,413,569
JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 IMP
IBA
ISS
(PMID:9034191)
(PMID:21873635)
BHF-UCL
GO_Central
UniProt
PMID:9034191, PMID:21873635 GO_REF:0000024 NCBI chr 3:126,795,513...126,853,995
Ensembl chr 3:126,795,426...126,853,995
JBrowse link
G ADAM19 ADAM metallopeptidase domain 19 IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr16:65,715,445...65,814,761
Ensembl chr16:65,715,622...65,814,760
JBrowse link
G ADAM9 ADAM metallopeptidase domain 9 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:47,523,768...47,601,722
Ensembl chr15:47,523,211...47,601,710
JBrowse link
G APH1A aph-1 homolog A, gamma-secretase subunit IEA Ensembl GO_REF:0000107 NCBI chr 4:98,817,574...98,821,255
Ensembl chr 4:98,817,627...98,925,948
JBrowse link
G BACE1 beta-secretase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:44,640,389...44,665,863
Ensembl chr 9:44,640,392...44,665,835
JBrowse link
G BACE2 beta-secretase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:204,600,740...204,720,215 JBrowse link
G DAG1 dystroglycan 1 IEA Ensembl GO_REF:0000107 NCBI chr13:32,028,019...32,092,450
Ensembl chr13:32,029,329...32,092,453
JBrowse link
G ERAP1 endoplasmic reticulum aminopeptidase 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:103,378,428...103,415,066
Ensembl chr 2:103,378,429...103,408,759
JBrowse link
G HM13 histocompatibility minor 13 NOT ISO (PMID:17965014) UniProtKB PMID:17965014 NCBI chr17:35,248,575...35,288,431
Ensembl chr17:35,248,569...35,288,424
JBrowse link
G MMP7 matrix metallopeptidase 7 ISO (PMID:23437250) ARUK-UCL PMID:23437250 NCBI chr 9:33,214,590...33,225,080
Ensembl chr 9:33,214,594...33,225,080
JBrowse link
G MYH9 myosin heavy chain 9 ISO (PMID:16186248) UniProtKB PMID:16186248 NCBI chr 5:11,365,603...11,456,475 JBrowse link
G NCSTN nicastrin IEA Ensembl GO_REF:0000107 NCBI chr 4:90,121,209...90,142,934
Ensembl chr 4:90,118,998...90,142,890
JBrowse link
G P2RX7 purinergic receptor P2X 7 IEA Ensembl GO_REF:0000107 NCBI chr14:31,415,188...31,476,502
Ensembl chr14:31,415,192...31,476,472
JBrowse link
G PRKCQ protein kinase C theta IEA Ensembl GO_REF:0000107 NCBI chr10:64,442,588...64,596,528
Ensembl chr10:64,443,251...64,600,339
JBrowse link
G PRTN3 proteinase 3 IEA Ensembl GO_REF:0000107 NCBI chr 2:77,520,314...77,526,303
Ensembl chr 2:77,520,334...77,523,419
JBrowse link
G PSEN1 presenilin 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:96,478,179...96,567,884
Ensembl chr 7:96,478,181...96,569,132
JBrowse link
G PSEN2 presenilin 2 IEA Ensembl GO_REF:0000107 NCBI chr10:14,532,556...14,561,862
Ensembl chr10:14,532,550...14,561,858
JBrowse link
G PSENEN presenilin enhancer, gamma-secretase subunit IEA Ensembl GO_REF:0000107 NCBI chr 6:45,171,825...45,174,112
Ensembl chr 6:45,171,825...45,177,203
JBrowse link
G RBMX RNA binding motif protein X-linked IEA Ensembl GO_REF:0000107 NCBI chr  X:111,965,859...111,974,544
Ensembl chr  X:111,962,632...112,011,262
JBrowse link
G SPPL2A signal peptide peptidase like 2A IEA Ensembl GO_REF:0000107 NCBI chr 1:121,067,638...121,134,896
Ensembl chr 1:121,066,674...121,134,891
JBrowse link
G SPPL2B signal peptide peptidase like 2B IEA Ensembl GO_REF:0000107 NCBI chr 2:76,230,060...76,247,067
Ensembl chr 2:76,230,060...76,247,052
JBrowse link
G SPPL2C signal peptide peptidase like 2C NOT ISO (PMID:17965014) UniProtKB PMID:17965014 NCBI chr12:17,238,339...17,245,060
Ensembl chr12:17,240,736...17,242,823
JBrowse link
G SPPL3 signal peptide peptidase like 3 NOT ISO (PMID:16829952), (PMID:17965014) UniProtKB PMID:16829952, PMID:17965014 NCBI chr14:40,699,931...40,870,288
Ensembl chr14:40,699,936...40,822,761
JBrowse link
membrane protein intracellular domain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM9 ADAM metallopeptidase domain 9 ISO (PMID:23437250) ARUK-UCL PMID:23437250 NCBI chr15:47,523,768...47,601,722
Ensembl chr15:47,523,211...47,601,710
JBrowse link
G APH1A aph-1 homolog A, gamma-secretase subunit IEA Ensembl GO_REF:0000107 NCBI chr 4:98,817,574...98,821,255
Ensembl chr 4:98,817,627...98,925,948
JBrowse link
G HM13 histocompatibility minor 13 NOT ISO (PMID:16829952) UniProtKB PMID:16829952 NCBI chr17:35,248,575...35,288,431
Ensembl chr17:35,248,569...35,288,424
JBrowse link
G MBTPS2 membrane bound transcription factor peptidase, site 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:18,013,360...18,054,250 JBrowse link
G MMP7 matrix metallopeptidase 7 ISO (PMID:23437250) ARUK-UCL PMID:23437250 NCBI chr 9:33,214,590...33,225,080
Ensembl chr 9:33,214,594...33,225,080
JBrowse link
G RHBDD1 rhomboid domain containing 1 IEA Ensembl GO_REF:0000107 NCBI chr15:128,346,315...128,499,151
Ensembl chr15:128,346,373...128,469,213
JBrowse link
G SPPL2A signal peptide peptidase like 2A IEA Ensembl
InterPro
GO_REF:0000002, GO_REF:0000107 NCBI chr 1:121,067,638...121,134,896
Ensembl chr 1:121,066,674...121,134,891
JBrowse link
G SPPL2B signal peptide peptidase like 2B IEA Ensembl
InterPro
GO_REF:0000002, GO_REF:0000107 NCBI chr 2:76,230,060...76,247,067
Ensembl chr 2:76,230,060...76,247,052
JBrowse link
G SPPL2C signal peptide peptidase like 2C NOT ISO (PMID:16829952) UniProtKB PMID:16829952 NCBI chr12:17,238,339...17,245,060
Ensembl chr12:17,240,736...17,242,823
JBrowse link
G TGFB1 transforming growth factor beta 1 ISS UniProt GO_REF:0000024 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048
JBrowse link
membrane protein proteolysis involved in retrograde protein transport, ER to cytosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HM13 histocompatibility minor 13 IEA Ensembl GO_REF:0000107 NCBI chr17:35,248,575...35,288,431
Ensembl chr17:35,248,569...35,288,424
JBrowse link
G RHBDD1 rhomboid domain containing 1 IEA Ensembl GO_REF:0000107 NCBI chr15:128,346,315...128,499,151
Ensembl chr15:128,346,373...128,469,213
JBrowse link
negative regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL10 interleukin 10 IEA Ensembl GO_REF:0000107 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,727...67,405,711
JBrowse link
G LOC110261265 metalloproteinase inhibitor 1-like IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:10,760,556...10,762,615 JBrowse link
G LRIG2 leucine rich repeats and immunoglobulin like domains 2 IEA Ensembl GO_REF:0000107 NCBI chr 4:107,348,662...107,511,308
Ensembl chr 4:107,348,662...107,493,948
JBrowse link
G PTPN3 protein tyrosine phosphatase non-receptor type 3 IEA Ensembl GO_REF:0000107 NCBI chr 1:250,418,131...250,583,148
Ensembl chr 1:250,418,132...250,583,281
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:42,103,251...42,106,289
Ensembl chr  X:42,102,172...42,106,297
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:3,254,794...3,300,835
Ensembl chr12:3,254,493...3,300,835
JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:12,185,816...12,242,599
Ensembl chr 5:12,185,816...12,242,637
JBrowse link
G TIMP4 TIMP metallopeptidase inhibitor 4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:68,179,803...68,191,199
Ensembl chr13:68,179,805...68,190,942
JBrowse link
positive regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM8 ADAM metallopeptidase domain 8 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:141,221,177...141,233,728
Ensembl chr14:141,221,197...141,232,306
JBrowse link
G ADAM9 ADAM metallopeptidase domain 9 ISO (MGI:MGI:1326990|PMID:9857183) BHF-UCL PMID:9857183 MGI:MGI:1326990 NCBI chr15:47,523,768...47,601,722
Ensembl chr15:47,523,211...47,601,710
JBrowse link
G ADRA2A adrenoceptor alpha 2A IEA Ensembl GO_REF:0000107 NCBI chr14:121,469,572...121,470,924
Ensembl chr14:121,469,527...121,470,924
JBrowse link
G APOE apolipoprotein E IEA Ensembl GO_REF:0000107 NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,259...51,377,794
JBrowse link
G APP amyloid beta precursor protein ISO (PMID:25015123) ARUK-UCL PMID:25015123 NCBI chr13:189,434,854...189,716,120
Ensembl chr13:189,434,869...189,716,057
JBrowse link
G GPLD1 glycosylphosphatidylinositol specific phospholipase D1 IEA Ensembl GO_REF:0000107 NCBI chr 7:19,289,385...19,355,606
Ensembl chr 7:19,291,174...19,346,850
JBrowse link
G IFNG interferon gamma IEA Ensembl GO_REF:0000107 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752
JBrowse link
G LOC110258578 interleukin-1 beta-like ISO (PMID:18373975) BHF-UCL PMID:18373975
G NRDC nardilysin convertase IEA Ensembl GO_REF:0000107 NCBI chr 6:160,299,101...160,388,511
Ensembl chr 6:160,299,123...160,388,763
JBrowse link
G PACSIN3 protein kinase C and casein kinase substrate in neurons 3 IEA Ensembl GO_REF:0000107 NCBI chr 2:15,380,297...15,389,893
Ensembl chr 2:15,380,763...15,389,887
JBrowse link
G RGMA repulsive guidance molecule BMP co-receptor a IEA Ensembl GO_REF:0000107 NCBI chr 7:85,921,524...85,968,887
Ensembl chr 7:85,921,586...85,968,888
JBrowse link
G SH3D19 SH3 domain containing 19 IEA Ensembl GO_REF:0000107 NCBI chr 8:77,689,393...77,876,412
Ensembl chr 8:77,689,537...77,876,673
JBrowse link
G SNX33 sorting nexin 33 IEA Ensembl GO_REF:0000107 NCBI chr 7:57,999,447...58,015,598
Ensembl chr 7:57,991,790...58,014,972
JBrowse link
G SNX9 sorting nexin 9 IEA Ensembl GO_REF:0000107 NCBI chr 1:9,130,360...9,239,023
Ensembl chr 1:9,130,334...9,239,343
JBrowse link
G TNF tumor necrosis factor IEA Ensembl GO_REF:0000107 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 6:72,195,420...72,231,146
Ensembl chr 6:72,195,435...72,231,149
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16525
    metabolic process 10566
      primary metabolic process 9375
        protein metabolic process 5290
          proteolysis 1654
            membrane protein proteolysis 57
              membrane protein ectodomain proteolysis + 47
              membrane protein intracellular domain proteolysis + 10
              membrane protein proteolysis involved in retrograde protein transport, ER to cytosol 2
Path 2
Term Annotations click to browse term
  biological_process 16525
    metabolic process 10566
      organic substance metabolic process 10016
        macromolecule metabolic process 8712
          protein metabolic process 5290
            proteolysis 1654
              membrane protein proteolysis 57
                membrane protein ectodomain proteolysis + 47
                membrane protein intracellular domain proteolysis + 10
                membrane protein proteolysis involved in retrograde protein transport, ER to cytosol 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.