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ONTOLOGY REPORT - ANNOTATIONS


Term:membrane protein proteolysis
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Accession:GO:0033619 term browser browse the term
Definition:The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.


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membrane protein proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afg3l2 AFG3-like AAA ATPase 2 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr18:67,404,764...67,449,192
Ensembl chr18:67,404,764...67,449,172
JBrowse link
G Clpp caseinolytic mitochondrial matrix peptidase proteolytic subunit ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr17:56,990,264...56,996,371
Ensembl chr17:56,990,305...56,996,188
JBrowse link
G Ctsh cathepsin H IMP
ISO
(MGI:MGI:5306315|PMID:14766755) UniProtKB
MGI
PMID:14766755 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:5306315 NCBI chr 9:90,054,267...90,076,095
Ensembl chr 9:90,054,152...90,076,089
JBrowse link
G H13 histocompatibility 13 ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 2:152,669,422...152,708,668
Ensembl chr 2:152,669,461...152,708,670
JBrowse link
G Napsa napsin A aspartic peptidase IMP
ISO
(MGI:MGI:5306315|PMID:14766755) UniProtKB
MGI
PMID:14766755 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:5306315 NCBI chr 7:44,572,445...44,586,846
Ensembl chr 7:44,572,380...44,586,862
JBrowse link
G Parl presenilin associated, rhomboid-like ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr16:20,279,820...20,302,395
Ensembl chr16:20,279,818...20,302,387
JBrowse link
G Ret ret proto-oncogene ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 6:118,151,748...118,197,744
Ensembl chr 6:118,151,745...118,197,718
JBrowse link
G Rhbdd1 rhomboid domain containing 1 ISO
ISS
(MGI:MGI:5430885|PMID:18953687), (MGI:MGI:5431154|PMID:22624035) MGI
UniProtKB
PMID:18953687, PMID:22624035 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:5430885, MGI:MGI:5431154 NCBI chr 1:82,316,457...82,445,366
Ensembl chr 1:82,316,452...82,445,366
JBrowse link
G Sppl2a signal peptide peptidase like 2A ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 2:126,890,391...126,933,791
Ensembl chr 2:126,890,391...126,933,235
JBrowse link
G Sppl2b signal peptide peptidase like 2B ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr10:80,855,242...80,868,708
Ensembl chr10:80,855,275...80,868,708
JBrowse link
G Sppl2c signal peptide peptidase 2C IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr11:104,186,327...104,191,166
Ensembl chr11:104,186,327...104,191,163
JBrowse link
G Sppl3 signal peptide peptidase 3 ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 5:115,011,524...115,098,790
Ensembl chr 5:115,011,137...115,098,790
JBrowse link
G Tmprss6 transmembrane serine protease 6 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr15:78,439,667...78,468,648
Ensembl chr15:78,439,667...78,468,634
JBrowse link
constitutive protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 a disintegrin and metallopeptidase domain 10 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 9:70,678,944...70,780,229
Ensembl chr 9:70,678,997...70,780,229
JBrowse link
membrane protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 a disintegrin and metallopeptidase domain 10 ISO
IBA
IMP
IDA
(MGI:MGI:6201960|PMID:21873635)
(MGI:MGI:6294555|PMID:29430990), (MGI:MGI:6316502|PMID:29325091), (MGI:MGI:6316556|PMID:30639848)
(MGI:MGI:6294190|PMID:17245433)
MGI
GO_Central
UniProt
PMID:17245433, PMID:21873635, PMID:29325091, PMID:29430990, PMID:30639848 GO_REF:0000008, MGI:MGI:2154458, MGI:MGI:6201960, MGI:MGI:6294190, MGI:MGI:6294555, MGI:MGI:6316502, MGI:MGI:6316556 NCBI chr 9:70,678,944...70,780,229
Ensembl chr 9:70,678,997...70,780,229
JBrowse link
G Adam17 a disintegrin and metallopeptidase domain 17 ISO
IBA
IDA
IMP
(MGI:MGI:6201960|PMID:21873635)
(MGI:MGI:5702499|PMID:26651291), (MGI:MGI:6294190|PMID:17245433)
(MGI:MGI:5702499|PMID:26651291), (MGI:MGI:85910|PMID:9034190)
RGD
GO_Central
MGI
PMID:9034190, PMID:17245433, PMID:21873635, PMID:26651291 GO_REF:0000096, MGI:MGI:4417868, MGI:MGI:4834177, MGI:MGI:5702499, MGI:MGI:6201960, MGI:MGI:6294190, MGI:MGI:85910 NCBI chr12:21,323,509...21,373,632
Ensembl chr12:21,323,509...21,373,632
JBrowse link
G Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) IMP
IBA
IDA
(MGI:MGI:3617945|PMID:14975714)
(MGI:MGI:6201960|PMID:21873635)
(MGI:MGI:3625788|PMID:11116142)
MGI
GO_Central
PMID:11116142, PMID:14975714, PMID:21873635 MGI:MGI:3617945, MGI:MGI:3625788, MGI:MGI:6201960 NCBI chr11:46,054,502...46,147,347
Ensembl chr11:46,055,992...46,147,343
JBrowse link
G Adam9 a disintegrin and metallopeptidase domain 9 (meltrin gamma) ISO
IBA
IDA
(MGI:MGI:6201960|PMID:21873635)
(MGI:MGI:3847362|PMID:19273593), (MGI:MGI:5431199|PMID:22480688)
MGI
GO_Central
UniProtKB
PMID:19273593, PMID:21873635, PMID:22480688 GO_REF:0000096, MGI:MGI:3847362, MGI:MGI:4834177, MGI:MGI:5431199, MGI:MGI:6201960 NCBI chr 8:24,949,611...25,017,040
Ensembl chr 8:24,949,611...25,016,927
JBrowse link
G Aph1a aph1 homolog A, gamma secretase subunit ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 3:95,893,921...95,898,592
Ensembl chr 3:95,893,969...95,898,288
JBrowse link
G Bace1 beta-site APP cleaving enzyme 1 ISO
IBA
IMP
(MGI:MGI:6201960|PMID:21873635)
(MGI:MGI:6316502|PMID:29325091)
MGI
GO_Central
UniProt
PMID:21873635, PMID:29325091 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960, MGI:MGI:6316502 NCBI chr 9:45,838,545...45,862,484
Ensembl chr 9:45,838,580...45,864,399
JBrowse link
G Bace2 beta-site APP-cleaving enzyme 2 ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr16:97,356,728...97,442,936
Ensembl chr16:97,356,742...97,442,936
JBrowse link
G Dag1 dystroglycan 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 9:108,204,861...108,263,977
Ensembl chr 9:108,204,634...108,263,958
JBrowse link
G Erap1 endoplasmic reticulum aminopeptidase 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr13:74,639,573...74,693,205
Ensembl chr13:74,639,568...74,693,201
JBrowse link
G H13 histocompatibility 13 NOT ISO (PMID:17965014) UniProtKB PMID:17965014 NCBI chr 2:152,669,422...152,708,668
Ensembl chr 2:152,669,461...152,708,670
JBrowse link
G Mmp7 matrix metallopeptidase 7 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 9:7,692,090...7,699,585
Ensembl chr 9:7,692,090...7,699,585
JBrowse link
G Myh9 myosin, heavy polypeptide 9, non-muscle ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr15:77,760,585...77,842,175
Ensembl chr15:77,760,587...77,842,175
JBrowse link
G Ncstn nicastrin ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 1:172,066,013...172,082,789
Ensembl chr 1:172,066,013...172,082,795
JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 IMP (MGI:MGI:3700102|PMID:17286969) MGI PMID:17286969 MGI:MGI:3700102 NCBI chr 5:122,643,927...122,692,336
Ensembl chr 5:122,643,911...122,691,432
JBrowse link
G Prkcq protein kinase C, theta IDA (MGI:MGI:1326990|PMID:9857183) BHF-UCL PMID:9857183 MGI:MGI:1326990 NCBI chr 2:11,171,905...11,301,226
Ensembl chr 2:11,172,108...11,301,222
JBrowse link
G Prtn3 proteinase 3 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr10:79,879,667...79,883,174
Ensembl chr10:79,874,476...79,883,174
JBrowse link
G Psen1 presenilin 1 ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
RGD
PMID:21873635 GO_REF:0000096, MGI:MGI:4417868, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr12:83,688,152...83,735,095
Ensembl chr12:83,688,152...83,735,199
JBrowse link
G Psen2 presenilin 2 ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 1:180,227,004...180,263,467
Ensembl chr 1:180,227,004...180,263,438
JBrowse link
G Psenen presenilin enhancer gamma secretase subunit ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 7:30,561,865...30,563,627
Ensembl chr 7:30,561,863...30,563,627
JBrowse link
G Rbmx RNA binding motif protein, X chromosome ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr  X:57,383,348...57,393,046
Ensembl chr  X:57,383,530...57,393,036
JBrowse link
G Sppl2a signal peptide peptidase like 2A ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 2:126,890,391...126,933,791
Ensembl chr 2:126,890,391...126,933,235
JBrowse link
G Sppl2b signal peptide peptidase like 2B ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr10:80,855,242...80,868,708
Ensembl chr10:80,855,275...80,868,708
JBrowse link
G Sppl2c signal peptide peptidase 2C NOT ISO (PMID:17965014) UniProtKB PMID:17965014 NCBI chr11:104,186,327...104,191,166
Ensembl chr11:104,186,327...104,191,163
JBrowse link
G Sppl3 signal peptide peptidase 3 NOT ISO (PMID:16829952), (PMID:17965014) UniProtKB PMID:16829952, PMID:17965014 NCBI chr 5:115,011,524...115,098,790
Ensembl chr 5:115,011,137...115,098,790
JBrowse link
membrane protein intracellular domain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam9 a disintegrin and metallopeptidase domain 9 (meltrin gamma) ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 8:24,949,611...25,017,040
Ensembl chr 8:24,949,611...25,016,927
JBrowse link
G Aph1a aph1 homolog A, gamma secretase subunit ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 3:95,893,921...95,898,592
Ensembl chr 3:95,893,969...95,898,288
JBrowse link
G H13 histocompatibility 13 NOT ISO (PMID:16829952) UniProtKB PMID:16829952 NCBI chr 2:152,669,422...152,708,668
Ensembl chr 2:152,669,461...152,708,670
JBrowse link
G Mbtps2 membrane-bound transcription factor peptidase, site 2 ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr  X:157,547,822...157,598,715
Ensembl chr  X:157,535,371...157,598,715
JBrowse link
G Mmp7 matrix metallopeptidase 7 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 9:7,692,090...7,699,585
Ensembl chr 9:7,692,090...7,699,585
JBrowse link
G Rhbdd1 rhomboid domain containing 1 IDA (MGI:MGI:5437551|PMID:22795130) UniProtKB PMID:22795130 MGI:MGI:5437551 NCBI chr 1:82,316,457...82,445,366
Ensembl chr 1:82,316,452...82,445,366
JBrowse link
G Sppl2a signal peptide peptidase like 2A ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 2:126,890,391...126,933,791
Ensembl chr 2:126,890,391...126,933,235
JBrowse link
G Sppl2b signal peptide peptidase like 2B ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr10:80,855,242...80,868,708
Ensembl chr10:80,855,275...80,868,708
JBrowse link
G Sppl2c signal peptide peptidase 2C NOT ISO (PMID:16829952) UniProtKB PMID:16829952 NCBI chr11:104,186,327...104,191,166
Ensembl chr11:104,186,327...104,191,163
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
membrane protein proteolysis involved in retrograde protein transport, ER to cytosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G H13 histocompatibility 13 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 2:152,669,422...152,708,668
Ensembl chr 2:152,669,461...152,708,670
JBrowse link
G Rhbdd1 rhomboid domain containing 1 IDA (MGI:MGI:5437551|PMID:22795130) ParkinsonsUK-UCL PMID:22795130 MGI:MGI:5437551 NCBI chr 1:82,316,457...82,445,366
Ensembl chr 1:82,316,452...82,445,366
JBrowse link
negative regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Lrig2 leucine-rich repeats and immunoglobulin-like domains 2 IMP (MGI:MGI:5702499|PMID:26651291) MGI PMID:26651291 MGI:MGI:5702499 NCBI chr 3:104,453,980...104,511,918
Ensembl chr 3:104,396,418...104,511,918
JBrowse link
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 4:57,190,841...57,339,040
Ensembl chr 4:57,190,841...57,301,837
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr  X:20,870,166...20,874,737
Ensembl chr  X:20,870,166...20,874,735
JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr11:118,301,061...118,355,411
Ensembl chr11:118,301,069...118,355,740
JBrowse link
G Timp3 tissue inhibitor of metalloproteinase 3 ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr10:86,300,412...86,349,505
Ensembl chr10:86,300,372...86,349,506
JBrowse link
G Timp4 tissue inhibitor of metalloproteinase 4 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 6:115,244,444...115,252,205
Ensembl chr 6:115,241,892...115,252,205
JBrowse link
positive regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam8 a disintegrin and metallopeptidase domain 8 IDA
IBA
ISO
(MGI:MGI:3040545|PMID:14761956)
(MGI:MGI:6201960|PMID:21873635)
BHF-UCL
GO_Central
MGI
PMID:14761956, PMID:21873635 GO_REF:0000096, MGI:MGI:3040545, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 7:139,978,932...139,995,207
Ensembl chr 7:139,978,932...139,992,562
JBrowse link
G Adam9 a disintegrin and metallopeptidase domain 9 (meltrin gamma) IDA (MGI:MGI:1326990|PMID:9857183) BHF-UCL PMID:9857183 MGI:MGI:1326990 NCBI chr 8:24,949,611...25,017,040
Ensembl chr 8:24,949,611...25,016,927
JBrowse link
G Adra2a adrenergic receptor, alpha 2a ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr19:54,045,259...54,048,982
Ensembl chr19:54,044,151...54,048,982
JBrowse link
G Apoe apolipoprotein E ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 7:19,696,244...19,701,310
Ensembl chr 7:19,696,109...19,699,188
JBrowse link
G App amyloid beta (A4) precursor protein ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 IDA
ISO
(MGI:MGI:5447609|PMID:17720976) UniProtKB
MGI
PMID:17720976 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:5447609 NCBI chr13:24,937,785...24,991,936
Ensembl chr13:24,943,152...24,992,501
JBrowse link
G Ifng interferon gamma ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il1b interleukin 1 beta ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Nrd1 nardilysin, N-arginine dibasic convertase, NRD convertase 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 4:109,000,655...109,061,777
Ensembl chr 4:109,000,655...109,061,777
JBrowse link
G Pacsin3 protein kinase C and casein kinase substrate in neurons 3 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 2:91,255,875...91,264,680
Ensembl chr 2:91,255,954...91,264,679
JBrowse link
G Rgma repulsive guidance molecule family member A IDA (MGI:MGI:5702499|PMID:26651291) MGI PMID:26651291 MGI:MGI:5702499 NCBI chr 7:73,375,520...73,419,899
Ensembl chr 7:73,375,509...73,419,899
JBrowse link
G Sh3d19 SH3 domain protein D19 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 3:85,970,805...86,130,526
Ensembl chr 3:85,971,109...86,130,526
JBrowse link
G Snx33 sorting nexin 33 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 9:56,917,188...56,928,442
Ensembl chr 9:56,917,193...56,928,371
JBrowse link
G Snx9 sorting nexin 9 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr17:5,841,324...5,931,956
Ensembl chr17:5,841,329...5,931,954
JBrowse link
G Tnf tumor necrosis factor ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 4:145,212,368...145,246,870
Ensembl chr 4:145,213,463...145,246,870
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23366
    metabolic process 11278
      primary metabolic process 9909
        protein metabolic process 5408
          proteolysis 1743
            membrane protein proteolysis 56
              membrane protein ectodomain proteolysis + 46
              membrane protein intracellular domain proteolysis + 10
              membrane protein proteolysis involved in retrograde protein transport, ER to cytosol 2
Path 2
Term Annotations click to browse term
  biological_process 23366
    metabolic process 11278
      organic substance metabolic process 10742
        macromolecule metabolic process 9265
          protein metabolic process 5408
            proteolysis 1743
              membrane protein proteolysis 56
                membrane protein ectodomain proteolysis + 46
                membrane protein intracellular domain proteolysis + 10
                membrane protein proteolysis involved in retrograde protein transport, ER to cytosol 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.