Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:membrane protein proteolysis
go back to main search page
Accession:GO:0033619 term browser browse the term
Definition:The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.


show annotations for term's descendants           Sort by:
 
membrane protein proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AFG3L2 AFG3 like matrix AAA peptidase subunit 2 IEA Ensembl GO_REF:0000107 NCBI chr 7:77,749,029...77,787,466
Ensembl chr 7:77,737,808...77,787,472
JBrowse link
G CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit IEA Ensembl GO_REF:0000107 NCBI chr20:53,788,114...53,794,217
Ensembl chr20:53,788,164...53,794,174
JBrowse link
G CTSH cathepsin H ISS UniProt GO_REF:0000024 NCBI chr 3:58,103,284...58,113,958
Ensembl chr 3:58,103,291...58,113,718
JBrowse link
G HM13 histocompatibility minor 13 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr24:21,026,851...21,067,773
Ensembl chr24:21,026,366...21,071,165
JBrowse link
G NAPSA napsin A aspartic peptidase ISS
IEA
UniProtKB
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr 1:106,351,842...106,361,592
Ensembl chr 1:106,318,488...106,374,987
JBrowse link
G PARL presenilin associated rhomboid like ISO (PMID:22354088) UniProt PMID:22354088 NCBI chr34:16,790,049...16,837,557
Ensembl chr34:16,781,139...16,837,545
JBrowse link
G RET ret proto-oncogene IEA Ensembl GO_REF:0000107 NCBI chr28:3,946,132...3,995,505
Ensembl chr28:3,947,232...3,994,210
JBrowse link
G RHBDD1 rhomboid domain containing 1 ISO (PMID:18953687), (PMID:22624035) UniProtKB PMID:18953687, PMID:22624035 NCBI chr25:39,719,474...39,844,634
Ensembl chr25:39,719,872...39,842,289
JBrowse link
G SPPL2A signal peptide peptidase like 2A IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr30:16,593,834...16,638,435
Ensembl chr30:16,596,967...16,745,608
JBrowse link
G SPPL2B signal peptide peptidase like 2B IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr20:56,714,306...56,730,388
Ensembl chr20:56,712,390...56,757,938
JBrowse link
G SPPL2C signal peptide peptidase like 2C IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:9,703,119...9,705,300
Ensembl chr 9:9,703,230...9,705,212
JBrowse link
G SPPL3 signal peptide peptidase like 3 IEA Ensembl GO_REF:0000107 NCBI chr26:16,620,236...16,760,616
Ensembl chr26:16,621,455...16,760,623
JBrowse link
G TMPRSS6 transmembrane serine protease 6 IEA Ensembl GO_REF:0000107 NCBI chr10:27,393,650...27,435,893
Ensembl chr10:27,397,123...27,435,908
JBrowse link
constitutive protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM10 ADAM metallopeptidase domain 10 IEA Ensembl GO_REF:0000107 NCBI chr30:23,605,724...23,732,038
Ensembl chr30:23,606,517...23,731,823
JBrowse link
membrane protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM10 ADAM metallopeptidase domain 10 IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr30:23,605,724...23,732,038
Ensembl chr30:23,606,517...23,731,823
JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:6,589,874...6,638,788
Ensembl chr17:6,589,878...6,638,731
JBrowse link
G ADAM19 ADAM metallopeptidase domain 19 IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr 4:52,650,077...52,733,299
Ensembl chr 4:52,650,162...52,729,843
JBrowse link
G ADAM9 ADAM metallopeptidase domain 9 IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr16:26,413,345...26,551,293
Ensembl chr16:26,414,583...26,551,122
JBrowse link
G APH1A aph-1 homolog A, gamma-secretase subunit IEA Ensembl GO_REF:0000107 NCBI chr17:59,510,805...59,514,431
Ensembl chr17:59,502,523...59,514,403
JBrowse link
G BACE1 beta-secretase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:16,308,953...16,319,100
Ensembl chr 5:16,308,944...16,319,100
JBrowse link
G BACE2 beta-secretase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr31:35,714,003...35,760,686
Ensembl chr31:35,713,149...35,760,681
JBrowse link
G DAG1 dystroglycan 1 IEA Ensembl GO_REF:0000107 NCBI chr20:39,707,672...39,779,094
Ensembl chr20:39,708,053...39,778,550
JBrowse link
G ERAP1 endoplasmic reticulum aminopeptidase 1 IEA Ensembl GO_REF:0000107 NCBI chr 3:12,879,823...12,920,710
Ensembl chr 3:12,879,477...12,919,634
JBrowse link
G HM13 histocompatibility minor 13 NOT ISO (PMID:17965014) UniProtKB PMID:17965014 NCBI chr24:21,026,851...21,067,773
Ensembl chr24:21,026,366...21,071,165
JBrowse link
G MMP7 matrix metallopeptidase 7 ISO (PMID:23437250) ARUK-UCL PMID:23437250 NCBI chr 5:29,187,902...29,196,157
Ensembl chr 5:29,187,851...29,196,153
JBrowse link
G MYH9 myosin heavy chain 9 ISS
IEA
UniProtKB
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr10:28,063,626...28,122,953
Ensembl chr10:28,063,624...28,122,953
JBrowse link
G NCSTN nicastrin IEA Ensembl GO_REF:0000107 NCBI chr38:21,878,071...21,891,362
Ensembl chr38:21,685,868...21,892,097
JBrowse link
G P2RX7 purinergic receptor P2X 7 IEA Ensembl GO_REF:0000107 NCBI chr26:7,928,863...7,983,956
Ensembl chr26:7,940,985...7,983,740
JBrowse link
G PRKCQ protein kinase C theta IEA Ensembl GO_REF:0000107 NCBI chr 2:29,319,123...29,505,338
Ensembl chr 2:29,318,870...29,505,337
JBrowse link
G PSEN1 presenilin 1 ISS
IEA
IBA
(PMID:21873635) UniProtKB
Ensembl
GO_Central
PMID:21873635 GO_REF:0000024, GO_REF:0000107 NCBI chr 8:46,495,551...46,569,532
Ensembl chr 8:46,495,624...46,569,532
JBrowse link
G PSEN2 presenilin 2 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 7:38,147,157...38,163,023
Ensembl chr 7:38,147,173...38,166,722
JBrowse link
G PSENEN presenilin enhancer, gamma-secretase subunit IEA Ensembl GO_REF:0000107 NCBI chr 1:116,887,155...116,888,444
Ensembl chr 1:116,886,972...116,888,458
JBrowse link
G RBMX RNA binding motif protein X-linked IEA Ensembl GO_REF:0000107 NCBI chr  X:107,173,599...107,182,404
Ensembl chr  X:107,175,634...107,182,347
JBrowse link
G SPPL2A signal peptide peptidase like 2A IEA Ensembl GO_REF:0000107 NCBI chr30:16,593,834...16,638,435
Ensembl chr30:16,596,967...16,745,608
JBrowse link
G SPPL2B signal peptide peptidase like 2B IEA Ensembl GO_REF:0000107 NCBI chr20:56,714,306...56,730,388
Ensembl chr20:56,712,390...56,757,938
JBrowse link
G SPPL2C signal peptide peptidase like 2C NOT ISO (PMID:17965014) UniProtKB PMID:17965014 NCBI chr 9:9,703,119...9,705,300
Ensembl chr 9:9,703,230...9,705,212
JBrowse link
G SPPL3 signal peptide peptidase like 3 NOT ISO (PMID:16829952), (PMID:17965014) UniProtKB PMID:16829952, PMID:17965014 NCBI chr26:16,620,236...16,760,616
Ensembl chr26:16,621,455...16,760,623
JBrowse link
membrane protein intracellular domain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM9 ADAM metallopeptidase domain 9 ISO (PMID:23437250) ARUK-UCL PMID:23437250 NCBI chr16:26,413,345...26,551,293
Ensembl chr16:26,414,583...26,551,122
JBrowse link
G APH1A aph-1 homolog A, gamma-secretase subunit IEA Ensembl GO_REF:0000107 NCBI chr17:59,510,805...59,514,431
Ensembl chr17:59,502,523...59,514,403
JBrowse link
G B9D2 B9 domain containing 2 ISO (PMID:25310401) UniProtKB PMID:25310401 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885
JBrowse link
G HM13 histocompatibility minor 13 NOT ISO (PMID:16829952) UniProtKB PMID:16829952 NCBI chr24:21,026,851...21,067,773
Ensembl chr24:21,026,366...21,071,165
JBrowse link
G LINGO3 leucine rich repeat and Ig domain containing 3 IEA InterPro GO_REF:0000002 NCBI chr20:56,755,986...56,757,919 JBrowse link
G MBTPS2 membrane bound transcription factor peptidase, site 2 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr  X:17,655,295...17,718,960
Ensembl chr  X:17,655,363...17,710,288
JBrowse link
G MMP7 matrix metallopeptidase 7 ISO (PMID:23437250) ARUK-UCL PMID:23437250 NCBI chr 5:29,187,902...29,196,157
Ensembl chr 5:29,187,851...29,196,153
JBrowse link
G RHBDD1 rhomboid domain containing 1 IEA Ensembl GO_REF:0000107 NCBI chr25:39,719,474...39,844,634
Ensembl chr25:39,719,872...39,842,289
JBrowse link
G SPPL2A signal peptide peptidase like 2A IEA InterPro
Ensembl
GO_REF:0000002, GO_REF:0000107 NCBI chr30:16,593,834...16,638,435
Ensembl chr30:16,596,967...16,745,608
JBrowse link
G SPPL2B signal peptide peptidase like 2B IEA InterPro
Ensembl
GO_REF:0000002, GO_REF:0000107 NCBI chr20:56,714,306...56,730,388
Ensembl chr20:56,712,390...56,757,938
JBrowse link
G SPPL2C signal peptide peptidase like 2C NOT ISO (PMID:16829952) UniProtKB PMID:16829952 NCBI chr 9:9,703,119...9,705,300
Ensembl chr 9:9,703,230...9,705,212
JBrowse link
G TGFB1 transforming growth factor beta 1 ISS UniProtKB GO_REF:0000024 NCBI chr 1:112,629,476...112,643,885
Ensembl chr 1:112,621,633...112,643,885
JBrowse link
membrane protein proteolysis involved in retrograde protein transport, ER to cytosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HM13 histocompatibility minor 13 IEA Ensembl GO_REF:0000107 NCBI chr24:21,026,851...21,067,773
Ensembl chr24:21,026,366...21,071,165
JBrowse link
G RHBDD1 rhomboid domain containing 1 IEA Ensembl GO_REF:0000107 NCBI chr25:39,719,474...39,844,634
Ensembl chr25:39,719,872...39,842,289
JBrowse link
negative regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL10 interleukin 10 ISS
IEA
UniProtKB
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057
JBrowse link
G LRIG2 leucine rich repeats and immunoglobulin like domains 2 IEA Ensembl GO_REF:0000107 NCBI chr17:62,487,802...62,548,883
Ensembl chr17:62,489,462...62,548,666
JBrowse link
G PTPN3 protein tyrosine phosphatase non-receptor type 3 IEA Ensembl GO_REF:0000107 NCBI chr11:64,486,293...64,595,416
Ensembl chr11:64,489,446...64,630,004
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:41,201,623...41,205,314
Ensembl chr  X:41,201,638...41,205,310
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:2,521,882...2,533,883
Ensembl chr 9:2,521,882...2,533,989
JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 ISO (PMID:18383040) BHF-UCL PMID:18383040 NCBI chr10:30,627,154...30,681,520
Ensembl chr10:30,627,154...30,694,288
JBrowse link
G TIMP4 TIMP metallopeptidase inhibitor 4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr20:6,399,522...6,405,089
Ensembl chr20:6,399,522...6,405,089
JBrowse link
positive regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM8 ADAM metallopeptidase domain 8 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr28:40,853,665...40,865,604
Ensembl chr28:40,855,509...40,863,747
JBrowse link
G ADAM9 ADAM metallopeptidase domain 9 ISO (MGI:MGI:1326990|PMID:9857183) BHF-UCL PMID:9857183 MGI:MGI:1326990 NCBI chr16:26,413,345...26,551,293
Ensembl chr16:26,414,583...26,551,122
JBrowse link
G ADRA2A adrenoceptor alpha 2A IEA Ensembl GO_REF:0000107 NCBI chr28:22,366,989...22,392,163
Ensembl chr28:22,367,780...22,370,684
JBrowse link
G APOE apolipoprotein E IEA Ensembl GO_REF:0000107 NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440
JBrowse link
G APP amyloid beta precursor protein ISO (PMID:25015123) ARUK-UCL PMID:25015123 NCBI chr31:21,351,207...21,614,466
Ensembl chr31:21,351,207...21,614,337
JBrowse link
G GPLD1 glycosylphosphatidylinositol specific phospholipase D1 IEA Ensembl GO_REF:0000107 NCBI chr35:22,495,001...22,556,264
Ensembl chr35:22,495,073...22,554,105
JBrowse link
G IFNG interferon gamma IEA Ensembl GO_REF:0000107 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698
JBrowse link
G IL1B interleukin 1 beta IEA Ensembl GO_REF:0000107 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458
JBrowse link
G NRDC nardilysin convertase IEA Ensembl GO_REF:0000107 NCBI chr15:9,413,878...9,505,355
Ensembl chr15:9,413,295...9,505,448
JBrowse link
G PACSIN3 protein kinase C and casein kinase substrate in neurons 3 IEA Ensembl GO_REF:0000107 NCBI chr18:42,378,692...42,399,225
Ensembl chr18:42,389,951...42,398,924
JBrowse link
G RGMA repulsive guidance molecule BMP co-receptor a IEA Ensembl GO_REF:0000107 NCBI chr 3:47,044,342...47,089,923
Ensembl chr 3:47,061,910...47,089,294
JBrowse link
G SH3D19 SH3 domain containing 19 IEA Ensembl GO_REF:0000107 NCBI chr15:49,076,194...49,244,691
Ensembl chr15:49,081,803...49,168,312
JBrowse link
G SNX33 sorting nexin 33 IEA Ensembl GO_REF:0000107 NCBI chr30:38,441,311...38,453,477
Ensembl chr30:38,441,305...38,450,161
JBrowse link
G SNX9 sorting nexin 9 IEA Ensembl GO_REF:0000107 NCBI chr 1:47,346,214...47,457,417
Ensembl chr 1:47,343,668...47,455,937
JBrowse link
G TNF tumor necrosis factor IEA Ensembl GO_REF:0000107 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 2:84,140,179...84,151,219
Ensembl chr 2:84,141,911...84,157,191
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16162
    metabolic process 10639
      primary metabolic process 9452
        protein metabolic process 5376
          proteolysis 1647
            membrane protein proteolysis 57
              membrane protein ectodomain proteolysis + 45
              membrane protein intracellular domain proteolysis + 12
              membrane protein proteolysis involved in retrograde protein transport, ER to cytosol 2
Path 2
Term Annotations click to browse term
  biological_process 16162
    metabolic process 10639
      organic substance metabolic process 10116
        macromolecule metabolic process 8792
          protein metabolic process 5376
            proteolysis 1647
              membrane protein proteolysis 57
                membrane protein ectodomain proteolysis + 45
                membrane protein intracellular domain proteolysis + 12
                membrane protein proteolysis involved in retrograde protein transport, ER to cytosol 2
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.