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ONTOLOGY REPORT - ANNOTATIONS


Term:membrane protein proteolysis
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Accession:GO:0033619 term browser browse the term
Definition:The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.


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membrane protein proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afg3l2 AFG3 like matrix AAA peptidase subunit 2 ISO (PMID:22354088) UniProt PMID:22354088 NCBI chrNW_004955402:1,037,414...1,069,165 JBrowse link
G Clpp caseinolytic mitochondrial matrix peptidase proteolytic subunit ISO (PMID:22354088) UniProt PMID:22354088 NCBI chrNW_004955495:3,224,968...3,233,482 JBrowse link
G Ctsh cathepsin H ISO (PMID:14766755)
(MGI:MGI:5306315|PMID:14766755)
UniProtKB PMID:14766755 MGI:MGI:5306315 NCBI chrNW_004955533:39,237...54,881 JBrowse link
G Hm13 histocompatibility minor 13 ISO (PMID:14741365) UniProtKB PMID:14741365 NCBI chrNW_004955422:29,365,722...29,408,788 JBrowse link
G Napsa napsin A aspartic peptidase ISO (PMID:14766755)
(MGI:MGI:5306315|PMID:14766755)
UniProtKB PMID:14766755 MGI:MGI:5306315 NCBI chrNW_004955559:769,555...777,970 JBrowse link
G Parl presenilin associated rhomboid like ISO (PMID:22354088) UniProt PMID:22354088 NCBI chrNW_004955420:23,549,125...23,581,782 JBrowse link
G Ret ret proto-oncogene ISO (PMID:21357690) UniProtKB PMID:21357690 NCBI chrNW_004955546:1,221,995...1,252,147 JBrowse link
G Rhbdd1 rhomboid domain containing 1 ISO (PMID:18953687), (PMID:22624035) UniProtKB PMID:18953687, PMID:22624035 NCBI chrNW_004955453:7,527,090...7,656,689 JBrowse link
G Sppl2a signal peptide peptidase like 2A ISO (PMID:2313285) UniProtKB PMID:2313285 NCBI chrNW_004955409:3,642,113...3,670,779 JBrowse link
G Sppl2b signal peptide peptidase like 2B ISO (PMID:2313285) UniProtKB PMID:2313285 NCBI chrNW_004955495:5,816,979...5,829,938 JBrowse link
G Sppl3 signal peptide peptidase like 3 ISO (PMID:2313285) UniProtKB PMID:2313285 NCBI chrNW_004955455:10,849,627...10,905,515 JBrowse link
G Tmprss6 transmembrane serine protease 6 ISO (PMID:25156943) UniProtKB PMID:25156943 NCBI chrNW_004955413:23,579,946...23,615,277 JBrowse link
constitutive protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 ADAM metallopeptidase domain 10 ISO (PMID:12714508) UniProtKB PMID:12714508 NCBI chrNW_004955450:15,853,372...15,927,966 JBrowse link
membrane protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 ADAM metallopeptidase domain 10 ISO (MGI:MGI:6294190|PMID:17245433)
(PMID:12714508), (PMID:17557115), (PMID:18355449), (PMID:18419754), (PMID:18676862), (PMID:19114711)
(PMID:17965014), (PMID:18355445), (PMID:18373975), (PMID:20711474), (PMID:24990881), (PMID:28164773), (PMID:28855301), (PMID:29430990)
(MGI:MGI:6294555|PMID:29430990), (MGI:MGI:6316502|PMID:29325091), (MGI:MGI:6316556|PMID:30639848)
UniProt
MGI
BHF-UCL
PMID:12714508, PMID:17245433, PMID:17557115, PMID:17965014, PMID:18355445, PMID:18355449, PMID:18373975, PMID:18419754, PMID:18676862, PMID:19114711, PMID:20711474, PMID:24990881, PMID:28164773, PMID:28855301, PMID:29325091, PMID:29430990, PMID:30639848 MGI:MGI:6294190, MGI:MGI:6294555, MGI:MGI:6316502, MGI:MGI:6316556 NCBI chrNW_004955450:15,853,372...15,927,966 JBrowse link
G Adam17 ADAM metallopeptidase domain 17 ISO (MGI:MGI:5702499|PMID:26651291), (MGI:MGI:85910|PMID:9034190)
(PMID:12743035), (PMID:16034137), (PMID:18373975), (PMID:21170088), (PMID:24990881), (PMID:9034191)
(PMID:9034191)
(MGI:MGI:5702499|PMID:26651291), (MGI:MGI:6294190|PMID:17245433)
(PMID:17786981), (PMID:18676862), (PMID:9034190), (PMID:9574564)
RGD
MGI
BHF-UCL
PMID:9034190, PMID:9034191, PMID:9574564, PMID:12743035, PMID:15284022, PMID:16034137, PMID:17245433, PMID:17786981, PMID:18373975, PMID:18676862, PMID:21170088, PMID:24990881, PMID:26651291 MGI:MGI:5702499, MGI:MGI:6294190, MGI:MGI:85910, RGD:2317978 NCBI chrNW_004955487:5,180,241...5,218,298 JBrowse link
G Adam19 ADAM metallopeptidase domain 19 ISO (MGI:MGI:3625788|PMID:11116142)
(MGI:MGI:3617945|PMID:14975714)
MGI PMID:11116142, PMID:14975714 MGI:MGI:3617945, MGI:MGI:3625788 NCBI chrNW_004955408:11,651,298...11,746,391 JBrowse link
G Adam9 ADAM metallopeptidase domain 9 ISO (PMID:9920899)
(PMID:22480688), (PMID:23437250)
(MGI:MGI:3847362|PMID:19273593), (MGI:MGI:5431199|PMID:22480688)
BHF-UCL
ARUK-UCL
UniProtKB
PMID:9920899, PMID:19273593, PMID:22480688, PMID:23437250 MGI:MGI:3847362, MGI:MGI:5431199 NCBI chrNW_004955463:14,545,425...14,646,498 JBrowse link
G Aph1a aph-1 homolog A, gamma-secretase subunit ISO (PMID:15274632) HGNC PMID:15274632 NCBI chrNW_004955413:506,297...509,787 JBrowse link
G Bace1 beta-secretase 1 ISO (MGI:MGI:6316502|PMID:29325091)
(PMID:18353773)
UniProt
UniProtKB
PMID:18353773, PMID:29325091 MGI:MGI:6316502 NCBI chrNW_004955412:18,596,643...18,620,089 JBrowse link
G Bace2 beta-secretase 2 ISO (PMID:21907142)
(PMID:10591213)
UniProtKB PMID:10591213, PMID:21907142 NCBI chrNW_004955407:40,792,089...40,879,872 JBrowse link
G Dag1 dystroglycan 1 ISO (PMID:19946898) UniProtKB PMID:19946898 NCBI chrNW_004955532:1,446,553...1,465,310 JBrowse link
G Erap1 endoplasmic reticulum aminopeptidase 1 ISO (PMID:12748171) UniProtKB PMID:12748171 NCBI chrNW_004955418:15,827,560...15,859,720 JBrowse link
G Hm13 histocompatibility minor 13 NOT ISO (PMID:17965014) UniProtKB PMID:17965014 NCBI chrNW_004955422:29,365,722...29,408,788 JBrowse link
G Mmp7 matrix metallopeptidase 7 ISO (PMID:23437250) ARUK-UCL PMID:23437250 NCBI chrNW_004955412:5,780,772...5,792,485 JBrowse link
G Myh9 myosin heavy chain 9 ISO (PMID:16186248) UniProtKB PMID:16186248 NCBI chrNW_004955413:22,881,759...22,972,182 JBrowse link
G Ncstn nicastrin ISO (PMID:15274632) HGNC PMID:15274632 NCBI chrNW_004955468:12,111,078...12,126,404 JBrowse link
G P2rx7 purinergic receptor P2X 7 ISO (MGI:MGI:3700102|PMID:17286969) MGI PMID:17286969 MGI:MGI:3700102 NCBI chrNW_004955482:7,048,674...7,087,525 JBrowse link
G Prkcq protein kinase C theta ISO (MGI:MGI:1326990|PMID:9857183) BHF-UCL PMID:9857183 MGI:MGI:1326990 NCBI chrNW_004955421:23,072,607...23,151,591 JBrowse link
G Psen1 presenilin 1 ISO (PMID:15274632) RGD
HGNC
PMID:15274632, PMID:17433308 RGD:1626321 NCBI chrNW_004955523:2,128,529...2,210,737 JBrowse link
G Psen2 presenilin 2 ISO (PMID:15274632) HGNC PMID:15274632 NCBI chrNW_004955406:5,727,367...5,748,798 JBrowse link
G Psenen presenilin enhancer, gamma-secretase subunit ISO (PMID:15274632) HGNC PMID:15274632 NCBI chrNW_004955468:2,805,153...2,806,573 JBrowse link
G Rbmx RNA binding motif protein X-linked ISO (PMID:18445477) UniProtKB PMID:18445477 NCBI chrNW_004955489:8,280,842...8,286,252 JBrowse link
G Sppl2a signal peptide peptidase like 2A ISO (PMID:16829951), (PMID:17965014) UniProtKB PMID:16829951, PMID:17965014 NCBI chrNW_004955409:3,642,113...3,670,779 JBrowse link
G Sppl2b signal peptide peptidase like 2B ISO (PMID:16829951), (PMID:17965014) UniProtKB PMID:16829951, PMID:17965014 NCBI chrNW_004955495:5,816,979...5,829,938 JBrowse link
G Sppl2c signal peptide peptidase like 2C NOT ISO (PMID:17965014) UniProtKB PMID:17965014 NCBI chrNW_004955478:10,368,379...10,370,624 JBrowse link
G Sppl3 signal peptide peptidase like 3 NOT ISO (PMID:16829952), (PMID:17965014) UniProtKB PMID:16829952, PMID:17965014 NCBI chrNW_004955455:10,849,627...10,905,515 JBrowse link
membrane protein intracellular domain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam9 ADAM metallopeptidase domain 9 ISO (PMID:23437250) ARUK-UCL PMID:23437250 NCBI chrNW_004955463:14,545,425...14,646,498 JBrowse link
G Aph1a aph-1 homolog A, gamma-secretase subunit ISO (PMID:12297508) UniProtKB PMID:12297508 NCBI chrNW_004955413:506,297...509,787 JBrowse link
G Hm13 histocompatibility minor 13 NOT ISO (PMID:16829952) UniProtKB PMID:16829952 NCBI chrNW_004955422:29,365,722...29,408,788 JBrowse link
G Mbtps2 membrane bound transcription factor peptidase, site 2 ISO (PMID:11163209) ParkinsonsUK-UCL PMID:11163209 NCBI chrNW_004955509:2,185,054...2,222,497 JBrowse link
G Mmp7 matrix metallopeptidase 7 ISO (PMID:23437250) ARUK-UCL PMID:23437250 NCBI chrNW_004955412:5,780,772...5,792,485 JBrowse link
G Rhbdd1 rhomboid domain containing 1 ISO (MGI:MGI:5437551|PMID:22795130) UniProtKB PMID:22795130 MGI:MGI:5437551 NCBI chrNW_004955453:7,527,090...7,656,689 JBrowse link
G Sppl2a signal peptide peptidase like 2A ISO (PMID:16829952)
(PMID:16829951), (PMID:17557115)
UniProtKB PMID:16829951, PMID:16829952, PMID:17557115 NCBI chrNW_004955409:3,642,113...3,670,779 JBrowse link
G Sppl2b signal peptide peptidase like 2B ISO (PMID:16829952), (PMID:22194595)
(PMID:16829951), (PMID:19114711)
UniProtKB PMID:16829951, PMID:16829952, PMID:19114711, PMID:22194595 NCBI chrNW_004955495:5,816,979...5,829,938 JBrowse link
G Sppl2c signal peptide peptidase like 2C NOT ISO (PMID:16829952) UniProtKB PMID:16829952 NCBI chrNW_004955478:10,368,379...10,370,624 JBrowse link
G Tgfb1 transforming growth factor beta 1 ISO (PMID:25310401) UniProtKB PMID:25310401 NCBI chrNW_004955555:274,405...288,441 JBrowse link
membrane protein proteolysis involved in retrograde protein transport, ER to cytosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hm13 histocompatibility minor 13 ISO (PMID:25239945) ParkinsonsUK-UCL PMID:25239945 NCBI chrNW_004955422:29,365,722...29,408,788 JBrowse link
G Rhbdd1 rhomboid domain containing 1 ISO (MGI:MGI:5437551|PMID:22795130) ParkinsonsUK-UCL PMID:22795130 MGI:MGI:5437551 NCBI chrNW_004955453:7,527,090...7,656,689 JBrowse link
negative regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 ISO (PMID:18383040) BHF-UCL PMID:18383040 NCBI chrNW_004955406:42,307,789...42,312,255 JBrowse link
G Lrig2 leucine rich repeats and immunoglobulin like domains 2 ISO (MGI:MGI:5702499|PMID:26651291) MGI PMID:26651291 MGI:MGI:5702499 NCBI chrNW_004955435:16,468,300...16,522,503 JBrowse link
G Ptpn3 protein tyrosine phosphatase non-receptor type 3 ISO (PMID:12207026) BHF-UCL PMID:12207026 NCBI chrNW_004955419:17,560,664...17,645,420 JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 ISO (PMID:12714508) UniProtKB PMID:12714508 NCBI chrNW_004955516:507,113...511,360 JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 ISO (PMID:18383040) BHF-UCL PMID:18383040 NCBI chrNW_004955405:41,613,976...41,655,813 JBrowse link
positive regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam8 ADAM metallopeptidase domain 8 ISO (PMID:15220135), (PMID:17548643)
(MGI:MGI:3040545|PMID:14761956)
BHF-UCL PMID:14761956, PMID:15220135, PMID:17548643 MGI:MGI:3040545 NCBI chrNW_004955477:10,894,288...10,906,961 JBrowse link
G Adam9 ADAM metallopeptidase domain 9 ISO (MGI:MGI:1326990|PMID:9857183) BHF-UCL PMID:9857183 MGI:MGI:1326990 NCBI chrNW_004955463:14,545,425...14,646,498 JBrowse link
G Adra2a adrenoceptor alpha 2A ISO (PMID:17655843) BHF-UCL PMID:17655843 NCBI chrNW_004955485:384,405...387,332 JBrowse link
G Apoe apolipoprotein E ISO (PMID:15950758)
(PMID:25015123)
BHF-UCL
ARUK-UCL
PMID:15950758, PMID:25015123 NCBI chrNW_004955555:1,998,170...2,002,003 JBrowse link
G App amyloid beta precursor protein ISO (PMID:25015123) ARUK-UCL PMID:25015123 NCBI chrNW_004955407:25,725,259...25,973,582 JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 ISO (PMID:17720976)
(MGI:MGI:5447609|PMID:17720976)
UniProtKB PMID:17720976 MGI:MGI:5447609 NCBI chrNW_004955483:2,501,751...2,552,855 JBrowse link
G Ifng interferon gamma ISO (PMID:18373975) BHF-UCL PMID:18373975 NCBI chrNW_004955458:14,643,333...14,648,020 JBrowse link
G Il1b interleukin 1 beta ISO (PMID:18373975) BHF-UCL PMID:18373975 NCBI chrNW_004955470:1,486,936...1,491,888 JBrowse link
G Nrdc nardilysin convertase ISO (PMID:18355445) BHF-UCL PMID:18355445 NCBI chrNW_004955464:7,222,948...7,298,234 JBrowse link
G Pacsin3 protein kinase C and casein kinase substrate in neurons 3 ISO (PMID:15280379) BHF-UCL PMID:15280379 NCBI chrNW_004955422:989,605...995,140 JBrowse link
G Rgma repulsive guidance molecule BMP co-receptor a ISO (MGI:MGI:5702499|PMID:26651291) MGI PMID:26651291 MGI:MGI:5702499 NCBI chrNW_004955416:21,221,023...21,261,831 JBrowse link
G Sh3d19 SH3 domain containing 19 ISO (PMID:15280379) BHF-UCL PMID:15280379 NCBI chrNW_004955471:5,724,303...5,810,868 JBrowse link
G Snx33 sorting nexin 33 ISO (PMID:18353773), (PMID:18419754) UniProtKB PMID:18353773, PMID:18419754 NCBI chrNW_004955450:2,669,993...2,682,503 JBrowse link
G Snx9 sorting nexin 9 ISO (PMID:18353773) UniProtKB PMID:18353773 NCBI chrNW_004955439:4,422,385...4,503,408 JBrowse link
G Tnf tumor necrosis factor ISO (PMID:18373975) BHF-UCL PMID:18373975 NCBI chrNW_004955437:117,267...119,899 JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO (PMID:22480688) BHF-UCL PMID:22480688 NCBI chrNW_004955486:1,790,531...1,817,986 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11860
    metabolic process 7594
      primary metabolic process 6731
        protein metabolic process 3841
          proteolysis 1052
            membrane protein proteolysis 53
              membrane protein ectodomain proteolysis + 43
              membrane protein intracellular domain proteolysis + 10
              membrane protein proteolysis involved in retrograde protein transport, ER to cytosol 2
Path 2
Term Annotations click to browse term
  biological_process 11860
    metabolic process 7594
      organic substance metabolic process 7300
        macromolecule metabolic process 6338
          protein metabolic process 3841
            proteolysis 1052
              membrane protein proteolysis 53
                membrane protein ectodomain proteolysis + 43
                membrane protein intracellular domain proteolysis + 10
                membrane protein proteolysis involved in retrograde protein transport, ER to cytosol 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.