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ONTOLOGY REPORT - ANNOTATIONS

Term:mammary gland epithelial cell proliferation
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Accession:GO:0033598 term browser browse the term
Definition:The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.


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mammary gland epithelial cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 acts_upstream_of ISO MGI:4439325|MGI:88313 (PMID:20075866) RGD PMID:20075866 NCBI chr 7:62,897,282...62,914,295
Ensembl chr 7:62,897,282...62,914,295 		JBrowse link
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase acts_upstream_of_or_within ISO MGI:3055737 (PMID:15340078) RGD PMID:15340078 NCBI chr 1:244,210,299...244,380,126
Ensembl chr 1:244,210,314...244,376,721 		JBrowse link
G Ccnd1 cyclin D1 involved_in
acts_upstream_of
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3580016 (PMID:20075866)
MGI:99484 (PMID:11747812)		 Ensembl
RGD		 PMID:11747812 PMID:20075866 GO_REF:0000107 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A acts_upstream_of ISO MGI:1926877 (PMID:15105443) RGD PMID:15105443 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2149329 (PMID:10683373)		 Ensembl
RGD		 PMID:10683373 GO_REF:0000107 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex acts_upstream_of_or_within ISO MGI:3045616|MGI:88313 (PMID:11747812) RGD PMID:11747812 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Epha2 Eph receptor A2 involved_in ISO (MGI:5284750|PMID:19321667) RGD PMID:19321667 MGI:5284750 NCBI chr 5:153,605,644...153,634,115
Ensembl chr 5:153,605,644...153,634,117 		JBrowse link
G Id2 inhibitor of DNA binding 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:2446740|PMID:12456807)		 UniProt
RGD		 PMID:12456807 GO_REF:0000024 MGI:2446740 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Iqgap3 IQ motif containing GTPase activating protein 3 acts_upstream_of ISO (PMID:18604197) RGD PMID:18604197 NCBI chr 2:173,542,151...173,583,956
Ensembl chr 2:173,542,110...173,583,956 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:18604197)		 Ensembl
RGD		 PMID:18604197 GO_REF:0000107 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Med1 mediator complex subunit 1 acts_upstream_of_or_within ISO MGI:3511276|MGI:4443002 (PMID:15843544), (PMID:20351249) RGD PMID:15843544 PMID:20351249 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299 		JBrowse link
G Phb2 prohibitin 2 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
MGI:3574361 (PMID:17065319)		 Ensembl
RGD		 PMID:17065319 GO_REF:0000107 NCBI chr 4:157,517,662...157,522,268
Ensembl chr 4:157,517,577...157,522,272 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within ISO MGI:1888385 (PMID:22588720) RGD PMID:22588720 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
G Tnfsf11 TNF superfamily member 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1859962 (PMID:11051546)		 Ensembl
RGD		 PMID:11051546 GO_REF:0000107 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
epithelial cell proliferation involved in mammary gland duct elongation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Areg amphiregulin acts_upstream_of_or_within ISO MGI:2176531 (PMID:17369357) RGD PMID:17369357 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Esr1 estrogen receptor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2150897 (PMID:12021201)		 Ensembl
RGD		 PMID:12021201 GO_REF:0000107 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Med1 mediator complex subunit 1 acts_upstream_of_or_within ISO MGI:3511276 (PMID:15647257) RGD PMID:15647257 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299 		JBrowse link
G Tfap2c transcription factor AP-2 gamma acts_upstream_of_or_within ISO MGI:3040993 (PMID:20131354) RGD PMID:20131354 NCBI chr 3:161,315,114...161,322,998
Ensembl chr 3:161,315,031...161,322,995 		JBrowse link
G Wnt5a Wnt family member 5A involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:17898001)		 Ensembl
RGD		 PMID:17898001 GO_REF:0000107 NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
negative regulation of mammary gland epithelial cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca2 BRCA2, DNA repair associated involved_in ISO
IEA		 (PMID:15930293)
GO_REF:0000107		 RGD
Ensembl		 PMID:15930293 GO_REF:0000107 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A acts_upstream_of_or_within ISO MGI:1926877 (PMID:15105443) RGD PMID:15105443 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Etv4 ETS variant transcription factor 4 acts_upstream_of_or_within ISO MGI:2445834 (PMID:18977342) RGD PMID:18977342 NCBI chr10:86,706,749...86,721,974
Ensembl chr10:86,706,749...86,721,974 		JBrowse link
G Gata3 GATA binding protein 3 involved_in ISO (PMID:19483726) RGD PMID:19483726 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Phb2 prohibitin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3574361 (PMID:17065319)		 Ensembl
RGD		 PMID:17065319 GO_REF:0000107 NCBI chr 4:157,517,662...157,522,268
Ensembl chr 4:157,517,577...157,522,272 		JBrowse link
G Robo1 roundabout guidance receptor 1 involved_in ISO (PMID:18829537) RGD PMID:18829537 NCBI chr11:10,580,863...11,621,675
Ensembl chr11:10,580,908...11,620,203 		JBrowse link
positive regulation of mammary gland epithelial cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 acts_upstream_of_or_within ISO MGI:4439325|MGI:88313 (PMID:20075866) RGD PMID:20075866 NCBI chr 7:62,897,282...62,914,295
Ensembl chr 7:62,897,282...62,914,295 		JBrowse link
G Ccnd1 cyclin D1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3580016 (PMID:20075866)		 Ensembl
RGD		 PMID:20075866 GO_REF:0000107 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Iqgap3 IQ motif containing GTPase activating protein 3 acts_upstream_of_or_within ISO (PMID:18604197) RGD PMID:18604197 NCBI chr 2:173,542,151...173,583,956
Ensembl chr 2:173,542,110...173,583,956 		JBrowse link
G Kdm5b lysine demethylase 5B acts_upstream_of_or_within ISO MGI:4329395 (PMID:24802759) RGD PMID:24802759 NCBI chr13:46,001,589...46,073,868
Ensembl chr13:46,002,542...46,073,872 		JBrowse link
G Mst1 macrophage stimulating 1 acts_upstream_of_or_within ISO MGI:2445230 (PMID:25049204) RGD PMID:25049204 NCBI chr 8:108,767,886...108,773,425
Ensembl chr 8:108,768,839...108,773,416 		JBrowse link
G Rreb1 ras responsive element binding protein 1 involved_in ISO (PMID:18394891) RGD PMID:18394891 NCBI chr17:26,876,687...27,002,554
Ensembl chr17:26,876,697...27,002,615 		JBrowse link
G Rtn4 reticulon 4 involved_in ISO
IEA		 (PMID:27353365)
GO_REF:0000107		 RGD
Ensembl		 PMID:27353365 GO_REF:0000107 NCBI chr14:103,450,074...103,497,687
Ensembl chr14:103,449,930...103,497,686 		JBrowse link
G Zfp703 zinc finger protein 703 involved_in ISO (PMID:21337521)
(MGI:4940410|PMID:21317240)		 RGD PMID:21317240 PMID:21337521 MGI:4940410 NCBI chr16:65,076,507...65,080,677
Ensembl chr16:65,076,507...65,080,677 		JBrowse link
regulation of mammary gland epithelial cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within ISO MGI:1857429 (PMID:10363969) RGD PMID:10363969 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Deaf1 DEAF1 transcription factor involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:3822223|PMID:18826651)
GO_REF:0000107
(PMID:18826651)		 UniProt
RGD
Ensembl		 PMID:18826651 GO_REF:0000024 GO_REF:0000107 MGI:3822223 NCBI chr 1:196,401,857...196,435,541
Ensembl chr 1:196,401,857...196,435,541 		JBrowse link
G Gpx1 glutathione peroxidase 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:16945136)		 Ensembl
RGD		 PMID:16945136 GO_REF:0000107 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Hoxa5 homeo box A5 acts_upstream_of_or_within ISO MGI:2150397 (PMID:16607641) RGD PMID:16607641 NCBI chr 4:81,302,341...81,306,234
Ensembl chr 4:81,302,353...81,306,234 		JBrowse link
G Pygo2 pygopus family PHD finger 2 acts_upstream_of_or_within ISO MGI:3711738 (PMID:19487454) RGD PMID:19487454 NCBI chr 2:174,849,670...174,854,758
Ensembl chr 2:174,849,936...174,854,758 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    cellular process 18812
      cell population proliferation 2308
        epithelial cell proliferation 573
          mammary gland epithelial cell proliferation 32
            epithelial cell proliferation involved in mammary gland bud elongation + 0
            epithelial cell proliferation involved in mammary gland duct elongation 5
            negative regulation of mammary gland epithelial cell proliferation 6
            positive regulation of mammary gland epithelial cell proliferation 8
            regulation of mammary gland epithelial cell proliferation + 19
Path 2
Term Annotations click to browse term
  biological_process 20413
    developmental process 7068
      anatomical structure development 6575
        animal organ development 3686
          gland development 687
            mammary gland development 205
              mammary gland epithelium development 82
                mammary gland epithelial cell proliferation 32
                  epithelial cell proliferation involved in mammary gland bud elongation + 0
                  epithelial cell proliferation involved in mammary gland duct elongation 5
                  negative regulation of mammary gland epithelial cell proliferation 6
                  positive regulation of mammary gland epithelial cell proliferation 8
                  regulation of mammary gland epithelial cell proliferation + 19
paths to the root