Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:TSC1-TSC2 complex
go back to main search page
Accession:GO:0033596 term browser browse the term
Definition:A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
Synonyms:exact_synonym: tuberin-hamartin complex;   tuberous sclerosis complex


show annotations for term's descendants           Sort by:
TSC1-TSC2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tbc1d7 TBC1 domain family, member 7 part_of ISO (PMID:22795129), (PMID:24529379), (PMID:33436626) RGD PMID:22795129 PMID:24529379 PMID:33436626 NCBI chr17:21,530,709...21,548,556
Ensembl chr17:21,531,016...21,548,553 		JBrowse link
G Tsc1 TSC complex subunit 1 is_active_in
part_of		 ISO
IEA
ISS
IBA		 (PMID:26893383)
GO_REF:0000107
GO_REF:0000024
GO_REF:0000033
(PMID:12172553), (PMID:12842888), (PMID:12906785), (PMID:22795129), (PMID:24529379), (PMID:33436626), (PMID:9580671)		 RGD
Ensembl
UniProt
GO_Central		 PMID:9580671 PMID:12172553 PMID:12842888 PMID:12906785 PMID:22795129 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:11,969,547...12,018,591
Ensembl chr 3:11,979,729...12,015,674 		JBrowse link
G Tsc2 TSC complex subunit 2 part_of IEA
ISS
ISO
IBA		 GO_REF:0000107
GO_REF:0000002
GO_REF:0000024
(MGI:7510306|PMID:12820960)
GO_REF:0000033
(PMID:12172553), (PMID:12842888), (PMID:12906785), (PMID:22795129), (PMID:24529379), (PMID:33436626), (PMID:9580671)		 Ensembl
InterPro
UniProt
RGD
GO_Central		 PMID:9580671 PMID:12172553 PMID:12820960 PMID:12842888 PMID:12906785 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:7510306 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
G Tsc2_v1 TSC complex subunit 2, variant 1 part_of ISS
IBA		 GO_REF:0000024
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033
G Tsc2_v2 TSC complex subunit 2, variant 2 part_of ISS
IBA		 GO_REF:0000024
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20814
    protein-containing complex 6438
      TSC1-TSC2 complex 5
Path 2
Term Annotations click to browse term
  cellular_component 20814
    cellular anatomical structure 20574
      intracellular anatomical structure 15185
        cytoplasm 11875
          cytosol 4233
            TSC1-TSC2 complex 5
paths to the root