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ONTOLOGY REPORT - ANNOTATIONS


Term:TSC1-TSC2 complex
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Accession:GO:0033596 term browser browse the term
Definition:A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
Synonyms:exact_synonym: tuberin-hamartin complex;   tuberous sclerosis complex



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TSC1-TSC2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tbc1d7 TBC1 domain family, member 7 located_in ISO (PMID:22795129) RGD PMID:22795129 NCBI chr17:21,530,709...21,548,556
Ensembl chr17:21,531,016...21,548,553
JBrowse link
G Tsc1 TSC complex subunit 1 part_of
located_in
IBA
ISO
PMID:21873635
(PMID:22795129)
(PMID:9580671)
RGD PMID:9580671 PMID:22795129 PMID:21873635 RGD:13792537 NCBI chr 3:11,969,547...12,018,591
Ensembl chr 3:11,979,729...12,015,674
JBrowse link
G Tsc2 TSC complex subunit 2 part_of
located_in
ISO
IEA
IBA
(PMID:9580671)
(PMID:22795129)
GO_REF:0000002
GO_REF:0000107
PMID:21873635
RGD
InterPro
Ensembl
PMID:9580671 PMID:22795129 PMID:21873635 GO_REF:0000002 GO_REF:0000107, RGD:13792537 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951
JBrowse link
G Tsc2_v1 TSC complex subunit 2, variant 1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Tsc2_v2 TSC complex subunit 2, variant 2 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19969
    protein-containing complex 6165
      TSC1-TSC2 complex 5
Path 2
Term Annotations click to browse term
  cellular_component 19969
    cellular anatomical entity 19676
      intracellular anatomical structure 14364
        cytoplasm 11373
          cytosol 4227
            TSC1-TSC2 complex 5
paths to the root