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ONTOLOGY REPORT - ANNOTATIONS


Term:TSC1-TSC2 complex
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Accession:GO:0033596 term browser browse the term
Definition:A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
Synonyms:exact_synonym: tuberin-hamartin complex;   tuberous sclerosis complex


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TSC1-TSC2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tsc1 TSC complex subunit 1 part_of IBA
ISO
PMID:21873635
(PMID:9580671)
RGD PMID:9580671, PMID:21873635 RGD:13792537 NCBI chr 3:7,219,955...7,269,063
Ensembl chr 3:7,237,192...7,265,145
JBrowse link
G Tsc2 TSC complex subunit 2 part_of ISO
IEA
IBA
(PMID:9580671)
GO_REF:0000002
GO_REF:0000107
PMID:21873635
RGD
InterPro
Ensembl
PMID:9580671, PMID:21873635 GO_REF:0000002 GO_REF:0000107, RGD:13792537 NCBI chr10:13,962,006...13,996,684
Ensembl chr10:13,961,947...13,996,584
JBrowse link
G Tsc2_v1 TSC complex subunit 2, variant 1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Tsc2_v2 TSC complex subunit 2, variant 2 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20142
    protein-containing complex 6031
      TSC1-TSC2 complex 4
Path 2
Term Annotations click to browse term
  cellular_component 20142
    cellular anatomical entity 19842
      intracellular anatomical structure 14431
        cytoplasm 11417
          cytosol 4243
            TSC1-TSC2 complex 4
paths to the root