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ONTOLOGY REPORT - ANNOTATIONS


Term:cholesterol efflux
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Accession:GO:0033344 term browser browse the term
Definition:The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
Synonyms:exact_synonym: cholesterol export


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cholesterol efflux term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 ISO UniProtKB:P02647|UniProtKB:P02649 (PMID:10431236), (PMID:11162594), (PMID:16443932), (PMID:16702602), (PMID:19556522), (PMID:23931754), (PMID:28373057)
MGI:1935192|MGI:3613250 (MGI:2675932|PMID:12869555), (MGI:3056863|PMID:15269218), (MGI:3513719|PMID:15520449), (MGI:3706212|PMID:17148552), (MGI:5427333|PMID:22179027)
RGD PMID:10431236 PMID:11162594 PMID:12869555 PMID:15269218 PMID:15520449 PMID:16443932 PMID:16702602 PMID:17148552 PMID:19556522 PMID:22179027 PMID:23931754 PMID:28373057 MGI:2675932 MGI:3056863 MGI:3513719 MGI:3706212 MGI:5427333 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abca5 ATP binding cassette subfamily A member 5 IEA
ISO
GO_REF:0000107
(MGI:4454250|PMID:20382126)
Ensembl
RGD
PMID:20382126 GO_REF:0000107 MGI:4454250 NCBI chr10:98,573,226...98,645,028
Ensembl chr10:98,576,039...98,644,938
JBrowse link
G Abca7 ATP binding cassette subfamily A member 7 ISO
IBA
IEA
ISS
(PMID:14570867)
PMID:21873635
(MGI:6271506|PMID:27472885)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
Alzheimers_University_of_Toronto
PMID:14570867 PMID:27472885, PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:6271506, RGD:13792537 NCBI chr 7:12,742,433...12,762,423
Ensembl chr 7:12,742,433...12,762,341
JBrowse link
G Abca8 ATP binding cassette subfamily A member 8 ISO (PMID:29300488) RGD PMID:29300488 NCBI chr10:98,236,919...98,308,288
Ensembl chr10:98,237,141...98,294,522
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 ISO
IBA
(PMID:15994327), (PMID:16702602), (PMID:24576892)
PMID:21873635
(MGI:3852307|PMID:16556852), (MGI:5634884|PMID:21481393)
RGD PMID:15994327 PMID:16556852 PMID:16702602 PMID:21481393 PMID:24576892, PMID:21873635 MGI:3852307 MGI:5634884, RGD:13792537 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G Abcg4 ATP binding cassette subfamily G member 4 NOT ISO
IBA
(MGI:3852307|PMID:16556852)
PMID:21873635
RGD PMID:16556852, PMID:21873635 MGI:3852307, RGD:13792537 NCBI chr 8:48,604,915...48,626,219
Ensembl chr 8:48,606,403...48,619,592
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 ISS
ISO
GO_REF:0000024
(MGI:2681374|PMID:14504269)
UniProtKB:Q99PE8 (PMID:14504269), (PMID:27144356)
UniProt
RGD
PMID:14504269 PMID:27144356 GO_REF:0000024 MGI:2681374 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 ISO UniProtKB:Q9DBM0|UniProtKB:Q9H222 (PMID:14504269), (PMID:27144356)
(MGI:2681374|PMID:14504269)
RGD PMID:14504269 PMID:27144356 MGI:2681374 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
JBrowse link
G Apoa1 apolipoprotein A1 ISO
IBA
(PMID:11162594), (PMID:12202492), (PMID:14703508), (PMID:15358760), (PMID:16443932), (PMID:21481393)
PMID:21873635
MGI:2180783 (MGI:1096304|PMID:9275209), (MGI:2176648|PMID:11744719), (MGI:2675932|PMID:12869555), (MGI:3056863|PMID:15269218), (MGI:892202|PMID:9186920)
RGD PMID:9186920 PMID:9275209 PMID:11162594 PMID:11744719 PMID:12202492 PMID:12869555 PMID:14703508 PMID:15269218 PMID:15358760 PMID:16443932 PMID:21481393, PMID:21873635 MGI:1096304 MGI:2176648 MGI:2675932 MGI:3056863 MGI:892202, RGD:13792537 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoa2 apolipoprotein A2 ISO (PMID:11162594) RGD PMID:11162594 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802
JBrowse link
G Apoa4 apolipoprotein A4 IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(PMID:11162594), (PMID:1935934)
Ensembl
RGD
PMID:1935934 PMID:11162594, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Apoa5 apolipoprotein A5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:50,559,079...50,561,720
Ensembl chr 8:50,559,126...50,561,736
JBrowse link
G Apob apolipoprotein B ISO MGI:104539 (MGI:5428098|PMID:22363685) RGD PMID:22363685 MGI:5428098 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Apoc1 apolipoprotein C1 ISO (PMID:11162594) RGD PMID:11162594 NCBI chr 1:80,606,638...80,609,921
Ensembl chr 1:80,606,638...80,609,921
JBrowse link
G Apoc2 apolipoprotein C2 ISO (PMID:11162594) RGD PMID:11162594 NCBI chr 1:80,589,023...80,593,991
Ensembl chr 1:80,589,023...80,594,136
JBrowse link
G Apoc3 apolipoprotein C3 ISO (PMID:11162594), (PMID:16443932) RGD PMID:11162594 PMID:16443932 NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498
JBrowse link
G Apoe apolipoprotein E IEA
ISO
ISS
GO_REF:0000107
MGI:2137814 (MGI:2151732|PMID:11551841), (MGI:3056863|PMID:15269218)
(PMID:11162594), (PMID:16443932), (PMID:23620513)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:11162594 PMID:11551841 PMID:15269218 PMID:16443932 PMID:23620513 GO_REF:0000024 GO_REF:0000107 MGI:2151732 MGI:3056863 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Apof apolipoprotein F ISO MGI:88052 (MGI:5428098|PMID:22363685) RGD PMID:22363685 MGI:5428098 NCBI chr 7:2,689,501...2,690,938
Ensembl chr 7:2,689,501...2,690,936
JBrowse link
G Apom apolipoprotein M ISO
IBA
(PMID:15793583), (PMID:16682745)
PMID:21873635
(MGI:3575626|PMID:15793583)
RGD PMID:15793583 PMID:16682745, PMID:21873635 MGI:3575626, RGD:13792537 NCBI chr20:5,120,473...5,123,073
Ensembl chr20:5,120,474...5,123,073
JBrowse link
G Cav1 caveolin 1 IMP RGD PMID:17499231 RGD:2289119 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 ISO (PMID:16141411)
MGI:1857409 (MGI:3706212|PMID:17148552)
RGD PMID:16141411 PMID:17148552 MGI:3706212 NCBI chr18:3,616,878...3,662,656
Ensembl chr18:3,616,878...3,662,683
JBrowse link
G Npc2 NPC intracellular cholesterol transporter 2 ISO
IBA
(PMID:16141411)
PMID:21873635
(MGI:5465528|PMID:21315718)
RGD PMID:16141411 PMID:21315718, PMID:21873635 MGI:5465528, RGD:13792537 NCBI chr 6:108,467,410...108,488,330
Ensembl chr 6:108,467,410...108,488,330
JBrowse link
G Scarb1 scavenger receptor class B, member 1 ISO
IBA
(PMID:12202492)
PMID:21873635
(MGI:3843437|PMID:14718538), (MGI:5634884|PMID:21481393)
RGD PMID:12202492 PMID:14718538 PMID:21481393, PMID:21873635 MGI:3843437 MGI:5634884, RGD:13792537 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Soat1 sterol O-acyltransferase 1 ISO
IBA
IEA
(PMID:15308631)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:15308631, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr13:74,035,258...74,077,759
Ensembl chr13:74,035,080...74,077,783
JBrowse link
G Soat2 sterol O-acyltransferase 2 ISO
IBA
IEA
(PMID:15308631)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:15308631, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 7:143,754,892...143,767,989
Ensembl chr 7:143,754,892...143,767,989
JBrowse link
G Stx12 syntaxin 12 ISO
IEA
(PMID:15469992)
GO_REF:0000107
RGD
Ensembl
PMID:15469992 GO_REF:0000107 NCBI chr 5:151,044,050...151,072,893
Ensembl chr 5:151,044,329...151,072,904
JBrowse link
G Tsku tsukushi, small leucine rich proteoglycan ISO
IEA
ISS
(MGI:6407480|PMID:31391339)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:31391339 GO_REF:0000024 GO_REF:0000107 MGI:6407480 NCBI chr 1:163,317,281...163,328,697
Ensembl chr 1:163,317,282...163,328,591
JBrowse link
negative regulation of cholesterol efflux term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 ISO (PMID:21810484) RGD PMID:21810484 NCBI chr 3:2,648,787...2,668,770
Ensembl chr 3:2,648,885...2,668,809
JBrowse link
G Apoe apolipoprotein E ISO (PMID:12042316) RGD PMID:12042316 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Egf epidermal growth factor ISO (MGI:4460848|PMID:20037141) RGD PMID:20037141 MGI:4460848 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 ISO (MGI:4411947|PMID:19752193) RGD PMID:19752193 MGI:4411947 NCBI chr  X:156,716,469...156,726,367
Ensembl chr  X:156,716,604...156,725,977
JBrowse link
G Pla2g10 phospholipase A2, group X IEA
ISO
GO_REF:0000107
(MGI:5051938|PMID:20844270)
Ensembl
RGD
PMID:20844270 GO_REF:0000107 MGI:5051938 NCBI chr10:1,509,732...1,520,970
Ensembl chr10:1,509,732...1,520,970
JBrowse link
G Shh sonic hedgehog signaling molecule IEA
ISO
GO_REF:0000107
(MGI:5306540|PMID:21931618)
Ensembl
RGD
PMID:21931618 GO_REF:0000107 MGI:5306540 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 ISO
IEA
(PMID:15358760)
GO_REF:0000107
RGD
Ensembl
PMID:15358760 GO_REF:0000107 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
positive regulation of cholesterol efflux term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 ISO (PMID:25084135)
(MGI:3047008|PMID:15210959)
RGD PMID:15210959 PMID:25084135 MGI:3047008 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abca12 ATP binding cassette subfamily A member 12 ISO (PMID:23931754)
MGI:1352463|MGI:4461044 (MGI:5510615|PMID:23931754)
RGD PMID:23931754 MGI:5510615 NCBI chr 9:78,521,477...78,693,421
Ensembl chr 9:78,522,464...78,693,028
JBrowse link
G Abca3 ATP binding cassette subfamily A member 3 ISO
ISS
(PMID:25817392)
GO_REF:0000024
RGD
UniProt
PMID:25817392 GO_REF:0000024 NCBI chr10:13,723,365...13,780,558
Ensembl chr10:13,723,405...13,779,963
JBrowse link
G Abca7 ATP binding cassette subfamily A member 7 ISS
ISO
GO_REF:0000024
(MGI:5553242|PMID:18429932)
Alzheimers_University_of_Toronto
RGD
PMID:18429932 GO_REF:0000024 MGI:5553242 NCBI chr 7:12,742,433...12,762,423
Ensembl chr 7:12,742,433...12,762,341
JBrowse link
G Abca8 ATP binding cassette subfamily A member 8 ISO
IEA
(PMID:23560799)
GO_REF:0000107
RGD
Ensembl
PMID:23560799 GO_REF:0000107 NCBI chr10:98,236,919...98,308,288
Ensembl chr10:98,237,141...98,294,522
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 ISO (MGI:3047008|PMID:15210959) RGD PMID:15210959 MGI:3047008 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO
ISS
(PMID:18703020)
GO_REF:0000024
RGD
BHF-UCL
PMID:18703020 GO_REF:0000024 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Apoa1 apolipoprotein A1 ISS
ISO
GO_REF:0000024
(PMID:27472885)
UniProt
RGD
PMID:27472885 GO_REF:0000024 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoe apolipoprotein E IEA
ISO
GO_REF:0000107
UniProtKB:P08226 (PMID:12042316), (PMID:12401887), (PMID:14754908)
Ensembl
RGD
PMID:12042316 PMID:12401887 PMID:14754908 GO_REF:0000107 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Cav1 caveolin 1 ISO
IEA
(PMID:24576892)
GO_REF:0000107
RGD
Ensembl
PMID:24576892 GO_REF:0000107 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ces1d carboxylesterase 1D ISO (PMID:16971496), (PMID:18599737), (PMID:18762277) RGD PMID:16971496 PMID:18599737 PMID:18762277 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Eepd1 endonuclease/exonuclease/phosphatase family domain containing 1 ISO (PMID:28082258)
(MGI:6162611|PMID:28082258)
RGD PMID:28082258 MGI:6162611 NCBI chr 8:26,651,241...26,758,330
Ensembl chr 8:26,652,121...26,758,325
JBrowse link
G Gps2 G protein pathway suppressor 2 ISO (PMID:19481530) RGD PMID:19481530 NCBI chr10:56,524,327...56,527,447
Ensembl chr10:56,524,468...56,526,987
JBrowse link
G Lrp1 LDL receptor related protein 1 ISO (MGI:4358638|PMID:19718435) RGD PMID:19718435 MGI:4358638 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
JBrowse link
G Nfkbia NFKB inhibitor alpha ISO (PMID:16938301) RGD PMID:16938301 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 ISO (PMID:17186944)
MGI:2676312 (MGI:3720271|PMID:17657314), (MGI:3794353|PMID:16825483), (MGI:5510615|PMID:23931754)
RGD PMID:16825483 PMID:17186944 PMID:17657314 PMID:23931754 MGI:3720271 MGI:3794353 MGI:5510615 NCBI chr 1:100,554,577...100,559,896
Ensembl chr 1:100,554,544...100,559,942
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:3794353|PMID:16825483)
(PMID:16141411), (PMID:17186944), (PMID:19481530)
UniProt
Ensembl
RGD
PMID:16141411 PMID:16825483 PMID:17186944 PMID:19481530 GO_REF:0000024 GO_REF:0000107 MGI:3794353 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Pltp phospholipid transfer protein ISO (PMID:24369175) RGD PMID:24369175 NCBI chr 3:161,304,469...161,322,289
Ensembl chr 3:161,304,469...161,322,289
JBrowse link
G Pon1 paraoxonase 1 ISO (PMID:15721011) RGD PMID:15721011 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Ptch1 patched 1 ISO (PMID:21931618) RGD PMID:21931618 NCBI chr17:1,032,242...1,085,885
Ensembl chr17:1,029,048...1,093,873
JBrowse link
G Sirt1 sirtuin 1 ISO (MGI:3790014|PMID:17936707) RGD PMID:17936707 MGI:3790014 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Zdhhc8 zinc finger DHHC-type palmitoyltransferase 8 ISO (PMID:19556522) RGD PMID:19556522 NCBI chr11:86,903,122...86,917,261
Ensembl chr11:86,903,122...86,915,715
JBrowse link
regulation of cholesterol efflux term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8 ATP binding cassette subfamily A member 8 ISO (PMID:28882873) RGD PMID:28882873 NCBI chr10:98,236,919...98,308,288
Ensembl chr10:98,237,141...98,294,522
JBrowse link
G Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 ISO
ISS
(PMID:20544018)
GO_REF:0000024
RGD
UniProt
PMID:20544018 GO_REF:0000024 NCBI chr 1:166,991,474...166,997,045
Ensembl chr 1:166,991,474...166,997,045
JBrowse link
G LOC100361543 RhoA activator C11orf59-like ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr  X:37,261,428...37,262,470
Ensembl chr 1:166,991,474...166,997,045
JBrowse link
G Naxe NAD(P)HX epimerase ISS
ISO
GO_REF:0000024
ZFIN:ZDB-MRPHLNO-130813-3 (PMID:23719382)
UniProt
RGD
PMID:23719382 GO_REF:0000024 NCBI chr 2:187,424,319...187,426,410
Ensembl chr 2:187,424,327...187,426,375
JBrowse link
G Ttc39b tetratricopeptide repeat domain 39B ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(MGI:5800596|PMID:27383786)
UniProt
RGD
PMID:27383786, PMID:21873635 GO_REF:0000024 MGI:5800596, RGD:13792537 NCBI chr 5:101,304,982...101,405,689
Ensembl chr 5:101,304,982...101,405,656
JBrowse link
G Ttc39d tetratricopeptide repeat domain 39D IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:2,886,764...2,895,118
Ensembl chr 6:2,886,764...2,895,118
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20045
    localization 6483
      macromolecule localization 3105
        lipid localization 531
          lipid transport 479
            sterol transport 115
              cholesterol transport 101
                cholesterol efflux 53
                  negative regulation of cholesterol efflux 7
                  positive regulation of cholesterol efflux 22
                  regulation of cholesterol efflux + 33
Path 2
Term Annotations click to browse term
  biological_process 20045
    localization 6483
      establishment of localization 4908
        transport 4745
          ion transport 3509
            anion transport 2693
              organic substance transport 2569
                lipid transport 479
                  sterol transport 115
                    cholesterol transport 101
                      cholesterol efflux 53
                        negative regulation of cholesterol efflux 7
                        positive regulation of cholesterol efflux 22
                        regulation of cholesterol efflux + 33
paths to the root