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ONTOLOGY REPORT - ANNOTATIONS


Term:Leydig cell differentiation
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Accession:GO:0033327 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis.


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Leydig cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor ISO
IEA
MGI:MGI:3717246 (MGI:MGI:4430676|PMID:19574395)
GO_REF:0000107
RGD
Ensembl
PMID:19574395 GO_REF:0000107, MGI:MGI:4430676 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Ccnd1 cyclin D1 IMP RGD PMID:17303663 RGD:2289137 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 IEP RGD PMID:18502897 RGD:4781870 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 IEP RGD PMID:18502897 RGD:4781870 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Dhh desert hedgehog signaling molecule ISO MGI:MGI:1095403|MGI:MGI:1934259 (MGI:MGI:2450504|PMID:12050120), (MGI:MGI:3769860|PMID:17495005) RGD PMID:12050120, PMID:17495005 MGI:MGI:2450504, MGI:MGI:3769860 NCBI chr 7:140,575,288...140,580,783
Ensembl chr 7:140,575,288...140,580,783
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 IEP RGD PMID:12810569 RGD:2302236 NCBI chr  X:21,696,796...21,699,241
Ensembl chr  X:21,696,772...21,699,241
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 IEP RGD PMID:18502897 RGD:4781870 NCBI chr17:1,579,319...1,610,745
Ensembl chr17:1,579,319...1,610,745
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 IEP RGD PMID:18502897 RGD:4781870
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 IEP RGD PMID:18502897 RGD:4781870 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
JBrowse link
G Map7 microtubule-associated protein 7 ISO MGI:MGI:2148221 (MGI:MGI:1859100|PMID:10837026) RGD PMID:10837026 MGI:MGI:1859100 NCBI chr 1:15,620,665...15,748,203
Ensembl chr 1:15,620,653...15,748,203
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 IEP RGD PMID:15149725 RGD:2302287 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Nkx2-1 NK2 homeobox 1 ISO
IEA
MGI:MGI:1857494 (MGI:MGI:2445907|PMID:12399445)
GO_REF:0000107
RGD
Ensembl
PMID:12399445 GO_REF:0000107, MGI:MGI:2445907 NCBI chr 6:77,418,096...77,423,383
Ensembl chr 6:77,418,096...77,421,286
JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 ISO
IEA
MGI:MGI:2159321 (MGI:MGI:2150593|PMID:11564714)
GO_REF:0000107
RGD
Ensembl
PMID:11564714 GO_REF:0000107, MGI:MGI:2150593 NCBI chr  X:54,734,385...54,738,513
Ensembl chr  X:54,734,385...54,738,513
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha ISO
IEA
MGI:MGI:2449440|MGI:MGI:3689423 (MGI:MGI:3820330|PMID:19056881)
GO_REF:0000107
RGD
Ensembl
PMID:19056881 GO_REF:0000107, MGI:MGI:3820330 NCBI chr14:35,527,926...35,581,130
Ensembl chr14:35,527,927...35,581,031
JBrowse link
G Plekha1 pleckstrin homology domain containing A1 ISO MGI:MGI:3526857 (MGI:MGI:3820330|PMID:19056881) RGD PMID:19056881 MGI:MGI:3820330 NCBI chr 1:201,429,716...201,481,411
Ensembl chr 1:201,429,771...201,480,877
JBrowse link
G Sf1 splicing factor 1 ISO MGI:MGI:94891 (MGI:MGI:3769860|PMID:17495005) RGD PMID:17495005 MGI:MGI:3769860 NCBI chr 1:221,735,512...221,749,216
Ensembl chr 1:221,735,517...221,749,086
JBrowse link
G Sgpl1 sphingosine-1-phosphate lyase 1 ISO MGI:MGI:3526851 (MGI:MGI:3820330|PMID:19056881) RGD PMID:19056881 MGI:MGI:3820330 NCBI chr20:30,699,936...30,769,178
Ensembl chr20:30,699,872...30,749,940
JBrowse link
G Tmf1 TATA element modulatory factor 1 ISO MGI:MGI:4867392 (MGI:MGI:5469555|PMID:23000399) RGD PMID:23000399 MGI:MGI:5469555 NCBI chr 4:129,521,986...129,546,024
Ensembl chr 4:129,521,991...129,544,506
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    developmental process 6827
      developmental process involved in reproduction 1189
        Leydig cell differentiation 18
Path 2
Term Annotations click to browse term
  biological_process 20028
    developmental process 6827
      anatomical structure development 6269
        multicellular organism development 5744
          system development 5280
            reproductive system development 593
              reproductive structure development 588
                gonad development 326
                  male gonad development 202
                    Leydig cell differentiation 18
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.