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ONTOLOGY REPORT - ANNOTATIONS


Term:iron import into cell
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Accession:GO:0033212 term browser browse the term
Definition:The directed movement of iron ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis.
Synonyms:narrow_synonym: ferrous ion import;   ferrous iron import;   ferrous iron uptake
 related_synonym: iron assimilation
 alt_id: GO:0070627



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iron import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc11a2 solute carrier family 11 member 2 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000107
(PMID:17109629)
MGI:1856400 (MGI:3691553|PMID:11739192)
(MGI:3037617|PMID:15024413)
PMID:21873635
Ensembl
RGD
PMID:11739192 PMID:15024413 PMID:17109629 PMID:21873635 GO_REF:0000107 MGI:3037617 MGI:3691553, RGD:13792537 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
JBrowse link
G Slc39a14 solute carrier family 39 member 14 involved_in ISO (PMID:20682781)
(MGI:6392986|PMID:20682781)
RGD PMID:20682781 MGI:6392986 NCBI chr15:45,376,806...45,423,549
Ensembl chr15:45,376,917...45,423,524
JBrowse link
G Steap3 STEAP3 metalloreductase acts_upstream_of_or_within ISO (MGI:3807452|PMID:16609065) RGD PMID:16609065 MGI:3807452 NCBI chr13:31,351,954...31,397,344
Ensembl chr13:31,351,954...31,396,519
JBrowse link
G Steap4 STEAP4 metalloreductase acts_upstream_of_or_within ISO (MGI:3807452|PMID:16609065) RGD PMID:16609065 MGI:3807452 NCBI chr 4:26,077,182...26,099,859
Ensembl chr 4:26,054,671...26,099,859
JBrowse link
endocytic iron import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tfr2 transferrin receptor 2 involved_in IBA
ISO
PMID:21873635
UniProtKB:P02787|UniProtKB:Q07891 (PMID:18353247)
RGD PMID:18353247 PMID:21873635 RGD:13792537 NCBI chr12:19,107,673...19,124,622
Ensembl chr12:19,107,673...19,124,591
JBrowse link
iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hfe homeostatic iron regulator involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502
JBrowse link
G Slc39a8 solute carrier family 39 member 8 involved_in ISO
IDA
(PMID:22898811)
(MGI:6383325|PMID:30015240)
RGD PMID:22898811 PMID:30015240 PMID:22898811 MGI:6383325, RGD:15090842 NCBI chr 2:224,171,787...224,319,326
Ensembl chr 2:224,256,654...224,319,129
JBrowse link
G Steap2 STEAP2 metalloreductase acts_upstream_of_or_within ISO (MGI:3807452|PMID:16609065) RGD PMID:16609065 MGI:3807452 NCBI chr 4:28,347,769...28,368,177
Ensembl chr 4:28,348,362...28,375,791
JBrowse link
negative regulation of iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Iscu iron-sulfur cluster assembly enzyme involved_in ISO (PMID:20436681) RGD PMID:20436681 NCBI chr12:42,852,305...42,858,150
Ensembl chr12:42,852,305...42,858,150
JBrowse link
positive regulation of iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in ISO (MGI:6304699|PMID:29061364) RGD PMID:29061364 MGI:6304699 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Lcn2 lipocalin 2 IDA RGD PMID:25557118 RGD:126790477 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Mir210 microRNA 210 involved_in ISO (PMID:20436681) RGD PMID:20436681 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454
JBrowse link
G Slc6a9 solute carrier family 6 member 9 acts_upstream_of ISO (MGI:6450351|PMID:28495915) RGD PMID:28495915 MGI:6450351 NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20099
    localization 5650
      cellular localization 3595
        establishment of localization in cell 2294
          iron import into cell 13
            endocytic iron import into cell + 1
            ferric-enterobactin import into cell 0
            heme import into cell + 0
            iron ion import across plasma membrane + 8
            reductive iron assimilation 0
            siderophore-dependent iron import into cell + 0
Path 2
Term Annotations click to browse term
  biological_process 20099
    biological regulation 13928
      regulation of biological quality 4234
        homeostatic process 1943
          chemical homeostasis 1222
            ion homeostasis 688
              cellular ion homeostasis 565
                cellular cation homeostasis 547
                  cellular metal ion homeostasis 474
                    cellular transition metal ion homeostasis 130
                      cellular iron ion homeostasis 87
                        iron import into cell 13
                          endocytic iron import into cell + 1
                          ferric-enterobactin import into cell 0
                          heme import into cell + 0
                          iron ion import across plasma membrane + 8
                          reductive iron assimilation 0
                          siderophore-dependent iron import into cell + 0
paths to the root