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ONTOLOGY REPORT - ANNOTATIONS


Term:iron import into cell
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Accession:GO:0033212 term browser browse the term
Definition:The directed movement of iron ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis.
Synonyms:narrow_synonym: ferrous ion import;   ferrous iron import;   ferrous iron uptake
 related_synonym: iron assimilation
 alt_id: GO:0070627


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iron import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc11a2 solute carrier family 11 member 2 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000107
MGI:1856400 (MGI:3691553|PMID:11739192)
(MGI:3037617|PMID:15024413)
PMID:21873635
(PMID:17109629)
Ensembl
RGD
PMID:11739192 PMID:15024413 PMID:17109629, PMID:21873635 GO_REF:0000107 MGI:3037617 MGI:3691553, RGD:13792537 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Slc39a14 solute carrier family 39 member 14 involved_in ISO (PMID:20682781)
(MGI:6392986|PMID:20682781)
RGD PMID:20682781 MGI:6392986 NCBI chr15:51,982,872...52,029,841
Ensembl chr15:51,982,982...52,029,816
JBrowse link
G Steap3 STEAP3 metalloreductase acts_upstream_of_or_within ISO (MGI:3807452|PMID:16609065) RGD PMID:16609065 MGI:3807452 NCBI chr13:36,257,220...36,274,144
Ensembl chr13:36,257,112...36,290,531
JBrowse link
G Steap4 STEAP4 metalloreductase acts_upstream_of_or_within ISO (MGI:3807452|PMID:16609065) RGD PMID:16609065 MGI:3807452 NCBI chr 4:23,112,682...23,135,354
Ensembl chr 4:23,090,029...23,135,354
JBrowse link
endocytic iron import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tfr2 transferrin receptor 2 involved_in IBA
ISO
PMID:21873635
UniProtKB:P02787|UniProtKB:Q07891 (PMID:18353247)
RGD PMID:18353247, PMID:21873635 RGD:13792537 NCBI chr12:22,177,382...22,194,330
Ensembl chr12:22,177,382...22,194,299
JBrowse link
iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hfe homeostatic iron regulator involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985
JBrowse link
G Slc39a8 solute carrier family 39 member 8 involved_in ISO
IDA
(PMID:22898811)
(MGI:6383325|PMID:30015240)
RGD PMID:22898811 PMID:30015240, PMID:22898811 MGI:6383325, RGD:15090842 NCBI chr 2:241,028,851...241,092,584
Ensembl chr 2:241,029,693...241,092,582
JBrowse link
G Steap2 STEAP2 metalloreductase acts_upstream_of_or_within ISO (MGI:3807452|PMID:16609065) RGD PMID:16609065 MGI:3807452 NCBI chr 4:25,506,604...25,527,088
Ensembl chr 4:25,507,463...25,527,087
JBrowse link
negative regulation of iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Iscu iron-sulfur cluster assembly enzyme involved_in ISO (PMID:20436681) RGD PMID:20436681 NCBI chr12:48,621,454...48,627,297
Ensembl chr12:48,621,454...48,627,297
JBrowse link
positive regulation of iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in ISO (MGI:6304699|PMID:29061364) RGD PMID:29061364 MGI:6304699 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Lcn2 lipocalin 2 IDA RGD PMID:25557118 RGD:126790477 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Slc6a9 solute carrier family 6 member 9 acts_upstream_of ISO (MGI:6450351|PMID:28495915) RGD PMID:28495915 MGI:6450351 NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    localization 6443
      cellular localization 2990
        establishment of localization in cell 2184
          iron import into cell 12
            endocytic iron import into cell 1
            ferric-enterobactin import into cell 0
            heme import into cell + 0
            iron ion import across plasma membrane + 7
            reductive iron assimilation 0
            regulation of iron ion import into cell by regulation of transcription from RNA polymerase II promoter 0
            siderophore-dependent iron import into cell + 0
Path 2
Term Annotations click to browse term
  biological_process 19491
    biological regulation 13515
      regulation of biological quality 4175
        homeostatic process 1988
          chemical homeostasis 1353
            ion homeostasis 870
              cellular ion homeostasis 739
                cellular cation homeostasis 723
                  cellular metal ion homeostasis 656
                    cellular transition metal ion homeostasis 123
                      cellular iron ion homeostasis 81
                        iron import into cell 12
                          endocytic iron import into cell 1
                          ferric-enterobactin import into cell 0
                          heme import into cell + 0
                          iron ion import across plasma membrane + 7
                          reductive iron assimilation 0
                          regulation of iron ion import into cell by regulation of transcription from RNA polymerase II promoter 0
                          siderophore-dependent iron import into cell + 0
paths to the root