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ONTOLOGY REPORT - ANNOTATIONS

Term:calmodulin-dependent protein phosphatase activity
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Accession:GO:0033192 term browser browse the term
Definition:Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin.
Synonyms:exact_synonym: calcium- and calmodulin-dependent protein phosphatase activity;   calcium/calmodulin-dependent protein phosphatase activity
 narrow_synonym: calcineurin activity
 related_synonym: Ca2+/CaM-dependent protein phosphatase activity
 xref: reactome:R-HSA-2730849 "Calcineurin binds and dephosphorylates NFAT";   reactome:R-HSA-4551451 "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling"


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calmodulin-dependent protein phosphatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A enables IDA (PMID:11559703) UniProt PMID:11559703 NCBI chr14:60,245,750...60,299,087
Ensembl chr14:60,245,752...60,299,087 		JBrowse link
G PPM1F protein phosphatase, Mg2+/Mn2+ dependent 1F enables IDA (PMID:11559703), (PMID:15140879) UniProt PMID:11559703 PMID:15140879 NCBI chr22:21,919,425...21,952,848
Ensembl chr22:21,919,425...21,952,848 		JBrowse link
G PPP3CA protein phosphatase 3 catalytic subunit alpha enables IEA
IBA
IDA
IMP
TAS		 (PMID:18815128), (PMID:19154138), (PMID:23468591), (PMID:30718414)
(PMID:30254215)
(PMID:2556704)		 Ensembl
TreeGrafter
GO_Central
UniProt
InterPro		 PMID:2556704 PMID:18815128 PMID:19154138 PMID:23468591 PMID:30254215 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:101,023,418...101,347,526
Ensembl chr 4:101,023,409...101,348,278 		JBrowse link
G PPP3CB protein phosphatase 3 catalytic subunit beta enables ISS
IEA
IBA
IDA
TAS		 (PMID:19154138), (PMID:25720963), (PMID:26794871), (PMID:32753672)
(PMID:2556704)		 UniProt
TreeGrafter
GO_Central
Ensembl
InterPro		 PMID:2556704 PMID:19154138 PMID:25720963 PMID:26794871 PMID:32753672 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr10:73,436,433...73,496,024
Ensembl chr10:73,436,433...73,496,024 		JBrowse link
G PPP3CC protein phosphatase 3 catalytic subunit gamma enables IEA
IDA
IBA		 (PMID:19154138) InterPro
UniProt
GO_Central		 PMID:19154138 GO_REF:0000002 GO_REF:0000033 NCBI chr 8:22,441,078...22,541,125
Ensembl chr 8:22,440,819...22,541,142 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19566
    catalytic activity 5977
      catalytic activity, acting on a protein 2452
        phosphoprotein phosphatase activity 194
          protein serine/threonine phosphatase activity 112
            calcium-dependent protein serine/threonine phosphatase activity 8
              calmodulin-dependent protein phosphatase activity 5
Path 2
Term Annotations click to browse term
  molecular_function 19566
    catalytic activity 5977
      hydrolase activity 2627
        hydrolase activity, acting on ester bonds 844
          phosphoric ester hydrolase activity 395
            phosphatase activity 298
              phosphoprotein phosphatase activity 194
                protein serine/threonine phosphatase activity 112
                  calcium-dependent protein serine/threonine phosphatase activity 8
                    calmodulin-dependent protein phosphatase activity 5
paths to the root