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ONTOLOGY REPORT - ANNOTATIONS


Term:V(D)J recombination
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Accession:GO:0033151 term browser browse the term
Definition:The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).
Synonyms:exact_synonym: V(D)J joining;   V-J joining;   V-J recombination
 xref: Wikipedia:V(D)J_recombination


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V(D)J recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATM ATM serine/threonine kinase JBrowse link 11 106,584,228 106,728,457 RGD:9068941
G DCAF1 DDB1 and CUL4 associated factor 1 JBrowse link 3 52,560,427 52,668,919 RGD:9068941
G DCLRE1C DNA cross-link repair 1C JBrowse link 10 15,229,515 15,625,331 RGD:9068941
G HMGB1 high mobility group box 1 JBrowse link 13 30,173,875 30,179,527 RGD:9068941
G HMGB2 high mobility group box 2 JBrowse link 4 177,797,457 177,800,952 RGD:9068941
G LIG1 DNA ligase 1 JBrowse link 19 53,706,778 53,761,088 RGD:9068941
G LIG3 DNA ligase 3 JBrowse link 17 22,073,487 22,097,754 RGD:9068941
G LIG4 DNA ligase 4 JBrowse link 13 108,474,718 108,485,421 RGD:9068941
G RAG1 recombination activating 1 JBrowse link 11 36,356,483 36,418,891 RGD:9068941
G RAG2 recombination activating 2 JBrowse link 11 36,431,067 36,437,390 RGD:9068941
immunoglobulin heavy chain V-D-J recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G POLB DNA polymerase beta JBrowse link 8 39,026,991 39,060,464 RGD:9068941
immunoglobulin V(D)J recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LIG4 DNA ligase 4 JBrowse link 13 108,474,718 108,485,421 RGD:9068941
G PRKDC protein kinase, DNA-activated, catalytic subunit JBrowse link 8 41,593,022 41,778,299 RGD:9068941
G TCF3 transcription factor 3 JBrowse link 19 1,582,297 1,622,025 RGD:9068941
G XRCC4 X-ray repair cross complementing 4 JBrowse link 5 32,246,959 32,521,724 RGD:9068941
T cell receptor V(D)J recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BCL11B BAF chromatin remodeling complex subunit BCL11B JBrowse link 14 99,122,231 99,205,962 RGD:9068941
G LEF1 lymphoid enhancer binding factor 1 JBrowse link 4 111,125,312 111,245,980 RGD:9068941
G LIG4 DNA ligase 4 JBrowse link 13 108,474,718 108,485,421 RGD:9068941
G PRKDC protein kinase, DNA-activated, catalytic subunit JBrowse link 8 41,593,022 41,778,299 RGD:9068941
G TCF7 transcription factor 7 JBrowse link 5 135,671,630 135,704,417 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15758
    immune system process 2763
      somatic diversification of immune receptors 75
        somatic diversification of immune receptors via germline recombination within a single locus 67
          V(D)J recombination 17
            T cell receptor V(D)J recombination 5
            immunoglobulin V(D)J recombination + 5
Path 2
Term Annotations click to browse term
  biological_process 15758
    metabolic process 10722
      cellular metabolic process 9943
        cellular aromatic compound metabolic process 5409
          nucleobase-containing compound metabolic process 5212
            nucleic acid metabolic process 4710
              DNA metabolic process 906
                DNA recombination 288
                  somatic cell DNA recombination 67
                    somatic diversification of immune receptors via germline recombination within a single locus 67
                      V(D)J recombination 17
                        T cell receptor V(D)J recombination 5
                        immunoglobulin V(D)J recombination + 5
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.