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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of glucokinase activity
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Accession:GO:0033131 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule.
Synonyms:narrow_synonym: glucokinase regulator


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negative regulation of glucokinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cox11 cytochrome c oxidase copper chaperone COX11 acts_upstream_of_or_within ISO (MGI:3693040|PMID:17069463) RGD PMID:17069463 MGI:3693040 NCBI chr10:75,458,735...75,465,322
Ensembl chr10:75,458,749...75,465,322
JBrowse link
G Foxa2 forkhead box A2 involved_in ISO (MGI:5142372|PMID:11875061) RGD PMID:11875061 MGI:5142372 NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
JBrowse link
G Gckr glucokinase regulator involved_in
acts_upstream_of_or_within
IDA
ISO
IBA
PMID:14627435
MGI:2386670 (MGI:1354534|PMID:10713097)
PMID:21873635
(PMID:14627435), (PMID:23621087)
RGD PMID:10713097 PMID:14627435 PMID:23621087 PMID:14627435 PMID:21873635 MGI:1354534, RGD:1598592, RGD:13792537 NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
JBrowse link
G Midn midnolin acts_upstream_of_or_within IDA PMID:24187134 MGI PMID:24187134 RGD:8655525 NCBI chr 7:9,548,100...9,559,605
Ensembl chr 7:9,549,650...9,559,752
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(PMID:24187134)
ParkinsonsUK-UCL
RGD
PMID:24187134 GO_REF:0000024 NCBI chr 1:48,688,651...49,882,520 JBrowse link
positive regulation of glucokinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death involved_in ISS
ISO
GO_REF:0000024
(MGI:3778846|PMID:18223655)
UniProt
RGD
PMID:18223655 GO_REF:0000024 MGI:3778846 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Dusp12 dual specificity phosphatase 12 involved_in IDA
IBA
increases glucokinase activity by direct dephosphorylation
PMID:21873635
RGD
GO_Central
PMID:10913113 PMID:21873635 RGD:68242, RGD:13792537 NCBI chr13:83,122,192...83,131,800
Ensembl chr13:83,122,193...83,131,285
JBrowse link
G Gckr glucokinase regulator involved_in ISO (MGI:1354534|PMID:10713097) RGD PMID:10713097 MGI:1354534 NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
JBrowse link
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 IMP RGD PMID:15047617 RGD:2302684 NCBI chr  X:19,508,522...19,562,165
Ensembl chr  X:19,508,546...19,562,182
JBrowse link
G Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 IDA RGD PMID:16980436 RGD:2304071 NCBI chr13:42,147,473...42,174,699
Ensembl chr13:42,147,478...42,174,699
JBrowse link
G Ranbp2 RAN binding protein 2 acts_upstream_of_or_within ISO (MGI:3693040|PMID:17069463) RGD PMID:17069463 MGI:3693040 NCBI chr20:26,442,156...26,493,481
Ensembl chr20:26,442,217...26,493,481
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19494
    metabolic process 11798
      small molecule metabolic process 1791
        regulation of small molecule metabolic process 372
          regulation of glucose metabolic process 135
            regulation of glucokinase activity 10
              negative regulation of glucokinase activity 5
              positive regulation of glucokinase activity 6
Path 2
Term Annotations click to browse term
  biological_process 19494
    biological regulation 13507
      regulation of biological process 12763
        regulation of metabolic process 6742
          regulation of cellular metabolic process 5893
            regulation of phosphorus metabolic process 1476
              regulation of phosphate metabolic process 1475
                regulation of phosphorylation 1323
                  regulation of kinase activity 785
                    regulation of hexokinase activity 11
                      regulation of glucokinase activity 10
                        negative regulation of glucokinase activity 5
                        positive regulation of glucokinase activity 6
paths to the root