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ONTOLOGY REPORT - ANNOTATIONS


Term:Weibel-Palade body
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Accession:GO:0033093 term browser browse the term
Definition:A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses.
Synonyms:xref: Wikipedia:Weibel-Palade_body


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Weibel-Palade body term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ece1 endothelin converting enzyme 1 JBrowse link 5 156,215,469 156,318,652 RGD:1624291
RGD:1600115
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:8662311
G Rab27a RAB27A, member RAS oncogene family JBrowse link 8 79,722,334 79,776,228 RGD:10047177
G Unc13d unc-13 homolog D JBrowse link 10 104,613,907 104,628,664 RGD:1600115
RGD:1624291
G Vwf von Willebrand factor JBrowse link 4 158,085,059 158,219,525 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19644
    cellular anatomical entity 19270
      endomembrane system 3811
        secretory granule 392
          Weibel-Palade body 5
Path 2
Term Annotations click to browse term
  cellular_component 19644
    cellular anatomical entity 19270
      organelle 12422
        membrane-bounded organelle 10803
          vesicle 1929
            intracellular vesicle 1786
              cytoplasmic vesicle 1781
                secretory vesicle 645
                  secretory granule 392
                    Weibel-Palade body 5
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.