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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of T cell differentiation in thymus
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Accession:GO:0033085 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: negative regulation of thymic T cell differentiation;   negative regulation of thymocyte cell differentiation;   negative regulation of thymocyte differentiation
 related_synonym: negative regulation of T cell development in thymus



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negative regulation of T cell differentiation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in ISO (PMID:12421925) RGD PMID:12421925 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Foxj1 forkhead box J1 involved_in ISO (MGI:3713603|PMID:16339515) RGD PMID:16339515 MGI:3713603 NCBI chr10:101,566,299...101,570,249
Ensembl chr10:101,566,304...101,570,237
JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in ISO (MGI:3836494|PMID:19109233) RGD PMID:19109233 MGI:3836494 NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532
JBrowse link
G Nfkbid NFKB inhibitor delta acts_upstream_of_or_within ISO (MGI:2177878|PMID:11931770) RGD PMID:11931770 MGI:2177878 NCBI chr 1:85,679,353...85,690,415
Ensembl chr 1:85,680,861...85,690,447
JBrowse link
G Rag2 recombination activating 2 IMP RGD PMID:30206106 RGD:38508903 NCBI chr 3:87,902,373...87,910,227
Ensembl chr 3:87,902,238...87,911,066
JBrowse link
G Shh sonic hedgehog signaling molecule acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1888832|PMID:10981962)
GO_REF:0000107
RGD
Ensembl
PMID:10981962 GO_REF:0000107 MGI:1888832 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Zc3h8 zinc finger CCCH type containing 8 involved_in ISO (PMID:12153508) RGD PMID:12153508 NCBI chr 3:116,176,779...116,193,752
Ensembl chr 3:116,176,798...116,193,787
JBrowse link
negative regulation of immature T cell proliferation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:12421925)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:12421925 GO_REF:0000024 GO_REF:0000107 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A involved_in ISO (MGI:3615850|PMID:15964995) RGD PMID:15964995 MGI:3615850 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Clec4g C-type lectin domain family 4, member G acts_upstream_of_or_within ISO MGI:5510586 (MGI:5475030|PMID:23487419) RGD PMID:23487419 MGI:5475030 NCBI chr12:1,780,370...1,785,027
Ensembl chr12:1,780,371...1,784,985
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 acts_upstream_of_or_within ISO (MGI:3695084|PMID:16230479) RGD PMID:16230479 MGI:3695084 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in ISO (MGI:3836494|PMID:19109233) RGD PMID:19109233 MGI:3836494 NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532
JBrowse link
G Tmem131l transmembrane 131 like involved_in ISO (PMID:23690469) RGD PMID:23690469 NCBI chr 2:169,257,659...169,391,773
Ensembl chr 2:169,258,289...169,391,711
JBrowse link
negative regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:5320871|PMID:22080863)
UniProt
RGD
PMID:22080863 GO_REF:0000024 MGI:5320871 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20094
    immune system process 2562
      leukocyte activation 1033
        lymphocyte activation 845
          lymphocyte differentiation 436
            T cell differentiation 311
              T cell differentiation in thymus 104
                negative regulation of T cell differentiation in thymus 12
                  negative regulation of immature T cell proliferation in thymus 6
                  negative regulation of positive thymic T cell selection 1
Path 2
Term Annotations click to browse term
  biological_process 20094
    cellular process 18691
      cellular developmental process 4636
        cell differentiation 4613
          cell development 3213
            hemopoiesis 1027
              leukocyte differentiation 647
                mononuclear cell differentiation 495
                  lymphocyte differentiation 436
                    T cell differentiation 311
                      T cell differentiation in thymus 104
                        regulation of T cell differentiation in thymus 28
                          negative regulation of T cell differentiation in thymus 12
                            negative regulation of immature T cell proliferation in thymus 6
                            negative regulation of positive thymic T cell selection 1
paths to the root