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ONTOLOGY REPORT - ANNOTATIONS

Term:T cell differentiation in thymus
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Accession:GO:0033077 term browser browse the term
Definition:The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: thymic T cell differentiation;   thymocyte cell differentiation;   thymocyte differentiation
 related_synonym: T cell development in thymus


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T cell differentiation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of ISO MGI:1857117|MGI:2683027 (MGI:3620422|PMID:12163459), (MGI:3640996|PMID:11435465), (MGI:3690682|PMID:11067867), (MGI:3774231|PMID:16670300) RGD PMID:11067867 PMID:11435465 PMID:12163459 PMID:16670300 MGI:3620422 MGI:3640996 MGI:3690682 MGI:3774231 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 involved_in ISO (MGI:3828349|PMID:17371977) RGD PMID:17371977 MGI:3828349 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Apc APC regulator of WNT signaling pathway acts_upstream_of_or_within ISO MGI:3589207 (MGI:3588595|PMID:16025118) RGD PMID:16025118 MGI:3588595 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G B2m beta-2 microglobulin acts_upstream_of_or_within ISO MGI:95663 (MGI:3817343|PMID:18776904) RGD PMID:18776904 MGI:3817343 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766 		JBrowse link
G Bcl11b BCL11 transcription factor B acts_upstream_of_or_within ISO MGI:2663971 (MGI:3774202|PMID:16670294) RGD PMID:16670294 MGI:3774202 NCBI chr 6:126,834,531...126,927,720
Ensembl chr 6:126,834,531...126,928,224 		JBrowse link
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within ISO MGI:2156165 (MGI:2156164|PMID:8170972), (MGI:85476|PMID:9028316) RGD PMID:8170972 PMID:9028316 MGI:2156164 MGI:85476 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase acts_upstream_of_or_within ISO MGI:3711006 (MGI:5473721|PMID:23334952) RGD PMID:23334952 MGI:5473721 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Cd3e CD3 epsilon subunit of T-cell receptor complex IEP RGD PMID:11896936 RGD:2313407 NCBI chr 8:45,303,848...45,315,297
Ensembl chr 8:45,303,852...45,315,022 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 acts_upstream_of_or_within ISO MGI:3833563|MGI:5141514 (MGI:5140640|PMID:21508411) RGD PMID:21508411 MGI:5140640 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Ctnnb1 catenin beta 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:1858008 (MGI:3588595|PMID:16025118)
GO_REF:0000107		 RGD
Ensembl		 PMID:16025118 GO_REF:0000107 MGI:3588595 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 acts_upstream_of_or_within ISO MGI:2448686|MGI:3040717 (MGI:3580938|PMID:15879105) RGD PMID:15879105 MGI:3580938 NCBI chr10:10,855,510...10,880,175
Ensembl chr10:10,854,732...10,880,161 		JBrowse link
G Fadd Fas associated via death domain involved_in ISO
ISS		 (MGI:5291865|PMID:21876153)
GO_REF:0000024		 RGD
UniProt		 PMID:21876153 GO_REF:0000024 MGI:5291865 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fzd5 frizzled class receptor 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:1929591|PMID:11265645)		 Ensembl
RGD		 PMID:11265645 GO_REF:0000107 MGI:1929591 NCBI chr 9:66,117,370...66,119,127
Ensembl chr 9:66,113,112...66,121,457 		JBrowse link
G Fzd7 frizzled class receptor 7 acts_upstream_of_or_within ISO (MGI:1929591|PMID:11265645) RGD PMID:11265645 MGI:1929591 NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781 		JBrowse link
G Fzd8 frizzled class receptor 8 acts_upstream_of_or_within ISO (MGI:1929591|PMID:11265645) RGD PMID:11265645 MGI:1929591 NCBI chr17:57,312,924...57,320,551
Ensembl chr17:57,314,450...57,320,650 		JBrowse link
G Gata3 GATA binding protein 3 acts_upstream_of_or_within ISO MGI:2153825|MGI:2683927|MGI:4418042|MGI:88127 (MGI:2682543|PMID:14670303), (MGI:3817343|PMID:18776904), (MGI:4415096|PMID:19934022), (MGI:84497|PMID:8945476) RGD PMID:8945476 PMID:14670303 PMID:18776904 PMID:19934022 MGI:2682543 MGI:3817343 MGI:4415096 MGI:84497 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Gba glucosylceramidase beta acts_upstream_of_or_within ISO (MGI:5429097|PMID:22665763) RGD PMID:22665763 MGI:5429097 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263 		JBrowse link
G Gli3 GLI family zinc finger 3 acts_upstream_of_or_within ISO MGI:1856276 (MGI:3695957|PMID:15855276) RGD PMID:15855276 MGI:3695957 NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma acts_upstream_of ISO MGI:1857455|MGI:2429736 (MGI:1095961|PMID:9252128), (MGI:1327709|PMID:9916699) RGD PMID:9252128 PMID:9916699 MGI:1095961 MGI:1327709 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Il7r interleukin 7 receptor acts_upstream_of ISO MGI:1857198 (MGI:893320|PMID:9215626) RGD PMID:9215626 MGI:893320 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757 		JBrowse link
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase acts_upstream_of_or_within ISO MGI:3043930 (MGI:3042820|PMID:14715629) RGD PMID:14715629 MGI:3042820 NCBI chr10:102,041,131...102,047,182
Ensembl chr10:102,041,120...102,047,182 		JBrowse link
G Mafb MAF bZIP transcription factor B acts_upstream_of_or_within ISO MGI:3663168 (MGI:3839521|PMID:19164599) RGD PMID:19164599 MGI:3839521 NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031 		JBrowse link
G Mpzl2 myelin protein zero-like 2 acts_upstream_of_or_within ISO (MGI:4367133|PMID:19851463) RGD PMID:19851463 MGI:4367133 NCBI chr 8:45,348,285...45,359,298
Ensembl chr 8:45,348,285...45,359,298 		JBrowse link
G Mr1 major histocompatibility complex, class I-related involved_in ISO
IEA		 (MGI:3664456|PMID:12634786)
GO_REF:0000107		 RGD
Ensembl		 PMID:12634786 GO_REF:0000107 MGI:3664456 NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970 		JBrowse link
G Ncaph2 non-SMC condensin II complex, subunit H2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3710093 (MGI:3717964|PMID:17640884)		 Ensembl
RGD		 PMID:17640884 GO_REF:0000107 MGI:3717964 NCBI chr 7:120,422,926...120,439,942
Ensembl chr 7:120,422,956...120,439,938 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 acts_upstream_of_or_within ISO MGI:2677822 (MGI:1926554|PMID:11030619) RGD PMID:11030619 MGI:1926554 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032 		JBrowse link
G Nfkbid NFKB inhibitor delta acts_upstream_of ISO (MGI:2177878|PMID:11931770) RGD PMID:11931770 MGI:2177878 NCBI chr 1:85,679,353...85,690,415
Ensembl chr 1:85,680,861...85,690,447 		JBrowse link
G Nkap NFKB activating protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3765313|MGI:4839023 (MGI:4838711|PMID:20610818)		 Ensembl
RGD		 PMID:20610818 GO_REF:0000107 MGI:4838711 NCBI chr  X:116,373,031...116,392,677
Ensembl chr  X:116,372,839...116,394,945 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within ISO MGI:2383951 (MGI:1290043|PMID:9768755) RGD PMID:9768755 MGI:1290043 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Prr7 proline rich 7 (synaptic) involved_in ISO MGI:4399196 (MGI:5816780|PMID:27657535) RGD PMID:27657535 MGI:5816780 NCBI chr17:9,164,375...9,173,669
Ensembl chr17:9,165,269...9,172,536 		JBrowse link
G Psmb11 proteasome subunit beta 11 acts_upstream_of_or_within ISO (MGI:6392185|PMID:31915251) RGD PMID:31915251 MGI:6392185 NCBI chr15:28,081,148...28,087,326 JBrowse link
G Rabl3 RAB, member of RAS oncogene family-like 3 involved_in ISO (MGI:6405642|PMID:32220963) RGD PMID:32220963 MGI:6405642 NCBI chr11:63,153,281...63,182,240
Ensembl chr11:63,152,792...63,182,671 		JBrowse link
G Rag1 recombination activating 1 involved_in
acts_upstream_of_or_within		 ISO (MGI:50458|PMID:1547488)
MGI:2448994 (MGI:893318|PMID:9215624)		 RGD PMID:1547488 PMID:9215624 MGI:50458 MGI:893318 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291 		JBrowse link
G Rag2 recombination activating 2 involved_in ISO (MGI:50458|PMID:1547488) RGD PMID:1547488 MGI:50458 NCBI chr 3:87,902,373...87,910,227
Ensembl chr 3:87,902,238...87,911,066 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISO
ISS		 UniProtKB:Q61160 (MGI:5291865|PMID:21876153)
GO_REF:0000024		 RGD
UniProt		 PMID:21876153 GO_REF:0000024 MGI:5291865 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Rorc RAR-related orphan receptor C acts_upstream_of_or_within ISO MGI:3026635 (MGI:3047471|PMID:15247480) RGD PMID:15247480 MGI:3047471 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
G Rps6 ribosomal protein S6 acts_upstream_of_or_within ISO MGI:2387471|MGI:98834 (MGI:3610868|PMID:16357222) RGD PMID:16357222 MGI:3610868 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in
acts_upstream_of		 ISO
ISS		 (MGI:3847177|PMID:19273836)
(MGI:1888832|PMID:10981962)
GO_REF:0000024		 RGD
UniProt		 PMID:10981962 PMID:19273836 GO_REF:0000024 MGI:1888832 MGI:3847177 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO MGI:103035 (MGI:3054293|PMID:15294943) RGD PMID:15294943 MGI:3054293 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:103036 (MGI:3054293|PMID:15294943)		 Ensembl
RGD		 PMID:15294943 GO_REF:0000107 MGI:3054293 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Tcf3 transcription factor 3 acts_upstream_of_or_within ISO MGI:2178112 (MGI:3829828|PMID:18958875) RGD PMID:18958875 MGI:3829828 NCBI chr 7:9,280,571...9,302,315
Ensembl chr 7:9,280,571...9,302,314 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO MGI:98159 (MGI:3610868|PMID:16357222) RGD PMID:16357222 MGI:3610868 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Wnt1 Wnt family member 1 acts_upstream_of_or_within ISO (MGI:1929591|PMID:11265645) RGD PMID:11265645 MGI:1929591 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651 		JBrowse link
G Wnt4 Wnt family member 4 acts_upstream_of_or_within ISO (MGI:1929591|PMID:11265645) RGD PMID:11265645 MGI:1929591 NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859 		JBrowse link
G Zbtb1 zinc finger and BTB domain containing 1 acts_upstream_of_or_within ISO MGI:5300200 (MGI:5300225|PMID:22201126) RGD PMID:22201126 MGI:5300225 NCBI chr 6:95,096,838...95,125,811
Ensembl chr 6:95,096,387...95,118,996 		JBrowse link
G Zfp36l1 zinc finger protein 36, C3H type-like 1 involved_in ISO
ISS		 UniProtKB:P23949 (MGI:4818820|PMID:20622884)
GO_REF:0000024		 RGD
UniProt		 PMID:20622884 GO_REF:0000024 MGI:4818820 NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748 		JBrowse link
G Zfp36l2 zinc finger protein 36, C3H type-like 2 involved_in ISO UniProtKB:P23950 (MGI:4818820|PMID:20622884) RGD PMID:20622884 MGI:4818820 NCBI chr 6:10,490,032...10,494,073
Ensembl chr 6:10,490,032...10,494,064 		JBrowse link
DN2 thymocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr6 C-C motif chemokine receptor 6 involved_in ISO (MGI:5784970|PMID:24638065) RGD PMID:24638065 MGI:5784970 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603 		JBrowse link
G Lig4 DNA ligase 4 acts_upstream_of_or_within ISO MGI:1857732 (MGI:1312981|PMID:9823897), (MGI:1860400|PMID:10911993) RGD PMID:9823897 PMID:10911993 MGI:1312981 MGI:1860400 NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040 		JBrowse link
G Rag2 recombination activating 2 acts_upstream_of_or_within ISO MGI:1858556 (MGI:1913213|PMID:9875844) RGD PMID:9875844 MGI:1913213 NCBI chr 3:87,902,373...87,910,227
Ensembl chr 3:87,902,238...87,911,066 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO MGI:1926771 (MGI:1913213|PMID:9875844) RGD PMID:9875844 MGI:1913213 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
DN3 thymocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr6 C-C motif chemokine receptor 6 involved_in ISO (MGI:5784970|PMID:24638065) RGD PMID:24638065 MGI:5784970 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603 		JBrowse link
DN4 thymocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:87860 (MGI:4399009|PMID:18025176) RGD PMID:18025176 MGI:4399009 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:87859 (MGI:4399009|PMID:18025176) RGD PMID:18025176 MGI:4399009 NCBI chr13:68,673,702...68,839,742
Ensembl chr13:68,673,722...68,839,742 		JBrowse link
G Blm BLM RecQ like helicase acts_upstream_of_or_within ISO MGI:3053044|MGI:3663359 (MGI:3700903|PMID:17210642) RGD PMID:17210642 MGI:3700903 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312 		JBrowse link
immature T cell proliferation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blm BLM RecQ like helicase acts_upstream_of ISO MGI:3053044|MGI:3663359 (MGI:3700903|PMID:17210642) RGD PMID:17210642 MGI:3700903 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312 		JBrowse link
G Clec4g C-type lectin domain family 4, member G acts_upstream_of ISO MGI:5510586 (MGI:5475030|PMID:23487419) RGD PMID:23487419 MGI:5475030 NCBI chr12:1,780,370...1,785,027
Ensembl chr12:1,780,371...1,784,985 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 acts_upstream_of ISO (MGI:3695084|PMID:16230479) RGD PMID:16230479 MGI:3695084 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of ISO MGI:1857034 (MGI:3695084|PMID:16230479) RGD PMID:16230479 MGI:3695084 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Ifnar2 interferon alpha and beta receptor subunit 2 acts_upstream_of_or_within ISO (MGI:1929548|PMID:11154225) RGD PMID:11154225 MGI:1929548 NCBI chr11:30,613,576...30,645,958
Ensembl chr11:30,613,767...30,668,124 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of ISO MGI:2660793 (MGI:2176422|PMID:11894098) RGD PMID:11894098 MGI:2176422 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G Wnt4 Wnt family member 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857453 (MGI:3803049|PMID:18617424)		 Ensembl
RGD		 PMID:18617424 GO_REF:0000107 MGI:3803049 NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859 		JBrowse link
negative regulation of immature T cell proliferation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:12421925)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:12421925 GO_REF:0000024 GO_REF:0000107 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A involved_in ISO (MGI:3615850|PMID:15964995) RGD PMID:15964995 MGI:3615850 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Clec4g C-type lectin domain family 4, member G acts_upstream_of_or_within ISO MGI:5510586 (MGI:5475030|PMID:23487419) RGD PMID:23487419 MGI:5475030 NCBI chr12:1,780,370...1,785,027
Ensembl chr12:1,780,371...1,784,985 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 acts_upstream_of_or_within ISO (MGI:3695084|PMID:16230479) RGD PMID:16230479 MGI:3695084 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in ISO (MGI:3836494|PMID:19109233) RGD PMID:19109233 MGI:3836494 NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532 		JBrowse link
G Tmem131l transmembrane 131 like involved_in ISO (PMID:23690469) RGD PMID:23690469 NCBI chr 2:169,257,659...169,391,773
Ensembl chr 2:169,258,289...169,391,711 		JBrowse link
negative regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5320871|PMID:22080863)		 UniProt
RGD		 PMID:22080863 GO_REF:0000024 MGI:5320871 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
negative regulation of T cell differentiation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in ISO (PMID:12421925) RGD PMID:12421925 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Foxj1 forkhead box J1 involved_in ISO (MGI:3713603|PMID:16339515) RGD PMID:16339515 MGI:3713603 NCBI chr10:101,566,299...101,570,249
Ensembl chr10:101,566,304...101,570,237 		JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in ISO (MGI:3836494|PMID:19109233) RGD PMID:19109233 MGI:3836494 NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532 		JBrowse link
G Nfkbid NFKB inhibitor delta acts_upstream_of_or_within ISO (MGI:2177878|PMID:11931770) RGD PMID:11931770 MGI:2177878 NCBI chr 1:85,679,353...85,690,415
Ensembl chr 1:85,680,861...85,690,447 		JBrowse link
G Rag2 recombination activating 2 IMP RGD PMID:30206106 RGD:38508903 NCBI chr 3:87,902,373...87,910,227
Ensembl chr 3:87,902,238...87,911,066 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:1888832|PMID:10981962)		 Ensembl
RGD		 PMID:10981962 GO_REF:0000107 MGI:1888832 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Zc3h8 zinc finger CCCH type containing 8 involved_in ISO (PMID:12153508) RGD PMID:12153508 NCBI chr 3:116,176,779...116,193,752
Ensembl chr 3:116,176,798...116,193,787 		JBrowse link
negative thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aire autoimmune regulator acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:1277186 (MGI:5488556|PMID:23382543)
PMID:21873635		 RGD PMID:23382543 PMID:21873635 MGI:5488556, RGD:13792537 NCBI chr20:10,636,058...10,651,060
Ensembl chr20:10,636,123...10,651,060 		JBrowse link
G Atg5 autophagy related 5 acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:1338803|MGI:3612279 (MGI:5488556|PMID:23382543)
GO_REF:0000107		 RGD
Ensembl		 PMID:23382543 GO_REF:0000107 MGI:5488556 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 involved_in ISO (MGI:3847607|PMID:17785582) RGD PMID:17785582 MGI:3847607 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309 		JBrowse link
G Cd28 Cd28 molecule acts_upstream_of_or_within ISO MGI:1857150 (MGI:1340173|PMID:10429671) RGD PMID:10429671 MGI:1340173 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685 		JBrowse link
G Cd3e CD3 epsilon subunit of T-cell receptor complex acts_upstream_of_or_within ISO (MGI:75253|PMID:7630421) RGD PMID:7630421 MGI:75253 NCBI chr 8:45,303,848...45,315,297
Ensembl chr 8:45,303,852...45,315,022 		JBrowse link
G Cd74 CD74 molecule acts_upstream_of_or_within ISO MGI:1927205 (MGI:52620|PMID:7679955) RGD PMID:7679955 MGI:52620 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Dock2 dedicator of cytokinesis 2 acts_upstream_of_or_within ISO MGI:2152031 (MGI:2668308|PMID:12871644) RGD PMID:12871644 MGI:2668308 NCBI chr10:18,827,237...19,244,823
Ensembl chr10:18,827,239...19,244,808 		JBrowse link
G Fas Fas cell surface death receptor acts_upstream_of_or_within ISO MGI:1856334 (MGI:1340173|PMID:10429671) RGD PMID:10429671 MGI:1340173 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Gli3 GLI family zinc finger 3 involved_in ISO (MGI:4355451|PMID:19667090) RGD PMID:19667090 MGI:4355451 NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712 		JBrowse link
G Mink1 misshapen-like kinase 1 acts_upstream_of_or_within ISO (MGI:3521627|PMID:15608642) RGD PMID:15608642 MGI:3521627 NCBI chr10:55,278,293...55,330,782
Ensembl chr10:55,278,391...55,330,782 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO MGI:1857277 (MGI:80946|PMID:8666928) RGD PMID:8666928 MGI:80946 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in ISO
ISS
IEA		 (MGI:3834308|PMID:17227833)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:17227833 GO_REF:0000024 GO_REF:0000107 MGI:3834308 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Spn sialophorin acts_upstream_of_or_within ISO MGI:1857246 (MGI:1340173|PMID:10429671) RGD PMID:10429671 MGI:1340173 NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628 		JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 acts_upstream_of_or_within ISO MGI:2677447 (MGI:75253|PMID:7630421) RGD PMID:7630421 MGI:75253 NCBI chr 9:38,989,750...39,011,701
Ensembl chr 9:38,989,750...39,011,700 		JBrowse link
positive regulation of immature T cell proliferation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blm BLM RecQ like helicase acts_upstream_of_or_within ISO MGI:3053044|MGI:3663359 (MGI:3700903|PMID:17210642) RGD PMID:17210642 MGI:3700903 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312 		JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger involved_in ISO (MGI:3615850|PMID:15964995) RGD PMID:15964995 MGI:3615850 NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:1857034 (MGI:3695084|PMID:16230479) RGD PMID:16230479 MGI:3695084 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Il1a interleukin 1 alpha involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta involved_in IDA
IBA		 PMID:21873635 RGD
GO_Central		 PMID:8590311 PMID:21873635 RGD:7401228, RGD:13792537 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within ISO MGI:2660793 (MGI:2176422|PMID:11894098) RGD PMID:11894098 MGI:2176422 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:3029054|PMID:14764698), (MGI:3847177|PMID:19273836)		 UniProt
Ensembl
RGD		 PMID:14764698 PMID:19273836 GO_REF:0000024 GO_REF:0000107 MGI:3029054 MGI:3847177 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
positive regulation of T cell differentiation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of_or_within ISO MGI:1857117|MGI:2683027 (MGI:3620422|PMID:12163459), (MGI:3640996|PMID:11435465), (MGI:3690682|PMID:11067867), (MGI:3774231|PMID:16670300) RGD PMID:11067867 PMID:11435465 PMID:12163459 PMID:16670300 MGI:3620422 MGI:3640996 MGI:3690682 MGI:3774231 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Adam8 ADAM metallopeptidase domain 8 involved_in ISO (MGI:4836302|PMID:20856819) RGD PMID:20856819 MGI:4836302 NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801 		JBrowse link
G Egr3 early growth response 3 acts_upstream_of_or_within ISO (MGI:5139961|PMID:21737317) RGD PMID:21737317 MGI:5139961 NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627 		JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in ISO (MGI:3836494|PMID:19109233) RGD PMID:19109233 MGI:3836494 NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma acts_upstream_of_or_within ISO MGI:1857455|MGI:2429736 (MGI:1095961|PMID:9252128), (MGI:1327709|PMID:9916699) RGD PMID:9252128 PMID:9916699 MGI:1095961 MGI:1327709 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Il7r interleukin 7 receptor acts_upstream_of_or_within ISO MGI:1857198 (MGI:893320|PMID:9215626) RGD PMID:9215626 MGI:893320 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757 		JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 involved_in ISO (MGI:1891792|PMID:11017103) RGD PMID:11017103 MGI:1891792 NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:3836494|PMID:19109233)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:19109233 GO_REF:0000024 GO_REF:0000107 MGI:3836494 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Vnn1 vanin 1 involved_in ISO (MGI:84472|PMID:8934567) RGD PMID:8934567 MGI:84472 NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395 		JBrowse link
positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 molecule acts_upstream_of_or_within ISO MGI:2180711 (MGI:87097|PMID:9133426) RGD PMID:9133426 MGI:87097 NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089 		JBrowse link
G Cd3d CD3 delta subunit of T-cell receptor complex involved_in IBA
ISS
ISO		 PMID:21873635
GO_REF:0000024
(MGI:87267|PMID:9135151)		 UniProt
RGD		 PMID:9135151 PMID:21873635 GO_REF:0000024 MGI:87267, RGD:13792537 NCBI chr 8:45,287,803...45,293,342
Ensembl chr 8:45,288,749...45,301,809 		JBrowse link
G Cd3e CD3 epsilon subunit of T-cell receptor complex involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:45,303,848...45,315,297
Ensembl chr 8:45,303,852...45,315,022 		JBrowse link
G Cd3g CD3 gamma subunit of T-cell receptor complex involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:45,280,797...45,287,271
Ensembl chr 8:45,281,204...45,287,147 		JBrowse link
G Cd74 CD74 molecule acts_upstream_of_or_within ISO MGI:1927205|MGI:1927530 (MGI:3033881|PMID:9432982), (MGI:52620|PMID:7679955), (MGI:79110|PMID:8598040) RGD PMID:7679955 PMID:8598040 PMID:9432982 MGI:3033881 MGI:52620 MGI:79110 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Dock2 dedicator of cytokinesis 2 acts_upstream_of_or_within ISO MGI:2152031 (MGI:2668308|PMID:12871644) RGD PMID:12871644 MGI:2668308 NCBI chr10:18,827,237...19,244,823
Ensembl chr10:18,827,239...19,244,808 		JBrowse link
G Itpkb inositol-trisphosphate 3-kinase B acts_upstream_of_or_within ISO MGI:3039799 (MGI:3039326|PMID:15064401) RGD PMID:15064401 MGI:3039326 NCBI chr13:92,069,160...92,164,281
Ensembl chr13:92,069,216...92,162,004 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO MGI:1857277 (MGI:80946|PMID:8666928) RGD PMID:8666928 MGI:80946 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G RT1-DMa RT1 class II, locus DMa acts_upstream_of_or_within ISO MGI:1861933|MGI:2384509|MGI:2652160 (MGI:3033881|PMID:9432982), (MGI:79110|PMID:8598040), (MGI:79111|PMID:8598041), (MGI:79272|PMID:8638109) RGD PMID:8598040 PMID:8598041 PMID:8638109 PMID:9432982 MGI:3033881 MGI:79110 MGI:79111 MGI:79272 NCBI chr20:4,707,028...4,710,432
Ensembl chr20:4,707,028...4,710,432 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:3834308|PMID:17227833)		 UniProt
Ensembl
RGD		 PMID:17227833 GO_REF:0000024 GO_REF:0000107 MGI:3834308 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Srf serum response factor acts_upstream_of_or_within ISO MGI:2449947|MGI:3046779 (MGI:4940955|PMID:21098124) RGD PMID:21098124 MGI:4940955 NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733 		JBrowse link
G Stk11 serine/threonine kinase 11 acts_upstream_of_or_within ISO MGI:2386448|MGI:2387402|MGI:3054844 (MGI:5003385|PMID:21487392) RGD PMID:21487392 MGI:5003385 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 acts_upstream_of_or_within ISO (PMID:7630421)
MGI:2677447 (MGI:75253|PMID:7630421)		 RGD PMID:7630421 MGI:75253 NCBI chr 9:38,989,750...39,011,701
Ensembl chr 9:38,989,750...39,011,700 		JBrowse link
regulation of immature T cell proliferation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 molecule involved_in ISO (MGI:3759394|PMID:11550008) RGD PMID:11550008 MGI:3759394 NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089 		JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 acts_upstream_of_or_within ISO (MGI:63416|PMID:8405064) RGD PMID:8405064 MGI:63416 NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000 		JBrowse link
G Tnfsf9 TNF superfamily member 9 acts_upstream_of_or_within ISO (MGI:63416|PMID:8405064) RGD PMID:8405064 MGI:63416 NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345 		JBrowse link
regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxn1 forkhead box N1 involved_in ISO (MGI:5554515|PMID:24184560) RGD PMID:24184560 MGI:5554515 NCBI chr10:63,251,400...63,273,710
Ensembl chr10:63,251,400...63,273,710 		JBrowse link
G Tox thymocyte selection-associated high mobility group box involved_in ISO (MGI:3773459|PMID:18195075) RGD PMID:18195075 MGI:3773459 NCBI chr 5:19,874,994...20,171,272
Ensembl chr 5:19,874,467...20,171,272 		JBrowse link
regulation of T cell differentiation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase IMP RGD PMID:3876160 RGD:152995412 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Adrm1 ADRM1 26S proteasome ubiquitin receptor involved_in ISO (MGI:4849324|PMID:21048919) RGD PMID:21048919 MGI:4849324 NCBI chr 3:167,265,435...167,270,197
Ensembl chr 3:167,265,296...167,270,195 		JBrowse link
G Ankle1 ankyrin repeat and LEM domain containing 1 NOT|involved_in ISO (MGI:5800654|PMID:27010503) RGD PMID:27010503 MGI:5800654 NCBI chr16:18,076,413...18,082,356
Ensembl chr16:18,076,492...18,083,729 		JBrowse link
G Clptm1 CLPTM1 regulator of GABA type A receptor forward trafficking involved_in ISO (MGI:1095293|PMID:9218588) RGD PMID:9218588 MGI:1095293 NCBI chr 1:79,289,478...79,321,079
Ensembl chr 1:79,289,477...79,321,092 		JBrowse link
G Foxn1 forkhead box N1 acts_upstream_of_or_within ISO MGI:5297717 (MGI:5296987|PMID:22072979) RGD PMID:22072979 MGI:5296987 NCBI chr10:63,251,400...63,273,710
Ensembl chr10:63,251,400...63,273,710 		JBrowse link
G Lgals9 galectin 9 NOT|involved_in ISO (MGI:5688819|PMID:25065622) RGD PMID:25065622 MGI:5688819 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO MGI:98355 (MGI:5547878|PMID:24043312) RGD PMID:24043312 MGI:5547878 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 acts_upstream_of_or_within ISO MGI:98354 (MGI:5547878|PMID:24043312) RGD PMID:24043312 MGI:5547878 NCBI chr 6:88,042,966...88,156,140
Ensembl chr 6:88,042,966...88,156,692 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857515|MGI:1857799 (MGI:1195626|PMID:9389660), (MGI:87214|PMID:9126927)		 Ensembl
RGD		 PMID:9126927 PMID:9389660 GO_REF:0000107 MGI:1195626 MGI:87214 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214 		JBrowse link
thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Card11 caspase recruitment domain family, member 11 acts_upstream_of_or_within ISO MGI:3039682 (MGI:3039643|PMID:12867038) RGD PMID:12867038 MGI:3039643 NCBI chr12:13,620,979...13,758,115
Ensembl chr12:13,621,087...13,758,112 		JBrowse link
G Gata3 GATA binding protein 3 acts_upstream_of_or_within ISO MGI:2683927 (MGI:2682543|PMID:14670303) RGD PMID:14670303 MGI:2682543 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Itpkb inositol-trisphosphate 3-kinase B acts_upstream_of_or_within ISO MGI:2680720 (MGI:2679165|PMID:14517551) RGD PMID:14517551 MGI:2679165 NCBI chr13:92,069,160...92,164,281
Ensembl chr13:92,069,216...92,162,004 		JBrowse link
G Jag2 jagged canonical Notch ligand 2 involved_in IEA
ISS
ISO		 GO_REF:0000107
PMID:10383933
(PMID:10383933)		 Ensembl
RGD		 PMID:10383933 PMID:10383933 GO_REF:0000107, RGD:8553281 NCBI chr 6:131,983,056...132,005,359
Ensembl chr 6:131,983,056...132,005,818 		JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 acts_upstream_of_or_within ISO MGI:2677447|MGI:3526403 (MGI:893249|PMID:9208839) RGD PMID:9208839 MGI:893249 NCBI chr 9:38,989,750...39,011,701
Ensembl chr 9:38,989,750...39,011,700 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19746
    immune system process 2582
      leukocyte activation 1013
        lymphocyte activation 820
          lymphocyte differentiation 438
            T cell differentiation 313
              T cell differentiation in thymus 103
                DN2 thymocyte differentiation 4
                DN3 thymocyte differentiation 1
                DN4 thymocyte differentiation 3
                immature T cell proliferation in thymus + 18
                negative regulation of T cell differentiation in thymus + 12
                positive regulation of T cell differentiation in thymus + 9
                regulation of T cell differentiation in thymus + 28
                thymic T cell selection + 27
Path 2
Term Annotations click to browse term
  biological_process 19746
    developmental process 6931
      cellular developmental process 4611
        cell differentiation 4586
          cell development 3185
            hemopoiesis 1037
              leukocyte differentiation 658
                mononuclear cell differentiation 495
                  lymphocyte differentiation 438
                    T cell differentiation 313
                      T cell differentiation in thymus 103
                        DN2 thymocyte differentiation 4
                        DN3 thymocyte differentiation 1
                        DN4 thymocyte differentiation 3
                        immature T cell proliferation in thymus + 18
                        negative regulation of T cell differentiation in thymus + 12
                        positive regulation of T cell differentiation in thymus + 9
                        regulation of T cell differentiation in thymus + 28
                        thymic T cell selection + 27
paths to the root