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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA recombinase mediator complex
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Accession:GO:0033061 term browser browse the term
Definition:A protein complex containing accessory proteins which bind a recombinase (e.g. Rad51) and bind single-stranded DNA (ssDNA), and promote nucleation of the recombinase onto ssDNA through facilitating recombinase-RPA exchange.
Comment:Many paralogs of Rad51 act as recombinase mediators. These paralogs dimerize (or occasionally form tetramers) amongst themselves to form complexes with ssDNA-binding activity, and which act as mediators of Rad51 presynaptic filament assembly.


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Rad51B-Rad51C-Rad51D-XRCC2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RAD51B RAD51 paralog B part_of IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 7:91,592,413...92,301,383
Ensembl chr 7:91,592,424...92,345,294 		JBrowse link
G RAD51C RAD51 paralog C part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr12:34,975,949...35,018,112
Ensembl chr12:34,975,957...35,019,016 		JBrowse link
G RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr12:40,054,175...40,072,831
Ensembl chr12:40,054,181...40,072,822 		JBrowse link
G XRCC2 X-ray repair cross complementing 2 part_of IEA
IBA		 InterPro
Ensembl
GO_Central
TreeGrafter		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr18:4,808,428...4,834,281
Ensembl chr18:4,808,470...4,835,802 		JBrowse link
Rad51C-XRCC3 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RAD51C RAD51 paralog C part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr12:34,975,949...35,018,112
Ensembl chr12:34,975,957...35,019,016 		JBrowse link
G XRCC3 X-ray repair cross complementing 3 part_of IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118
Swi5-Sfr1 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SFR1 SWI5 dependent homologous recombination repair protein 1 part_of IEA Ensembl
InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr14:115,064,955...115,073,856
Ensembl chr14:115,065,057...115,073,855 		JBrowse link
G SWI5 SWI5 homologous recombination repair protein part_of IBA GO_Central GO_REF:0000033 NCBI chr 1:268,720,232...268,726,527
Ensembl chr 1:268,720,355...268,726,521 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 18685
    protein-containing complex 6006
      DNA recombinase mediator complex 7
        Rad51B-Rad51C complex 0
        Rad51B-Rad51C-Rad51D-XRCC2 complex 4
        Rad51C-XRCC3 complex 2
        Swi5-Sfr1 complex 2
        XRCC2-RAD51D complex 0
paths to the root