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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA recombinase mediator complex
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Accession:GO:0033061 term browser browse the term
Definition:A protein complex containing accessory proteins which bind a recombinase (e.g. Rad51) and bind single-stranded DNA (ssDNA), and promote nucleation of the recombinase onto ssDNA through facilitating recombinase-RPA exchange.
Comment:Many paralogs of Rad51 act as recombinase mediators. These paralogs dimerize (or occasionally form tetramers) amongst themselves to form complexes with ssDNA-binding activity, and which act as mediators of Rad51 presynaptic filament assembly.


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Rad51B-Rad51C-Rad51D-XRCC2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rad51b RAD51 paralog B part_of ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr12:79,344,032...79,895,034
Ensembl chr12:79,344,056...79,861,464 		JBrowse link
G Rad51c RAD51 paralog C part_of ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr11:87,267,471...87,295,780
Ensembl chr11:87,267,471...87,295,780 		JBrowse link
G Rad51d RAD51 paralog D part_of ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr11:82,762,786...82,781,571
Ensembl chr11:82,767,260...82,781,440 		JBrowse link
G Xrcc2 X-ray repair complementing defective repair in Chinese hamster cells 2 part_of ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 5:25,894,812...25,910,795
Ensembl chr 5:25,894,810...25,910,823 		JBrowse link
Rad51C-XRCC3 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rad51c RAD51 paralog C part_of ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr11:87,267,471...87,295,780
Ensembl chr11:87,267,471...87,295,780 		JBrowse link
G Xrcc3 X-ray repair complementing defective repair in Chinese hamster cells 3 part_of ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr12:111,769,626...111,780,326
Ensembl chr12:111,769,626...111,780,307 		JBrowse link
Swi5-Sfr1 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sfr1 SWI5 dependent recombination repair 1 part_of IDA
ISO
IBA		 (MGI:4868525|PMID:20976249) UniProt
MGI
GO_Central		 PMID:20976249 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:4868525 NCBI chr19:47,720,159...47,724,027
Ensembl chr19:47,720,121...47,724,027 		JBrowse link
G Swi5 SWI5 recombination repair homolog (yeast) part_of IDA
IBA
ISO		 (MGI:4868525|PMID:20976249) UniProt
GO_Central
MGI		 PMID:20976249 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:4868525 NCBI chr 2:32,168,817...32,178,154
Ensembl chr 2:32,168,828...32,178,087 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 28583
    protein-containing complex 6171
      DNA recombinase mediator complex 7
        Rad51B-Rad51C complex 0
        Rad51B-Rad51C-Rad51D-XRCC2 complex 4
        Rad51C-XRCC3 complex 2
        Swi5-Sfr1 complex 2
        XRCC2-RAD51D complex 0
paths to the root