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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA recombinase mediator complex
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Accession:GO:0033061 term browser browse the term
Definition:A protein complex containing accessory proteins which bind a recombinase (e.g. Rad51) and bind single-stranded DNA (ssDNA), and promote nucleation of the recombinase onto ssDNA through facilitating recombinase-RPA exchange.
Comment:Many paralogs of Rad51 act as recombinase mediators. These paralogs dimerize (or occasionally form tetramers) amongst themselves to form complexes with ssDNA-binding activity, and which act as mediators of Rad51 presynaptic filament assembly.


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Rad51B-Rad51C-Rad51D-XRCC2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rad51b RAD51 paralog B part_of ISO
IBA
(PMID:11751635)
PMID:21873635
RGD PMID:11751635 PMID:21873635 RGD:13792537 NCBI chr 6:98,096,525...98,640,988
Ensembl chr 6:98,098,868...98,640,979
JBrowse link
G Rad51c RAD51 paralog C part_of ISO
IBA
(PMID:11751635)
PMID:21873635
RGD PMID:11751635 PMID:21873635 RGD:13792537 NCBI chr10:72,205,032...72,231,643
Ensembl chr10:72,205,032...72,231,248
JBrowse link
G Rad51d RAD51 paralog D part_of ISO
IBA
(PMID:11751635)
PMID:21873635
RGD PMID:11751635 PMID:21873635 RGD:13792537 NCBI chr10:67,805,720...67,824,452 JBrowse link
G Xrcc2 X-ray repair cross complementing 2 part_of ISO
IBA
(PMID:11751635)
PMID:21873635
RGD PMID:11751635 PMID:21873635 RGD:13792537 NCBI chr 4:9,423,873...9,502,980
Ensembl chr 4:9,423,898...9,442,482
JBrowse link
Rad51C-XRCC3 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rad51c RAD51 paralog C part_of IBA
ISO
PMID:21873635
(PMID:11751635)
RGD PMID:11751635 PMID:21873635 RGD:13792537 NCBI chr10:72,205,032...72,231,643
Ensembl chr10:72,205,032...72,231,248
JBrowse link
G Xrcc3 X-ray repair cross complementing 3 part_of IBA
ISO
PMID:21873635
(PMID:11751635)
RGD PMID:11751635 PMID:21873635 RGD:13792537 NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444
JBrowse link
Swi5-Sfr1 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07067300.1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G AC134087.1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G RGD1561465 similar to RIKEN cDNA 2900010J23 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:145,014,246...145,014,612
Ensembl chr 5:145,014,261...145,014,509
JBrowse link
G Sfr1 SWI5-dependent homologous recombination repair protein 1 part_of IBA
ISO
IEA
ISS
PMID:21873635
(MGI:4868525|PMID:20976249)
GO_REF:0000107
GO_REF:0000024
(PMID:21252223)
RGD
Ensembl
UniProt
PMID:20976249 PMID:21252223 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:4868525, RGD:13792537 NCBI chr 1:246,619,235...246,623,250
Ensembl chr 1:246,597,044...246,623,250
JBrowse link
G Swi5 SWI5 homologous recombination repair protein part_of IBA
ISO
ISS
PMID:21873635
(MGI:4868525|PMID:20976249)
GO_REF:0000024
(PMID:21252223)
RGD
UniProt
PMID:20976249 PMID:21252223 PMID:21873635 GO_REF:0000024 MGI:4868525, RGD:13792537 NCBI chr 3:15,574,687...15,583,760
Ensembl chr 3:15,564,715...15,583,805
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20010
    protein-containing complex 6011
      DNA recombinase mediator complex 10
        Rad51B-Rad51C complex 0
        Rad51B-Rad51C-Rad51D-XRCC2 complex 4
        Rad51C-XRCC3 complex 2
        Rhp55-Rhp57 complex 0
        Swi5-Sfr1 complex 5
        XRCC2-RAD51D complex 0
paths to the root