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ONTOLOGY REPORT - ANNOTATIONS

Term:tetrapyrrole metabolic process
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Accession:GO:0033013 term browser browse the term
Definition:The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
Synonyms:exact_synonym: tetrapyrrole metabolism


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tetrapyrrole metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB6 ATP binding cassette subfamily B member 6 (LAN blood group) involved_in IMP (PMID:23792964) UniProt PMID:23792964 NCBI chr 2:219,209,772...219,218,958
Ensembl chr 2:219,209,772...219,218,994 		JBrowse link
bilirubin conjugation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 involved_in TAS (PMID:1339448) Reactome PMID:1339448 Reactome:R-HSA-9632039 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A4 UDP glucuronosyltransferase family 1 member A4 involved_in TAS Reactome Reactome:R-HSA-159194 NCBI chr 2:233,718,736...233,773,300
Ensembl chr 2:233,718,736...233,773,300 		JBrowse link
cobalamin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CUBN cubilin ISO RGD PMID:14576052 RGD:8554807 NCBI chr10:16,823,966...17,129,811
Ensembl chr10:16,823,966...17,129,811 		JBrowse link
cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCD4 ATP binding cassette subfamily D member 4 involved_in IMP
IDA		 (PMID:22922874)
(PMID:33845046)		 UniProt
MGI		 PMID:22922874 PMID:33845046 NCBI chr14:74,285,269...74,302,934
Ensembl chr14:74,285,269...74,303,055 		JBrowse link
G AMN amnion associated transmembrane protein involved_in IDA (PMID:14576052) MGI PMID:14576052 NCBI chr14:102,922,663...102,930,842
Ensembl chr14:102,922,663...102,933,596 		JBrowse link
G CUBN cubilin involved_in IDA (PMID:14576052) MGI PMID:14576052 NCBI chr10:16,823,966...17,129,811
Ensembl chr10:16,823,966...17,129,811 		JBrowse link
G MMAA metabolism of cobalamin associated A involved_in IDA
TAS		 (PMID:31056463)
(PMID:28497574)		 MGI
UniProt		 PMID:28497574 PMID:31056463 NCBI chr 4:145,619,385...145,660,033
Ensembl chr 4:145,599,042...145,660,033 		JBrowse link
G MMAB metabolism of cobalamin associated B involved_in IDA
TAS		 (PMID:12514191)
(PMID:28497574)		 UniProt
Reactome		 PMID:12514191 PMID:28497574 Reactome:R-HSA-9759218 NCBI chr12:109,553,715...109,573,504
Ensembl chr12:109,553,715...109,573,580 		JBrowse link
G MMACHC metabolism of cobalamin associated C involved_in IDA
IBA
IMP
TAS		 (PMID:19700356), (PMID:22642810)
(PMID:23825108)		 UniProt
GO_Central
BHF-UCL
Reactome		 PMID:19700356 PMID:22642810 PMID:23825108 GO_REF:0000033 Reactome:R-HSA-9759218 NCBI chr 1:45,500,300...45,513,382
Ensembl chr 1:45,500,300...45,513,382 		JBrowse link
G MMADHC metabolism of cobalamin associated D involved_in IDA
IEA		 (PMID:22156578), (PMID:24722857) MGI
InterPro		 PMID:22156578 PMID:24722857 GO_REF:0000002 NCBI chr 2:149,569,637...149,587,775
Ensembl chr 2:149,569,637...149,587,778 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase involved_in IEA
IMP		 (PMID:23825108) Ensembl
BHF-UCL		 PMID:23825108 GO_REF:0000107 NCBI chr 1:236,795,281...236,903,981
Ensembl chr 1:236,795,260...236,921,278 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISO (PMID:17369066) MGI PMID:17369066 NCBI chr 5:7,850,859...7,901,113
Ensembl chr 5:7,851,186...7,906,025 		JBrowse link
heme A biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AL133353.2 novel transcript involved_in IEA InterPro GO_REF:0000002 Ensembl chr10:99,651,595...99,732,112 JBrowse link
G ALAD aminolevulinate dehydratase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290 		JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:52,198,083...52,214,327
Ensembl chr 3:52,198,086...52,214,327 		JBrowse link
G COX10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO
IMP		 (PMID:16782876)
(PMID:16103131)
(PMID:12928484)		 Ensembl
GO_Central
MGI
HGNC-UCL		 PMID:12928484 PMID:16103131 PMID:16782876 GO_REF:0000033 GO_REF:0000107 NCBI chr17:14,069,504...14,208,677
Ensembl chr17:14,069,490...14,231,736 		JBrowse link
G COX15 cytochrome c oxidase assembly homolog COX15 involved_in IEA
IBA
IGI		 (PMID:12474143) UniProt
GO_Central
TreeGrafter
InterPro
HGNC-UCL		 PMID:12474143 GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 GO_REF:0000118 NCBI chr10:99,694,293...99,732,127
Ensembl chr10:99,710,868...99,732,127 		JBrowse link
G CPOX coproporphyrinogen oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:98,570,488...98,593,611
Ensembl chr 3:98,579,446...98,593,648 		JBrowse link
G FECH ferrochelatase involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:57,544,377...57,586,702
Ensembl chr18:57,544,377...57,586,732 		JBrowse link
G HMBS hydroxymethylbilane synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834 		JBrowse link
G PPOX protoporphyrinogen oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:161,165,728...161,178,013
Ensembl chr 1:161,166,056...161,178,013 		JBrowse link
G UROD uroporphyrinogen decarboxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:45,012,254...45,015,575
Ensembl chr 1:45,010,950...45,015,575 		JBrowse link
G UROS uroporphyrinogen III synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:125,784,980...125,823,258
Ensembl chr10:125,784,980...125,823,288 		JBrowse link
heme B biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB6 ATP binding cassette subfamily B member 6 (LAN blood group) NOT|involved_in IMP (PMID:22655043) UniProt PMID:22655043 NCBI chr 2:219,209,772...219,218,958
Ensembl chr 2:219,209,772...219,218,994 		JBrowse link
G ALAD aminolevulinate dehydratase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290 		JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:52,198,083...52,214,327
Ensembl chr 3:52,198,086...52,214,327 		JBrowse link
G CPOX coproporphyrinogen oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:98,570,488...98,593,611
Ensembl chr 3:98,579,446...98,593,648 		JBrowse link
G FECH ferrochelatase involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:57,544,377...57,586,702
Ensembl chr18:57,544,377...57,586,732 		JBrowse link
G HMBS hydroxymethylbilane synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834 		JBrowse link
G PPOX protoporphyrinogen oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:161,165,728...161,178,013
Ensembl chr 1:161,166,056...161,178,013 		JBrowse link
G UROD uroporphyrinogen decarboxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:45,012,254...45,015,575
Ensembl chr 1:45,010,950...45,015,575 		JBrowse link
G UROS uroporphyrinogen III synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:125,784,980...125,823,258
Ensembl chr10:125,784,980...125,823,288 		JBrowse link
heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB10 ATP binding cassette subfamily B member 10 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:229,516,582...229,558,707
Ensembl chr 1:229,516,582...229,558,707 		JBrowse link
G AL133353.2 novel transcript involved_in IEA UniProt GO_REF:0000043 Ensembl chr10:99,651,595...99,732,112 JBrowse link
G ALAD aminolevulinate dehydratase acts_upstream_of_or_within
involved_in		 ISO
IBA
IEA
IDA
TAS		 (PMID:14050799), (PMID:4959158), (PMID:4981581)
(PMID:11032836)
(PMID:3758678)		 RGD
MGI
GO_Central
TreeGrafter
UniProt
Ensembl
PINC		 PMID:1764448 PMID:3758678 PMID:4959158 PMID:4981581 PMID:11032836 More... GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 RGD:1599020 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290 		JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 involved_in TAS
IEA
IBA		 (PMID:2347585) PINC
TreeGrafter
GO_Central
UniProt		 PMID:2347585 GO_REF:0000033 GO_REF:0000043 GO_REF:0000118 NCBI chr 3:52,198,083...52,214,327
Ensembl chr 3:52,198,086...52,214,327 		JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 involved_in ISS
IBA
IEA
NAS		 (PMID:14643893) UniProt
GO_Central
Ensembl		 PMID:14643893 GO_REF:0000024 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr  X:55,009,055...55,030,977
Ensembl chr  X:55,009,055...55,030,977 		JBrowse link
G ATP5IF1 ATP synthase inhibitory factor subunit 1 involved_in IEA
IBA
IMP		 (PMID:23135403) Ensembl
GO_Central
UniProt		 PMID:23135403 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:28,236,124...28,238,100
Ensembl chr 1:28,236,109...28,246,906 		JBrowse link
G COX10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 involved_in IEA
TAS		 UniProt
InterPro
Reactome		 GO_REF:0000002 GO_REF:0000043 Reactome:R-HSA-189451 NCBI chr17:14,069,504...14,208,677
Ensembl chr17:14,069,490...14,231,736 		JBrowse link
G COX15 cytochrome c oxidase assembly homolog COX15 involved_in TAS
IEA		 Reactome
UniProt		 GO_REF:0000043 Reactome:R-HSA-189451 NCBI chr10:99,694,293...99,732,127
Ensembl chr10:99,710,868...99,732,127 		JBrowse link
G CPOX coproporphyrinogen oxidase acts_upstream_of_or_within
involved_in		 ISO
IEA
TAS		 (PMID:8407975)
(PMID:8159699)		 RGD
MGI
Ensembl
UniProt
PINC		 PMID:3955059 PMID:8159699 PMID:8407975 GO_REF:0000043 GO_REF:0000107 GO_REF:0000117 RGD:1600961 NCBI chr 3:98,570,488...98,593,611
Ensembl chr 3:98,579,446...98,593,648 		JBrowse link
G FECH ferrochelatase acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA
TAS
IDA		 (PMID:9989256)
(PMID:8611576)
(PMID:15496139), (PMID:16503645)
(PMID:16306232)
(PMID:1729699)
(PMID:27599036)		 RGD
MGI
TreeGrafter
GO_Central
Ensembl
PINC
UniProt
InterPro		 PMID:1729699 PMID:3955059 PMID:8611576 PMID:9989256 PMID:15496139 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:1600961 NCBI chr18:57,544,377...57,586,702
Ensembl chr18:57,544,377...57,586,732 		JBrowse link
G FLVCR1 FLVCR choline and heme transporter 1 involved_in TAS Reactome Reactome:R-HSA-189451 NCBI chr 1:212,858,275...212,899,363
Ensembl chr 1:212,858,275...212,899,363 		JBrowse link
G FXN frataxin involved_in NAS
IEA		 (PMID:15123683) BHF-UCL
UniProt		 PMID:15123683 GO_REF:0000043 NCBI chr 9:69,035,752...69,079,076
Ensembl chr 9:69,035,751...69,079,076 		JBrowse link
G HMBS hydroxymethylbilane synthase involved_in IDA
IEA
IBA
IC		 (PMID:18936296)
(PMID:18004775)		 UniProt
TreeGrafter
GO_Central		 PMID:18004775 PMID:18936296 GO_REF:0000033 GO_REF:0000043 GO_REF:0000118 NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834 		JBrowse link
G HNF1A HNF1 homeobox A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10617683) Ensembl
MGI		 PMID:10617683 GO_REF:0000107 NCBI chr12:120,978,543...121,002,512
Ensembl chr12:120,978,543...121,002,512 		JBrowse link
G IBA57 iron-sulfur cluster assembly factor IBA57 involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:228,165,804...228,182,257
Ensembl chr 1:228,165,804...228,182,257 		JBrowse link
G NFE2L1 NFE2 like bZIP transcription factor 1 involved_in TAS (PMID:9501099) PINC PMID:9501099 NCBI chr17:48,048,359...48,061,545
Ensembl chr17:48,048,329...48,061,545 		JBrowse link
G PGRMC1 progesterone receptor membrane component 1 involved_in IDA (PMID:27599036) UniProt PMID:27599036 NCBI chr  X:119,236,285...119,244,466
Ensembl chr  X:119,236,245...119,244,466 		JBrowse link
G PPOX protoporphyrinogen oxidase acts_upstream_of_or_within
involved_in		 ISO
IBA
IDA
IEA		 (PMID:3346226)
(PMID:7713909)		 RGD
MGI
GO_Central
UniProt
Ensembl		 PMID:3346226 PMID:3955059 PMID:7713909 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 RGD:1600961 NCBI chr 1:161,165,728...161,178,013
Ensembl chr 1:161,166,056...161,178,013 		JBrowse link
G SLC11A2 solute carrier family 11 member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11739192) Ensembl
MGI		 PMID:11739192 GO_REF:0000107 NCBI chr12:50,952,263...51,028,886
Ensembl chr12:50,979,401...51,028,566 		JBrowse link
G SLC25A38 solute carrier family 25 member 38 involved_in TAS (PMID:19412178) UniProt PMID:19412178 NCBI chr 3:39,383,370...39,397,351
Ensembl chr 3:39,383,370...39,397,351 		JBrowse link
G SLC25A39 solute carrier family 25 member 39 involved_in IEA UniProt GO_REF:0000043 NCBI chr17:44,319,628...44,324,823
Ensembl chr17:44,319,625...44,324,870 		JBrowse link
G SRRD SRR1 domain containing involved_in IEA UniProt GO_REF:0000043 NCBI chr22:26,483,877...26,494,658
Ensembl chr22:26,483,877...26,494,658 		JBrowse link
G TMEM14C transmembrane protein 14C involved_in IEA UniProt GO_REF:0000043 NCBI chr 6:10,723,070...10,731,127
Ensembl chr 6:10,722,915...10,731,129 		JBrowse link
G TSPO translocator protein involved_in TAS (PMID:16822554) HGNC-UCL PMID:16822554 NCBI chr22:43,151,559...43,163,242
Ensembl chr22:43,151,547...43,163,242 		JBrowse link
G UROD uroporphyrinogen decarboxylase involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA
IC		 (PMID:17360334)
(PMID:18004775)		 Ensembl
TreeGrafter
MGI
GO_Central
UniProt		 PMID:17360334 PMID:18004775 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:45,012,254...45,015,575
Ensembl chr 1:45,010,950...45,015,575 		JBrowse link
G UROS uroporphyrinogen III synthase involved_in IDA
IEA
TAS
IC		 (PMID:3805019)
(PMID:18004775)		 UniProt
Reactome		 PMID:3805019 PMID:18004775 GO_REF:0000043 Reactome:R-HSA-189451 NCBI chr10:125,784,980...125,823,258
Ensembl chr10:125,784,980...125,823,288 		JBrowse link
heme catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) involved_in TAS Reactome Reactome:R-HSA-189483 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 involved_in TAS Reactome Reactome:R-HSA-189483 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G AMBP alpha-1-microglobulin/bikunin precursor involved_in NAS (PMID:11877257) UniProt PMID:11877257 NCBI chr 9:114,060,127...114,078,300
Ensembl chr 9:114,060,127...114,078,328 		JBrowse link
G BLVRA biliverdin reductase A involved_in IEA
IDA		 (PMID:10858451) InterPro
UniProt		 PMID:10858451 GO_REF:0000002 GO_REF:0000104 NCBI chr 7:43,758,122...43,807,342
Ensembl chr 7:43,758,680...43,807,342 		JBrowse link
G BLVRB biliverdin reductase B involved_in IDA (PMID:10858451), (PMID:7929092) UniProt PMID:7929092 PMID:10858451 NCBI chr19:40,447,768...40,465,745
Ensembl chr19:40,447,765...40,465,764 		JBrowse link
G HMOX1 heme oxygenase 1 involved_in
acts_upstream_of_or_within		 ISO
IBA
IEA
IDA		 (PMID:31571584)
(PMID:17915953)		 RGD
GO_Central
MGI
TreeGrafter
Ensembl
BHF-UCL		 PMID:15226268 PMID:17915953 PMID:31571584 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 RGD:1547877 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HMOX2 heme oxygenase 2 involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr16:4,474,736...4,510,347
Ensembl chr16:4,474,690...4,510,347 		JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 involved_in TAS Reactome Reactome:R-HSA-189483 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796 		JBrowse link
G SLCO1B3 solute carrier organic anion transporter family member 1B3 involved_in TAS Reactome Reactome:R-HSA-189483 NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911 		JBrowse link
G SLCO2B1 solute carrier organic anion transporter family member 2B1 involved_in TAS Reactome Reactome:R-HSA-189483 NCBI chr11:75,151,107...75,206,549
Ensembl chr11:75,100,563...75,206,549 		JBrowse link
G UGT1A4 UDP glucuronosyltransferase family 1 member A4 involved_in TAS Reactome Reactome:R-HSA-189483 NCBI chr 2:233,718,736...233,773,300
Ensembl chr 2:233,718,736...233,773,300 		JBrowse link
heme metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB6 ATP binding cassette subfamily B member 6 (LAN blood group) involved_in IDA (PMID:33007128) UniProt PMID:33007128 NCBI chr 2:219,209,772...219,218,958
Ensembl chr 2:219,209,772...219,218,994 		JBrowse link
G BDH2 3-hydroxybutyrate dehydrogenase 2 involved_in ISS UniProt GO_REF:0000024 NCBI chr 4:103,077,592...103,099,834
Ensembl chr 4:103,077,592...103,099,870 		JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 acts_upstream_of_or_within ISO (PMID:16183037) MGI PMID:16183037 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447 		JBrowse link
G HMOX1 heme oxygenase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16183037) Ensembl
MGI		 PMID:16183037 GO_REF:0000107 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HPX hemopexin involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:18556779) Ensembl
MGI
GO_Central		 PMID:18556779 GO_REF:0000033 GO_REF:0000107 NCBI chr11:6,431,049...6,440,987
Ensembl chr11:6,431,049...6,442,617 		JBrowse link
G SLC46A1 solute carrier family 46 member 1 involved_in TAS Reactome Reactome:R-HSA-9707616 NCBI chr17:28,394,642...28,406,592
Ensembl chr17:28,394,642...28,407,197 		JBrowse link
G SLC48A1 solute carrier family 48 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:47,753,934...47,782,751
Ensembl chr12:47,753,916...47,782,751 		JBrowse link
G UROD uroporphyrinogen decarboxylase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11134514) Ensembl
MGI		 PMID:11134514 GO_REF:0000107 NCBI chr 1:45,012,254...45,015,575
Ensembl chr 1:45,010,950...45,015,575 		JBrowse link
heme O biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALAD aminolevulinate dehydratase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290 		JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:52,198,083...52,214,327
Ensembl chr 3:52,198,086...52,214,327 		JBrowse link
G COX10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:14,069,504...14,208,677
Ensembl chr17:14,069,490...14,231,736 		JBrowse link
G CPOX coproporphyrinogen oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:98,570,488...98,593,611
Ensembl chr 3:98,579,446...98,593,648 		JBrowse link
G FECH ferrochelatase involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:57,544,377...57,586,702
Ensembl chr18:57,544,377...57,586,732 		JBrowse link
G HMBS hydroxymethylbilane synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834 		JBrowse link
G PPOX protoporphyrinogen oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:161,165,728...161,178,013
Ensembl chr 1:161,166,056...161,178,013 		JBrowse link
G UROD uroporphyrinogen decarboxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:45,012,254...45,015,575
Ensembl chr 1:45,010,950...45,015,575 		JBrowse link
G UROS uroporphyrinogen III synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:125,784,980...125,823,258
Ensembl chr10:125,784,980...125,823,288 		JBrowse link
heme oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HMOX1 heme oxygenase 1 involved_in IEA
IBA
IDA		 (PMID:17915953) InterPro
TreeGrafter
GO_Central
BHF-UCL
UniProt		 PMID:17915953 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000118 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HMOX2 heme oxygenase 2 involved_in IEA
IBA		 UniProt
GO_Central
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000118 NCBI chr16:4,474,736...4,510,347
Ensembl chr16:4,474,690...4,510,347 		JBrowse link
porphyrin-containing compound biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB6 ATP binding cassette subfamily B member 6 (LAN blood group) involved_in IDA (PMID:17006453) UniProt PMID:17006453 NCBI chr 2:219,209,772...219,218,958
Ensembl chr 2:219,209,772...219,218,994 		JBrowse link
G AC021660.3 novel transcript involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 Ensembl chr 3:98,521,133...98,585,498 JBrowse link
G ANK1 ankyrin 1 acts_upstream_of_or_within ISO (PMID:658175) MGI PMID:658175 NCBI chr 8:41,653,225...41,896,741
Ensembl chr 8:41,653,220...41,896,741 		JBrowse link
G CPOX coproporphyrinogen oxidase involved_in IEA InterPro GO_REF:0000002 NCBI chr 3:98,570,488...98,593,611
Ensembl chr 3:98,579,446...98,593,648 		JBrowse link
G FECH ferrochelatase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12149233) Ensembl
MGI		 PMID:12149233 GO_REF:0000107 NCBI chr18:57,544,377...57,586,702
Ensembl chr18:57,544,377...57,586,732 		JBrowse link
G HMBS hydroxymethylbilane synthase involved_in ISO
IEA		 Uroporphyrinogen
Urophorphyrin I
uroporphyrin I
Uroporphyrin I		 RGD
UniProt		 PMID:971328 PMID:994723 PMID:1781034 PMID:3179323 PMID:3702597 More... GO_REF:0000043 GO_REF:0000117 RGD:2301707 RGD:25330343 RGD:25394583 RGD:25394584 RGD:25440495 RGD:25440497 RGD:26923962 RGD:26923963 RGD:4144783 RGD:4144803 RGD:4144820 NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834 		JBrowse link
G PPOX protoporphyrinogen oxidase involved_in ISO
IDA
IEA		 (PMID:7713909) RGD
UniProt
InterPro		 PMID:3663105 PMID:7713909 GO_REF:0000002 RGD:1599180 NCBI chr 1:161,165,728...161,178,013
Ensembl chr 1:161,166,056...161,178,013 		JBrowse link
G RSAD1 radical S-adenosyl methionine domain containing 1 involved_in IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr17:50,478,860...50,485,974
Ensembl chr17:50,478,860...50,485,974 		JBrowse link
G SLC11A2 solute carrier family 11 member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:658175) Ensembl
MGI		 PMID:658175 GO_REF:0000107 NCBI chr12:50,952,263...51,028,886
Ensembl chr12:50,979,401...51,028,566 		JBrowse link
G SPTA1 spectrin alpha, erythrocytic 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:658175) Ensembl
MGI		 PMID:658175 GO_REF:0000107 NCBI chr 1:158,610,704...158,686,715
Ensembl chr 1:158,610,704...158,686,715 		JBrowse link
G SPTB spectrin beta, erythrocytic acts_upstream_of_or_within ISO (PMID:658175) MGI PMID:658175 NCBI chr14:64,746,283...64,879,907
Ensembl chr14:64,746,283...64,879,907 		JBrowse link
G UROD uroporphyrinogen decarboxylase involved_in ISO
IEA		 RGD
InterPro		 PMID:12381387 GO_REF:0000002 RGD:4144825 NCBI chr 1:45,012,254...45,015,575
Ensembl chr 1:45,010,950...45,015,575 		JBrowse link
G UROS uroporphyrinogen III synthase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:7607680) MGI
UniProt
Ensembl		 PMID:7607680 GO_REF:0000107 GO_REF:0000117 MGI:3620006 NCBI chr10:125,784,980...125,823,258
Ensembl chr10:125,784,980...125,823,288 		JBrowse link
porphyrin-containing compound catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UROD uroporphyrinogen decarboxylase involved_in IDA (PMID:11069625), (PMID:11719352), (PMID:14633982), (PMID:21668429) UniProt PMID:11069625 PMID:11719352 PMID:14633982 PMID:21668429 NCBI chr 1:45,012,254...45,015,575
Ensembl chr 1:45,010,950...45,015,575 		JBrowse link
porphyrin-containing compound metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB6 ATP binding cassette subfamily B member 6 (LAN blood group) involved_in IEA
IDA
IMP		 (PMID:27507172)
(PMID:33007128)		 Ensembl
UniProt		 PMID:27507172 PMID:33007128 GO_REF:0000107 NCBI chr 2:219,209,772...219,218,958
Ensembl chr 2:219,209,772...219,218,994 		JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr 3:52,198,083...52,214,327
Ensembl chr 3:52,198,086...52,214,327 		JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr  X:55,009,055...55,030,977
Ensembl chr  X:55,009,055...55,030,977 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 involved_in ISO
IEA		 Uroporphyrinogen oxidation, generating hydrogen peroxide RGD
Ensembl		 PMID:12907239 GO_REF:0000107 RGD:2306674 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11274970), (PMID:9461503) Ensembl
MGI		 PMID:9461503 PMID:11274970 GO_REF:0000107 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G HMBS hydroxymethylbilane synthase ISO Porphobilinogen
Uroporphyrinogen 		RGD PMID:593266 PMID:971328 PMID:994723 PMID:1781034 PMID:3179323 More... RGD:2301707 RGD:25394583 RGD:25394584 RGD:25440495 RGD:25440497 RGD:26884337 RGD:26923962 RGD:26923963 RGD:4144783 RGD:4144803 RGD:4144820 NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834 		JBrowse link
G SLC11A2 solute carrier family 11 member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:4404581) Ensembl
MGI		 PMID:4404581 GO_REF:0000107 NCBI chr12:50,952,263...51,028,886
Ensembl chr12:50,979,401...51,028,566 		JBrowse link
G UROD uroporphyrinogen decarboxylase involved_in IDA
IEA		 (PMID:12071824) UniProt PMID:12071824 GO_REF:0000117 NCBI chr 1:45,012,254...45,015,575
Ensembl chr 1:45,010,950...45,015,575 		JBrowse link
positive regulation of cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLYBL citramalyl-CoA lyase involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:99,606,690...99,909,444
Ensembl chr13:99,606,669...99,909,459 		JBrowse link
positive regulation of heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB10 ATP binding cassette subfamily B member 10 involved_in ISS UniProt GO_REF:0000024 NCBI chr 1:229,516,582...229,558,707
Ensembl chr 1:229,516,582...229,558,707 		JBrowse link
G ABCB7 ATP binding cassette subfamily B member 7 involved_in IMP
ISS
IEA		 (PMID:30765471) UniProt
Ensembl		 PMID:30765471 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:75,051,048...75,156,283
Ensembl chr  X:75,051,048...75,156,732 		JBrowse link
G SLC6A9 solute carrier family 6 member 9 involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr 1:43,996,483...44,031,462
Ensembl chr 1:43,991,500...44,031,467 		JBrowse link
protoporphyrinogen IX biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC021660.3 novel transcript involved_in IEA UniProt GO_REF:0000041 Ensembl chr 3:98,521,133...98,585,498 JBrowse link
G ALAD aminolevulinate dehydratase involved_in IEA UniProt GO_REF:0000041 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290 		JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 involved_in IEA UniProt GO_REF:0000041 GO_REF:0000104 NCBI chr 3:52,198,083...52,214,327
Ensembl chr 3:52,198,086...52,214,327 		JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 involved_in IEA UniProt GO_REF:0000041 NCBI chr  X:55,009,055...55,030,977
Ensembl chr  X:55,009,055...55,030,977 		JBrowse link
G CPOX coproporphyrinogen oxidase involved_in ISO
IBA
IEA		 RGD
GO_Central
UniProt		 PMID:3814086 GO_REF:0000033 GO_REF:0000041 RGD:4145128 NCBI chr 3:98,570,488...98,593,611
Ensembl chr 3:98,579,446...98,593,648 		JBrowse link
G HMBS hydroxymethylbilane synthase involved_in IEA UniProt GO_REF:0000041 NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834 		JBrowse link
G IREB2 iron responsive element binding protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15831703) Ensembl
MGI		 PMID:15831703 GO_REF:0000107 NCBI chr15:78,437,431...78,501,453
Ensembl chr15:78,437,431...78,501,453 		JBrowse link
G PPOX protoporphyrinogen oxidase involved_in IEA UniProt GO_REF:0000041 GO_REF:0000104 NCBI chr 1:161,165,728...161,178,013
Ensembl chr 1:161,166,056...161,178,013 		JBrowse link
G UROD uroporphyrinogen decarboxylase involved_in IEA UniProt GO_REF:0000041 NCBI chr 1:45,012,254...45,015,575
Ensembl chr 1:45,010,950...45,015,575 		JBrowse link
G UROS uroporphyrinogen III synthase involved_in IEA UniProt GO_REF:0000041 NCBI chr10:125,784,980...125,823,258
Ensembl chr10:125,784,980...125,823,288 		JBrowse link
protoporphyrinogen IX metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EIF2AK1 eukaryotic translation initiation factor 2 alpha kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15931390) Ensembl
MGI		 PMID:15931390 GO_REF:0000107 NCBI chr 7:6,022,247...6,059,175
Ensembl chr 7:6,022,247...6,059,175 		JBrowse link
G FECH ferrochelatase involved_in
acts_upstream_of_or_within		 IDA
ISO
IEA		 (PMID:15123683)
(PMID:15931390)		 BHF-UCL
MGI
Ensembl		 PMID:15123683 PMID:15931390 GO_REF:0000107 NCBI chr18:57,544,377...57,586,702
Ensembl chr18:57,544,377...57,586,732 		JBrowse link
G PPOX protoporphyrinogen oxidase ISO RGD PMID:3663105 RGD:1599180 NCBI chr 1:161,165,728...161,178,013
Ensembl chr 1:161,166,056...161,178,013 		JBrowse link
regulation of cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLYBL citramalyl-CoA lyase involved_in IEA
IBA
IDA		 (PMID:29056341) Ensembl
GO_Central
TreeGrafter
UniProt		 PMID:29056341 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr13:99,606,690...99,909,444
Ensembl chr13:99,606,669...99,909,459 		JBrowse link
regulation of heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SRRD SRR1 domain containing involved_in ISS UniProt GO_REF:0000024 NCBI chr22:26,483,877...26,494,658
Ensembl chr22:26,483,877...26,494,658 		JBrowse link
G TMEM14A transmembrane protein 14A involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:52,671,113...52,686,588
Ensembl chr 6:52,671,113...52,686,588 		JBrowse link
G TMEM14B transmembrane protein 14B involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 6:10,747,759...10,759,774
Ensembl chr 6:10,747,759...10,852,753 		JBrowse link
G TMEM14C transmembrane protein 14C involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:25157825) Ensembl
MGI
TreeGrafter
GO_Central		 PMID:25157825 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:10,723,070...10,731,127
Ensembl chr 6:10,722,915...10,731,129 		JBrowse link
G TMEM14DP transmembrane protein 14D, pseudogene involved_in IBA GO_Central GO_REF:0000033 NCBI chr10:68,544,026...68,544,940
Ensembl chr10:68,544,489...68,544,833 		JBrowse link
G TMEM14EP transmembrane protein 14E, pseudogene involved_in IBA GO_Central GO_REF:0000033 NCBI chr 3:152,339,698...152,340,990
Ensembl chr 3:152,339,695...152,340,990
Ensembl chr 3:152,339,695...152,340,990 		JBrowse link
succinyl-CoA pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SUCLA2 succinate-CoA ligase ADP-forming subunit beta involved_in NAS (PMID:10727444) UniProt PMID:10727444 NCBI chr13:47,942,656...48,001,273
Ensembl chr13:47,745,736...48,037,968 		JBrowse link
tetrapyrrole biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALAD aminolevulinate dehydratase involved_in IEA InterPro GO_REF:0000002 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290 		JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr 3:52,198,083...52,214,327
Ensembl chr 3:52,198,086...52,214,327 		JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr  X:55,009,055...55,030,977
Ensembl chr  X:55,009,055...55,030,977 		JBrowse link
G HMBS hydroxymethylbilane synthase involved_in ISO
IEA		 RGD
InterPro		 PMID:6712591 PMID:9344466 PMID:12127573 PMID:18760440 GO_REF:0000002 RGD:2301691 RGD:2301695 RGD:2301704 RGD:2301858 NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834 		JBrowse link
G UROS uroporphyrinogen III synthase involved_in IEA InterPro GO_REF:0000002 NCBI chr10:125,784,980...125,823,258
Ensembl chr10:125,784,980...125,823,288 		JBrowse link
uroporphyrinogen III biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UROS uroporphyrinogen III synthase involved_in ISO
IEA
IBA
IDA		 (PMID:18004775), (PMID:3174619), (PMID:3805019) RGD
TreeGrafter
GO_Central
Ensembl
InterPro
UniProt		 PMID:3174619 PMID:3805019 PMID:17763925 PMID:18004775 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 RGD:4144811 NCBI chr10:125,784,980...125,823,258
Ensembl chr10:125,784,980...125,823,288 		JBrowse link
uroporphyrinogen III metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UROD uroporphyrinogen decarboxylase ISO converts uroporphyrinogen to coproporphyrinogen via hepta-, hexa- and penta-carboxyporphyrinogen RGD PMID:15736160 RGD:2301379 NCBI chr 1:45,012,254...45,015,575
Ensembl chr 1:45,010,950...45,015,575 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    metabolic process 12464
      organic substance metabolic process 11967
        organonitrogen compound metabolic process 5570
          tetrapyrrole metabolic process 70
            cobalamin metabolic process + 10
            corrin metabolic process + 0
            negative regulation of tetrapyrrole metabolic process + 0
            nickel-tetrapyrrole coenzyme metabolic process + 0
            phytochromobilin metabolic process + 0
            porphyrin-containing compound metabolic process + 60
            positive regulation of tetrapyrrole metabolic process + 4
            regulation of tetrapyrrole metabolic process + 10
            tetrapyrrole biosynthetic process + 40
            tetrapyrrole catabolic process + 14
paths to the root