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ONTOLOGY REPORT - ANNOTATIONS

Term:tetrapyrrole metabolic process
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Accession:GO:0033013 term browser browse the term
Definition:The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
Synonyms:exact_synonym: tetrapyrrole metabolism


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tetrapyrrole metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB6 ATP binding cassette subfamily B member 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:25,760,478...25,767,753
Ensembl chr37:25,760,477...25,769,841 		JBrowse link
cobalamin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CUBN cubilin ISO RGD PMID:14576052 RGD:8554807 NCBI chr 2:19,784,125...20,041,840
Ensembl chr 2:19,784,198...20,041,839 		JBrowse link
cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCD4 ATP binding cassette subfamily D member 4 involved_in ISO (PMID:22922874)
(PMID:33845046)		 UniProt
MGI		 PMID:22922874 PMID:33845046 NCBI chr 8:47,488,414...47,507,041
Ensembl chr 8:47,488,475...47,504,654 		JBrowse link
G AMN amnion associated transmembrane protein involved_in ISO (PMID:14576052) MGI PMID:14576052 NCBI chr 8:70,800,435...70,807,835 JBrowse link
G CUBN cubilin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:19,784,125...20,041,840
Ensembl chr 2:19,784,198...20,041,839 		JBrowse link
G MMAA metabolism of cobalamin associated A involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:44,221,082...44,243,530
Ensembl chr15:44,220,934...44,241,101 		JBrowse link
G MMAB metabolism of cobalamin associated B involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:17,519,158...17,531,200
Ensembl chr26:17,519,199...17,529,514 		JBrowse link
G MMACHC metabolism of cobalamin associated C involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr15:14,857,236...14,863,211
Ensembl chr15:14,857,231...14,863,113 		JBrowse link
G MMADHC metabolism of cobalamin associated D involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr19:51,154,227...51,177,950
Ensembl chr19:51,154,249...51,177,836 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:3,219,851...3,328,000
Ensembl chr 4:3,215,090...3,328,115 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISO (PMID:17369066) MGI PMID:17369066 NCBI chr34:6,068,572...6,119,580
Ensembl chr34:6,070,046...6,098,312 		JBrowse link
heme A biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALAD aminolevulinate dehydratase involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:67,736,643...67,752,399
Ensembl chr11:67,741,390...67,752,321 		JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:37,552,813...37,566,417
Ensembl chr20:37,552,814...37,566,638 		JBrowse link
G COX10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16103131)
(PMID:16782876)		 Ensembl
MGI
TreeGrafter		 PMID:16103131 PMID:16782876 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:37,853,495...37,982,228
Ensembl chr 5:37,852,875...37,982,243 		JBrowse link
G COX15 cytochrome c oxidase assembly homolog COX15 involved_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr28:12,609,690...12,625,467
Ensembl chr28:12,610,401...12,624,087 		JBrowse link
G CPOX coproporphyrinogen oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr33:5,446,022...5,459,152
Ensembl chr33:5,447,414...5,459,461 		JBrowse link
G FECH ferrochelatase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:18,352,184...18,384,251
Ensembl chr 1:18,345,811...18,383,092 		JBrowse link
G HMBS hydroxymethylbilane synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:14,767,306...14,775,205
Ensembl chr 5:14,767,666...14,775,082 		JBrowse link
G PPOX protoporphyrinogen oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr38:21,306,973...21,310,892
Ensembl chr38:21,306,974...21,311,012 		JBrowse link
G UROD uroporphyrinogen decarboxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:15,313,808...15,317,130
Ensembl chr15:15,312,674...15,320,010 		JBrowse link
G UROS uroporphyrinogen III synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:34,952,074...34,983,532
Ensembl chr28:34,948,003...34,983,532 		JBrowse link
heme B biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB6 ATP binding cassette subfamily B member 6 NOT|involved_in ISO (PMID:22655043) UniProt PMID:22655043 NCBI chr37:25,760,478...25,767,753
Ensembl chr37:25,760,477...25,769,841 		JBrowse link
G ALAD aminolevulinate dehydratase involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:67,736,643...67,752,399
Ensembl chr11:67,741,390...67,752,321 		JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:37,552,813...37,566,417
Ensembl chr20:37,552,814...37,566,638 		JBrowse link
G CPOX coproporphyrinogen oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr33:5,446,022...5,459,152
Ensembl chr33:5,447,414...5,459,461 		JBrowse link
G FECH ferrochelatase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:18,352,184...18,384,251
Ensembl chr 1:18,345,811...18,383,092 		JBrowse link
G HMBS hydroxymethylbilane synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:14,767,306...14,775,205
Ensembl chr 5:14,767,666...14,775,082 		JBrowse link
G PPOX protoporphyrinogen oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr38:21,306,973...21,310,892
Ensembl chr38:21,306,974...21,311,012 		JBrowse link
G UROD uroporphyrinogen decarboxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:15,313,808...15,317,130
Ensembl chr15:15,312,674...15,320,010 		JBrowse link
G UROS uroporphyrinogen III synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:34,952,074...34,983,532
Ensembl chr28:34,948,003...34,983,532 		JBrowse link
heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB10 ATP binding cassette subfamily B member 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:9,711,509...9,746,785
Ensembl chr 4:9,711,100...9,745,106 		JBrowse link
G ALAD aminolevulinate dehydratase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14050799), (PMID:4959158), (PMID:4981581) RGD
MGI
TreeGrafter
UniProt
Ensembl		 PMID:1764448 PMID:4959158 PMID:4981581 PMID:14050799 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 RGD:1599020 NCBI chr11:67,736,643...67,752,399
Ensembl chr11:67,741,390...67,752,321 		JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 involved_in IEA UniProt
TreeGrafter		 GO_REF:0000043 GO_REF:0000118 NCBI chr20:37,552,813...37,566,417
Ensembl chr20:37,552,814...37,566,638 		JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 involved_in IEA UniProt
TreeGrafter		 GO_REF:0000043 GO_REF:0000118 NCBI chr  X:46,703,477...46,731,767
Ensembl chr  X:46,703,477...46,723,529 		JBrowse link
G ATP5IF1 ATP synthase inhibitory factor subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:72,188,562...72,191,344
Ensembl chr 2:72,188,266...72,191,326 		JBrowse link
G COX10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr 5:37,853,495...37,982,228
Ensembl chr 5:37,852,875...37,982,243 		JBrowse link
G COX15 cytochrome c oxidase assembly homolog COX15 involved_in IEA UniProt GO_REF:0000043 NCBI chr28:12,609,690...12,625,467
Ensembl chr28:12,610,401...12,624,087 		JBrowse link
G CPOX coproporphyrinogen oxidase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:8407975) RGD
MGI
UniProt
Ensembl		 PMID:3955059 PMID:8407975 GO_REF:0000107 GO_REF:0000117 RGD:1600961 NCBI chr33:5,446,022...5,459,152
Ensembl chr33:5,447,414...5,459,461 		JBrowse link
G FECH ferrochelatase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9989256)
(PMID:15496139), (PMID:16503645)
(PMID:16306232)
(PMID:8611576)		 RGD
MGI
TreeGrafter
Ensembl
UniProt
InterPro		 PMID:3955059 PMID:8611576 PMID:9989256 PMID:15496139 PMID:16306232 More... GO_REF:0000002 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:1600961 NCBI chr 1:18,352,184...18,384,251
Ensembl chr 1:18,345,811...18,383,092 		JBrowse link
G HMBS hydroxymethylbilane synthase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:14,767,306...14,775,205
Ensembl chr 5:14,767,666...14,775,082 		JBrowse link
G HNF1A HNF1 homeobox A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10617683) Ensembl
MGI		 PMID:10617683 GO_REF:0000107 NCBI chr26:16,805,690...16,826,065
Ensembl chr26:16,805,690...16,824,790 		JBrowse link
G LOC100684734 transmembrane protein 14C pseudogene involved_in IEA UniProt GO_REF:0000043 NCBI chr23:24,126,258...24,126,584 JBrowse link
G LOC478720 transmembrane protein 14C involved_in IEA UniProt GO_REF:0000043 NCBI chr35:10,454,501...10,462,296 JBrowse link
G PGRMC1 progesterone receptor membrane component 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:91,329,243...91,337,951
Ensembl chr  X:91,329,243...91,337,951 		JBrowse link
G PPOX protoporphyrinogen oxidase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:3346226) RGD
MGI
Ensembl
UniProt		 PMID:3346226 PMID:3955059 GO_REF:0000043 GO_REF:0000107 RGD:1600961 NCBI chr38:21,306,973...21,310,892
Ensembl chr38:21,306,974...21,311,012 		JBrowse link
G SLC11A2 solute carrier family 11 member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11739192) Ensembl
MGI		 PMID:11739192 GO_REF:0000107 NCBI chr27:3,788,785...3,823,852
Ensembl chr27:3,787,855...3,822,672 		JBrowse link
G SLC25A39 solute carrier family 25 member 39 involved_in IEA UniProt GO_REF:0000043 NCBI chr 9:19,103,104...19,107,691
Ensembl chr 9:19,102,787...19,107,694 		JBrowse link
G UROD uroporphyrinogen decarboxylase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17360334) UniProt
TreeGrafter
MGI
Ensembl		 PMID:17360334 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 NCBI chr15:15,313,808...15,317,130
Ensembl chr15:15,312,674...15,320,010 		JBrowse link
G UROS uroporphyrinogen III synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:34,952,074...34,983,532
Ensembl chr28:34,948,003...34,983,532 		JBrowse link
heme catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BLVRA biliverdin reductase A involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr18:6,424,833...6,506,399
Ensembl chr18:6,426,255...6,495,647 		JBrowse link
G BLVRB biliverdin reductase B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:113,244,484...113,258,170
Ensembl chr 1:113,244,503...113,258,073 		JBrowse link
G HMOX1 heme oxygenase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:31571584) RGD
MGI
Ensembl
TreeGrafter		 PMID:15226268 PMID:31571584 GO_REF:0000107 GO_REF:0000118 RGD:1547877 NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773 		JBrowse link
G HMOX2 heme oxygenase 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:36,881,073...36,898,062
Ensembl chr 6:36,881,506...36,898,042 		JBrowse link
heme metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB6 ATP binding cassette subfamily B member 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:25,760,478...25,767,753
Ensembl chr37:25,760,477...25,769,841 		JBrowse link
G CYP2A13 cytochrome P450 family 2 subfamily A polypeptide 13 acts_upstream_of_or_within ISO (PMID:16183037) MGI PMID:16183037 NCBI chr 1:112,932,246...112,938,248
Ensembl chr 1:112,931,985...112,938,350 		JBrowse link
G HMOX1 heme oxygenase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16183037) Ensembl
MGI		 PMID:16183037 GO_REF:0000107 NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773 		JBrowse link
G HPX hemopexin acts_upstream_of_or_within ISO (PMID:18556779) MGI PMID:18556779 NCBI chr21:29,749,913...29,759,176
Ensembl chr21:29,719,589...29,759,046 		JBrowse link
G SLC48A1 solute carrier family 48 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:6,970,510...6,978,837
Ensembl chr27:6,971,402...6,978,942 		JBrowse link
G UROD uroporphyrinogen decarboxylase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11134514) Ensembl
MGI		 PMID:11134514 GO_REF:0000107 NCBI chr15:15,313,808...15,317,130
Ensembl chr15:15,312,674...15,320,010 		JBrowse link
heme O biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALAD aminolevulinate dehydratase involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:67,736,643...67,752,399
Ensembl chr11:67,741,390...67,752,321 		JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:37,552,813...37,566,417
Ensembl chr20:37,552,814...37,566,638 		JBrowse link
G COX10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:37,853,495...37,982,228
Ensembl chr 5:37,852,875...37,982,243 		JBrowse link
G CPOX coproporphyrinogen oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr33:5,446,022...5,459,152
Ensembl chr33:5,447,414...5,459,461 		JBrowse link
G FECH ferrochelatase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:18,352,184...18,384,251
Ensembl chr 1:18,345,811...18,383,092 		JBrowse link
G HMBS hydroxymethylbilane synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:14,767,306...14,775,205
Ensembl chr 5:14,767,666...14,775,082 		JBrowse link
G PPOX protoporphyrinogen oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr38:21,306,973...21,310,892
Ensembl chr38:21,306,974...21,311,012 		JBrowse link
G UROD uroporphyrinogen decarboxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:15,313,808...15,317,130
Ensembl chr15:15,312,674...15,320,010 		JBrowse link
G UROS uroporphyrinogen III synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:34,952,074...34,983,532
Ensembl chr28:34,948,003...34,983,532 		JBrowse link
heme oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HMOX1 heme oxygenase 1 involved_in IEA InterPro
TreeGrafter
UniProt
Ensembl		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773 		JBrowse link
G HMOX2 heme oxygenase 2 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 6:36,881,073...36,898,062
Ensembl chr 6:36,881,506...36,898,042 		JBrowse link
porphyrin-containing compound biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB6 ATP binding cassette subfamily B member 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:25,760,478...25,767,753
Ensembl chr37:25,760,477...25,769,841 		JBrowse link
G ANK1 ankyrin 1 acts_upstream_of_or_within ISO (PMID:658175) MGI PMID:658175 NCBI chr16:23,858,299...23,966,181
Ensembl chr16:23,766,193...23,964,226 		JBrowse link
G CPOX coproporphyrinogen oxidase involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr33:5,446,022...5,459,152
Ensembl chr33:5,447,414...5,459,461 		JBrowse link
G FECH ferrochelatase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12149233) Ensembl
MGI		 PMID:12149233 GO_REF:0000107 NCBI chr 1:18,352,184...18,384,251
Ensembl chr 1:18,345,811...18,383,092 		JBrowse link
G HMBS hydroxymethylbilane synthase involved_in ISO
IEA		 Uroporphyrin I
Urophorphyrin I
uroporphyrin I
Uroporphyrinogen		 RGD
UniProt		 PMID:971328 PMID:994723 PMID:1781034 PMID:3179323 PMID:3702597 More... GO_REF:0000043 GO_REF:0000117 RGD:2301707 RGD:25330343 RGD:25394583 RGD:25394584 RGD:25440495 RGD:25440497 RGD:26923962 RGD:26923963 RGD:4144783 RGD:4144803 RGD:4144820 NCBI chr 5:14,767,306...14,775,205
Ensembl chr 5:14,767,666...14,775,082 		JBrowse link
G PPOX protoporphyrinogen oxidase involved_in ISO
IEA		 RGD
Ensembl
InterPro		 PMID:3663105 GO_REF:0000002 GO_REF:0000107 RGD:1599180 NCBI chr38:21,306,973...21,310,892
Ensembl chr38:21,306,974...21,311,012 		JBrowse link
G RSAD1 radical S-adenosyl methionine domain containing 1 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 9:26,408,736...26,417,398
Ensembl chr 9:26,409,536...26,415,440 		JBrowse link
G SLC11A2 solute carrier family 11 member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:658175) Ensembl
MGI		 PMID:658175 GO_REF:0000107 NCBI chr27:3,788,785...3,823,852
Ensembl chr27:3,787,855...3,822,672 		JBrowse link
G SPTA1 spectrin alpha, erythrocytic 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:658175) Ensembl
MGI		 PMID:658175 GO_REF:0000107 NCBI chr38:23,052,046...23,118,933
Ensembl chr38:23,051,563...23,118,966 		JBrowse link
G SPTB spectrin beta, erythrocytic acts_upstream_of_or_within ISO (PMID:658175) MGI PMID:658175 NCBI chr 8:39,156,388...39,300,908
Ensembl chr 8:39,158,795...39,221,193 		JBrowse link
G UROD uroporphyrinogen decarboxylase involved_in ISO
IEA		 RGD
InterPro		 PMID:12381387 GO_REF:0000002 RGD:4144825 NCBI chr15:15,313,808...15,317,130
Ensembl chr15:15,312,674...15,320,010 		JBrowse link
G UROS uroporphyrinogen III synthase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:7607680) MGI
Ensembl
UniProt		 PMID:7607680 GO_REF:0000107 GO_REF:0000117 MGI:3620006 NCBI chr28:34,952,074...34,983,532
Ensembl chr28:34,948,003...34,983,532 		JBrowse link
porphyrin-containing compound catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UROD uroporphyrinogen decarboxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:15,313,808...15,317,130
Ensembl chr15:15,312,674...15,320,010 		JBrowse link
porphyrin-containing compound metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB6 ATP binding cassette subfamily B member 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:25,760,478...25,767,753
Ensembl chr37:25,760,477...25,769,841 		JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr20:37,552,813...37,566,417
Ensembl chr20:37,552,814...37,566,638 		JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr  X:46,703,477...46,731,767
Ensembl chr  X:46,703,477...46,723,529 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 ISO Uroporphyrinogen oxidation, generating hydrogen peroxide RGD PMID:12907239 RGD:2306674 NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11274970), (PMID:9461503) Ensembl
MGI		 PMID:9461503 PMID:11274970 GO_REF:0000107 NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135 		JBrowse link
G HMBS hydroxymethylbilane synthase ISO Porphobilinogen
Uroporphyrinogen
Porphobilinogen 		RGD PMID:593266 PMID:971328 PMID:994723 PMID:1781034 PMID:3179323 More... RGD:2301707 RGD:25394583 RGD:25394584 RGD:25440495 RGD:25440497 RGD:26884337 RGD:26923962 RGD:26923963 RGD:4144783 RGD:4144803 RGD:4144820 NCBI chr 5:14,767,306...14,775,205
Ensembl chr 5:14,767,666...14,775,082 		JBrowse link
G SLC11A2 solute carrier family 11 member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:4404581) Ensembl
MGI		 PMID:4404581 GO_REF:0000107 NCBI chr27:3,788,785...3,823,852
Ensembl chr27:3,787,855...3,822,672 		JBrowse link
G UROD uroporphyrinogen decarboxylase involved_in IEA Ensembl
UniProt		 GO_REF:0000107 GO_REF:0000117 NCBI chr15:15,313,808...15,317,130
Ensembl chr15:15,312,674...15,320,010 		JBrowse link
positive regulation of cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLYBL citramalyl-CoA lyase involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:49,608,997...49,893,766
Ensembl chr22:49,608,358...49,871,572 		JBrowse link
positive regulation of heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB7 ATP binding cassette subfamily B member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:58,305,804...58,470,827
Ensembl chr  X:58,306,776...58,471,417 		JBrowse link
G SLC6A9 solute carrier family 6 member 9 involved_in ISO (MGI:6450351|PMID:28495915) ARUK-UCL PMID:28495915 MGI:6450351 NCBI chr15:16,235,342...16,267,161
Ensembl chr15:16,235,482...16,267,933 		JBrowse link
protoporphyrinogen IX biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALAD aminolevulinate dehydratase involved_in IEA UniProt GO_REF:0000041 NCBI chr11:67,736,643...67,752,399
Ensembl chr11:67,741,390...67,752,321 		JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 involved_in IEA UniProt GO_REF:0000041 NCBI chr20:37,552,813...37,566,417
Ensembl chr20:37,552,814...37,566,638 		JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 involved_in IEA UniProt GO_REF:0000041 GO_REF:0000104 NCBI chr  X:46,703,477...46,731,767
Ensembl chr  X:46,703,477...46,723,529 		JBrowse link
G CPOX coproporphyrinogen oxidase involved_in ISO
IEA		 RGD
TreeGrafter
UniProt		 PMID:3814086 GO_REF:0000041 GO_REF:0000118 RGD:4145128 NCBI chr33:5,446,022...5,459,152
Ensembl chr33:5,447,414...5,459,461 		JBrowse link
G HMBS hydroxymethylbilane synthase involved_in IEA UniProt GO_REF:0000041 NCBI chr 5:14,767,306...14,775,205
Ensembl chr 5:14,767,666...14,775,082 		JBrowse link
G IREB2 iron responsive element binding protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15831703) Ensembl
MGI		 PMID:15831703 GO_REF:0000107 NCBI chr13:38,398,445...38,441,128
Ensembl chr13:38,400,591...38,441,015 		JBrowse link
G PPOX protoporphyrinogen oxidase involved_in IEA UniProt GO_REF:0000041 GO_REF:0000104 NCBI chr38:21,306,973...21,310,892
Ensembl chr38:21,306,974...21,311,012 		JBrowse link
G UROD uroporphyrinogen decarboxylase involved_in IEA UniProt GO_REF:0000041 NCBI chr15:15,313,808...15,317,130
Ensembl chr15:15,312,674...15,320,010 		JBrowse link
G UROS uroporphyrinogen III synthase involved_in IEA UniProt GO_REF:0000041 NCBI chr28:34,952,074...34,983,532
Ensembl chr28:34,948,003...34,983,532 		JBrowse link
protoporphyrinogen IX metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EIF2AK1 eukaryotic translation initiation factor 2 alpha kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15931390) Ensembl
MGI		 PMID:15931390 GO_REF:0000107 NCBI chr 6:11,447,225...11,478,611
Ensembl chr 6:11,447,081...11,478,658 		JBrowse link
G FECH ferrochelatase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15931390) Ensembl
MGI		 PMID:15931390 GO_REF:0000107 NCBI chr 1:18,352,184...18,384,251
Ensembl chr 1:18,345,811...18,383,092 		JBrowse link
G PPOX protoporphyrinogen oxidase ISO RGD PMID:3663105 RGD:1599180 NCBI chr38:21,306,973...21,310,892
Ensembl chr38:21,306,974...21,311,012 		JBrowse link
regulation of cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLYBL citramalyl-CoA lyase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr22:49,608,997...49,893,766
Ensembl chr22:49,608,358...49,871,572 		JBrowse link
regulation of heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100684734 transmembrane protein 14C pseudogene involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr23:24,126,258...24,126,584 JBrowse link
G LOC478720 transmembrane protein 14C involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25157825) TreeGrafter
MGI		 PMID:25157825 GO_REF:0000118 NCBI chr35:10,454,501...10,462,296 JBrowse link
G SRRD SRR1 domain containing involved_in ISO (MGI:6282940|PMID:28802827) UniProt PMID:28802827 MGI:6282940 NCBI chr26:20,172,236...20,186,236 JBrowse link
G TMEM14A transmembrane protein 14A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr12:20,303,724...20,318,336 JBrowse link
tetrapyrrole biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALAD aminolevulinate dehydratase involved_in IEA InterPro GO_REF:0000002 NCBI chr11:67,736,643...67,752,399
Ensembl chr11:67,741,390...67,752,321 		JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr20:37,552,813...37,566,417
Ensembl chr20:37,552,814...37,566,638 		JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr  X:46,703,477...46,731,767
Ensembl chr  X:46,703,477...46,723,529 		JBrowse link
G HMBS hydroxymethylbilane synthase involved_in ISO
IEA		 RGD
InterPro		 PMID:6712591 PMID:9344466 PMID:12127573 PMID:18760440 GO_REF:0000002 RGD:2301691 RGD:2301695 RGD:2301704 RGD:2301858 NCBI chr 5:14,767,306...14,775,205
Ensembl chr 5:14,767,666...14,775,082 		JBrowse link
uroporphyrinogen III biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UROS uroporphyrinogen III synthase involved_in ISO
IEA		 RGD
TreeGrafter
Ensembl
InterPro		 PMID:17763925 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:4144811 NCBI chr28:34,952,074...34,983,532
Ensembl chr28:34,948,003...34,983,532 		JBrowse link
uroporphyrinogen III metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UROD uroporphyrinogen decarboxylase ISO converts uroporphyrinogen to coproporphyrinogen via hepta-, hexa- and penta-carboxyporphyrinogen RGD PMID:15736160 RGD:2301379 NCBI chr15:15,313,808...15,317,130
Ensembl chr15:15,312,674...15,320,010 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17917
    metabolic process 10998
      organic substance metabolic process 10554
        organonitrogen compound metabolic process 5384
          tetrapyrrole metabolic process 49
            cobalamin metabolic process + 10
            corrin metabolic process + 0
            negative regulation of tetrapyrrole metabolic process + 0
            nickel-tetrapyrrole coenzyme metabolic process + 0
            phytochromobilin metabolic process + 0
            porphyrin-containing compound metabolic process + 39
            positive regulation of tetrapyrrole metabolic process + 3
            regulation of tetrapyrrole metabolic process + 7
            tetrapyrrole biosynthetic process + 29
            tetrapyrrole catabolic process + 6
paths to the root