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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of mast cell activation
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Accession:GO:0033003 term browser browse the term
Definition:Any process that modulates the frequency, rate, or extent of mast cell activation.


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regulation of mast cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISS
ISO		 GO_REF:0000024
(MGI:3703139|PMID:16272347)		 UniProt
RGD		 PMID:16272347 GO_REF:0000024 MGI:3703139 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Plscr1 phospholipid scramblase 1 involved_in IMP PMID:18579528 UniProt PMID:18579528 RGD:2303650 NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692 		JBrowse link
G Ptpre protein tyrosine phosphatase, receptor type, E involved_in ISO (MGI:4412219|PMID:19508371) RGD PMID:19508371 MGI:4412219 NCBI chr 1:190,344,331...190,494,815
Ensembl chr 1:190,344,401...190,489,534 		JBrowse link
negative regulation of mast cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300lf Cd300 molecule-like family member F involved_in ISO
ISS		 (PMID:24035150)
(MGI:5451118|PMID:23123064)
GO_REF:0000024		 RGD
UniProt		 PMID:23123064 PMID:24035150 GO_REF:0000024 MGI:5451118 NCBI chr10:100,359,942...100,376,130
Ensembl chr10:100,359,943...100,376,041 		JBrowse link
G Cd84 CD84 molecule involved_in ISO (PMID:22068234) RGD PMID:22068234 NCBI chr13:84,327,580...84,367,153
Ensembl chr13:84,327,553...84,362,076 		JBrowse link
G Cnr1 cannabinoid receptor 1 IDA RGD PMID:18552882 RGD:2316220 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Cnr2 cannabinoid receptor 2 IDA RGD PMID:18552882 RGD:2316220 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548 		JBrowse link
G Milr1 mast cell immunoglobulin-like receptor 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:4461821|PMID:20526344)
GO_REF:0000002		 UniProt
RGD
InterPro		 PMID:20526344 GO_REF:0000002 GO_REF:0000024 MGI:4461821 NCBI chr10:91,684,288...91,705,284
Ensembl chr10:91,687,831...91,705,282 		JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO MGI:3051384 (MGI:3050742|PMID:15235600) RGD PMID:15235600 MGI:3050742 NCBI chr12:26,459,190...26,503,790
Ensembl chr12:26,460,175...26,503,744 		JBrowse link
negative regulation of mast cell activation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a Cd300a molecule involved_in ISO (PMID:16339535) RGD PMID:16339535 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674 		JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5660449|PMID:25692702)		 UniProt
RGD		 PMID:25692702 GO_REF:0000024 MGI:5660449 NCBI chr 1:20,563,700...20,635,044
Ensembl chr 1:20,563,697...20,635,041 		JBrowse link
G Fer FER tyrosine kinase involved_in ISS
ISO		 GO_REF:0000024
(MGI:3694314|PMID:16731527)		 UniProt
RGD		 PMID:16731527 GO_REF:0000024 MGI:3694314 NCBI chr 9:103,520,452...103,827,364
Ensembl chr 9:103,520,493...103,821,451 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 involved_in IEA
ISO		 GO_REF:0000107
(MGI:6827314|PMID:10026201)		 Ensembl
RGD		 PMID:10026201 GO_REF:0000107 MGI:6827314 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
negative regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a Cd300a molecule involved_in
acts_upstream_of_or_within		 ISO (PMID:16339535)
(MGI:3721168|PMID:12874256)		 RGD PMID:12874256 PMID:16339535 MGI:3721168 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674 		JBrowse link
G Cd84 CD84 molecule involved_in ISO (PMID:22068234) RGD PMID:22068234 NCBI chr13:84,327,580...84,367,153
Ensembl chr13:84,327,553...84,362,076 		JBrowse link
G Foxf1 forkhead box F1 acts_upstream_of_or_within ISO MGI:2179135 (MGI:4367570|PMID:18421012) RGD PMID:18421012 MGI:4367570 NCBI chr19:49,153,729...49,157,741
Ensembl chr19:49,153,699...49,157,738 		JBrowse link
G Hmox1 heme oxygenase 1 IDA RGD PMID:17234154 RGD:1601626 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:2653910 (MGI:3589858|PMID:15944273)
GO_REF:0000107		 RGD
Ensembl		 PMID:15944273 GO_REF:0000107 MGI:3589858 NCBI chr  X:111,002,590...111,074,053
Ensembl chr  X:111,002,592...111,072,381 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:24465902) RGD PMID:24465902 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO MGI:3051384 (MGI:3050742|PMID:15235600) RGD PMID:15235600 MGI:3050742 NCBI chr12:26,459,190...26,503,790
Ensembl chr12:26,460,175...26,503,744 		JBrowse link
positive regulation of histamine secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nppa natriuretic peptide A involved_in IDA PMID:9663691 UniProt PMID:9663691 RGD:13461752 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Pla2g3 phospholipase A2, group III involved_in ISO (PMID:23624557)
(MGI:5492190|PMID:23624557)		 RGD PMID:23624557 MGI:5492190 NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913 		JBrowse link
G Snx4 sorting nexin 4 involved_in ISO (PMID:18253931) RGD PMID:18253931 NCBI chr11:67,460,872...67,518,143
Ensembl chr11:67,460,870...67,518,174 		JBrowse link
G Vamp7 vesicle-associated membrane protein 7 involved_in ISO (PMID:18253931) RGD PMID:18253931 NCBI chr12:16,728,477...16,764,261
Ensembl chr12:16,728,524...16,764,097 		JBrowse link
G Vamp8 vesicle-associated membrane protein 8 involved_in IEA
ISO		 GO_REF:0000107
(PMID:18253931)		 Ensembl
RGD		 PMID:18253931 GO_REF:0000107 NCBI chr 4:104,442,383...104,452,884
Ensembl chr 4:104,442,393...104,452,897 		JBrowse link
positive regulation of mast cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd226 CD226 molecule involved_in ISO
IBA		 (PMID:16831868)
PMID:21873635		 RGD PMID:16831868 PMID:21873635 RGD:13792537 NCBI chr18:82,449,924...82,545,107
Ensembl chr18:82,450,568...82,543,051 		JBrowse link
G Cd300lb CD300 molecule-like family member b acts_upstream_of_or_within ISO (MGI:4821898|PMID:20566714) RGD PMID:20566714 MGI:4821898 NCBI chr10:99,964,801...99,974,790
Ensembl chr10:99,964,801...99,974,790 		JBrowse link
G Cftr CF transmembrane conductance regulator IMP RGD PMID:11781380 RGD:11567226 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Crlf2 cytokine receptor-like factor 2 involved_in ISO (PMID:17242164) RGD PMID:17242164 NCBI chr14:103,943...108,643
Ensembl chr14:103,939...108,642 		JBrowse link
G Dppa1 developmental pluripotency associated 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:30,998,049...31,017,756
Ensembl chr10:30,998,049...31,017,756 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:4821898|PMID:20566714)		 RGD PMID:20566714 PMID:21873635 MGI:4821898, RGD:13792537 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G LOC100359777 mCG12681-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:30,919,860...30,941,388
Ensembl chr10:30,923,809...30,941,108 		JBrowse link
G LOC689968 similar to kidney injury molecule 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:30,963,058...30,983,169
Ensembl chr10:30,968,739...30,981,979 		JBrowse link
G Nectin2 nectin cell adhesion molecule 2 involved_in IBA
ISO		 PMID:21873635
(PMID:16831868)		 RGD PMID:16831868 PMID:21873635 RGD:13792537 NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360 		JBrowse link
G Timd2 T-cell immunoglobulin and mucin domain containing 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:31,060,308...31,101,262
Ensembl chr10:31,060,326...31,094,623 		JBrowse link
G Tslp thymic stromal lymphopoietin involved_in ISO (PMID:17242164) RGD PMID:17242164 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548 		JBrowse link
positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5586645|PMID:24586680)		 UniProt
RGD		 PMID:24586680 GO_REF:0000024 MGI:5586645 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733 		JBrowse link
positive regulation of mast cell activation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sphk2 sphingosine kinase 2 involved_in ISO (MGI:3703830|PMID:17346996) RGD PMID:17346996 MGI:3703830 NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391 		JBrowse link
positive regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2B receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:3776334|PMID:11454903)		 Ensembl
RGD		 PMID:11454903 GO_REF:0000107 MGI:3776334 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772 		JBrowse link
G Adora3 adenosine A3 receptor acts_upstream_of_or_within ISO MGI:2155986 (MGI:2664591|PMID:12817016) RGD PMID:12817016 MGI:2664591 NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IMP RGD PMID:18209484 RGD:5130941 NCBI chr10:89,040,203...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Fcer1a Fc epsilon receptor Ia acts_upstream_of_or_within ISO (MGI:85068|PMID:9000133) RGD PMID:9000133 MGI:85068 NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351 		JBrowse link
G Fcer1g Fc epsilon receptor Ig acts_upstream_of_or_within ISO MGI:2384004 (MGI:3029067|PMID:14764707) RGD PMID:14764707 MGI:3029067 NCBI chr13:83,649,447...83,654,215
Ensembl chr13:83,649,449...83,671,443 		JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase involved_in ISS
ISO		 GO_REF:0000024
(MGI:5294498|PMID:21746961)		 UniProt
RGD		 PMID:21746961 GO_REF:0000024 MGI:5294498 NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326 		JBrowse link
G Gab2 GRB2-associated binding protein 2 involved_in ISO
ISS		 (MGI:2137187|PMID:11449275)
GO_REF:0000024		 RGD
UniProt		 PMID:11449275 GO_REF:0000024 MGI:2137187 NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031 		JBrowse link
G Gata1 GATA binding protein 1 IMP RGD PMID:22390417 RGD:9587812 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530 		JBrowse link
G Gata2 GATA binding protein 2 IMP RGD PMID:22390417 RGD:9587812 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761 		JBrowse link
G Il13 interleukin 13 acts_upstream_of_or_within ISO MGI:1931804|MGI:96556 (MGI:3589858|PMID:15944273) RGD PMID:15944273 MGI:3589858 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il4 interleukin 4 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:1857195|MGI:96541 (MGI:3589858|PMID:15944273)		 RGD PMID:15944273 PMID:21873635 MGI:3589858, RGD:13792537 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO MGI:1861951 (MGI:3589858|PMID:15944273) RGD PMID:15944273 MGI:3589858 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980 		JBrowse link
G Ms4a2 membrane spanning 4-domains A2 IMP RGD PMID:16177098 RGD:1578516 NCBI chr 1:208,440,179...208,448,716
Ensembl chr 1:208,440,361...208,448,310 		JBrowse link
G Nppc natriuretic peptide C involved_in IDA PMID:9663691 UniProt PMID:9663691 RGD:13461752 NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251 		JBrowse link
G Pld2 phospholipase D2 IMP RGD PMID:16861349 RGD:2299903 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808 		JBrowse link
G Sphk2 sphingosine kinase 2 involved_in ISO (MGI:3703830|PMID:17346996) RGD PMID:17346996 MGI:3703830 NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391 		JBrowse link
G Stxbp1 syntaxin binding protein 1 IMP RGD PMID:23487749 RGD:12904029 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369 		JBrowse link
G Stxbp2 syntaxin binding protein 2 IMP RGD PMID:23487749 RGD:12904029 NCBI chr12:1,689,364...1,701,145
Ensembl chr12:1,689,410...1,700,458 		JBrowse link
G Syk spleen associated tyrosine kinase acts_upstream_of_or_within
involved_in		 IMP
ISO
IBA
IEA		 MGI:2384078 (MGI:85068|PMID:9000133)
PMID:21873635
GO_REF:0000107		 RGD
Ensembl		 PMID:9000133 PMID:16861349 PMID:21873635 GO_REF:0000107 MGI:85068, RGD:2299903, RGD:13792537 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blk BLK proto-oncogene, Src family tyrosine kinase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:37,626,746...37,665,053
Ensembl chr15:37,627,039...37,665,031 		JBrowse link
G Fer FER tyrosine kinase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:103,520,452...103,827,364
Ensembl chr 9:103,520,493...103,821,451 		JBrowse link
G Fes FES proto-oncogene, tyrosine kinase involved_in ISO
IBA		 (PMID:19001085)
PMID:21873635		 RGD PMID:19001085 PMID:21873635 RGD:13792537 NCBI chr 1:134,337,698...134,346,934
Ensembl chr 1:134,337,698...134,346,934 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in IBA
ISS
ISO		 PMID:21873635
GO_REF:0000024
(MGI:3703139|PMID:16272347)		 UniProt
RGD		 PMID:16272347 PMID:21873635 GO_REF:0000024 MGI:3703139, RGD:13792537 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 involved_in ISO (MGI:5298334|PMID:21063107) RGD PMID:21063107 MGI:5298334 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Rac2 Rac family small GTPase 2 involved_in ISO (MGI:3655336|PMID:10843388) RGD PMID:10843388 MGI:3655336 NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720 		JBrowse link
G RGD1311164 similar to DNA segment, Chr 6, Wayne State University 163, expressed involved_in IBA
IDA		 PMID:21873635
PMID:25122211		 GO_Central
UniProt		 PMID:21873635 PMID:25122211 RGD:13792537, RGD:10047193 NCBI chr 4:159,772,693...159,809,322
Ensembl chr 4:159,772,786...159,806,382 		JBrowse link
G Stxbp2 syntaxin binding protein 2 IMP RGD PMID:12482918 RGD:2312429 NCBI chr12:1,689,364...1,701,145
Ensembl chr12:1,689,410...1,700,458 		JBrowse link
G Unc13d unc-13 homolog D involved_in ISO
IEA		 (PMID:15548590)
GO_REF:0000107		 RGD
Ensembl		 PMID:15548590 GO_REF:0000107 NCBI chr10:101,296,755...101,311,513
Ensembl chr10:101,296,776...101,311,687 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18734
    immune system process 2730
      leukocyte activation 1025
        regulation of leukocyte activation 662
          regulation of mast cell activation 59
            negative regulation of mast cell activation + 14
            positive regulation of mast cell activation + 36
            regulation of mast cell activation involved in immune response + 41
Path 2
Term Annotations click to browse term
  biological_process 18734
    biological regulation 13314
      regulation of biological process 12594
        regulation of cellular process 11909
          regulation of cell activation 718
            regulation of leukocyte activation 662
              regulation of mast cell activation 59
                negative regulation of mast cell activation + 14
                positive regulation of mast cell activation + 36
                regulation of mast cell activation involved in immune response + 41
paths to the root