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ONTOLOGY REPORT - ANNOTATIONS


Term:protein-containing complex
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Accession:GO:0032991 term browser browse the term
Definition:A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
Comment:A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole.
Synonyms:exact_synonym: macromolecular complex;   macromolecule complex
 narrow_synonym: protein complex;   protein-protein complex
 alt_id: GO:0043234


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  cellular_component 11994
    protein-containing complex 3809
      3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex 0
      3M complex 5
      ABIN2-NFKB1-MAP3K8 complex 0
      ADPG pyrophosphorylase complex + 0
      AIP1-IRE1 complex 2
      APC-IQGAP complex 0
      APC-IQGAP1-CLIP-170 complex 0
      APC-IQGAP1-Cdc42 complex 0
      APC-IQGAP1-Rac1 complex 0
      APC-tubulin-IQGAP1 complex 0
      ASAP complex 3
      ASTRA complex 0
      ATPase inhibitor complex + 0
      ATR-ATRIP complex 0
      Aim21-Tda2 complex 0
      AnxA2-p11 complex 2
      Arp2/3 protein complex 7
      B800-820 antenna complex 0
      B800-850 antenna complex 0
      B875 antenna complex 0
      BBSome 8
      BID-BCL-xl complex 0
      BLOC complex + 19
      BORC complex 8
      BRCA1-A complex 7
      BRCA1-B complex 0
      BRCA1-C complex 0
      BRCA1-Rad51 complex 0
      BRCA2-BRAF35 complex 0
      BRCA2-MAGE-D1 complex 1
      BRISC complex 5
      Bcl-2 family protein complex + 5
      Bcl3-Bcl10 complex 1
      CAF-1 complex 3
      CAK-ERCC2 complex 4
      CBF3 complex 0
      CBM complex 3
      CCR4-NOT complex + 16
      CCR4-NOT core complex 0
      CD20-Lck-Fyn complex 0
      CD20-Lck-Lyn-Fyn complex 0
      CENP-A recruiting complex 0
      CENP-T-W-S-X complex 0
      CHOP-ATF3 complex 2
      CIA complex 5
      CNTFR-CLCF1 complex 2
      COMA complex 0
      COP9 signalosome 32
      CRD-mediated mRNA stability complex 6
      CRLF-CLCF1 complex 2
      CSF1-CSF1R complex 2
      CSK-GAP-A.p62 complex 0
      CUGBP1-eIF2 complex 0
      CURI complex 0
      Cbf1-Met4-Met28 complex 0
      Cbp3p-Cbp6 complex 0
      Cdc24p-Far1p-Gbetagamma complex 0
      Cdc42 GTPase complex 0
      CoA-synthesizing protein complex 0
      Ctf18 RFC-like complex 8
      Cvt complex 0
      DBIRD complex 2
      DNA bending complex + 0
      DNA ligase III-XRCC1 complex 1
      DNA ligase IV complex 2
      DNA packaging complex + 27
      DNA polymerase III, clamp loader chi/psi subcomplex 0
      DNA polymerase III, clamp loader complex + 0
      DNA polymerase III, core complex + 0
      DNA polymerase III, proofreading complex 0
      DNA polymerase processivity factor complex + 1
      DNA recombinase mediator complex + 7
      DNA repair complex + 31
      DNA replication factor A complex 13
      DNA replication factor C complex + 5
      DNA replication factor C core complex 0
      DNA topoisomerase III-beta-TDRD3 complex 0
      DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex + 1
      DUBm complex 2
      Dbf4-dependent protein kinase complex 0
      DiaA complex 0
      DnaB-DnaC complex 0
      Dom34-Hbs1 complex 0
      Dxr protein complex 0
      E.F.G complex 0
      EARP complex 5
      EDS1 disease-resistance complex 0
      EKC/KEOPS complex 5
      ER membrane insertion complex + 3
      ESCRT complex + 20
      Elongator holoenzyme complex 6
      F-actin capping protein complex + 7
      FAL1-SGD1 complex 0
      FANCM-MHF complex 3
      FAR/SIN/STRIPAK complex 3
      FHF complex 5
      Fanconi anaemia nuclear complex 12
      G-protein alpha(13)-synembrin complex 0
      G-protein alpha(i)1-synembrin complex 0
      G-protein alpha(o)-synembrin complex 0
      G-protein alpha(q)-synembrin complex 0
      G-protein beta/gamma-Btk complex 0
      G-protein beta/gamma-Raf-1 complex 0
      G-protein beta/gamma-subunit complex 2
      GAIT complex 4
      GATA1-TAL1-TCF3-Lmo2 complex 0
      GATA2-TAL1-TCF3-Lmo2 complex 0
      GATOR1 complex 6
      GATOR2 complex 11
      GET complex 0
      GID complex 0
      GLI-SUFU complex 0
      Gemin3-Gemin4-Gemin5 complex 0
      Gemin6-Gemin7-unrip complex 0
      Gtr1-Gtr2 GTPase complex 0
      H-NS-Hha complex 0
      HICS complex 0
      HIR complex 0
      Hedgehog signaling complex 0
      I-kappaB/NF-kappaB complex + 2
      IKKalpha-IKKalpha complex 0
      IRE1-RACK1-PP2A complex 2
      KICSTOR complex 5
      Kelch-containing formin regulatory complex 0
      Kibra-Ex-Mer complex 0
      Ku70:Ku80 complex 3
      L-cysteine desulfurase complex + 1
      Lid2 complex 0
      LinE complex 0
      Lsd1/2 complex 1
      MAD1 complex 0
      MAML1-RBP-Jkappa- ICN1 complex 3
      MAML2-RBP-Jkappa-ICN1 complex 0
      MAML2-RBP-Jkappa-ICN2 complex 0
      MAML2-RBP-Jkappa-ICN3 complex 0
      MAML2-RBP-Jkappa-ICN4 complex 0
      MAML3-RBP-Jkappa-ICN1 complex 0
      MAML3-RBP-Jkappa-ICN2 complex 0
      MAML3-RBP-Jkappa-ICN3 complex 0
      MAML3-RBP-Jkappa-ICN4 complex 0
      MCM complex + 11
      MCM core complex 0
      MECO complex 0
      MIH complex 0
      MIS12/MIND type complex + 3
      MKS complex 14
      MMXD complex 5
      MWP complex 0
      Mcs4 RR-MAPKKK complex 0
      Mis6-Sim4 complex 0
      Mon1-Ccz1 complex 4
      Mpp10 complex 2
      Mre11 complex 5
      MutSgamma complex 0
      Myb complex 2
      Myo2p-Vac17p-Vac8p transport complex 0
      NAD(P)+ transhydrogenase complex (AB-specific) 0
      NF-kappaB complex + 2
      NHE3/E3KARP/ACTN4 complex 0
      NMS complex + 4
      NOS2-CD74 complex 1
      NPHP complex 0
      NURS complex 0
      NVT complex 0
      Ndc80 complex 4
      Nicalin-NOMO complex 0
      Noc complex + 1
      Nrd1 complex 0
      Nsk1-Dlc1 complex 0
      P-TEFb-cap methyltransferase complex 0
      PAN complex 2
      PCNA-p21 complex 2
      PCSK9-AnxA2 complex 2
      PCSK9-LDLR complex 2
      PDX1-PBX1b-MRG1 complex 0
      PET complex 3
      PTEX complex 0
      PYM-mago-Y14 complex 0
      Par3-APC-KIF3A complex 0
      PcG protein complex + 42
      PeBoW complex 3
      Pex17p-Pex14p docking complex + 0
      Prp19 complex 6
      Pwp2p-containing subcomplex of 90S preribosome 0
      R2TP complex 4
      RAVE complex 0
      RC-1 DNA recombination complex 0
      RCAF complex 0
      RES complex 0
      RGS6-DNMT1-DMAP1 complex 0
      RNA cap binding complex + 9
      RPAP3/R2TP/prefoldin-like complex 0
      RPB4-RPB7 complex 0
      RQC complex 0
      RZZ complex 3
      Rad17 RFC-like complex 0
      RasGAP-Fyn-Lyn-Yes complex 0
      RecFOR complex 0
      RecQ family helicase-topoisomerase III complex 0
      Rhino-Deadlock-Cutoff Complex 0
      Rix1 complex 0
      Rvs161p-Rvs167p complex 0
      S100A8 complex 0
      SCAR complex 8
      SLAC complex 0
      SMAD protein complex + 5
      SMC loading complex + 2
      SOD1-Bcl-2 complex 0
      SOD1-calcineurin complex 0
      SOSS complex 4
      Scrib-APC complex 0
      Scrib-APC-beta-catenin complex 3
      Seh1-associated complex + 16
      Sid2-Mob1 complex 0
      Ski complex 3
      Slx1-Slx4 complex 2
      Sm-like protein family complex + 51
      SsuD-SsuE complex 0
      Ste12p-Dig1p-Dig2p complex 0
      Swi5-Swi2 complex 0
      Syp1 complex 0
      TACC/TOG complex 0
      TAM protein secretion complex 0
      TBK1-IKKE-DDX3 complex 0
      TCR signalosome 3
      TEAD-2 multiprotein complex 0
      THO complex + 6
      TOC-TIC supercomplex I 0
      TOR complex + 13
      TRAF2-GSTP1 complex 2
      TRAMP complex 3
      TSC1-TSC2 complex 2
      TTT complex 0
      Tec1p-Ste12p-Dig1p complex 0
      Tor2-Mei2-Ste11 complex 0
      U2AF complex 2
      UFD1-NPL4 complex 2
      USH2 complex 4
      UTP-C complex 0
      Ubp3-Bre5 deubiquitination complex 0
      VCP-NSFL1C complex 2
      VRK3/VHR/ERK complex 0
      Vma12-Vma22 assembly complex 0
      WASH complex 8
      Wnt signalosome 9
      Y-shaped link 0
      Yae1-Lto1 complex 0
      acetyl-CoA decarbonylase/synthase-carbon monoxide dehydrogenase complex 0
      actin cytoskeleton-regulatory complex 0
      activin complex + 1
      acyl-CoA ceramide synthase complex 0
      aminoacyl-tRNA synthetase multienzyme complex 12
      aminodeoxychorismate synthase complex 0
      amyloid-beta complex 2
      anaerobic ribonucleoside-triphosphate reductase complex 0
      angiogenin-PRI complex 1
      apolipoprotein B mRNA editing enzyme complex 1
      apoptosome 3
      axonemal heterotrimeric kinesin-II complex 0
      axonemal nexin link 0
      beta-catenin destruction complex 8
      bub1-bub3 complex 0
      bursicon neuropeptide hormone complex 0
      cAMP-dependent protein kinase complex 8
      calcium- and calmodulin-dependent protein kinase complex 5
      calprotectin complex 0
      catalytic complex + 1046
      catenin-TCF7L2 complex + 4
      cell envelope Sec protein transport complex 0
      centralspindlin complex 3
      centriolar subdistal appendage 9
      chaperone complex + 23
      checkpoint clamp complex 0
      chromatin silencing complex + 10
      ciliary transition fiber 10
      citrate lyase complex 0
      classical-complement-pathway C3/C5 convertase complex 0
      cohesin complex + 11
      collagen trimer + 25
      complement component C1 complex 1
      complement component C1q complex 0
      condensed chromosome inner kinetochore + 2
      condensed chromosome outer kinetochore + 14
      condensin core heterodimer 2
      counting factor complex 0
      curli 0
      cytochrome complex + 12
      cytosolic tRNA wobble base thiouridylase complex 0
      divisome complex + 0
      dosage compensation complex + 0
      egasyn-beta-glucuronidase complex 0
      eisosome filament 0
      endopeptidase Clp complex + 2
      endoplasmic reticulum chaperone complex 11
      enterobactin synthetase complex 0
      enzyme activator complex + 3
      eukaryotic translation elongation factor 1 complex 1
      eukaryotic translation initiation factor 2 complex 5
      eukaryotic translation initiation factor 2B complex 6
      eukaryotic translation initiation factor 3 complex + 13
      eukaryotic translation initiation factor 4F complex 4
      exomer complex 0
      exon-exon junction complex + 19
      extracellular exosome complex + 0
      fatty acid beta-oxidation multienzyme complex + 2
      fatty acid synthase complex 0
      ferritin complex + 1
      fibrinogen complex 6
      filamentous actin 23
      formyl-methanofuran dehydrogenase (molybdenum enzyme) complex 0
      formyl-methanofuran dehydrogenase (tungsten enzyme) complex 0
      gamma-tubulin complex + 13
      glucosidase II complex 2
      glutamyl-tRNA(Gln) amidotransferase complex 3
      glycoprotein complex + 12
      growth factor complex + 5
      guanyl-nucleotide exchange factor complex + 13
      guanylate cyclase complex, soluble 2
      haptoglobin-hemoglobin complex 1
      hemidesmosome associated protein complex + 0
      hemoglobin complex 1
      histone mRNA stem-loop binding complex 0
      immunoglobulin complex + 6
      inflammasome complex + 6
      inhibin complex + 3
      integrator complex 15
      interferon regulatory factor complex + 0
      interleukin-12 complex 2
      interleukin-23 complex 2
      interleukin-27 complex 0
      interleukin-35 complex 0
      intraciliary transport particle + 25
      intraciliary transport particle A 7
      intraciliary transport particle B 18
      iron-sulfur cluster assembly complex + 0
      junctional membrane complex 7
      laminin complex + 9
      large latent transforming growth factor-beta complex 1
      larval serum protein complex 0
      lateral cortical node 0
      light-harvesting complex + 0
      luminal surveillance complex 0
      lymphotoxin complex 0
      lysosomal multienzyme complex 0
      mCRD-mediated mRNA stability complex 0
      mRNA cleavage factor complex + 13
      mRNA editing complex + 9
      matrilin complex 0
      mediator complex 30
      meiotic recombination initiation complex 0
      membrane fusion priming complex 0
      membrane protein complex + 802
      metallochaperone complex + 0
      methionyl glutamyl tRNA synthetase complex 0
      methyl accepting chemotaxis protein complex 0
      methyl-tetrahydromethanopterin:coenzyme M methyltransferase complex 0
      microtubule associated complex + 75
      mitochondrial iron-sulfur cluster assembly complex 0
      mitochondrial protein complex + 197
      mitotic checkpoint complex + 0
      mitotic checkpoint complex, CDC20-MAD2 subcomplex 0
      mitotic spindle assembly checkpoint MAD1-MAD2 complex 0
      molybdopterin synthase complex 1
      monopolin complex 0
      muscle thin filament tropomyosin 0
      myosin complex + 17
      nascent polypeptide-associated complex 0
      nitrite reductase complex [NAD(P)H] 0
      nuclear RNA export factor complex 0
      nuclear exosome targeting complex 0
      nuclear pore + 43
      nuclear pore central transport channel 1
      nuclear pore cytoplasmic filaments 2
      nuclear pore inner ring 0
      nuclear pore linkers 0
      nuclear pore nuclear basket 11
      nuclear pore outer ring 10
      nuclear pore transmembrane ring 0
      nucleocytoplasmic transport complex + 3
      nucleosome disassembly/reassembly complex 0
      nucleotide-excision repair, DNA damage recognition complex + 0
      origin recognition complex + 8
      ornithine carbamoyltransferase inhibitor complex 0
      outer dynein arm docking complex 1
      paraferritin complex 0
      peptidase inhibitor complex + 2
      phosphoenolpyruvate-dependent sugar phosphotransferase complex 0
      pituitary gonadotropin complex + 2
      polarisome + 0
      polkadots 2
      polycystin complex 2
      polyketide synthase complex + 0
      prefoldin complex 1
      procentriole replication complex 0
      proteasome accessory complex + 20
      proteasome activator complex 0
      proteasome core complex + 18
      proteasome core complex, alpha-subunit complex + 4
      proteasome core complex, beta-subunit complex + 0
      proteasome regulatory particle + 12
      proteasome regulatory particle, base subcomplex + 3
      proteasome regulatory particle, lid subcomplex + 1
      proteasome-activating nucleotidase complex 0
      protein complex involved in cell adhesion + 32
      protein kinase CK2 complex 2
      protein phosphatase inhibitor complex 0
      protein-DNA complex + 102
      protein-DNA-RNA complex + 0
      protein-carbohydrate complex + 0
      protein-lipid complex + 23
      protein-lipid-RNA complex + 0
      pyrophosphate-dependent phosphofructokinase complex + 0
      pyrophosphate-dependent phosphofructokinase complex, alpha-subunit complex 0
      pyrophosphate-dependent phosphofructokinase complex, beta-subunit complex 0
      pyroptosome complex 0
      radial spoke + 1
      radial spoke head 1
      radial spoke stalk 0
      raps-insc complex 0
      receptor complex + 294
      reelin complex 0
      replication fork protection complex 0
      replication inhibiting complex + 0
      ribonuclease H2 complex 3
      ribonucleoprotein complex + 481
      septin complex + 9
      single-stranded DNA-binding protein complex 0
      spectrin 4
      sperm individualization complex + 0
      spitzenkorper 0
      stereocilia ankle link complex 5
      steroid hormone aporeceptor complex 0
      sulfite reductase complex (NADPH) 0
      sumoylated E2 ligase complex 1
      survivin complex 0
      t-UTP complex 2
      tRNA-splicing ligase complex 6
      thrombospondin complex 0
      titin-telethonin complex 0
      trans-synaptic protein complex 0
      transcription elongation factor complex + 41
      transcription export complex + 12
      transcription export complex 2 5
      transcription regulator complex + 343
      transforming growth factor beta activated kinase 1 complex 0
      transforming growth factor beta complex 0
      translation release factor complex 0
      translation repressor complex + 0
      transporter complex + 234
      tricarboxylic acid cycle enzyme complex + 9
      troponin complex + 8
      tubulin complex 1
      tubulin folding cofactor complex 0
      tubulobulbar complex + 3
      type I protein secretion system complex 0
      type II protein secretion system complex 0
      type III protein secretion system complex 0
      type IV secretion system complex 0
      type V protein secretion system complex 0
      type VI protein secretion system complex 0
      ubiquinone biosynthesis complex 0
      vesicle tethering complex + 54
      viral integration complex 0
      viral portal complex 0
      viral scaffold 0
      viral terminase complex + 0
      viral terminase, small subunit 0
      viral transcriptional complex 0
      zona pellucida receptor complex 11
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.