regulation of actin filament-based process - Ontology Report

(PMID:21873635)

NCBI chr 1:25,432,314...25,447,016
Ensembl chr 1:25,432,706...25,447,594

CNN2

calponin 2

acts_upstream_of_or_within
involved_in

(PMID:16236705)

PMID:16236705

GO_REF:0000107

NCBI chr 2:77,376,020...77,385,594
Ensembl chr 2:77,375,983...77,385,571

FRMD6

FERM domain containing 6

acts_upstream_of_or_within

(MGI:5086051|PMID:21685893)

PMID:21685893

MGI:5086051

NCBI chr 1:181,338,404...181,416,813
Ensembl chr 1:181,338,525...181,416,840

PARD3

par-3 family cell polarity regulator

acts_upstream_of_or_within

(MGI:5086051|PMID:21685893)

PMID:21685893

MGI:5086051

NCBI chr10:56,968,100...57,600,515
Ensembl chr10:56,967,434...57,600,456

ROCK1

Rho associated coiled-coil containing protein kinase 1

involved_in
acts_upstream_of_or_within

IEA
ISO

(MGI:5086051|PMID:21685893)

Ensembl
MGI

PMID:21685893

GO_REF:0000107 MGI:5086051

NCBI chr 6:106,163,899...106,314,998
Ensembl chr 6:106,163,989...106,314,944

actin filament capping

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AVIL

advillin

involved_in

GO_REF:0000043

NCBI chr 5:23,087,946...23,110,602
Ensembl chr 5:23,087,956...23,110,602

CAPZA1

capping actin protein of muscle Z-line subunit alpha 1

involved_in

GO_REF:0000043

NCBI chr 4:107,769,570...107,821,806
Ensembl chr 4:107,768,079...107,821,819

CAPZA2

capping actin protein of muscle Z-line subunit alpha 2

involved_in

GO_REF:0000043

NCBI chr18:29,316,384...29,365,062
Ensembl chr18:29,310,759...29,365,143

CAPZA3

capping actin protein of muscle Z-line subunit alpha 3

involved_in

GO_REF:0000043

NCBI chr 5:54,406,245...54,408,330
Ensembl chr 5:54,406,523...54,413,565

CAPZB

capping actin protein of muscle Z-line subunit beta

involved_in

GO_REF:0000043

NCBI chr 6:77,780,682...77,912,653
Ensembl chr 6:77,780,682...77,912,617

gelsolin

involved_in

GO_REF:0000043 GO_REF:0000107

NCBI chr 1:261,295,711...261,372,848
Ensembl chr 1:261,307,008...261,372,848

LOC100037956

F-actin capping protein subunit beta 2

involved_in

GO_REF:0000043

MYH9

myosin heavy chain 9

NOT|involved_in

(MGI:5619440|PMID:23325791)

PMID:23325791

MGI:5619440

NCBI chr 5:11,365,603...11,456,475
Ensembl chr 5:11,360,660...11,456,472

RDX

radixin

involved_in

GO_REF:0000043

NCBI chr 9:38,243,608...38,299,561
Ensembl chr 9:38,220,447...38,322,097

scinderin

involved_in

GO_REF:0000043 GO_REF:0000107

NCBI chr 9:82,103,271...82,185,254
Ensembl chr 9:82,103,087...82,185,283

SPTA1

spectrin alpha, erythrocytic 1

involved_in

GO_REF:0000043

NCBI chr 4:91,573,470...91,640,057
Ensembl chr 4:91,485,067...91,640,063

SPTAN1

spectrin alpha, non-erythrocytic 1

involved_in

GO_REF:0000043

NCBI chr 1:268,936,120...269,002,261
Ensembl chr 1:268,936,025...269,002,256

SPTB

spectrin beta, erythrocytic

involved_in

GO_REF:0000043 GO_REF:0000104

NCBI chr 7:88,812,717...88,954,471
Ensembl chr 7:88,812,718...88,954,306

SPTBN1

spectrin beta, non-erythrocytic 1

involved_in

GO_REF:0000043 GO_REF:0000104

NCBI chr 3:86,585,225...86,784,316
Ensembl chr 3:86,585,054...86,784,149

SPTBN2

spectrin beta, non-erythrocytic 2

involved_in

GO_REF:0000043 GO_REF:0000104

NCBI chr 2:5,683,414...5,739,418
Ensembl chr 2:5,695,836...5,739,415

SPTBN4

spectrin beta, non-erythrocytic 4

involved_in

GO_REF:0000043 GO_REF:0000104

NCBI chr 6:48,729,839...48,812,799
Ensembl chr 6:48,729,419...48,812,796

tropomyosin 1

NCBI chr 1:108,986,981...109,016,090
Ensembl chr 1:108,986,986...109,020,035

villin 1

involved_in

GO_REF:0000024 GO_REF:0000043 GO_REF:0000107

NCBI chr15:120,463,470...120,494,772
Ensembl chr15:120,463,566...120,492,580

VILL

villin like

involved_in

GO_REF:0000043

NCBI chr13:22,831,867...22,851,282
Ensembl chr13:22,831,915...22,851,275

actin filament uncapping

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ACTN2

actinin alpha 2

involved_in

GO_REF:0000107

NCBI chr14:54,670,727...54,742,717
Ensembl chr14:54,666,623...54,742,778

barbed-end actin filament capping

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ADD1

adducin 1

involved_in

(PMID:21873635)

NCBI chr 8:1,627,146...1,710,653
Ensembl chr 8:1,627,062...1,710,650

ADD2

adducin 2

involved_in

(PMID:21873635)

GO_REF:0000107

NCBI chr 3:71,729,882...71,845,761
Ensembl chr 3:71,730,003...71,840,861

ADD3

adducin 3

involved_in

(PMID:21873635)

NCBI chr14:120,451,421...120,583,725
Ensembl chr14:120,451,575...120,583,722

AVIL

advillin

involved_in

(PMID:21873635)

NCBI chr 5:23,087,946...23,110,602
Ensembl chr 5:23,087,956...23,110,602

CAPG

capping actin protein, gelsolin like

involved_in

(PMID:21873635)

NCBI chr 3:59,335,483...59,366,855
Ensembl chr 3:59,339,966...59,366,846

CAPZA1

capping actin protein of muscle Z-line subunit alpha 1

acts_upstream_of_or_within
involved_in

MGI
InterPro
GO_Central
UniProt

(MGI:3758397|PMID:17656356)
(PMID:21873635)

PMID:17656356 PMID:21873635

GO_REF:0000002 GO_REF:0000104 MGI:3758397

NCBI chr 4:107,769,570...107,821,806
Ensembl chr 4:107,768,079...107,821,819

CAPZA2

capping actin protein of muscle Z-line subunit alpha 2

involved_in

UniProt
InterPro
GO_Central

(PMID:21873635)

GO_REF:0000002 GO_REF:0000104

NCBI chr18:29,316,384...29,365,062
Ensembl chr18:29,310,759...29,365,143

CAPZA3

capping actin protein of muscle Z-line subunit alpha 3

involved_in

MGI
GO_Central
UniProt
InterPro

InterPro
UniProt

GO_REF:0000002 GO_REF:0000104

NCBI chr 5:54,406,245...54,408,330
Ensembl chr 5:54,406,523...54,413,565

CAPZB

capping actin protein of muscle Z-line subunit beta

acts_upstream_of_or_within
involved_in

ISO
IBA
IEA

(MGI:3758397|PMID:17656356)
(PMID:21873635)

PMID:17656356 PMID:21873635

GO_REF:0000002 GO_REF:0000104 MGI:3758397

NCBI chr 6:77,780,682...77,912,653
Ensembl chr 6:77,780,682...77,912,617

DBNL

drebrin like

NOT|acts_upstream_of_or_within

(MGI:1353214|PMID:10637315)

PMID:10637315

MGI:1353214

NCBI chr18:48,713,335...48,725,692
Ensembl chr18:48,713,340...48,725,697

EPS8

epidermal growth factor receptor pathway substrate 8

involved_in

GO_REF:0000107

NCBI chr 5:56,817,445...57,005,117
Ensembl chr 5:56,817,606...57,005,113

gelsolin

involved_in

(PMID:21873635)

GO_Central
UniProt

GO_REF:0000104

NCBI chr 1:261,295,711...261,372,848
Ensembl chr 1:261,307,008...261,372,848

LOC100037956

F-actin capping protein subunit beta 2

involved_in

InterPro
UniProt

GO_REF:0000002 GO_REF:0000104

radixin

NCBI chr 9:38,243,608...38,299,561
Ensembl chr 9:38,220,447...38,322,097

scinderin

involved_in

(PMID:21873635)

NCBI chr 9:82,103,271...82,185,254
Ensembl chr 9:82,103,087...82,185,283

SVIL

supervillin

involved_in

(PMID:21873635)

NCBI chr10:41,176,358...41,462,750
Ensembl chr10:41,282,412...41,462,764

twinfilin actin binding protein 1

involved_in

(PMID:21873635)

GO_REF:0000107

NCBI chr 5:74,868,586...74,881,220
Ensembl chr 5:74,868,585...74,893,698

twinfilin actin binding protein 2

involved_in

(PMID:21873635)

NCBI chr13:34,361,294...34,370,997
Ensembl chr13:34,361,297...34,371,277

villin 1

involved_in

(PMID:21873635)

GO_REF:0000107

NCBI chr15:120,463,470...120,494,772
Ensembl chr15:120,463,566...120,492,580

VILL

villin like

involved_in

(PMID:21873635)

NCBI chr13:22,831,867...22,851,282
Ensembl chr13:22,831,915...22,851,275

barbed-end actin filament uncapping

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

capping protein regulator and myosin 1 linker 1

involved_in

GO_REF:0000107

NCBI chr 7:20,036,430...20,353,431
Ensembl chr 7:20,036,944...20,353,420

negative regulation of actin filament bundle assembly

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

cofilin 1

NCBI chr 2:6,471,558...6,475,019
Ensembl chr 2:6,469,254...6,475,035

drebrin 1

NCBI chr 2:80,480,603...80,495,797
Ensembl chr 2:80,479,460...80,495,796

MAP3K1

mitogen-activated protein kinase kinase kinase 1

prevents phenylephrine-induced actin organization

PMID:9155015

RGD:2293527

NCBI chr16:35,872,301...35,947,097
Ensembl chr16:35,872,131...35,946,987

profilin 1

involved_in

(PMID:23153535)

NCBI chr12:51,962,642...51,965,570
Ensembl chr12:51,961,952...51,965,464

PRKN

parkin RBR E3 ubiquitin protein ligase

involved_in

GO_REF:0000107

NCBI chr 1:5,698,508...6,731,132
Ensembl chr 1:5,465,312...6,730,872

SHANK1

SH3 and multiple ankyrin repeat domains 1

acts_upstream_of_or_within
involved_in

(MGI:3846509|PMID:19208628)

PMID:19208628

GO_REF:0000107 MGI:3846509

NCBI chr 6:55,452,095...55,496,304
Ensembl chr 6:55,451,094...55,499,031

SHANK3

SH3 and multiple ankyrin repeat domains 3

acts_upstream_of_or_within

(MGI:3846509|PMID:19208628)

PMID:19208628

MGI:3846509

NCBI chr 5:41,376...93,033
Ensembl chr 5:41,786...93,177

negative regulation of actin filament depolymerization

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

cofilin 1

NCBI chr 2:6,471,558...6,475,019
Ensembl chr 2:6,469,254...6,475,035

LIMA1

LIM domain and actin binding 1

involved_in

GO_REF:0000107

NCBI chr 5:16,074,436...16,177,122
Ensembl chr 5:16,074,438...16,177,103

PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

involved_in

GO_REF:0000107

NCBI chr13:117,193,935...117,282,151
Ensembl chr13:117,180,544...117,274,587

PLEKHH2

pleckstrin homology, MyTH4 and FERM domain containing H2

involved_in

GO_REF:0000107

NCBI chr 3:96,707,397...96,833,431
Ensembl chr 3:96,709,059...96,833,410

SHROOM2

shroom family member 2

acts_upstream_of_or_within

(MGI:3723326|PMID:17666436)

PMID:17666436

MGI:3723326

NCBI chr  X:6,296,212...6,450,401
NCBI chr  Y:4,753,733...4,785,766
Ensembl chr  X:6,296,219...6,448,992

SPECC1L

sperm antigen with calponin homology and coiled-coil domains 1 like

acts_upstream_of_or_within

(MGI:5433266|PMID:21703590)

PMID:21703590

MGI:5433266

NCBI chr14:49,332,937...49,463,965
Ensembl chr14:49,333,009...49,463,963

SWAP70

switching B cell complex subunit SWAP70

involved_in

GO_REF:0000107

NCBI chr 2:49,721,120...49,805,262
Ensembl chr 2:49,719,669...49,805,049

negative regulation of actin filament polymerization

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

adducin 1

NCBI chr 8:1,627,146...1,710,653
Ensembl chr 8:1,627,062...1,710,650

ARFGEF1

ADP ribosylation factor guanine nucleotide exchange factor 1

involved_in

GO_REF:0000107

NCBI chr 4:67,465,517...67,613,611
Ensembl chr 4:67,465,529...67,613,611

BBS4

Bardet-Biedl syndrome 4

acts_upstream_of_or_within
involved_in

(MGI:5510934|PMID:23716571)

GO_REF:0000107 MGI:5510934

NCBI chr 7:60,631,913...60,693,359
Ensembl chr 7:60,631,914...60,693,334

calpain 1

NCBI chr 2:6,997,513...7,024,410
Ensembl chr 2:6,997,985...7,022,684

CYRIB

CYFIP related Rac1 interactor B

involved_in

(PMID:30250061)

PMID:30250061

NCBI chr 4:10,476,137...10,643,395

FHOD3

formin homology 2 domain containing 3

acts_upstream_of_or_within
involved_in

(MGI:4422153|PMID:19706596)

PMID:19706596

GO_REF:0000107 MGI:4422153

NCBI chr 6:120,036,824...120,585,987
Ensembl chr 6:120,036,845...120,586,816

HIP1R

huntingtin interacting protein 1 related

involved_in

GO_REF:0000107

NCBI chr14:29,996,388...30,024,343
Ensembl chr14:29,993,655...30,024,216

KANK1

KN motif and ankyrin repeat domains 1

acts_upstream_of_or_within
involved_in

MGI
InterPro
Ensembl
GO_Central

(PMID:17996375)
(PMID:21873635)

PMID:17996375 PMID:21873635

GO_REF:0000002 GO_REF:0000107

NCBI chr 1:221,015,042...221,218,875
Ensembl chr 1:221,015,046...221,078,245

KANK2

KN motif and ankyrin repeat domains 2

involved_in

GO_REF:0000002

NCBI chr 2:69,896,116...69,925,194
Ensembl chr 2:69,896,120...69,924,919

KANK3

KN motif and ankyrin repeat domains 3

involved_in

(PMID:21873635)

GO_Central
InterPro

GO_REF:0000002

NCBI chr 2:70,938,732...70,953,543
Ensembl chr 2:70,938,787...70,953,543

KANK4

KN motif and ankyrin repeat domains 4

involved_in

GO_REF:0000002

NCBI chr 6:150,106,628...150,185,667
Ensembl chr 6:150,143,912...150,184,120

MKKS

MKKS centrosomal shuttling protein

acts_upstream_of_or_within
involved_in

(MGI:5510934|PMID:23716571)

GO_REF:0000107 MGI:5510934

NCBI chr17:19,341,024...19,363,007
Ensembl chr17:19,341,636...19,362,871

MYADM

myeloid associated differentiation marker

involved_in

(PMID:23264465)

PMID:23264465

NCBI chr 6:56,236,306...56,278,577
Ensembl chr 6:56,236,311...56,244,185

PECAM1

platelet and endothelial cell adhesion molecule 1

NCBI chr12:14,667,643...14,723,296
Ensembl chr12:14,649,044...14,723,293

profilin 1

involved_in

(PMID:7758455)

PMID:7758455

NCBI chr12:51,962,642...51,965,570
Ensembl chr12:51,961,952...51,965,464

profilin 2

involved_in
acts_upstream_of_or_within

PMID:7758455 PMID:18001770

(PMID:7758455)
(MGI:4844066|PMID:18001770)

UniProt
MGI

MGI:4844066

NCBI chr13:90,177,534...90,185,978
Ensembl chr13:90,177,540...90,183,742

PRKCD

protein kinase C delta

involved_in

GO_REF:0000107

NCBI chr13:35,290,835...35,323,245
Ensembl chr13:35,290,610...35,323,356

SLIT2

slit guidance ligand 2

involved_in

GO_REF:0000107

NCBI chr 8:14,758,426...15,149,515
Ensembl chr 8:14,758,335...15,149,510

SSH1

slingshot protein phosphatase 1

involved_in

(PMID:21873635)

InterPro
GO_Central

GO_REF:0000002

NCBI chr14:41,963,946...42,030,842
Ensembl chr14:41,968,466...42,025,726

SSH2

slingshot protein phosphatase 2

involved_in

GO_REF:0000002

NCBI chr12:45,818,103...46,085,720
Ensembl chr12:45,823,002...46,015,446

SSH3

slingshot protein phosphatase 3

involved_in

GO_REF:0000002

NCBI chr 2:5,185,480...5,193,875
Ensembl chr 2:5,185,503...5,193,155

TLR2

toll like receptor 2

involved_in

(MGI:5307186|PMID:22198949)

ARUK-UCL

PMID:22198949

MGI:5307186

NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330

twinfilin actin binding protein 1

involved_in

Ensembl
InterPro

GO_REF:0000002 GO_REF:0000107

NCBI chr 5:74,868,586...74,881,220
Ensembl chr 5:74,868,585...74,893,698

twinfilin actin binding protein 2

involved_in

Ensembl
InterPro

GO_REF:0000002 GO_REF:0000107

NCBI chr13:34,361,294...34,370,997
Ensembl chr13:34,361,297...34,371,277

negative regulation of actin filament severing

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CSRP3

cysteine and glycine rich protein 3

acts_upstream_of_or_within

(PMID:24860983)

PMID:24860983

NCBI chr 2:40,219,288...40,240,614
Ensembl chr 2:40,215,353...40,240,616

MYH9

myosin heavy chain 9

involved_in

GO_REF:0000024 GO_REF:0000107

NCBI chr 5:11,365,603...11,456,475
Ensembl chr 5:11,360,660...11,456,472

negative regulation of actin nucleation

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ARPIN

actin related protein 2/3 complex inhibitor

involved_in

GO_Central
Ensembl
InterPro

(PMID:21873635)

GO_REF:0000002 GO_REF:0000107

NCBI chr 7:55,469,015...55,483,632
Ensembl chr 7:55,468,568...55,483,536

coronin 1A

involved_in

GO_REF:0000107

NCBI chr 3:18,336,813...18,342,381
Ensembl chr 3:18,336,898...18,342,396

negative regulation of Arp2/3 complex-mediated actin nucleation

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CORO1B

coronin 1B

involved_in

GO_REF:0000107

NCBI chr 2:5,081,294...5,086,698
Ensembl chr 2:5,080,660...5,086,690

CTNNA2

catenin alpha 2

involved_in

(PMID:30013181)

PMID:30013181

NCBI chr 3:63,205,073...64,417,990
Ensembl chr 3:63,205,084...63,455,471

DNAI3

dynein axonemal intermediate chain 3

involved_in

GO_REF:0000107

NCBI chr 4:130,765,580...130,826,828
Ensembl chr 4:130,765,354...130,826,630

GMFB

glia maturation factor beta

involved_in

(PMID:21873635)

NCBI chr 1:183,846,672...183,863,396
Ensembl chr 1:183,846,680...183,863,398

GMFG

glia maturation factor gamma

acts_upstream_of_or_within
involved_in

(MGI:5505367|PMID:23727094)

PMID:23727094

GO_REF:0000107 MGI:5505367

NCBI chr 6:47,990,241...47,997,332
Ensembl chr 6:47,990,237...47,997,260

HIP1R

huntingtin interacting protein 1 related

involved_in

GO_REF:0000107

NCBI chr14:29,996,388...30,024,343
Ensembl chr14:29,993,655...30,024,216

PICK1

protein interacting with PRKCA 1

involved_in

PMID:18297063

NCBI chr 5:9,808,444...9,829,677
Ensembl chr 5:9,808,451...9,825,539

negative regulation of barbed-end actin filament capping

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

capping protein regulator and myosin 1 linker 1

involved_in

GO_REF:0000107

NCBI chr 7:20,036,430...20,353,431
Ensembl chr 7:20,036,944...20,353,420

CARMIL2

capping protein regulator and myosin 1 linker 2

involved_in

GO_REF:0000107

NCBI chr 6:28,265,130...28,277,649
Ensembl chr 6:28,265,135...28,277,641

CRACD

capping protein inhibiting regulator of actin dynamics

involved_in

(PMID:21873635)

GO_REF:0000107

NCBI chr 8:55,336,363...55,600,931
Ensembl chr 8:55,537,546...55,600,939

LOC100522401

WASH complex subunit 2A

involved_in

(PMID:20498093)

PMID:20498093

NCBI chr14:90,582,399...90,640,494

negative regulation of cardiac muscle cell contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

adenylate cyclase 10

NCBI chr 4:83,103,768...83,205,015
Ensembl chr 4:83,098,290...83,205,454

negative regulation of cardiac myofibril assembly

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

SMAD4

SMAD family member 4

involved_in

GO_REF:0000107

NCBI chr 1:100,521,843...100,633,501
Ensembl chr 1:100,589,850...100,628,029

negative regulation of hepatic stellate cell contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

NOS1

nitric oxide synthase 1

NCBI chr14:35,112,898...35,299,297
Ensembl chr14:35,113,184...35,295,944

negative regulation of muscle filament sliding

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

drebrin 1

NCBI chr 2:80,480,603...80,495,797
Ensembl chr 2:80,479,460...80,495,796

negative regulation of sarcomere organization

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CAV3

caveolin 3

involved_in

GO_REF:0000107

NCBI chr13:65,117,868...65,130,886
Ensembl chr13:65,117,795...65,131,273

mitofusin 2

NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,028,499...72,056,438

negative regulation of stress fiber assembly

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ARAP1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

involved_in

PMID:21873635 PMID:25211221

GO_REF:0000107

NCBI chr 9:7,238,043...7,301,085
Ensembl chr 9:7,233,911...7,301,073

ARHGAP28

Rho GTPase activating protein 28

acts_upstream_of_or_within
involved_in

ISO
IBA
IEA

(MGI:5644775|PMID:25211221)
(PMID:21873635)

MGI
GO_Central
Ensembl

GO_REF:0000107 MGI:5644775

NCBI chr 6:100,494,385...100,681,008
Ensembl chr 6:100,494,652...100,655,708

ARHGAP6

Rho GTPase activating protein 6

involved_in

(PMID:10699171)

PMID:10699171

NCBI chr X:7,910,851...8,441,579
Ensembl chr X:7,910,858...8,120,386

ARHGEF18

Rho/Rac guanine nucleotide exchange factor 18

involved_in

GO_REF:0000107

NCBI chr 2:71,651,096...71,747,513
Ensembl chr 2:71,651,100...71,747,409

CGNL1

cingulin like 1

involved_in

GO_REF:0000107

NCBI chr 1:114,424,148...114,628,331
Ensembl chr 1:114,424,151...114,598,823

CLASP1

cytoplasmic linker associated protein 1

involved_in

(PMID:24859005)

PMID:24859005

NCBI chr15:29,782,613...30,042,727
Ensembl chr15:29,782,746...30,042,734

CLASP2

cytoplasmic linker associated protein 2

involved_in

(PMID:24859005)

PMID:24859005

NCBI chr13:19,305,430...19,510,589
Ensembl chr13:19,305,181...19,510,585

CORO2B

coronin 2B

acts_upstream_of_or_within
involved_in

(MGI:6110508|PMID:29162887)

PMID:29162887

GO_REF:0000107 MGI:6110508

NCBI chr 1:166,465,870...166,608,840
Ensembl chr 1:166,465,953...166,608,363

DLC1

DLC1 Rho GTPase activating protein

involved_in

GO_REF:0000107

NCBI chr17:1,169,709...1,637,171
Ensembl chr17:1,170,208...1,637,114

F11R

F11 receptor

involved_in

GO_REF:0000107

NCBI chr 4:89,425,101...89,447,889
Ensembl chr 4:89,425,018...89,449,599

FRMD7

FERM domain containing 7

acts_upstream_of_or_within
involved_in

(MGI:5546532|PMID:23967341)

PMID:23967341

GO_REF:0000107 MGI:5546532

NCBI chr X:108,241,116...108,294,188
Ensembl chr X:108,240,573...108,294,206

INPP5K

inositol polyphosphate-5-phosphatase K

involved_in

IEA
ISS

GO_REF:0000024 GO_REF:0000107

NCBI chr12:47,717,898...47,738,540
Ensembl chr12:47,718,491...47,738,475

MET

MET proto-oncogene, receptor tyrosine kinase

involved_in

GO_REF:0000107

NCBI chr18:29,426,044...29,541,526
Ensembl chr18:29,426,048...29,541,512

MIR138

microRNA mir-138

involved_in

(PMID:20232393)

PMID:20232393

NCBI chr13:27,450,130...27,450,214
Ensembl chr13:27,450,130...27,450,214

MIR20A

microRNA mir-20a

involved_in

(PMID:22696064)

PMID:22696064

NCBI chr11:60,735,109...60,735,179
Ensembl chr11:60,735,099...60,735,196

MIR21

microRNA mir-21

involved_in

(PMID:21347332)

PMID:21347332

NCBI chr12:36,065,267...36,065,358
Ensembl chr12:36,065,267...36,065,358

MYOC

myocilin

involved_in

GO_REF:0000107

NCBI chr 9:114,087,370...114,098,765
Ensembl chr 9:114,087,378...114,098,745

PAK2

p21 (RAC1) activated kinase 2

involved_in

GO_REF:0000107

NCBI chr13:133,276,122...133,383,506
Ensembl chr13:133,273,112...133,389,458

profilin 1

involved_in

(PMID:23153535)

NCBI chr12:51,962,642...51,965,570
Ensembl chr12:51,961,952...51,965,464

PHLDB2

pleckstrin homology like domain family B member 2

involved_in

GO_REF:0000107

NCBI chr13:147,778,420...148,025,943
Ensembl chr13:147,778,370...147,879,794

PHLDB2

pleckstrin homology like domain family B member 2

involved_in

GO_REF:0000107

NCBI chr13:148,033,712...148,087,766
Ensembl chr13:148,033,704...148,087,744

PIK3R1

phosphoinositide-3-kinase regulatory subunit 1

involved_in

GO_REF:0000107

NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,511,521...46,523,609

PPFIA1

PTPRF interacting protein alpha 1

acts_upstream_of_or_within
involved_in

(MGI:5492034|PMID:22266902)
(PMID:22266902)

PMID:22266902

GO_REF:0000107 MGI:5492034

NCBI chr 2:3,073,236...3,165,476
Ensembl chr 2:3,073,241...3,164,235

PPP1R9A

protein phosphatase 1 regulatory subunit 9A

NCBI chr 9:74,635,285...74,944,050
Ensembl chr 9:74,635,403...74,940,362

RHPN1

rhophilin Rho GTPase binding protein 1

acts_upstream_of_or_within
involved_in

PMID:21873635 PMID:25071083

(MGI:6316493|PMID:25071083)
(PMID:21873635)

MGI
GO_Central

MGI:6316493

NCBI chr 4:1,123,098...1,133,030
Ensembl chr 4:1,123,105...1,132,966

RHPN2

rhophilin Rho GTPase binding protein 2

acts_upstream_of_or_within
involved_in

ISO
IBA
IEA

(PMID:25071083)
(PMID:21873635)

MGI
GO_Central
Ensembl

PMID:21873635 PMID:25071083

GO_REF:0000107

NCBI chr 6:42,820,564...42,891,340
Ensembl chr 6:42,820,568...42,891,346

S1PR1

sphingosine-1-phosphate receptor 1

NCBI chr 4:117,064,632...117,069,724
Ensembl chr 4:117,064,755...117,069,650

STMN1

stathmin 1

involved_in

GO_REF:0000107

NCBI chr 6:83,356,404...83,362,546
Ensembl chr 6:83,356,412...83,362,500

TACSTD2

tumor associated calcium signal transducer 2

involved_in

ISS

GO_REF:0000024

NCBI chr 6:153,859,488...153,861,508
Ensembl chr 6:153,859,482...153,861,492

TJP1

tight junction protein 1

involved_in

GO_REF:0000107

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

TMEFF2

transmembrane protein with EGF like and two follistatin like domains 2

acts_upstream_of_or_within
involved_in

(PMID:24632071)

PMID:24632071

GO_REF:0000107

NCBI chr15:96,594,901...96,856,848
Ensembl chr15:96,594,970...96,855,743

WAS

WASP actin nucleation promoting factor

involved_in

GO_REF:0000107

NCBI chr X:42,774,597...42,793,055
Ensembl chr X:42,774,588...42,793,055

WASF2

WASP family member 2

involved_in

GO_REF:0000107

NCBI chr 6:84,621,742...84,697,428
Ensembl chr 6:84,622,800...84,697,429

negative regulation of ventricular cardiac muscle cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

BIN1

bridging integrator 1

involved_in

GO_REF:0000107

NCBI chr15:25,328,679...25,379,675
Ensembl chr15:25,328,674...25,383,652

pointed-end actin filament capping

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

LMOD1

leiomodin 1

involved_in

GO_REF:0000002

NCBI chr10:24,165,293...24,194,823
Ensembl chr10:24,164,792...24,193,820

LMOD2

leiomodin 2

involved_in

GO_REF:0000002

NCBI chr18:23,803,927...23,815,772
Ensembl chr18:23,803,682...23,812,479

LMOD3

leiomodin 3

involved_in

GO_REF:0000002

NCBI chr13:50,541,407...50,554,346
Ensembl chr13:50,541,414...50,554,696

NCBP1

nuclear cap binding protein subunit 1

involved_in

GO_REF:0000002

NCBI chr 1:239,492,573...239,543,925
Ensembl chr 1:239,492,721...239,535,825

NCBP1

nuclear cap binding protein subunit 1

involved_in

GO_REF:0000002

NCBI chr 1:239,375,150...239,468,387
Ensembl chr 1:239,396,097...239,467,758

TMOD2

tropomodulin 2

involved_in

GO_REF:0000002

NCBI chr 1:119,956,583...120,009,372
Ensembl chr 1:119,956,588...120,009,372

TMOD3

tropomodulin 3

involved_in

GO_REF:0000002

NCBI chr 1:119,864,878...119,948,795
Ensembl chr 1:119,862,244...119,948,880

TMOD4

tropomodulin 4

involved_in

GO_REF:0000002

NCBI chr 4:98,074,380...98,079,346
Ensembl chr 4:98,074,387...98,079,343

positive regulation of actin cytoskeleton reorganization

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

BAIAP2

BAR/IMD domain containing adaptor protein 2

involved_in

(PMID:21873635)

NCBI chr12:1,609,420...1,666,965
Ensembl chr12:1,603,540...1,670,075

BAR/IMD domain containing adaptor protein 2 like 1

involved_in

(PMID:21873635)

NCBI chr 3:5,472,305...5,567,926
Ensembl chr 3:5,472,315...5,567,876

BAIAP2L2

BAR/IMD domain containing adaptor protein 2 like 2

involved_in

(PMID:21873635)

NCBI chr 5:9,778,643...9,799,705
Ensembl chr 5:9,778,727...9,799,703

positive regulation of actin filament bundle assembly

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CX3CL1

C-X3-C motif chemokine ligand 1

involved_in

(PMID:10415068)

ARUK-UCL

PMID:10415068

NCBI chr 6:19,312,351...19,324,439

CX3CL1

C-X3-C motif chemokine ligand 1

involved_in

GO_REF:0000107

Ensembl chr 6:19,316,698...19,323,094

filamin A

NCBI chr X:124,889,934...124,915,000
Ensembl chr X:124,890,162...124,914,992

ID1

inhibitor of DNA binding 1

NCBI chr17:35,316,518...35,317,742
Ensembl chr17:35,316,514...35,317,736

LIMK1

LIM domain kinase 1

involved_in

GO_REF:0000107

NCBI chr 3:11,252,820...11,279,286
Ensembl chr 3:11,252,648...11,279,284

MTSS1

MTSS I-BAR domain containing 1

acts_upstream_of_or_within

(MGI:5317250|PMID:21406566)

PMID:21406566

MGI:5317250

NCBI chr 4:14,933,290...15,103,256
Ensembl chr 4:14,933,331...15,103,253

profilin 1

involved_in

(PMID:21873635)

NCBI chr12:51,962,642...51,965,570
Ensembl chr12:51,961,952...51,965,464

profilin 2

involved_in

(PMID:21873635)

NCBI chr13:90,177,534...90,185,978
Ensembl chr13:90,177,540...90,183,742

PLEK

pleckstrin

involved_in

GO_REF:0000107

NCBI chr 3:73,877,741...73,910,163
Ensembl chr 3:73,877,743...73,906,667

SWAP70

switching B cell complex subunit SWAP70

involved_in

GO_REF:0000107

NCBI chr 2:49,721,120...49,805,262
Ensembl chr 2:49,719,669...49,805,049

SYNPO

synaptopodin

involved_in

(PMID:21873635)

NCBI chr 2:151,571,264...151,634,103
Ensembl chr 2:151,599,597...151,632,099

SYNPO2

synaptopodin 2

involved_in

(PMID:21873635)

NCBI chr 8:104,677,580...104,844,169
Ensembl chr 8:104,677,583...104,873,791

villin 1

involved_in

GO_REF:0000024 GO_REF:0000107

NCBI chr15:120,463,470...120,494,772
Ensembl chr15:120,463,566...120,492,580

positive regulation of actin filament depolymerization

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CFL1

cofilin 1

involved_in
acts_upstream_of_or_within

PMID:15548599 PMID:23921380

(MGI:5554982|PMID:23921380)
(MGI:3575233|PMID:15548599)

CACAO
MGI

MGI:3575233 MGI:5554982

NCBI chr 2:6,471,558...6,475,019
Ensembl chr 2:6,469,254...6,475,035

CFL2

cofilin 2

involved_in

GO_REF:0000107

NCBI chr 7:65,090,170...65,094,521
Ensembl chr 7:65,090,276...65,094,512

DSTN

destrin, actin depolymerizing factor

acts_upstream_of_or_within
involved_in

ISO
ISS

(MGI:3575233|PMID:15548599)

MGI
AgBase

PMID:15548599

GO_REF:0000024 MGI:3575233

NCBI chr17:25,998,830...26,050,354
Ensembl chr17:26,043,079...26,050,353

F2RL1

F2R like trypsin receptor 1

involved_in

GO_REF:0000107

NCBI chr 2:85,732,082...85,747,552
Ensembl chr 2:85,732,189...85,750,858

PDXP

pyridoxal phosphatase

involved_in

GO_REF:0000107

NCBI chr 5:10,162,642...10,169,726
Ensembl chr 5:10,162,643...10,169,512

PLEK

pleckstrin

involved_in

GO_REF:0000107

NCBI chr 3:73,877,741...73,910,163
Ensembl chr 3:73,877,743...73,906,667

SEMA5A

semaphorin 5A

involved_in

(MGI:5526935|PMID:19850054)

PMID:19850054

MGI:5526935

NCBI chr16:72,796,453...73,335,974
Ensembl chr16:72,756,383...73,328,981

villin 1

involved_in

GO_REF:0000107

NCBI chr15:120,463,470...120,494,772
Ensembl chr15:120,463,566...120,492,580

WDR1

WD repeat domain 1

acts_upstream_of_or_within
involved_in

(MGI:5574550|PMID:24840128)

PMID:24840128

GO_REF:0000107 MGI:5574550

NCBI chr 8:6,413,338...6,452,383
Ensembl chr 8:6,413,347...6,452,346

positive regulation of actin filament polymerization

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ACTR3

actin related protein 3

NCBI chr15:20,104,808...20,171,721
Ensembl chr15:20,104,812...20,167,421

ALOX12

arachidonate 12-lipoxygenase, 12S type

involved_in

GO_REF:0000107

NCBI chr12:52,401,861...52,414,913
Ensembl chr12:52,401,810...52,414,903

ALOX15

arachidonate 15-lipoxygenase

involved_in

GO_REF:0000024 GO_REF:0000107

NCBI chr12:52,287,174...52,295,873
Ensembl chr12:52,287,160...52,295,871

ARF6

ADP ribosylation factor 6

involved_in

GO_REF:0000107

NCBI chr 1:179,697,582...179,717,299
Ensembl chr 1:179,713,299...179,717,841

ARPC2

actin related protein 2/3 complex subunit 2

acts_upstream_of_or_within
involved_in

(MGI:3818245|PMID:18836449)

PMID:18836449

GO_REF:0000107 MGI:3818245

NCBI chr15:120,297,122...120,328,795
Ensembl chr15:120,297,025...120,328,542

BAG4

BAG cochaperone 4

involved_in

GO_REF:0000107

NCBI chr15:48,299,456...48,348,810
Ensembl chr15:48,299,666...48,348,527

BAIAP2

BAR/IMD domain containing adaptor protein 2

involved_in

(PMID:21873635)

NCBI chr12:1,609,420...1,666,965
Ensembl chr12:1,603,540...1,670,075

BAR/IMD domain containing adaptor protein 2 like 1

involved_in

(PMID:21873635)

GO_REF:0000107

NCBI chr 3:5,472,305...5,567,926
Ensembl chr 3:5,472,315...5,567,876

BAIAP2L2

BAR/IMD domain containing adaptor protein 2 like 2

involved_in

(PMID:21873635)

NCBI chr 5:9,778,643...9,799,705
Ensembl chr 5:9,778,727...9,799,703

BIN1

bridging integrator 1

involved_in

GO_REF:0000107

NCBI chr15:25,328,679...25,379,675
Ensembl chr15:25,328,674...25,383,652

capping protein regulator and myosin 1 linker 1

involved_in

GO_REF:0000107

NCBI chr 7:20,036,430...20,353,431
Ensembl chr 7:20,036,944...20,353,420

CCL11

chemokine (C-C motif) ligand 11

involved_in

GO_REF:0000107

NCBI chr12:40,779,906...40,782,862
Ensembl chr12:40,779,173...40,782,893

CCL21

C-C motif chemokine ligand 21

involved_in

GO_REF:0000107

NCBI chr10:32,093,783...32,094,482
Ensembl chr10:32,093,763...32,096,224

CCL24

C-C motif chemokine ligand 24

involved_in

(PMID:19525930)

PMID:19525930

NCBI chr 3:10,347,397...10,361,500

CCL26

C-C motif chemokine ligand 26

involved_in

GO_REF:0000107

NCBI chr 3:10,381,306...10,385,677
Ensembl chr 3:10,381,306...10,385,677

CCL8

chemokine (C-C motif) ligand 8

involved_in

GO_REF:0000107

NCBI chr12:40,740,468...40,741,970
Ensembl chr12:40,740,023...40,742,022

CDC42EP1

CDC42 effector protein 1

involved_in

(PMID:21873635)

NCBI chr 5:10,244,625...10,253,430
Ensembl chr 5:10,241,691...10,252,986

CDC42EP2

CDC42 effector protein 2

involved_in

(PMID:21873635)

GO_REF:0000107

NCBI chr 2:6,897,497...6,904,040
Ensembl chr 2:6,895,847...6,904,040

CDC42EP3

CDC42 effector protein 3

involved_in

(PMID:21873635)

NCBI chr 3:102,537,662...102,567,669
Ensembl chr 3:102,538,586...102,567,796

CDC42EP4

CDC42 effector protein 4

involved_in

(PMID:21873635)

NCBI chr12:7,637,797...7,660,189
Ensembl chr12:7,638,085...7,660,186

CDC42EP5

CDC42 effector protein 5

involved_in

(PMID:21873635)

GO_REF:0000107

NCBI chr 6:58,852,426...58,857,622
Ensembl chr 6:58,852,751...58,857,621

CRACD

capping protein inhibiting regulator of actin dynamics

involved_in

GO_REF:0000107

NCBI chr 8:55,336,363...55,600,931
Ensembl chr 8:55,537,546...55,600,939

CSF3

colony stimulating factor 3

involved_in

GO_REF:0000107

NCBI chr12:22,333,445...22,335,949
Ensembl chr12:22,333,449...22,338,753

CTTN

cortactin

involved_in

GO_REF:0000107

NCBI chr 2:3,031,103...3,060,796
Ensembl chr 2:3,031,103...3,060,813

DLG1

discs large MAGUK scaffold protein 1

acts_upstream_of_or_within
involved_in

(MGI:3528803|PMID:15699074)

PMID:15699074

GO_REF:0000107 MGI:3528803

NCBI chr13:132,819,931...133,084,880
Ensembl chr13:132,820,870...133,086,841

EVL

Enah/Vasp-like

involved_in

(MGI:5545940|PMID:23153535)

MGI:5545940

NCBI chr 7:120,911,814...121,056,556
Ensembl chr 7:120,911,648...121,056,555

FCHSD1

FCH and double SH3 domains 1

involved_in

GO_REF:0000107

NCBI chr 2:143,289,854...143,301,921
Ensembl chr 2:143,289,859...143,301,900

FCHSD2

FCH and double SH3 domains 2

involved_in

GO_REF:0000107

NCBI chr 9:7,366,516...7,619,960
Ensembl chr 9:7,366,523...7,608,469

FER

FER tyrosine kinase

involved_in

GO_REF:0000107

NCBI chr 2:113,774,120...114,207,307
Ensembl chr 2:113,774,412...114,206,930

FMN1

formin 1

acts_upstream_of_or_within

(MGI:3027450|PMID:14647292)

PMID:14647292

MGI:3027450

NCBI chr 1:136,696,353...137,163,532
Ensembl chr 1:136,704,090...137,065,258

GCHFR

GTP cyclohydrolase I feedback regulator

involved_in

(PMID:21873635)

NCBI chr 1:130,559,223...130,563,598
Ensembl chr 1:130,554,978...130,559,597

GRB2

growth factor receptor bound protein 2

acts_upstream_of_or_within
involved_in

(MGI:3768467|PMID:17923684)

PMID:17923684

GO_REF:0000107 MGI:3768467

NCBI chr12:5,940,723...6,009,095
Ensembl chr12:5,940,647...6,010,835

ICAM1

intercellular adhesion molecule 1

NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205

KIRREL1

kirre like nephrin family adhesion molecule 1

acts_upstream_of_or_within

(MGI:3768467|PMID:17923684)

PMID:17923684

MGI:3768467

NCBI chr 4:92,173,897...92,290,887
Ensembl chr 4:92,176,746...92,290,610

LMOD1

leiomodin 1

involved_in

GO_REF:0000107

NCBI chr10:24,165,293...24,194,823
Ensembl chr10:24,164,792...24,193,820

LMOD2

leiomodin 2

involved_in

GO_REF:0000107

NCBI chr18:23,803,927...23,815,772
Ensembl chr18:23,803,682...23,812,479

MAP3K1

mitogen-activated protein kinase kinase kinase 1

acts_upstream_of_or_within

(MGI:2674169|PMID:12941696), (MGI:5608927|PMID:25224220)

PMID:12941696 PMID:25224220

MGI:2674169 MGI:5608927

NCBI chr16:35,872,301...35,947,097
Ensembl chr16:35,872,131...35,946,987

MLST8

MTOR associated protein, LST8 homolog

acts_upstream_of_or_within
involved_in

(MGI:3510095|PMID:15467718)

GO_REF:0000107 MGI:3510095

NCBI chr 3:39,778,746...39,786,206
Ensembl chr 3:39,778,754...39,788,285

MTOR

mechanistic target of rapamycin kinase

acts_upstream_of_or_within
involved_in

(MGI:3510095|PMID:15467718)

GO_REF:0000107 MGI:3510095

NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888

myosin IC

NCBI chr12:47,691,252...47,715,670
Ensembl chr12:47,691,256...47,718,337

NCK1

NCK adaptor protein 1

involved_in
acts_upstream_of_or_within

IEA
ISO

(MGI:3768467|PMID:17923684)

Ensembl
MGI
UniProt

PMID:17923684

GO_REF:0000104 GO_REF:0000107 MGI:3768467

NCBI chr13:77,863,655...77,940,944
Ensembl chr13:77,863,701...77,945,468

NCK2

NCK adaptor protein 2

involved_in

GO_REF:0000104 GO_REF:0000107

NCBI chr 3:49,063,813...49,222,274
Ensembl chr 3:49,063,991...49,198,664

NCKAP1

NCK associated protein 1

involved_in

(MGI:5897521|PMID:27927633)

PMID:27927633

MGI:5897521

NCBI chr15:88,425,861...88,528,417
Ensembl chr15:88,425,142...88,528,326

NCKAP1L

NCK associated protein 1 like

involved_in

GO_REF:0000107

NCBI chr 5:19,677,613...19,720,550
Ensembl chr 5:19,677,875...19,723,132

NPHS1

NPHS1 adhesion molecule, nephrin

involved_in

GO_REF:0000107

NCBI chr 6:45,248,325...45,271,892
Ensembl chr 6:45,248,325...45,274,577

profilin 1

involved_in

(PMID:23153535)

NCBI chr12:51,962,642...51,965,570
Ensembl chr12:51,961,952...51,965,464

profilin 2

acts_upstream_of_or_within
involved_in

PMID:17541406 PMID:23153535

(MGI:3714870|PMID:17541406)
(PMID:23153535)

MGI
UniProt

MGI:3714870

NCBI chr13:90,177,534...90,185,978
Ensembl chr13:90,177,540...90,183,742

PRKCE

protein kinase C epsilon

involved_in

GO_REF:0000107

NCBI chr 3:94,351,277...94,864,549
Ensembl chr 3:94,349,889...94,866,306

PTK2B

protein tyrosine kinase 2 beta

involved_in

GO_REF:0000107

NCBI chr14:11,063,662...11,194,196
Ensembl chr14:11,064,492...11,194,192

PYCARD

PYD and CARD domain containing

involved_in

GO_REF:0000107

NCBI chr 3:17,305,921...17,307,521
Ensembl chr 3:17,306,099...17,307,786

Rac family small GTPase 1

acts_upstream_of_or_within

(MGI:2668778|PMID:12853475)

PMID:12853475

MGI:2668778

NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,780...4,803,543

ras homolog family member A

involved_in

ISO
ISS

RGD
AgBase

PMID:17369454

GO_REF:0000024 RGD:1642965

NCBI chr13:31,918,484...31,991,207
Ensembl chr13:31,918,834...31,986,607

RICTOR

RPTOR independent companion of MTOR complex 2

acts_upstream_of_or_within
involved_in

(MGI:3510095|PMID:15467718)

GO_REF:0000107 MGI:3510095

NCBI chr16:24,109,934...24,250,019
Ensembl chr16:24,109,939...24,311,132

SNX9

sorting nexin 9

involved_in

GO_REF:0000107

NCBI chr 1:9,130,360...9,239,023
Ensembl chr 1:9,130,338...9,239,029

TENM1

teneurin transmembrane protein 1

involved_in

(MGI:5465054|PMID:22698694)

PMID:22698694

MGI:5465054

NCBI chr X:101,853,340...102,641,299
Ensembl chr X:101,856,267...102,641,186

VASP

vasodilator stimulated phosphoprotein

involved_in

GO_REF:0000107

NCBI chr 6:51,872,810...51,886,729
Ensembl chr 6:51,872,812...51,886,724

positive regulation of actin filament severing

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CSRP3

cysteine and glycine rich protein 3

acts_upstream_of_or_within

(PMID:24860983)

PMID:24860983

NCBI chr 2:40,219,288...40,240,614
Ensembl chr 2:40,215,353...40,240,616

positive regulation of actin nucleation

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

FMN1

formin 1

acts_upstream_of_or_within

(MGI:3027450|PMID:14647292)

PMID:14647292

MGI:3027450

NCBI chr 1:136,696,353...137,163,532
Ensembl chr 1:136,704,090...137,065,258

gelsolin

involved_in

GO_REF:0000107

NCBI chr 1:261,295,711...261,372,848
Ensembl chr 1:261,307,008...261,372,848

MAGEL2

MAGE family member L2

acts_upstream_of_or_within

(MGI:5603599|PMID:23452853)

PMID:23452853

MGI:5603599

NCBI chr 1:142,450,414...142,454,633
Ensembl chr 1:142,448,689...142,454,697

scinderin

involved_in

GO_REF:0000107

NCBI chr 9:82,103,271...82,185,254
Ensembl chr 9:82,103,087...82,185,283

TRIM27

tripartite motif containing 27

acts_upstream_of_or_within

(MGI:5603599|PMID:23452853)

WASP homolog associated with actin, golgi membranes and microtubules

involved_in

GO_REF:0000107

NCBI chr 7:52,108,867...52,140,333
Ensembl chr 7:52,108,869...52,140,203

positive regulation of Arp2/3 complex-mediated actin nucleation

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ABI2

abl interactor 2

involved_in

(PMID:21107423)

PMID:21107423

NCBI chr15:106,776,627...106,903,889
Ensembl chr15:106,776,631...106,900,333

BRK1

BRICK1 subunit of SCAR/WAVE actin nucleating complex

involved_in

GO_REF:0000107

NCBI chr13:66,315,438...66,324,641
Ensembl chr13:66,315,315...66,324,641

CYFIP1

cytoplasmic FMR1 interacting protein 1

involved_in

GO_REF:0000107

NCBI chr15:32,064,431...32,175,095
Ensembl chr15:32,064,475...32,175,094

FCHSD2

FCH and double SH3 domains 2

involved_in

GO_REF:0000107

NCBI chr 9:7,366,516...7,619,960
Ensembl chr 9:7,366,523...7,608,469

LOC110256054

wiskott-Aldrich syndrome protein family member 1-like

involved_in

(PMID:21873635)

NCBI chr12:41,049,943...41,076,524

NCKAP1

NCK associated protein 1

involved_in

GO_REF:0000107

NCBI chr15:88,425,861...88,528,417
Ensembl chr15:88,425,142...88,528,326

WASF1

WASP family member 1

involved_in

(PMID:21873635)

NCBI chr 1:76,107,595...76,180,335

WASF2

WASP family member 2

involved_in

(PMID:21873635)

NCBI chr 6:84,621,742...84,697,428
Ensembl chr 6:84,622,800...84,697,429

WASF3

WASP family member 3

involved_in

(PMID:21873635)

NCBI chr11:4,261,121...4,366,258
Ensembl chr11:4,261,177...4,366,253

positive regulation of atrial cardiac muscle cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

TRPM4

transient receptor potential cation channel subfamily M member 4

NCBI chr 6:54,342,774...54,377,557
Ensembl chr 6:54,342,784...54,377,155

positive regulation of barbed-end actin filament capping

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ARPC2

actin related protein 2/3 complex subunit 2

NCBI chr15:120,297,122...120,328,795
Ensembl chr15:120,297,025...120,328,542

cofilin 1

NCBI chr 2:6,471,558...6,475,019
Ensembl chr 2:6,469,254...6,475,035

positive regulation of cardiac muscle cell contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CACNA1H

calcium voltage-gated channel subunit alpha1 H

NCBI chr 3:40,637,420...40,694,616
Ensembl chr 3:40,637,427...40,695,177

positive regulation of hepatic stellate cell contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ACTA2

actin alpha 2, smooth muscle

NCBI chr14:100,868,145...100,886,732
Ensembl chr14:100,867,733...100,886,713

positive regulation of myofibroblast contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

PTGER3

prostaglandin E receptor 3

NCBI chr 6:141,958,955...142,160,437
Ensembl chr 6:141,958,955...142,161,286

ZEB2

zinc finger E-box binding homeobox 2

NCBI chr15:7,498,879...7,631,347
Ensembl chr15:7,499,026...7,632,655

positive regulation of sarcomere organization

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

BMP10

bone morphogenetic protein 10

involved_in

GO_REF:0000107

NCBI chr 3:73,519,904...73,530,448
Ensembl chr 3:73,519,934...73,529,950

EDN1

endothelin 1

involved_in

GO_REF:0000107

NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348

EP300

E1A binding protein p300

NCBI chr 5:7,311,165...7,394,515
Ensembl chr 5:7,311,171...7,393,760

MYLK3

myosin light chain kinase 3

involved_in

PMID:17885681

NCBI chr 6:37,850,117...37,920,862
Ensembl chr 6:37,850,754...37,920,754

protein kinase D1

NCBI chr 7:69,527,743...69,872,374
Ensembl chr 7:69,527,811...69,872,863

PROX1

prospero homeobox 1

involved_in

GO_REF:0000107

NCBI chr 9:129,527,704...129,583,693
Ensembl chr 9:129,532,184...129,580,982

positive regulation of stress fiber assembly

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ABL1

ABL proto-oncogene 1, non-receptor tyrosine kinase

involved_in

GO_REF:0000107

NCBI chr 1:270,761,641...270,906,708
Ensembl chr 1:270,761,668...270,906,708

APOA1

apolipoprotein A1

involved_in

GO_REF:0000107

NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713

ARHGEF10

Rho guanine nucleotide exchange factor 10

involved_in

GO_REF:0000107

NCBI chr15:33,370,093...33,465,852
Ensembl chr15:33,370,126...33,446,598

ARHGEF10L

Rho guanine nucleotide exchange factor 10 like

involved_in

GO_REF:0000107

NCBI chr 6:76,064,212...76,229,310
Ensembl chr 6:76,083,725...76,229,307

ARHGEF15

Rho guanine nucleotide exchange factor 15

involved_in

PMID:12775584

NCBI chr12:53,495,409...53,506,373
Ensembl chr12:53,495,453...53,506,352

ARHGEF5

Rho guanine nucleotide exchange factor 5

involved_in

GO_REF:0000107

NCBI chr 9:113,364,849...113,394,446
Ensembl chr 9:113,364,879...113,394,389

BAG4

BAG cochaperone 4

involved_in

GO_REF:0000107

NCBI chr15:48,299,456...48,348,810
Ensembl chr15:48,299,666...48,348,527

BRAF

B-Raf proto-oncogene, serine/threonine kinase

acts_upstream_of_or_within
involved_in

(MGI:3047520|PMID:15199148)

PMID:15199148

GO_REF:0000107 MGI:3047520

NCBI chr18:8,957,963...9,132,558
Ensembl chr18:8,957,991...9,132,553

capping protein regulator and myosin 1 linker 1

involved_in

GO_REF:0000107

NCBI chr 7:20,036,430...20,353,431
Ensembl chr 7:20,036,944...20,353,420

CCDC88A

coiled-coil domain containing 88A

involved_in

GO_REF:0000107

NCBI chr 3:85,811,043...85,971,162
Ensembl chr 3:85,811,127...85,941,864

CCN2

cellular communication network factor 2

involved_in

GO_REF:0000107

NCBI chr 1:31,674,398...31,677,697
Ensembl chr 1:31,674,394...31,677,691

CD47

CD47 molecule

involved_in

PMID:12023387

NCBI chr13:151,427,933...151,488,064
Ensembl chr13:151,429,288...151,488,544

CDC42

cell division cycle 42

involved_in

GO_REF:0000107

NCBI chr 6:80,035,034...80,089,243
Ensembl chr 6:80,035,123...80,089,233

EPHA1

EPH receptor A1

involved_in

GO_REF:0000024 GO_REF:0000107

NCBI chr18:6,843,305...6,860,976
Ensembl chr18:6,843,299...6,860,989

EVL

Enah/Vasp-like

involved_in

GO_REF:0000107

NCBI chr 7:120,911,814...121,056,556
Ensembl chr 7:120,911,648...121,056,555

FERMT2

FERM domain containing kindlin 2

involved_in

GO_REF:0000107

NCBI chr 1:182,519,681...182,606,890
Ensembl chr 1:182,519,684...182,606,869

FHOD1

formin homology 2 domain containing 1

involved_in

GO_REF:0000107

NCBI chr 6:27,867,499...27,883,077
Ensembl chr 6:27,867,502...27,883,079

GPR65

G protein-coupled receptor 65

involved_in

GO_REF:0000107

NCBI chr 7:109,978,913...109,997,688
Ensembl chr 7:109,985,307...109,989,280

ITGB1BP1

integrin subunit beta 1 binding protein 1

involved_in

GO_REF:0000107

NCBI chr 3:126,905,779...126,921,961
Ensembl chr 3:126,905,810...126,922,045

KISS1 receptor

NCBI chr 2:77,472,361...77,479,204
Ensembl chr 2:77,472,362...77,479,204

LIMCH1

LIM and calponin homology domains 1

involved_in

(PMID:21873635)

NCBI chr 8:32,433,035...32,792,553
Ensembl chr 8:32,433,318...32,792,546

LIMK1

LIM domain kinase 1

acts_upstream_of_or_within
involved_in

(MGI:3047520|PMID:15199148)

PMID:15199148

GO_REF:0000107 MGI:3047520

NCBI chr 3:11,252,820...11,279,286
Ensembl chr 3:11,252,648...11,279,284

LPAR1

lysophosphatidic acid receptor 1

involved_in

(MGI:5645214|PMID:9600933)

PMID:9600933

MGI:5645214

NCBI chr 1:251,811,583...251,979,828
Ensembl chr 1:251,811,584...251,979,159

MTOR

mechanistic target of rapamycin kinase

acts_upstream_of_or_within
involved_in

(MGI:3510095|PMID:15467718)

GO_REF:0000107 MGI:3510095

NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888

MYOC

myocilin

involved_in

GO_REF:0000107

NCBI chr 9:114,087,370...114,098,765
Ensembl chr 9:114,087,378...114,098,745

NF2

NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor

involved_in

GO_REF:0000107

NCBI chr14:46,653,869...46,726,421
Ensembl chr14:46,653,900...46,731,999

NADPH oxidase 4

NCBI chr 9:22,622,105...22,776,691
Ensembl chr 9:22,624,212...22,776,534

NRP1

neuropilin 1

involved_in

GO_REF:0000107

NCBI chr10:56,280,673...56,430,832
Ensembl chr10:56,280,665...56,430,777

PAK1

p21 (RAC1) activated kinase 1

involved_in

GO_REF:0000024 GO_REF:0000107

NCBI chr 9:11,830,095...11,973,074
Ensembl chr 9:11,830,095...12,020,415

PDLIM4

PDZ and LIM domain 4

involved_in

PMID:14729062
PMID:22659164

PMID:14729062 PMID:22659164

RGD:1300470 RGD:13432282

NCBI chr 2:134,555,367...134,570,356
Ensembl chr 2:134,555,666...134,570,348

profilin 1

NCBI chr12:51,962,642...51,965,570
Ensembl chr12:51,961,952...51,965,464

profilin 2

involved_in

(MGI:5545940|PMID:23153535)
(PMID:23153535)

MGI:5545940

NCBI chr13:90,177,534...90,185,978
Ensembl chr13:90,177,540...90,183,742

PPM1E

protein phosphatase, Mg2+/Mn2+ dependent 1E

involved_in

GO_REF:0000107

NCBI chr12:35,051,936...35,262,698
Ensembl chr12:35,051,952...35,262,703

PPM1F

protein phosphatase, Mg2+/Mn2+ dependent 1F

involved_in

GO_REF:0000107

NCBI chr14:50,040,612...50,083,047
Ensembl chr14:50,040,663...50,063,325

PRKCQ

protein kinase C theta

NCBI chr10:64,442,588...64,596,528
Ensembl chr10:64,458,180...64,600,339

PXN

paxillin

involved_in

(PMID:24863063)

PMID:24863063

NCBI chr14:40,227,894...40,278,785
Ensembl chr14:40,227,895...40,278,734

Rac family small GTPase 1

involved_in

GO_REF:0000107

NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,780...4,803,543

RAPGEF3

Rap guanine nucleotide exchange factor 3

involved_in

GO_REF:0000107

NCBI chr 5:78,101,286...78,134,150
Ensembl chr 5:78,101,299...78,134,105

RGCC

regulator of cell cycle

involved_in

GO_REF:0000107

NCBI chr11:25,481,845...25,496,548
Ensembl chr11:25,478,879...25,496,519

PMID:15467718 PMID:25071083

ras homolog family member A

acts_upstream_of_or_within
involved_in

ISO
ISS
IEA

(MGI:6316493|PMID:25071083)
(PMID:15467718)

MGI
AgBase
Ensembl

GO_REF:0000024 GO_REF:0000107 MGI:6316493

NCBI chr13:31,918,484...31,991,207
Ensembl chr13:31,918,834...31,986,607

RHOC

ras homolog family member C

involved_in

GO_REF:0000107

NCBI chr 4:107,731,713...107,737,705
Ensembl chr 4:107,731,539...107,737,705

ROCK2

Rho associated coiled-coil containing protein kinase 2

involved_in

GO_REF:0000107

NCBI chr 3:125,353,063...125,493,368
Ensembl chr 3:125,352,920...125,493,362

S100A10

S100 calcium binding protein A10

involved_in

GO_REF:0000107

NCBI chr 4:97,261,752...97,272,517
Ensembl chr 4:97,261,815...97,272,513

syndecan 4

NCBI chr17:47,650,387...47,670,499

SERPINF2

serpin family F member 2

involved_in

GO_REF:0000107

NCBI chr12:47,934,551...47,942,283
Ensembl chr12:47,933,864...47,942,285

SH3PXD2B

SH3 and PX domains 2B

involved_in

(MGI:5800302|PMID:27711054)

PMID:27711054

MGI:5800302

NCBI chr16:51,733,170...51,858,774
Ensembl chr16:51,733,135...51,858,772

SMAD3

SMAD family member 3

during transdifferentiation

PMID:15987742

RGD:2300418

NCBI chr 1:164,998,457...165,124,455
Ensembl chr 1:164,998,103...165,124,449

SORBS3

sorbin and SH3 domain containing 3

involved_in

GO_REF:0000107

NCBI chr14:6,802,944...6,831,152
Ensembl chr14:6,808,166...6,828,975

SYNPO2L

synaptopodin 2 like

involved_in

(MGI:6102963|PMID:29206857)

PMID:29206857

MGI:6102963

NCBI chr14:76,456,170...76,466,661
Ensembl chr14:76,456,168...76,466,641

TAC1

tachykinin precursor 1

NCBI chr 9:77,197,403...77,206,529
Ensembl chr 9:77,197,536...77,206,523

TACR1

tachykinin receptor 1

NCBI chr 3:67,839,367...68,021,733
Ensembl chr 3:67,839,411...68,021,724

TESK1

testis associated actin remodelling kinase 1

involved_in

(PMID:21873635)

NCBI chr 1:236,341,160...236,345,964
Ensembl chr 1:236,341,261...236,345,962

TGFB3

transforming growth factor beta 3

involved_in

GO_REF:0000107

NCBI chr 7:99,133,873...99,162,239
Ensembl chr 7:99,133,879...99,162,232

TGFBR1

transforming growth factor beta receptor 1

involved_in

GO_REF:0000107

NCBI chr 1:240,842,735...240,918,267
Ensembl chr 1:240,860,156...240,918,528

TPM1

tropomyosin 1

involved_in

PMID:15897890

NCBI chr 1:108,986,981...109,016,090
Ensembl chr 1:108,986,986...109,020,035

TSC1

TSC complex subunit 1

NCBI chr 1:272,636,530...272,685,948
Ensembl chr 1:272,636,532...272,685,951

WNT11

Wnt family member 11

involved_in

GO_REF:0000107

NCBI chr 9:10,413,182...10,435,158
Ensembl chr 9:10,413,263...10,435,100

WNT4

Wnt family member 4

involved_in

(MGI:5487484|PMID:23027131)

PMID:23027131

MGI:5487484

NCBI chr 6:80,110,238...80,138,165

regulation of actin cytoskeleton organization

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ABL1

ABL proto-oncogene 1, non-receptor tyrosine kinase

acts_upstream_of_or_within
involved_in

(MGI:1327082|PMID:9883720)
(MGI:4840122|PMID:20980600)

PMID:9883720 PMID:20980600

GO_REF:0000107 MGI:1327082 MGI:4840122

NCBI chr 1:270,761,641...270,906,708
Ensembl chr 1:270,761,668...270,906,708

ACTR3

actin related protein 3

positive regulation

NCBI chr15:20,104,808...20,171,721
Ensembl chr15:20,104,812...20,167,421

ARHGAP18

Rho GTPase activating protein 18

involved_in

GO_REF:0000107

NCBI chr 1:33,527,734...33,717,980
Ensembl chr 1:33,527,734...33,717,966

ARHGAP35

Rho GTPase activating protein 35

involved_in

GO_REF:0000107

NCBI chr 6:52,711,463...52,841,295
Ensembl chr 6:52,711,901...52,841,288

ARHGAP44

Rho GTPase activating protein 44

involved_in

(PMID:21873635)

GO_REF:0000107

NCBI chr12:57,049,900...57,206,706
Ensembl chr12:57,049,895...57,206,889

ARHGEF19

Rho guanine nucleotide exchange factor 19

acts_upstream_of_or_within
involved_in

PMID:20643356 PMID:21873635

(PMID:20643356)
(PMID:21873635)

MGI
Ensembl
GO_Central

GO_REF:0000107

NCBI chr 6:75,317,811...75,335,292
Ensembl chr 6:75,317,823...75,335,270

ARHGEF5

Rho guanine nucleotide exchange factor 5

involved_in

GO_REF:0000107

NCBI chr 9:113,364,849...113,394,446
Ensembl chr 9:113,364,879...113,394,389

ARPC2

actin related protein 2/3 complex subunit 2

positive regulation

NCBI chr15:120,297,122...120,328,795
Ensembl chr15:120,297,025...120,328,542

BAIAP2

BAR/IMD domain containing adaptor protein 2

involved_in

Ensembl
InterPro

GO_REF:0000002 GO_REF:0000107

NCBI chr12:1,609,420...1,666,965
Ensembl chr12:1,603,540...1,670,075

BAR/IMD domain containing adaptor protein 2 like 1

involved_in

GO_REF:0000107

NCBI chr 3:5,472,305...5,567,926
Ensembl chr 3:5,472,315...5,567,876

BCAS3

BCAS3 microtubule associated cell migration factor

involved_in

(MGI:5582152|PMID:22300583)

PMID:22300583

MGI:5582152

NCBI chr12:36,894,727...37,475,221
Ensembl chr12:36,894,401...37,475,151

BST1

bone marrow stromal cell antigen 1

involved_in

GO_REF:0000107

NCBI chr 8:11,011,131...11,043,622
Ensembl chr 8:11,011,241...11,047,541

BST2

bone marrow stromal cell antigen 2

involved_in

PMID:19273615

NCBI chr 2:60,305,306...60,308,295
Ensembl chr 2:60,305,283...60,309,697

CAPN10

calpain 10

involved_in

GO_REF:0000107

NCBI chr15:139,557,643...139,568,764
Ensembl chr15:139,557,469...139,568,767

CCDC88A

coiled-coil domain containing 88A

involved_in

GO_REF:0000107

NCBI chr 3:85,811,043...85,971,162
Ensembl chr 3:85,811,127...85,941,864

CCL27

C-C motif chemokine ligand 27

acts_upstream_of_or_within

(MGI:5515359|PMID:12133963)

PMID:12133963

MGI:5515359

NCBI chr10:32,138,232...32,138,980
Ensembl chr10:32,138,232...32,138,974

CD2AP

CD2 associated protein

acts_upstream_of_or_within
involved_in

(MGI:5297732|PMID:21911934)

PMID:21911934

GO_REF:0000107 MGI:5297732

NCBI chr 7:42,218,016...42,332,523
Ensembl chr 7:42,218,290...42,332,518

CDC42

cell division cycle 42

involved_in

GO_REF:0000107

NCBI chr 6:80,035,034...80,089,243
Ensembl chr 6:80,035,123...80,089,233

CDK10

cyclin dependent kinase 10

involved_in

GO_REF:0000107

NCBI chr 6:332,239...339,130
Ensembl chr 6:332,242...339,142

CDK5R1

cyclin dependent kinase 5 regulatory subunit 1

involved_in

GO_REF:0000107

NCBI chr12:42,456,063...42,494,494
Ensembl chr12:42,493,392...42,494,413

CLASP2

cytoplasmic linker associated protein 2

involved_in

(PMID:24520051)

PMID:24520051

NCBI chr13:19,305,430...19,510,589
Ensembl chr13:19,305,181...19,510,585

coronin 1A

involved_in

GO_REF:0000107

NCBI chr 3:18,336,813...18,342,381
Ensembl chr 3:18,336,898...18,342,396

CORO2B

coronin 2B

acts_upstream_of_or_within
involved_in

(PMID:29162887)

PMID:29162887

GO_REF:0000107

NCBI chr 1:166,465,870...166,608,840
Ensembl chr 1:166,465,953...166,608,363

CRK

CRK proto-oncogene, adaptor protein

involved_in
acts_upstream_of_or_within

PMID:11870224 PMID:20980600

(PMID:11870224)
(MGI:4840122|PMID:20980600)

UniProt
MGI

MGI:4840122

NCBI chr12:47,656,805...47,685,641

CSF1R

colony stimulating factor 1 receptor

involved_in

GO_REF:0000107

NCBI chr 2:151,102,138...151,130,311
Ensembl chr 2:151,102,147...151,147,633

CTSL

cathepsin L

acts_upstream_of_or_within

(MGI:5297732|PMID:21911934)

PMID:21911934

MGI:5297732

NCBI chr10:27,668,523...27,674,705
Ensembl chr10:27,668,264...27,674,618

DAAM2

dishevelled associated activator of morphogenesis 2

involved_in

GO_REF:0000107

NCBI chr 7:35,127,245...35,285,933
Ensembl chr 7:35,159,888...35,285,941

DAPK3

death associated protein kinase 3

involved_in

GO_REF:0000107

NCBI chr 2:74,758,962...74,776,355
Ensembl chr 2:74,759,004...74,775,330

DIXDC1

DIX domain containing 1

involved_in

(MGI:4821185|PMID:20624590)

DFLAT

PMID:20624590

MGI:4821185

NCBI chr 9:39,666,454...39,734,909

DLC1

DLC1 Rho GTPase activating protein

involved_in

GO_REF:0000107

NCBI chr17:1,169,709...1,637,171
Ensembl chr17:1,170,208...1,637,114

DMTN

dematin actin binding protein

involved_in

GO_REF:0000107

NCBI chr14:6,315,643...6,346,722
Ensembl chr14:6,321,870...6,346,865

EFNA5

ephrin A5

involved_in

(PMID:21873635)

GO_REF:0000107

NCBI chr 2:112,533,124...112,821,293
Ensembl chr 2:112,534,949...112,815,827

EPHA3

EPH receptor A3

involved_in

GO_REF:0000107

NCBI chr13:166,592,492...166,942,791
Ensembl chr13:166,592,493...166,942,767

EPHA5

EPH receptor A5

involved_in

(MGI:5294297|PMID:17448994)

PMID:17448994

MGI:5294297

NCBI chr 8:63,285,006...63,604,734
Ensembl chr 8:63,287,711...63,604,734

ESAM

endothelial cell adhesion molecule

involved_in

GO_REF:0000107

NCBI chr 9:51,983,019...51,992,415
Ensembl chr 9:51,983,023...51,992,393

EZR

ezrin

NOT|involved_in

(PMID:20551903)

PMID:20551903

NCBI chr 1:8,403,362...8,452,750
Ensembl chr 1:8,403,453...8,452,742

F11R

F11 receptor

involved_in

GO_REF:0000107

NCBI chr 4:89,425,101...89,447,889
Ensembl chr 4:89,425,018...89,449,599

FAM107A

family with sequence similarity 107 member A

involved_in

(PMID:21873635)

NCBI chr13:40,276,896...40,369,708

FSCN1

fascin actin-bundling protein 1

involved_in

GO_REF:0000107

NCBI chr 3:4,134,173...4,143,275
Ensembl chr 3:4,134,177...4,143,286

FZD10

frizzled class receptor 10

involved_in

GO_REF:0000107

NCBI chr14:24,919,483...24,922,554
Ensembl chr14:24,920,679...24,922,424

GPM6B

glycoprotein M6B

involved_in

GO_REF:0000107

NCBI chr X:10,429,496...10,582,768
Ensembl chr X:10,430,281...10,643,429

GRHL3

grainyhead like transcription factor 3

acts_upstream_of_or_within
involved_in

(PMID:20643356)

PMID:20643356

GO_REF:0000107

NCBI chr 6:82,014,022...82,050,240
Ensembl chr 6:82,013,969...82,050,236

HCK

HCK proto-oncogene, Src family tyrosine kinase

involved_in

GO_REF:0000107

NCBI chr17:35,708,549...35,751,590
Ensembl chr17:35,709,349...35,751,582

HIP1R

huntingtin interacting protein 1 related

involved_in

GO_REF:0000107

NCBI chr14:29,996,388...30,024,343
Ensembl chr14:29,993,655...30,024,216

HRAS

HRas proto-oncogene, GTPase

involved_in

GO_REF:0000107

NCBI chr 2:299,662...302,539
Ensembl chr 2:299,660...302,501

HRG

histidine rich glycoprotein

involved_in

GO_REF:0000107

NCBI chr13:124,505,305...124,516,387
Ensembl chr13:124,505,312...124,516,705

interleukin 1 alpha

NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119

ILK

integrin linked kinase

positive regulation of alpha smooth muscle actin organization in aging cells

PMID:17234816

RGD:2301768

NCBI chr 9:3,145,647...3,152,097
Ensembl chr 9:3,145,608...3,159,858

IQGAP2

IQ motif containing GTPase activating protein 2

involved_in

GO_REF:0000107

NCBI chr 2:85,294,423...85,633,645
Ensembl chr 2:85,294,530...85,633,642

ITGB3

integrin subunit beta 3

involved_in

GO_REF:0000107

NCBI chr12:16,694,466...16,752,228
Ensembl chr12:16,693,514...16,752,292

LOC102159820

cadherin EGF LAG seven-pass G-type receptor 1

acts_upstream_of_or_within
involved_in

(MGI:4452277|PMID:20223754)

PMID:20223754

GO_REF:0000107 MGI:4452277

NCBI chr 5:3,114,410...3,203,378
Ensembl chr 5:2,980,351...3,203,381

LRP1

LDL receptor related protein 1

involved_in

(MGI:4365879|PMID:19742316)

PMID:19742316

MGI:4365879

NCBI chr 5:22,435,636...22,519,276

MIR335

microRNA mir-335

involved_in

(PMID:24223803)

PMID:24223803

NCBI chr18:18,341,580...18,341,659
Ensembl chr18:18,341,568...18,341,659

MLST8

MTOR associated protein, LST8 homolog

involved_in

(PMID:21873635)

GO_REF:0000107

NCBI chr 3:39,778,746...39,786,206
Ensembl chr 3:39,778,754...39,788,285

MTOR

mechanistic target of rapamycin kinase

involved_in

GO_REF:0000107

NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888

MYO1F

myosin IF

acts_upstream_of_or_within

(MGI:3664353|PMID:17023661)

PMID:17023661

MGI:3664353

NCBI chr 2:70,753,143...70,792,938
Ensembl chr 2:70,753,138...70,792,936

NEDD9

neural precursor cell expressed, developmentally down-regulated 9

involved_in

GO_REF:0000107

NCBI chr 7:7,807,042...8,093,553
Ensembl chr 7:7,807,044...7,914,061

ODAM

odontogenic, ameloblast associated

involved_in

GO_REF:0000107

NCBI chr 8:67,059,284...67,068,117
Ensembl chr 8:67,058,472...67,066,564

PAK1

p21 (RAC1) activated kinase 1

involved_in

(PMID:21873635)

PMID:18347024 PMID:21873635

RGD:2299169

NCBI chr 9:11,830,095...11,973,074
Ensembl chr 9:11,830,095...12,020,415

PAK3

p21 (RAC1) activated kinase 3

NCBI chr X:90,941,976...91,244,331
Ensembl chr X:90,942,077...91,238,565

PAM

peptidylglycine alpha-amidating monooxygenase

NCBI chr 2:108,255,923...108,536,192
Ensembl chr 2:108,255,930...108,536,880

PDGFRB

platelet derived growth factor receptor beta

involved_in

(MGI:4365879|PMID:19742316)

PMID:19742316

MGI:4365879

NCBI chr 2:151,155,753...151,192,818
Ensembl chr 2:151,155,756...151,192,647

PEAK3

PEAK family member 3

involved_in

GO_REF:0000107

NCBI chr 2:76,285,163...76,291,295
Ensembl chr 2:76,285,882...76,291,290

PRKCD

protein kinase C delta

involved_in

GO_REF:0000107

NCBI chr13:35,290,835...35,323,245
Ensembl chr13:35,290,610...35,323,356

PTK2B

protein tyrosine kinase 2 beta

involved_in

GO_REF:0000107

NCBI chr14:11,063,662...11,194,196
Ensembl chr14:11,064,492...11,194,192

Rac family small GTPase 1

involved_in

(PMID:21873635)

NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,780...4,803,543

RAC3

Rac family small GTPase 3

involved_in

(PMID:21873635)

NCBI chr12:981,072...984,222
Ensembl chr12:981,074...984,227

RALA

RAS like proto-oncogene A

involved_in

GO_REF:0000107

NCBI chr18:54,548,523...54,630,746
Ensembl chr18:54,550,238...54,588,980

RAPGEF3

Rap guanine nucleotide exchange factor 3

involved_in

positive regulation

RGD
Ensembl

PMID:18323524

GO_REF:0000107 RGD:9835356

NCBI chr 5:78,101,286...78,134,150
Ensembl chr 5:78,101,299...78,134,105

ras homolog family member A

involved_in

IEA
ISS

Ensembl
AgBase

GO_REF:0000024 GO_REF:0000107

NCBI chr13:31,918,484...31,991,207
Ensembl chr13:31,918,834...31,986,607

RHOD

ras homolog family member D

involved_in

(MGI:5512821|PMID:23454120)

PMID:23454120

MGI:5512821

NCBI chr 2:5,392,546...5,404,214
Ensembl chr 2:5,392,547...5,404,339

RHOG

ras homolog family member G

involved_in

(PMID:21873635)

NCBI chr 9:6,283,558...6,295,376

RICTOR

RPTOR independent companion of MTOR complex 2

involved_in

GO_REF:0000107

NCBI chr16:24,109,934...24,250,019
Ensembl chr16:24,109,939...24,311,132

ROCK1

Rho associated coiled-coil containing protein kinase 1

involved_in

GO_REF:0000107

NCBI chr 6:106,163,899...106,314,998
Ensembl chr 6:106,163,989...106,314,944

ROCK2

Rho associated coiled-coil containing protein kinase 2

involved_in

GO_REF:0000002

NCBI chr 3:125,353,063...125,493,368
Ensembl chr 3:125,352,920...125,493,362

SH3BP1

SH3 domain binding protein 1

involved_in

(PMID:21873635)

GO_REF:0000107

NCBI chr 5:10,172,303...10,187,883
Ensembl chr 5:10,172,667...10,187,906

SIGLEC15

sialic acid binding Ig like lectin 15

acts_upstream_of_or_within
involved_in

PMID:21873635 PMID:22451653

(MGI:5467208|PMID:22451653)
(PMID:21873635)

MGI
Ensembl
GO_Central

GO_REF:0000107 MGI:5467208

NCBI chr 1:95,475,108...95,492,675
Ensembl chr 1:95,475,438...95,492,709

SLC4A2

solute carrier family 4 member 2

involved_in

(MGI:5469753|PMID:23341620)

PMID:23341620

MGI:5469753

NCBI chr18:6,149,459...6,166,622
Ensembl chr18:6,149,459...6,165,212

SMIM22

small integral membrane protein 22

involved_in

GO_REF:0000107

NCBI chr 3:37,599,574...37,601,316
Ensembl chr 3:37,599,576...37,601,086

STAU2

staufen double-stranded RNA binding protein 2

NCBI chr 4:62,139,456...62,455,509
Ensembl chr 4:62,139,464...62,455,499

TAOK1

TAO kinase 1

involved_in

PMID:18216281

NCBI chr12:45,597,067...45,750,117
Ensembl chr12:45,597,072...45,744,356

TAOK2

TAO kinase 2

involved_in

GO_REF:0000107

NCBI chr 3:18,178,347...18,198,092
Ensembl chr 3:18,177,737...18,198,085

TESK1

testis associated actin remodelling kinase 1

involved_in

GO_REF:0000107

NCBI chr 1:236,341,160...236,345,964
Ensembl chr 1:236,341,261...236,345,962

TGFB1

transforming growth factor beta 1

acts_upstream_of_or_within
involved_in

(MGI:5297732|PMID:21911934)

PMID:21911934

GO_REF:0000107 MGI:5297732

NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046

TGFB2

transforming growth factor beta 2

involved_in

(MGI:5688835|PMID:21984612)

PMID:21984612

MGI:5688835

NCBI chr10:8,306,136...8,435,307
Ensembl chr10:8,305,539...8,390,341

twinfilin actin binding protein 1

involved_in

GO_REF:0000117

NCBI chr 5:74,868,586...74,881,220
Ensembl chr 5:74,868,585...74,893,698

twinfilin actin binding protein 2

involved_in

GO_REF:0000107 GO_REF:0000117

NCBI chr13:34,361,294...34,370,997
Ensembl chr13:34,361,297...34,371,277

VANGL2

VANGL planar cell polarity protein 2

acts_upstream_of_or_within

(MGI:4452277|PMID:20223754)

PMID:20223754

MGI:4452277

NCBI chr 4:90,051,994...90,080,701
Ensembl chr 4:90,051,277...90,080,635

YWHAE

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon

involved_in

GO_REF:0000107

NCBI chr12:47,601,133...47,645,327
Ensembl chr12:47,600,745...47,645,301

regulation of actin cytoskeleton organization by cell-cell adhesion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

JAM3

junctional adhesion molecule 3

acts_upstream_of_or_within
involved_in

(MGI:3054279|PMID:15372036)

PMID:15372036

GO_REF:0000107 MGI:3054279

NCBI chr 9:60,629,245...60,738,979
Ensembl chr 9:60,613,400...60,738,924

regulation of actin cytoskeleton reorganization

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

TRPM2

transient receptor potential cation channel subfamily M member 2

involved_in

GO_REF:0000107

NCBI chr13:207,212,339...207,263,313
Ensembl chr13:207,212,457...207,262,064

regulation of actin filament bundle assembly

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

FLNA

filamin A

involved_in

(MGI:4838360|PMID:20713593)

PMID:20713593

MGI:4838360

NCBI chr X:124,889,934...124,915,000
Ensembl chr X:124,890,162...124,914,992

RDX

radixin

involved_in

GO_REF:0000107

NCBI chr 9:38,243,608...38,299,561
Ensembl chr 9:38,220,447...38,322,097

regulation of actin filament depolymerization

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

SH3BP1

SH3 domain binding protein 1

involved_in

GO_REF:0000107

NCBI chr 5:10,172,303...10,187,883
Ensembl chr 5:10,172,667...10,187,906

WDR1

WD repeat domain 1

involved_in

GO_REF:0000107

NCBI chr 8:6,413,338...6,452,383
Ensembl chr 8:6,413,347...6,452,346

regulation of actin filament length

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

EPS8

epidermal growth factor receptor pathway substrate 8

involved_in

GO_REF:0000107

NCBI chr 5:56,817,445...57,005,117
Ensembl chr 5:56,817,606...57,005,113

MYO3A

myosin IIIA

acts_upstream_of_or_within

(MGI:5766107|PMID:26754646)

PMID:26754646

MGI:5766107

NCBI chr10:49,392,119...49,623,575

MYO3B

myosin IIIB

acts_upstream_of_or_within

(MGI:5766107|PMID:26754646)

PMID:26754646

MGI:5766107

NCBI chr15:76,432,429...76,855,443
Ensembl chr15:76,401,963...76,855,429

regulation of actin filament organization

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

C9orf72

C9orf72-SMCR8 complex subunit

involved_in

GO_REF:0000107

NCBI chr10:38,389,366...38,415,903
Ensembl chr10:38,389,331...38,415,901

CSF3

colony stimulating factor 3

involved_in

GO_REF:0000107

NCBI chr12:22,333,445...22,335,949
Ensembl chr12:22,333,449...22,338,753

GJA1

gap junction protein alpha 1

NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156

HAX1

HCLS1 associated protein X-1

involved_in

GO_REF:0000107

NCBI chr 4:95,467,629...95,470,972
Ensembl chr 4:95,467,632...95,470,290

profilin 1

involved_in

GO_REF:0000117

NCBI chr12:51,962,642...51,965,570
Ensembl chr12:51,961,952...51,965,464

profilin 2

involved_in

GO_REF:0000117

NCBI chr13:90,177,534...90,185,978
Ensembl chr13:90,177,540...90,183,742

PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

involved_in

GO_REF:0000107

NCBI chr13:117,193,935...117,282,151
Ensembl chr13:117,180,544...117,274,587

RGS4

regulator of G protein signaling 4

NCBI chr 4:87,383,336...87,390,478
Ensembl chr 4:87,383,345...87,390,893

regulation of actin filament polymerization

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ABITRAM

actin binding transcription modulator

involved_in

(PMID:21873635)

NCBI chr 1:249,898,994...249,905,397

ARHGAP18

Rho GTPase activating protein 18

involved_in

(PMID:21873635)

GO_REF:0000107

NCBI chr 1:33,527,734...33,717,980
Ensembl chr 1:33,527,734...33,717,966

ARHGAP28

Rho GTPase activating protein 28

involved_in

(PMID:21873635)

NCBI chr 6:100,494,385...100,681,008
Ensembl chr 6:100,494,652...100,655,708

ARPC3

actin related protein 2/3 complex subunit 3

involved_in

GO_REF:0000002

NCBI chr14:31,814,382...31,823,452
Ensembl chr14:31,814,151...31,826,855

ARPC5

actin related protein 2/3 complex subunit 5

involved_in

GO_REF:0000002

NCBI chr 9:124,839,062...124,847,906
Ensembl chr 9:124,837,765...124,848,105

ARPC5L

actin related protein 2/3 complex subunit 5 like

involved_in

GO_REF:0000002

NCBI chr 1:265,645,800...265,653,513
Ensembl chr 1:265,642,260...265,654,018

BAR/IMD domain containing adaptor protein 2 like 1

involved_in

GO_REF:0000002

NCBI chr 3:5,472,305...5,567,926
Ensembl chr 3:5,472,315...5,567,876

coronin 1A

acts_upstream_of_or_within
involved_in

(MGI:3818245|PMID:18836449)

PMID:18836449

GO_REF:0000107 MGI:3818245

NCBI chr 3:18,336,813...18,342,381
Ensembl chr 3:18,336,898...18,342,396

CTTN

cortactin

involved_in

(PMID:21873635)

NCBI chr 2:3,031,103...3,060,796
Ensembl chr 2:3,031,103...3,060,813

CYFIP1

cytoplasmic FMR1 interacting protein 1

involved_in

GO_REF:0000002

NCBI chr15:32,064,431...32,175,095
Ensembl chr15:32,064,475...32,175,094

CYFIP2

cytoplasmic FMR1 interacting protein 2

involved_in

GO_REF:0000002

NCBI chr16:65,852,584...66,001,576
Ensembl chr16:65,852,588...66,001,559

CYRIA

CYFIP related Rac1 interactor A

involved_in

GO_REF:0000002

NCBI chr 3:120,968,016...121,069,372
Ensembl chr 3:120,968,060...121,069,240

CYRIB

CYFIP related Rac1 interactor B

involved_in

GO_REF:0000002

NCBI chr 4:10,476,137...10,643,395

DAAM2

dishevelled associated activator of morphogenesis 2

involved_in

GO_REF:0000107

NCBI chr 7:35,127,245...35,285,933
Ensembl chr 7:35,159,888...35,285,941

DBN1

drebrin 1

involved_in

(PMID:21873635)

PMID:19222710 PMID:21873635

RGD:10395284

NCBI chr 2:80,480,603...80,495,797
Ensembl chr 2:80,479,460...80,495,796

DBNL

drebrin like

involved_in

(PMID:21873635)

NCBI chr18:48,713,335...48,725,692
Ensembl chr18:48,713,340...48,725,697

ELN

elastin

acts_upstream_of_or_within
involved_in

(MGI:3027647|PMID:14614988)

PMID:14614988

GO_REF:0000107 MGI:3027647

NCBI chr 3:11,214,194...11,245,891
Ensembl chr 3:11,214,205...11,244,897

ESAM

endothelial cell adhesion molecule

involved_in

GO_REF:0000107

NCBI chr 9:51,983,019...51,992,415
Ensembl chr 9:51,983,023...51,992,393

GBA2

glucosylceramidase beta 2

involved_in

GO_REF:0000107

NCBI chr 1:236,456,238...236,467,887
Ensembl chr 1:236,455,240...236,468,210

HAX1

HCLS1 associated protein X-1

involved_in

(PMID:21873635)

GO_REF:0000107

NCBI chr 4:95,467,629...95,470,972
Ensembl chr 4:95,467,632...95,470,290

HCLS1

hematopoietic cell-specific Lyn substrate 1

involved_in

(PMID:21873635)

GO_REF:0000107

NCBI chr13:138,852,387...138,883,088
Ensembl chr13:138,855,144...138,889,281

LATS1

large tumor suppressor kinase 1

involved_in

GO_REF:0000107

NCBI chr 1:16,274,955...16,320,980
Ensembl chr 1:16,274,970...16,320,604

PAK3

p21 (RAC1) activated kinase 3

involved_in

GO_REF:0000107

NCBI chr X:90,941,976...91,244,331
Ensembl chr X:90,942,077...91,238,565

profilin 1

involved_in

(PMID:21873635)

NCBI chr12:51,962,642...51,965,570
Ensembl chr12:51,961,952...51,965,464

profilin 2

involved_in

(PMID:21873635)

PMID:11027290 PMID:21873635

RGD:727303

NCBI chr13:90,177,534...90,185,978
Ensembl chr13:90,177,540...90,183,742

PIK3R2

phosphoinositide-3-kinase regulatory subunit 2

acts_upstream_of_or_within
involved_in

(MGI:5613738|PMID:25217619)

PMID:25217619

GO_REF:0000107 MGI:5613738

NCBI chr 2:59,637,363...59,652,075
Ensembl chr 2:59,637,371...59,652,073

PLEKHG2

pleckstrin homology and RhoGEF domain containing G2

involved_in

(PMID:21873635)

GO_REF:0000107

NCBI chr 6:48,069,532...48,080,001
Ensembl chr 6:48,069,564...48,079,672

PPP1R9A

protein phosphatase 1 regulatory subunit 9A

NCBI chr 9:74,635,285...74,944,050
Ensembl chr 9:74,635,403...74,940,362

PREX1

phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1

NCBI chr17:50,352,273...50,550,402
Ensembl chr17:50,354,775...50,550,637

RASA1

RAS p21 protein activator 1

involved_in

GO_REF:0000107

NCBI chr 2:94,879,615...94,992,725
Ensembl chr 2:94,878,911...94,993,450

RSL1D1

ribosomal L1 domain containing 1

involved_in

(PMID:21873635)

NCBI chr 3:31,278,394...31,291,205
Ensembl chr 3:31,278,852...31,293,246

WASHC1

WASH complex subunit 1

acts_upstream_of_or_within

(MGI:5806548|PMID:26965651)

PMID:26965651

MGI:5806548

NCBI chr 5:67,395,737...67,412,408
Ensembl chr 5:67,394,875...67,412,431

regulation of actin nucleation

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

villin 1

involved_in

PMID:21873635 PMID:27390154

GO_REF:0000024 GO_REF:0000107

NCBI chr15:120,463,470...120,494,772
Ensembl chr15:120,463,566...120,492,580

WASHC5

WASH complex subunit 5

involved_in
acts_upstream_of_or_within

IEA
ISO
IBA

(MGI:5883184|PMID:27390154)
(PMID:21873635)

Ensembl
MGI
GO_Central

GO_REF:0000107 MGI:5883184

NCBI chr 4:14,598,133...14,667,535
Ensembl chr 4:14,598,150...14,668,313

regulation of actin phosphorylation

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

twinfilin actin binding protein 1

involved_in

GO_REF:0000107

NCBI chr 5:74,868,586...74,881,220
Ensembl chr 5:74,868,585...74,893,698

regulation of actin polymerization or depolymerization

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ARHGAP35

Rho GTPase activating protein 35

involved_in

GO_REF:0000107

NCBI chr 6:52,711,463...52,841,295
Ensembl chr 6:52,711,901...52,841,288

BRK1

BRICK1 subunit of SCAR/WAVE actin nucleating complex

involved_in

(PMID:21873635)

NCBI chr13:66,315,438...66,324,641
Ensembl chr13:66,315,315...66,324,641

CIT

citron rho-interacting serine/threonine kinase

NCBI chr14:33,009,828...33,195,985
Ensembl chr14:33,009,877...33,196,286

coronin 1A

acts_upstream_of_or_within
involved_in

(MGI:3654559|PMID:16902139)

PMID:16902139

GO_REF:0000107 MGI:3654559

NCBI chr 3:18,336,813...18,342,381
Ensembl chr 3:18,336,898...18,342,396

HYAL1

hyaluronidase 1

involved_in

GO_REF:0000107

NCBI chr13:32,798,135...32,800,705
Ensembl chr13:32,797,681...32,800,793

HYAL1

hyaluronidase 1

involved_in

GO_REF:0000107

NCBI chr13:32,793,784...32,794,650
Ensembl chr13:32,793,572...32,794,700

ras homolog family member A

NCBI chr13:31,918,484...31,991,207
Ensembl chr13:31,918,834...31,986,607

SWAP70

switching B cell complex subunit SWAP70

involved_in

GO_REF:0000107

NCBI chr 2:49,721,120...49,805,262
Ensembl chr 2:49,719,669...49,805,049

WAS

WASP actin nucleation promoting factor

involved_in

GO_REF:0000107

NCBI chr X:42,774,597...42,793,055
Ensembl chr X:42,774,588...42,793,055

regulation of Arp2/3 complex-mediated actin nucleation

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AP1AR

adaptor related protein complex 1 associated regulatory protein

acts_upstream_of_or_within
involved_in

(MGI:5429457|PMID:22689987)

MGI
InterPro
Ensembl

PMID:22689987

GO_REF:0000002 GO_REF:0000107 MGI:5429457

NCBI chr 8:110,386,145...110,420,548
Ensembl chr 8:110,386,783...110,420,542

ARF1

ADP ribosylation factor 1

involved_in

PMID:23889934

NCBI chr 2:51,219,597...51,237,640
Ensembl chr 2:51,219,667...51,237,639

ARFIP1

ADP ribosylation factor interacting protein 1

involved_in

(PMID:21873635)

NCBI chr 8:76,168,731...76,270,554
Ensembl chr 8:76,168,403...76,270,609

CARMIL3

capping protein regulator and myosin 1 linker 3

involved_in

(PMID:21873635)

NCBI chr 7:75,222,528...75,241,243
Ensembl chr 7:75,222,528...75,241,242

FAM241A

family with sequence similarity 241 member A

involved_in

GO_REF:0000002

NCBI chr 8:110,468,450...110,504,828
Ensembl chr 8:110,468,757...110,504,912

RNH1

ribonuclease/angiogenin inhibitor 1

involved_in

(PMID:21873635)

NCBI chr 2:281,919...290,522
Ensembl chr 2:281,928...290,079

regulation of atrial cardiac muscle cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ANK2

ankyrin 2

involved_in

(PMID:12571597)
(MGI:2449848|PMID:12571597)

PMID:12571597

MGI:2449848

NCBI chr 8:109,306,793...109,661,970

GJA5

gap junction protein alpha 5

involved_in

GO_REF:0000107

NCBI chr 4:99,854,129...99,871,288
Ensembl chr 4:99,854,392...99,871,286

RYR2

ryanodine receptor 2

involved_in

GO_REF:0000107

NCBI chr14:53,652,140...54,406,691
Ensembl chr14:53,652,485...54,192,063

regulation of barbed-end actin filament capping

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

IQANK1

IQ motif and ankyrin repeat containing 1

involved_in

(PMID:21873635)

NCBI chr 4:852,218...896,425
Ensembl chr 4:852,250...866,201

MTPN

myotrophin

involved_in

(PMID:21873635)

GO_REF:0000107

NCBI chr18:13,330,049...13,395,297
Ensembl chr18:13,330,029...13,395,460

regulation of cardiac muscle cell action potential involved in regulation of contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AKAP9

A-kinase anchoring protein 9

involved_in

GO_REF:0000107

NCBI chr 9:71,895,615...72,054,898
Ensembl chr 9:71,895,635...72,054,897

ATP2A2

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

involved_in

PMID:9851937

NCBI chr14:31,674,659...31,744,981
Ensembl chr14:31,674,757...31,744,969

CAV3

caveolin 3

involved_in

GO_REF:0000107

NCBI chr13:65,117,868...65,130,886
Ensembl chr13:65,117,795...65,131,273

FGF13

fibroblast growth factor 13

involved_in

(MGI:5437408|PMID:21817159)

PMID:21817159

MGI:5437408

NCBI chr X:113,460,191...113,955,691
Ensembl chr X:113,460,191...113,932,715

HCN4

hyperpolarization activated cyclic nucleotide gated potassium channel 4

involved_in

GO_REF:0000107

NCBI chr 7:60,010,396...60,052,258
Ensembl chr 7:60,010,283...60,050,689

RANGRF

RAN guanine nucleotide release factor

involved_in

GO_REF:0000107

NCBI chr12:53,484,584...53,486,716
Ensembl chr12:53,485,265...53,486,713

regulation of cardiac muscle cell contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ADORA1

adenosine A1 receptor

NCBI chr 9:113,835,279...113,875,899
Ensembl chr 9:113,835,921...113,872,365

ADRB1

adrenoceptor beta 1

PMID:19525381 PMID:22216755

RGD:2317914 RGD:6893639

NCBI chr14:124,400,330...124,401,739
Ensembl chr14:124,400,330...124,401,739

AKAP6

A-kinase anchoring protein 6

involved_in

PMID:11179196

NCBI chr 7:66,913,541...67,462,147
Ensembl chr 7:66,915,881...67,375,177

ANK2

ankyrin 2

involved_in

(PMID:17242276)
(MGI:3771114|PMID:17242276)

PMID:17242276

MGI:3771114

NCBI chr 8:109,306,793...109,661,970

ATP1A1

ATPase Na+/K+ transporting subunit alpha 1

NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,508...104,384,547

ATP1A2

ATPase Na+/K+ transporting subunit alpha 2

NCBI chr 4:90,341,316...90,371,040
Ensembl chr 4:90,341,322...90,370,996

CASQ2

calsequestrin 2

involved_in

PMID:17569730

NCBI chr 4:104,918,204...104,984,019
Ensembl chr 4:104,918,501...104,983,607

GATA4

GATA binding protein 4

NCBI chr14:14,858,470...14,938,156
Ensembl chr14:14,884,662...14,939,941

KCNJ2

potassium inwardly rectifying channel subfamily J member 2

NCBI chr12:10,351,959...10,380,631
Ensembl chr12:10,351,699...10,362,244

MYH7B

myosin heavy chain 7B

NCBI chr17:38,362,158...38,385,680
Ensembl chr17:38,362,452...38,386,469

PDE4B

phosphodiesterase 4B

involved_in

GO_REF:0000107

NCBI chr 6:146,167,262...146,720,105
Ensembl chr 6:146,166,688...146,719,682

PDE4D

phosphodiesterase 4D

involved_in

(PMID:21873635)

PMID:19801680 PMID:21873635

RGD:7327160

NCBI chr16:37,897,300...39,406,534
Ensembl chr16:37,897,302...39,306,364

PLN

phospholamban

acts_upstream_of_or_within
involved_in

(MGI:3655311|PMID:8620604)

PMID:8620604

GO_REF:0000107 MGI:3655311

NCBI chr 1:43,449,354...43,458,925
Ensembl chr 1:43,449,354...43,458,925

SCN5A

sodium voltage-gated channel alpha subunit 5

acts_upstream_of_or_within
involved_in

(MGI:3695100|PMID:16172272)

PMID:16172272

GO_REF:0000107 MGI:3695100

NCBI chr13:23,336,143...23,424,755
Ensembl chr13:23,336,153...23,424,755

SRI

sorcin

involved_in

GO_REF:0000107

NCBI chr 9:68,492,235...68,515,247
Ensembl chr 9:68,490,890...68,515,322

STC1

stanniocalcin 1

involved_in

GO_REF:0000107

NCBI chr14:7,952,175...7,961,365
Ensembl chr14:7,950,434...7,961,566

SUMO1

small ubiquitin like modifier 1

involved_in

(MGI:5292424|PMID:21900893)

PMID:21900893

MGI:5292424

NCBI chr15:105,820,237...105,850,099
Ensembl chr15:105,818,858...105,850,233

regulation of cytokinesis, actomyosin contractile ring assembly

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ECT2

epithelial cell transforming 2

involved_in

GO_REF:0000002

NCBI chr13:111,248,215...111,310,746
Ensembl chr13:111,248,131...111,314,828

regulation of muscle filament sliding

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

MYLK2

myosin light chain kinase 2

involved_in

GO_REF:0000107

NCBI chr17:35,499,828...35,513,096
Ensembl chr17:35,499,887...35,513,093

regulation of muscle filament sliding speed

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

TNNC1

troponin C1, slow skeletal and cardiac type

involved_in

GO_REF:0000107

NCBI chr13:34,591,571...34,594,320
Ensembl chr13:34,591,386...34,594,337

TNNT2

troponin T2, cardiac type

involved_in

PMID:10747195

NCBI chr10:23,749,528...23,759,696
Ensembl chr10:23,749,335...23,763,396

regulation of myofibroblast contraction

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

PDPN

podoplanin

involved_in

(PMID:21873635)

NCBI chr 6:73,019,063...73,050,000
Ensembl chr 6:73,019,057...73,049,996

regulation of myosin II filament organization

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ACTR3

actin related protein 3

NCBI chr15:20,104,808...20,171,721
Ensembl chr15:20,104,812...20,167,421

DAPK3

death associated protein kinase 3

involved_in

GO_REF:0000107

NCBI chr 2:74,758,962...74,776,355
Ensembl chr 2:74,759,004...74,775,330

regulation of sarcomere organization

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AKAP13

A-kinase anchoring protein 13

involved_in

(MGI:5308772|PMID:20139090)

PMID:20139090

MGI:5308772

NCBI chr 7:87,889,384...88,222,854

ANKRD23

ankyrin repeat domain 23

acts_upstream_of_or_within
involved_in

(MGI:3760007|PMID:17392382)

PMID:17392382

GO_REF:0000107 MGI:3760007

NCBI chr 3:56,776,824...56,781,223
Ensembl chr 3:56,776,812...56,782,654

HDAC2

histone deacetylase 2

acts_upstream_of_or_within

(MGI:3711360|PMID:17322895)

PMID:17322895

MGI:3711360

NCBI chr 1:79,867,713...79,901,597
Ensembl chr 1:79,863,094...79,901,585

MEF2C

myocyte enhancer factor 2C

acts_upstream_of_or_within

(MGI:3768576|PMID:17875930)

PMID:17875930

MGI:3768576

NCBI chr 2:96,122,407...96,296,927
Ensembl chr 2:96,124,168...96,296,810

regulation of stress fiber assembly

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ACTG1

actin gamma 1

involved_in

GO_REF:0000107

NCBI chr12:1,320,355...1,323,219
Ensembl chr12:1,313,641...1,323,217

ALMS1

ALMS1 centrosome and basal body associated protein

acts_upstream_of_or_within
involved_in

(PMID:22693585)

PMID:22693585

GO_REF:0000107

NCBI chr 3:69,253,742...69,417,043
Ensembl chr 3:69,253,750...69,417,189

ASAP3

ArfGAP with SH3 domain, ankyrin repeat and PH domain 3

involved_in

(PMID:21873635)

GO_REF:0000107

NCBI chr 6:81,309,748...81,360,054
Ensembl chr 6:81,309,748...81,360,043

BBS4

Bardet-Biedl syndrome 4

acts_upstream_of_or_within
involved_in

(MGI:5510934|PMID:23716571)

GO_REF:0000107 MGI:5510934

NCBI chr 7:60,631,913...60,693,359
Ensembl chr 7:60,631,914...60,693,334

CDC42

cell division cycle 42

involved_in

GO_REF:0000107

NCBI chr 6:80,035,034...80,089,243
Ensembl chr 6:80,035,123...80,089,233

FHOD1

formin homology 2 domain containing 1

involved_in

GO_REF:0000107

NCBI chr 6:27,867,499...27,883,077
Ensembl chr 6:27,867,502...27,883,079

MKKS

MKKS centrosomal shuttling protein

acts_upstream_of_or_within
involved_in

(MGI:5510934|PMID:23716571)

GO_REF:0000107 MGI:5510934

NCBI chr17:19,341,024...19,363,007
Ensembl chr17:19,341,636...19,362,871

PIK3R1

phosphoinositide-3-kinase regulatory subunit 1

acts_upstream_of_or_within
involved_in

(MGI:5613738|PMID:25217619)

PMID:25217619

GO_REF:0000107 MGI:5613738

NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,511,521...46,523,609

PIK3R2

phosphoinositide-3-kinase regulatory subunit 2

acts_upstream_of_or_within
involved_in

(MGI:5613738|PMID:25217619)

PMID:25217619

GO_REF:0000107 MGI:5613738

NCBI chr 2:59,637,363...59,652,075
Ensembl chr 2:59,637,371...59,652,073

PTGER4

prostaglandin E receptor 4

involved_in

GO_REF:0000107

NCBI chr16:25,670,832...25,686,556
Ensembl chr16:25,670,862...25,686,552

Rac family small GTPase 1

involved_in

GO_REF:0000107

NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,780...4,803,543

SYNPO

synaptopodin

involved_in

(MGI:3577135|PMID:15841212)

PMID:15841212

MGI:3577135

NCBI chr 2:151,571,264...151,634,103
Ensembl chr 2:151,599,597...151,632,099

TSC1

TSC complex subunit 1

involved_in

GO_REF:0000107

NCBI chr 1:272,636,530...272,685,948
Ensembl chr 1:272,636,532...272,685,951

TTC8

tetratricopeptide repeat domain 8

acts_upstream_of_or_within
involved_in

(MGI:5510934|PMID:23716571)

GO_REF:0000107 MGI:5510934

NCBI chr 7:110,731,729...110,783,999
Ensembl chr 7:110,731,731...110,784,853

WAS

WASP actin nucleation promoting factor

involved_in

GO_REF:0000107

NCBI chr X:42,774,597...42,793,055
Ensembl chr X:42,774,588...42,793,055

regulation of ventricular cardiac muscle cell action potential

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CACNA1C

calcium voltage-gated channel subunit alpha1 C

involved_in

GO_REF:0000107

NCBI chr 5:69,016,954...69,448,428
Ensembl chr 5:69,275,176...69,448,430

CAV1

caveolin 1

involved_in

GO_REF:0000107

NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465

CTNNA3

catenin alpha 3

involved_in

GO_REF:0000107

NCBI chr14:69,195,231...70,974,543
Ensembl chr14:69,195,961...70,938,204

DLG1

discs large MAGUK scaffold protein 1

involved_in

GO_REF:0000107

NCBI chr13:132,819,931...133,084,880
Ensembl chr13:132,820,870...133,086,841

DSC2

desmocollin 2

involved_in

GO_REF:0000107

NCBI chr 6:114,982,259...115,021,332
Ensembl chr 6:114,980,601...115,021,305

DSG2

desmoglein 2

involved_in

GO_REF:0000107

NCBI chr 6:115,400,223...115,453,763
Ensembl chr 6:115,400,243...115,454,340

DSP

desmoplakin

involved_in

GO_REF:0000107

NCBI chr 7:4,862,649...4,915,626
Ensembl chr 7:4,862,649...4,915,623

JUP

junction plakoglobin

involved_in

GO_REF:0000107

NCBI chr12:20,902,395...20,931,208
Ensembl chr12:20,901,396...20,931,210

PKP2

plakophilin 2

involved_in

GO_REF:0000107

NCBI chr 5:41,424,687...41,509,590
Ensembl chr 5:41,424,845...41,508,868

RYR2

ryanodine receptor 2

involved_in

GO_REF:0000107

NCBI chr14:53,652,140...54,406,691
Ensembl chr14:53,652,485...54,192,063

TRPM4

transient receptor potential cation channel subfamily M member 4

involved_in

GO_REF:0000107

NCBI chr 6:54,342,774...54,377,557
Ensembl chr 6:54,342,784...54,377,155

sequestering of actin monomers

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

gelsolin

involved_in

GO_REF:0000107

NCBI chr 1:261,295,711...261,372,848
Ensembl chr 1:261,307,008...261,372,848

PFN4

profilin family member 4

involved_in

(PMID:21873635)

NCBI chr 3:114,578,264...114,585,194
Ensembl chr 3:114,578,199...114,585,194

scinderin

involved_in

GO_REF:0000107

NCBI chr 9:82,103,271...82,185,254
Ensembl chr 9:82,103,087...82,185,283

TMSB10

thymosin beta 10

involved_in

(PMID:21873635)

NCBI chr 3:59,776,236...59,777,252
Ensembl chr 3:59,776,236...59,777,252

TMSB15B

thymosin beta 15B

involved_in

(PMID:21873635)

NCBI chr X:84,815,565...84,871,809

TMSB4X

thymosin beta 4 X-linked

involved_in

(PMID:21873635)

GO_REF:0000107

NCBI chr X:9,649,516...9,651,662
Ensembl chr X:9,650,179...9,651,661

twinfilin actin binding protein 1

involved_in

(PMID:21873635)

GO_REF:0000107

NCBI chr 5:74,868,586...74,881,220
Ensembl chr 5:74,868,585...74,893,698

twinfilin actin binding protein 2

involved_in

(PMID:21873635)