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ONTOLOGY REPORT - ANNOTATIONS

Term:collagen biosynthetic process
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Accession:GO:0032964 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
Synonyms:exact_synonym: collagen anabolism;   collagen biosynthesis;   collagen formation;   collagen synthesis


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collagen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif 3 involved_in IDA (PMID:11408482) BHF-UCL PMID:11408482 NCBI chr 4:72,280,969...72,569,221
Ensembl chr 4:72,280,969...72,569,221 		JBrowse link
G ARG1 arginase 1 ISO RGD PMID:20107769 RGD:4143276 NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332 		JBrowse link
G COL1A1 collagen type I alpha 1 chain involved_in IMP (PMID:15095409) UniProt PMID:15095409 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G COL5A1 collagen type V alpha 1 chain involved_in IMP (PMID:11278977), (PMID:15095409) UniProt PMID:11278977 PMID:15095409 NCBI chr 9:134,641,803...134,844,843
Ensembl chr 9:134,641,803...134,844,843 		JBrowse link
G FOSL2 FOS like 2, AP-1 transcription factor subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20837772) Ensembl
MGI		 PMID:20837772 GO_REF:0000107 NCBI chr 2:28,392,858...28,417,317
Ensembl chr 2:28,392,448...28,417,317 		JBrowse link
G P3H3 prolyl 3-hydroxylase 3 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:6,828,407...6,839,847
Ensembl chr12:6,828,407...6,839,847 		JBrowse link
G P3H4 prolyl 3-hydroxylase family member 4 (inactive) involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:41,801,953...41,811,949
Ensembl chr17:41,801,947...41,812,604 		JBrowse link
G PCOLCE procollagen C-endopeptidase enhancer involved_in TAS (PMID:7523404) PINC PMID:7523404 NCBI chr 7:100,602,363...100,608,175
Ensembl chr 7:100,602,363...100,608,175 		JBrowse link
G RCN3 reticulocalbin 3 involved_in IMP (PMID:28939891) UniProt PMID:28939891 NCBI chr19:49,528,003...49,543,633
Ensembl chr19:49,528,003...49,546,962 		JBrowse link
G SERPINH1 serpin family H member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10995453) Ensembl
MGI		 PMID:10995453 GO_REF:0000107 NCBI chr11:75,562,253...75,572,783
Ensembl chr11:75,562,056...75,572,783 		JBrowse link
G TRAM2 translocation associated membrane protein 2 involved_in IMP (PMID:14749390) UniProt PMID:14749390 NCBI chr 6:52,497,408...52,577,060
Ensembl chr 6:52,497,408...52,577,060 		JBrowse link
negative regulation of collagen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2B adenosine A2b receptor ISO RGD PMID:9535419 RGD:2316149 NCBI chr17:15,850,362...15,975,746
Ensembl chr17:15,945,130...15,975,746 		JBrowse link
G AGER advanced glycosylation end-product specific receptor ISO RGD PMID:21872885 RGD:7245949 NCBI chr 6:32,180,969...32,184,253
Ensembl chr 6:32,180,968...32,184,322 		JBrowse link
G CIITA class II major histocompatibility complex transactivator involved_in IC (PMID:19041327) BHF-UCL PMID:19041327 NCBI chr16:10,866,206...10,943,021
Ensembl chr16:10,866,222...10,943,021 		JBrowse link
G CYGB cytoglobin involved_in ISO
IEA		 RGD
Ensembl		 PMID:20719976 GO_REF:0000107 RGD:9685174 NCBI chr17:76,527,356...76,551,193
Ensembl chr17:76,527,356...76,551,175 		JBrowse link
G CYP2J2 cytochrome P450 family 2 subfamily J member 2 ISO RGD PMID:25840911 PMID:29656108 RGD:12904676 RGD:150520032 NCBI chr 1:59,893,308...59,969,212
Ensembl chr 1:59,893,308...59,926,773 		JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 involved_in ISO
IEA		 RGD
Ensembl		 PMID:15521018 GO_REF:0000107 RGD:15045602 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163 		JBrowse link
G EMILIN1 elastin microfibril interfacer 1 involved_in IEA
ISS		 Ensembl
BHF-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:27,078,615...27,086,403
Ensembl chr 2:27,078,615...27,086,403 		JBrowse link
G ERRFI1 ERBB receptor feedback inhibitor 1 ISO RGD PMID:19204184 RGD:9685562 NCBI chr 1:8,011,727...8,026,309
Ensembl chr 1:8,004,404...8,026,309 		JBrowse link
G FN1 fibronectin 1 ISO RGD PMID:15980055 RGD:1625201 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 ISO RGD PMID:26880260 RGD:13504840 NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624 		JBrowse link
G IL6 interleukin 6 involved_in IDA (PMID:12419823) BHF-UCL PMID:12419823 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IL6R interleukin 6 receptor involved_in IDA (PMID:12419823) BHF-UCL PMID:12419823 NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450 		JBrowse link
G MIR218-1 microRNA 218-1 involved_in IDA (PMID:19913496) BHF-UCL PMID:19913496 NCBI chr 4:20,528,275...20,528,384
Ensembl chr 4:20,528,275...20,528,384 		JBrowse link
G MIR218-2 microRNA 218-2 involved_in IDA (PMID:19913496) BHF-UCL PMID:19913496 NCBI chr 5:168,768,146...168,768,255
Ensembl chr 5:168,768,146...168,768,255 		JBrowse link
G MIR29A microRNA 29a involved_in IDA (PMID:20067797) BHF-UCL PMID:20067797 NCBI chr 7:130,876,747...130,876,810
Ensembl chr 7:130,876,747...130,876,810 		JBrowse link
G MIR29B1 microRNA 29b-1 involved_in IDA
IGI		 (PMID:19913496), (PMID:23221517)
(PMID:22269326)		 BHF-UCL PMID:19913496 PMID:22269326 PMID:23221517 NCBI chr 7:130,877,459...130,877,539
Ensembl chr 7:130,877,459...130,877,539 		JBrowse link
G MIR29B2 microRNA 29b-2 involved_in IGI
IDA		 (PMID:22269326)
(PMID:19913496), (PMID:23221517)		 BHF-UCL PMID:19913496 PMID:22269326 PMID:23221517 NCBI chr 1:207,802,443...207,802,523
Ensembl chr 1:207,802,443...207,802,523 		JBrowse link
G MIR92A1 microRNA 92a-1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr13:91,351,314...91,351,391
Ensembl chr13:91,351,314...91,351,391 		JBrowse link
G MIR92A2 microRNA 92a-2 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr  X:134,169,538...134,169,612
Ensembl chr  X:134,169,538...134,169,612 		JBrowse link
G NOTCH1 notch receptor 1 involved_in ISO
IEA		 RGD
Ensembl		 PMID:28100501 GO_REF:0000107 RGD:152995503 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048 		JBrowse link
G NPPC natriuretic peptide C involved_in ISO
IEA		 RGD
Ensembl		 PMID:12746286 GO_REF:0000107 RGD:1580115 NCBI chr 2:231,921,809...231,926,396
Ensembl chr 2:231,921,809...231,926,396 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 ISO RGD PMID:15980055 RGD:1625201 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
G PPARD peroxisome proliferator activated receptor delta ISO RGD PMID:17346664 RGD:2324888 NCBI chr 6:35,342,558...35,428,178
Ensembl chr 6:35,342,558...35,428,191 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma involved_in ISO
IEA		 RGD
Ensembl		 PMID:16202214 GO_REF:0000107 RGD:8553021 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G RAP1A RAP1A, member of RAS oncogene family ISO RGD PMID:22012077 RGD:9850086 NCBI chr 1:111,542,009...111,716,691
Ensembl chr 1:111,542,218...111,716,691 		JBrowse link
G RAPGEF3 Rap guanine nucleotide exchange factor 3 ISO RGD PMID:22012077 RGD:9850086 NCBI chr12:47,734,363...47,758,880
Ensembl chr12:47,734,363...47,771,040 		JBrowse link
positive regulation of collagen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1B activin A receptor type 1B ISO RGD PMID:27477354 RGD:151665478 NCBI chr12:51,951,699...51,997,078
Ensembl chr12:51,951,699...51,997,078 		JBrowse link
G AMELX amelogenin X-linked involved_in ISS (PMID:1734713) BHF-UCL PMID:1734713 NCBI chr  X:11,293,413...11,309,588
Ensembl chr  X:11,293,413...11,300,761 		JBrowse link
G ARRB2 arrestin beta 2 ISO RGD PMID:28274926 RGD:13506828 NCBI chr17:4,710,632...4,721,497
Ensembl chr17:4,710,596...4,721,499 		JBrowse link
G BMP4 bone morphogenetic protein 4 involved_in IDA (PMID:17720811) BHF-UCL PMID:17720811 NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761 		JBrowse link
G CBX8 chromobox 8 involved_in ISO
IEA		 RGD
Ensembl		 PMID:23572236 GO_REF:0000107 RGD:9586727 NCBI chr17:79,792,132...79,797,077
Ensembl chr17:79,792,132...79,801,683 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO RGD PMID:8663511 RGD:8549527 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCN2 cellular communication network factor 2 ISO RGD PMID:19570811 RGD:2314490 NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372 		JBrowse link
G CREB3L1 cAMP responsive element binding protein 3 like 1 involved_in IDA (PMID:25310401) UniProt PMID:25310401 NCBI chr11:46,277,662...46,321,409
Ensembl chr11:46,277,662...46,321,409 		JBrowse link
G DDR2 discoidin domain receptor tyrosine kinase 2 involved_in ISO
IEA		 RGD
Ensembl		 PMID:24938620 PMID:26674152 GO_REF:0000107 RGD:11554781 RGD:150429973 NCBI chr 1:162,630,863...162,787,405
Ensembl chr 1:162,631,373...162,787,405 		JBrowse link
G DICER1 dicer 1, ribonuclease III ISO RGD PMID:24337369 RGD:150340618 NCBI chr14:95,086,228...95,158,010
Ensembl chr14:95,086,228...95,158,010 		JBrowse link
G ENG endoglin involved_in ISO
IEA		 RGD
Ensembl		 PMID:20156938 GO_REF:0000107 RGD:7257540 NCBI chr 9:127,815,016...127,854,658
Ensembl chr 9:127,815,013...127,854,658 		JBrowse link
G EP300 E1A binding protein p300 ISO RGD PMID:18292803 RGD:2312266 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,592...41,180,077 		JBrowse link
G F2 coagulation factor II, thrombin involved_in IDA (PMID:9639571) BHF-UCL PMID:9639571 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506 		JBrowse link
G F2R coagulation factor II thrombin receptor involved_in IDA (PMID:9639571) BHF-UCL PMID:9639571 NCBI chr 5:76,716,126...76,735,770
Ensembl chr 5:76,716,126...76,735,770 		JBrowse link
G GLI2 GLI family zinc finger 2 ISO RGD PMID:26823780 RGD:155791684 NCBI chr 2:120,735,868...120,992,653
Ensembl chr 2:120,735,623...120,992,653 		JBrowse link
G HDAC2 histone deacetylase 2 involved_in IC (PMID:19041327) BHF-UCL PMID:19041327 NCBI chr 6:113,933,028...113,971,148
Ensembl chr 6:113,933,028...114,011,308 		JBrowse link
G IHH Indian hedgehog signaling molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10208865) Ensembl
MGI		 PMID:10208865 GO_REF:0000107 NCBI chr 2:219,054,424...219,060,921
Ensembl chr 2:219,054,424...219,060,921 		JBrowse link
G IL18 interleukin 18 ISO RGD PMID:20644901 RGD:4889158 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096 		JBrowse link
G INHBA inhibin subunit beta A involved_in ISO
IEA		 RGD
Ensembl		 PMID:27477354 GO_REF:0000107 RGD:151665478 NCBI chr 7:41,685,114...41,705,406
Ensembl chr 7:41,667,168...41,705,834 		JBrowse link
G ITGA2 integrin subunit alpha 2 involved_in ISO
IEA		 RGD
Ensembl		 PMID:10867645 GO_REF:0000107 RGD:2307406 NCBI chr 5:52,989,352...53,094,779
Ensembl chr 5:52,989,340...53,094,779 		JBrowse link
G LARP6 La ribonucleoprotein 6, translational regulator involved_in IMP (PMID:21746880) UniProt PMID:21746880 NCBI chr15:70,829,130...70,854,157
Ensembl chr15:70,829,130...70,854,157 		JBrowse link
G LTBP1 latent transforming growth factor beta binding protein 1 ISO RGD PMID:9607192 RGD:10412058 NCBI chr 2:32,946,953...33,399,509
Ensembl chr 2:32,946,953...33,399,509 		JBrowse link
G MIR149 microRNA 149 involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr 2:240,456,001...240,456,089
Ensembl chr 2:240,456,001...240,456,089 		JBrowse link
G MIR21 microRNA 21 ISO RGD PMID:29084974 RGD:41404715 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337 		JBrowse link
G MKX mohawk homeobox acts_upstream_of_or_within ISO (PMID:20498044) MGI PMID:20498044 NCBI chr10:27,672,874...27,745,819
Ensembl chr10:27,672,874...27,746,060 		JBrowse link
G MYB MYB proto-oncogene, transcription factor involved_in ISO
IEA		 RGD
Ensembl		 PMID:15534927 GO_REF:0000107 RGD:11532676 NCBI chr 6:135,181,308...135,219,172
Ensembl chr 6:135,181,308...135,219,173 		JBrowse link
G PDGFB platelet derived growth factor subunit B ISO RGD PMID:15358192 RGD:10449487 NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982 		JBrowse link
G PDGFRB platelet derived growth factor receptor beta ISO RGD PMID:15978205 RGD:2292205 NCBI chr 5:150,113,839...150,155,845
Ensembl chr 5:150,113,839...150,155,872 		JBrowse link
G PRDX5 peroxiredoxin 5 involved_in IDA (PMID:15276323) UniProt PMID:15276323 NCBI chr11:64,318,121...64,321,811
Ensembl chr11:64,318,121...64,321,811 		JBrowse link
G RGCC regulator of cell cycle involved_in IDA (PMID:19158077) BHF-UCL PMID:19158077 NCBI chr13:41,457,550...41,470,871
Ensembl chr13:41,457,550...41,470,871 		JBrowse link
G RUNX1 RUNX family transcription factor 1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr21:34,787,801...35,049,302
Ensembl chr21:34,787,801...36,004,667 		JBrowse link
G SCX scleraxis bHLH transcription factor involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:144,266,453...144,268,481
Ensembl chr 8:144,266,453...144,268,481 		JBrowse link
G SERPINB7 serpin family B member 7 involved_in ISO
IEA		 RGD
Ensembl		 PMID:21945418 GO_REF:0000107 RGD:7207383 NCBI chr18:63,753,057...63,805,370
Ensembl chr18:63,752,935...63,805,376 		JBrowse link
G SERPINE1 serpin family E member 1 ISO RGD PMID:15828931 RGD:13208547 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247 		JBrowse link
G SERPINF2 serpin family F member 2 involved_in IDA
IEA		 (PMID:17958745) BHF-UCL
Ensembl		 PMID:17958745 GO_REF:0000107 NCBI chr17:1,742,871...1,755,265
Ensembl chr17:1,742,836...1,755,265 		JBrowse link
G SUCO SUN domain containing ossification factor involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:172,532,349...172,611,833
Ensembl chr 1:172,532,349...172,611,833 		JBrowse link
G TGFB1 transforming growth factor beta 1 involved_in ISO
IMP
IDA
IEA
IGI		 (PMID:11158066)
(PMID:19734317), (PMID:22269326), (PMID:25310401)
(PMID:22269326)		 RGD
BHF-UCL
Ensembl		 PMID:11158066 PMID:19734317 PMID:22269326 PMID:25310401 PMID:26923362 GO_REF:0000107 RGD:11073665 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TGFB3 transforming growth factor beta 3 involved_in IMP (PMID:11158066) BHF-UCL PMID:11158066 NCBI chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011 		JBrowse link
G UCN urocortin involved_in ISO
IEA		 RGD
Ensembl		 PMID:11087261 GO_REF:0000107 RGD:1642796 NCBI chr 2:27,307,400...27,308,445
Ensembl chr 2:27,307,400...27,308,445 		JBrowse link
G UTS2 urotensin 2 ISO RGD PMID:17184580 PMID:18475149 RGD:2306811 RGD:2306814 NCBI chr 1:7,847,612...7,913,249
Ensembl chr 1:7,843,083...7,853,512 		JBrowse link
G VIM vimentin involved_in IMP (PMID:21746880) UniProt PMID:21746880 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593 		JBrowse link
G WNT4 Wnt family member 4 involved_in IDA (PMID:17720811) BHF-UCL PMID:17720811 NCBI chr 1:22,117,313...22,143,097
Ensembl chr 1:22,117,313...22,143,969 		JBrowse link
regulation of collagen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR145 microRNA 145 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 5:149,430,646...149,430,733
Ensembl chr 5:149,430,646...149,430,733 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19770
    metabolic process 12509
      collagen metabolic process 144
        collagen biosynthetic process 80
          negative regulation of collagen biosynthetic process 26
          positive regulation of collagen biosynthetic process 42
          regulation of collagen biosynthetic process + 69
paths to the root