The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.
Synonyms:
exact_synonym:
ER to nucleus sterol response pathway; ER-nuclear sterol response pathway; SREBP signalling; SREBP target gene transcriptional activation; SREBP-mediated signalling pathway; endoplasmic reticulum to nucleus sterol response pathway; endoplasmic reticulum-nuclear sterol response pathway; positive regulation of sterol regulatory element binding protein target gene transcription; positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response; sterol depletion response, SREBP target gene transcriptional activation; sterol response element binding protein signaling pathway; up regulation of sterol regulatory element binding protein target gene transcription; upregulation of sterol regulatory element binding protein target gene transcription
narrow_synonym:
activation of sterol regulatory element binding protein target gene transcription; positive regulation of transcription via sterol regulatory element binding; positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway; stimulation of sterol regulatory element binding protein target gene transcription
broad_synonym:
sterol regulatory element binding protein target gene transcriptional activation
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