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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:activin receptor signaling pathway
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Accession:GO:0032924 term browser browse the term
Definition:The series of molecular signals initiated by an extracellular ligand binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: activin receptor signalling pathway


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activin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:18326817), (PMID:19506109)
(MGI:1935017|PMID:11376112)		 RGD PMID:11376112 PMID:18326817 PMID:19506109 MGI:1935017 NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241 		JBrowse link
G Acvr1b activin A receptor type 1B involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:9884026), (PMID:9892009)
(MGI:3619747|PMID:16115198)
PMID:21873635		 RGD PMID:9884026 PMID:9892009 PMID:16115198 PMID:21873635 MGI:3619747, RGD:13792537 NCBI chr 7:132,286,266...132,329,679
Ensembl chr 7:132,286,275...132,329,673 		JBrowse link
G Acvr1c activin A receptor type 1C involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:42,815,490...42,892,423
Ensembl chr 3:42,822,610...42,892,327 		JBrowse link
G Acvr2a activin A receptor type 2A involved_in IEA
IBA
ISO		 GO_REF:0000107
PMID:21873635
(PMID:12665502), (PMID:18326817)		 Ensembl
RGD		 PMID:12665502 PMID:18326817 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 3:33,204,961...33,292,673
Ensembl chr 3:33,205,523...33,289,968 		JBrowse link
G Acvr2b activin A receptor type 2B involved_in ISO
IBA		 (PMID:18326817)
PMID:21873635		 RGD PMID:18326817 PMID:21873635 RGD:13792537 NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458 		JBrowse link
G Acvrl1 activin A receptor like type 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591 		JBrowse link
G Amhr2 anti-Mullerian hormone receptor type 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:133,579,152...133,588,874
Ensembl chr 7:133,579,393...133,588,258 		JBrowse link
G Bmp10 bone morphogenetic protein 10 involved_in ISO
IEA		 (PMID:16049014), (PMID:17068149)
GO_REF:0000107		 RGD
Ensembl		 PMID:16049014 PMID:17068149 GO_REF:0000107 NCBI chr 4:119,872,066...119,877,694
Ensembl chr 4:119,872,045...119,878,627 		JBrowse link
G Fgf9 fibroblast growth factor 9 acts_upstream_of ISO (MGI:5444317|PMID:23034635) RGD PMID:23034635 MGI:5444317 NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309 		JBrowse link
G Gdf2 growth differentiation factor 2 involved_in ISO (PMID:17068149) RGD PMID:17068149 NCBI chr16:9,255,430...9,261,429
Ensembl chr16:9,255,430...9,261,429 		JBrowse link
G Gdf6 growth differentiation factor 6 involved_in ISO (PMID:16049014) RGD PMID:16049014 NCBI chr 5:22,996,246...23,012,567
Ensembl chr 5:22,996,246...23,012,567 		JBrowse link
G Gdf7 growth differentiation factor 7 involved_in ISO (PMID:16049014) RGD PMID:16049014 NCBI chr 6:31,171,495...31,182,447
Ensembl chr 6:31,178,119...31,182,447 		JBrowse link
G Hjv hemojuvelin BMP co-receptor involved_in ISO UniProtKB:P27037 (PMID:18326817) RGD PMID:18326817 NCBI chr 2:184,065,970...184,069,851
Ensembl chr 2:184,065,970...184,069,850 		JBrowse link
G Inhba inhibin subunit beta A involved_in ISO
ISS		 (PMID:9884026)
GO_REF:0000024		 RGD
UniProt		 PMID:9884026 GO_REF:0000024 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982 		JBrowse link
G Inhbb inhibin subunit beta B involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:16650820)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:16650820 GO_REF:0000024 GO_REF:0000107 NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832 		JBrowse link
G Smad2 SMAD family member 2 involved_in ISO
IBA		 (PMID:15150278)
PMID:21873635		 RGD PMID:15150278 PMID:21873635 RGD:13792537 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 involved_in ISO
IBA		 (PMID:15150278)
PMID:21873635		 RGD PMID:15150278 PMID:21873635 RGD:13792537 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 involved_in ISS
IBA		 GO_REF:0000024
PMID:21873635		 AgBase PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
negative regulation of activin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in ISO (PMID:9884026) RGD PMID:9884026 NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241 		JBrowse link
G Cer1 cerberus 1, DAN family BMP antagonist involved_in ISO (PMID:9660951)
(MGI:1858315|PMID:10748465)		 RGD PMID:9660951 PMID:10748465 MGI:1858315 NCBI chr 5:97,306,427...97,309,783
Ensembl chr 5:97,306,431...97,309,783 		JBrowse link
G Fst follistatin involved_in IBA
ISO		 PMID:21873635
(PMID:11948405), (PMID:12697670), (PMID:12702211)		 RGD PMID:11948405 PMID:12697670 PMID:12702211 PMID:21873635 RGD:13792537 NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571 		JBrowse link
G Fstl3 follistatin like 3 involved_in ISO
IBA		 (PMID:11948405), (PMID:12697670)
PMID:21873635		 RGD PMID:11948405 PMID:12697670 PMID:21873635 RGD:13792537 NCBI chr 7:9,924,670...9,929,195
Ensembl chr 7:9,923,576...9,939,639 		JBrowse link
G Igsf1 immunoglobulin superfamily, member 1 involved_in ISO (PMID:11266516) RGD PMID:11266516 NCBI chr  X:129,069,891...129,085,331
Ensembl chr  X:129,069,896...129,085,139 		JBrowse link
G Lemd3 LEM domain containing 3 involved_in ISO (PMID:15647271) RGD PMID:15647271 NCBI chr 7:56,415,053...56,499,047
Ensembl chr 7:56,305,448...56,502,474 		JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:1353670|PMID:10681527)		 UniProt
RGD		 PMID:10681527 GO_REF:0000024 MGI:1353670 NCBI chr 4:14,388,322...15,870,036
Ensembl chr 4:14,386,399...15,870,240 		JBrowse link
G Mir210 microRNA 210 acts_upstream_of_or_within ISO (MGI:3851892|PMID:19520079) RGD PMID:19520079 MGI:3851892 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454 		JBrowse link
G Ski Ski proto-oncogene involved_in ISO (PMID:14699069) RGD PMID:14699069 NCBI chr 5:165,713,525...165,782,134
Ensembl chr 5:165,714,093...165,782,733 		JBrowse link
G Synj2bp synaptojanin 2 binding protein involved_in ISO (MGI:3623710|PMID:16648306) RGD PMID:16648306 MGI:3623710 NCBI chr 6:101,189,714...101,227,400
Ensembl chr 6:101,189,714...101,227,406 		JBrowse link
negative regulation of nodal receptor complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lefty1 left right determination factor 1 involved_in ISO (MGI:3042530|PMID:15062104) RGD PMID:15062104 MGI:3042530 NCBI chr13:92,649,226...92,659,722
Ensembl chr13:92,656,323...92,659,720 		JBrowse link
negative regulation of nodal signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dact2 dishevelled-binding antagonist of beta-catenin 2 involved_in IBA
ISO		 PMID:21873635
(MGI:3809364|PMID:18716284), (MGI:5437437|PMID:17197390)		 RGD PMID:17197390 PMID:18716284 PMID:21873635 MGI:3809364 MGI:5437437, RGD:13792537 NCBI chr 1:55,181,023...55,191,026
Ensembl chr 1:55,181,024...55,191,096 		JBrowse link
G Dand5 DAN domain BMP antagonist family member 5 involved_in ISO (MGI:3055649|PMID:15466485) RGD PMID:15466485 MGI:3055649 NCBI chr19:23,330,917...23,340,486
Ensembl chr19:23,334,164...23,339,589 		JBrowse link
G Lefty1 left right determination factor 1 involved_in ISO (MGI:3042530|PMID:15062104) RGD PMID:15062104 MGI:3042530 NCBI chr13:92,649,226...92,659,722
Ensembl chr13:92,656,323...92,659,720 		JBrowse link
negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cer1 cerberus 1, DAN family BMP antagonist involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:97,306,427...97,309,783
Ensembl chr 5:97,306,431...97,309,783 		JBrowse link
G Dand5 DAN domain BMP antagonist family member 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:23,330,917...23,340,486
Ensembl chr19:23,334,164...23,339,589 		JBrowse link
nodal signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1b activin A receptor type 1B involved_in ISO UniProtKB:P43021 (PMID:11389842) RGD PMID:11389842 NCBI chr 7:132,286,266...132,329,679
Ensembl chr 7:132,286,275...132,329,673 		JBrowse link
G Acvr1c activin A receptor type 1C involved_in ISO
IEA		 (PMID:15150278)
GO_REF:0000107		 RGD
Ensembl		 PMID:15150278 GO_REF:0000107 NCBI chr 3:42,815,490...42,892,423
Ensembl chr 3:42,822,610...42,892,327 		JBrowse link
G Cfc1 cripto, FRL-1, cryptic family 1 involved_in IBA
ISO		 PMID:21873635
(MGI:5318034|PMID:12052855)		 RGD PMID:12052855 PMID:21873635 MGI:5318034, RGD:13792537 NCBI chr 9:36,742,106...36,751,931
Ensembl chr 9:36,739,071...36,751,930 		JBrowse link
G Nodal nodal growth differentiation factor involved_in ISO (MGI:5318034|PMID:12052855) RGD PMID:12052855 MGI:5318034 NCBI chr20:29,368,436...29,376,837
Ensembl chr20:29,368,436...29,376,837 		JBrowse link
G Smad2 SMAD family member 2 involved_in ISO (PMID:15150278) RGD PMID:15150278 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 involved_in ISO (PMID:15150278) RGD PMID:15150278 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Tdgf1 teratocarcinoma-derived growth factor 1 involved_in IBA
ISO		 PMID:21873635
UniProtKB:P43021 (MGI:5318034|PMID:12052855), (MGI:5447629|PMID:11389842)		 RGD PMID:11389842 PMID:12052855 PMID:21873635 MGI:5318034 MGI:5447629, RGD:13792537 NCBI chr 8:110,924,774...110,938,545
Ensembl chr 8:110,925,024...110,930,308 		JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 acts_upstream_of_or_within ISO MGI:1915299 (MGI:4430444|PMID:20040491) RGD PMID:20040491 MGI:4430444 NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802 		JBrowse link
G Tgif2 TGFB-induced factor homeobox 2 acts_upstream_of_or_within ISO MGI:1194497 (MGI:4430444|PMID:20040491) RGD PMID:20040491 MGI:4430444 NCBI chr 3:145,333,152...145,348,599
Ensembl chr 3:145,333,418...145,348,596 		JBrowse link
nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 involved_in ISO (MGI:3054669|PMID:15475956) RGD PMID:15475956 MGI:3054669 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897 		JBrowse link
G Nodal nodal growth differentiation factor involved_in ISO (MGI:5315339|PMID:17507406) RGD PMID:17507406 MGI:5315339 NCBI chr20:29,368,436...29,376,837
Ensembl chr20:29,368,436...29,376,837 		JBrowse link
positive regulation of activin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1b activin A receptor type 1B involved_in ISO (PMID:16720724) RGD PMID:16720724 NCBI chr 7:132,286,266...132,329,679
Ensembl chr 7:132,286,275...132,329,673 		JBrowse link
G Acvr2a activin A receptor type 2A involved_in IEA
ISO		 GO_REF:0000107
(PMID:12665502)		 Ensembl
RGD		 PMID:12665502 GO_REF:0000107 NCBI chr 3:33,204,961...33,292,673
Ensembl chr 3:33,205,523...33,289,968 		JBrowse link
G Acvr2b activin A receptor type 2B involved_in ISO (PMID:8622651) RGD PMID:8622651 NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458 		JBrowse link
G Csnk2b casein kinase 2 beta involved_in ISO
IEA		 (PMID:19592636)
GO_REF:0000107		 RGD
Ensembl		 PMID:19592636 GO_REF:0000107 NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133 		JBrowse link
G Fgf9 fibroblast growth factor 9 acts_upstream_of_or_within ISO (MGI:5444317|PMID:23034635) RGD PMID:23034635 MGI:5444317 NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309 		JBrowse link
G Nodal nodal growth differentiation factor involved_in ISO UniProtKB:Q8NER5 (PMID:15150278) RGD PMID:15150278 NCBI chr20:29,368,436...29,376,837
Ensembl chr20:29,368,436...29,376,837 		JBrowse link
G Synj2bp synaptojanin 2 binding protein involved_in ISO (MGI:3623710|PMID:16648306) RGD PMID:16648306 MGI:3623710 NCBI chr 6:101,189,714...101,227,400
Ensembl chr 6:101,189,714...101,227,406 		JBrowse link
G Zc3h3 zinc finger CCCH type containing 3 acts_upstream_of_or_within ISO MGI:1338944 (MGI:3619747|PMID:16115198) RGD PMID:16115198 MGI:3619747 NCBI chr 7:107,440,694...107,525,451
Ensembl chr 7:107,440,694...107,525,451 		JBrowse link
positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad2 SMAD family member 2 involved_in ISO (PMID:17239842) RGD PMID:17239842 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Zic2 Zic family member 2 acts_upstream_of_or_within ISO MGI:1862004 (MGI:5584215|PMID:24585447) RGD PMID:24585447 MGI:5584215 NCBI chr15:99,576,697...99,581,522
Ensembl chr15:99,576,697...99,581,522 		JBrowse link
regulation of activin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within ISO MGI:1859647 (MGI:3588480|PMID:15958512) RGD PMID:15958512 MGI:3588480 NCBI chr 2:50,801,897...50,875,428
Ensembl chr 2:50,800,992...50,876,866 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A involved_in ISO (PMID:16720724) RGD PMID:16720724 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743 		JBrowse link
G Men1 menin 1 IMP RGD PMID:15031321 RGD:2290185 NCBI chr 1:203,638,905...203,644,871
Ensembl chr 1:203,639,000...203,644,871 		JBrowse link
G Smad7 SMAD family member 7 involved_in ISO
IEA		 (PMID:16720724)
GO_REF:0000107		 RGD
Ensembl		 PMID:16720724 GO_REF:0000107 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
regulation of nodal signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dact1 dishevelled-binding antagonist of beta-catenin 1 NOT|involved_in ISO (PMID:17197390)
(MGI:5437437|PMID:17197390)		 RGD PMID:17197390 MGI:5437437 NCBI chr 6:89,790,676...89,818,254
Ensembl chr 6:89,790,644...89,817,906 		JBrowse link
G Dmrt1 doublesex and mab-3 related transcription factor 1 acts_upstream_of_or_within ISO (MGI:5487845|PMID:23473982) RGD PMID:23473982 MGI:5487845 NCBI chr 1:223,142,859...223,241,333
Ensembl chr 1:223,142,859...223,241,333 		JBrowse link
sequestering of nodal from receptor via nodal binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dand5 DAN domain BMP antagonist family member 5 involved_in ISO (MGI:3055649|PMID:15466485) RGD PMID:15466485 MGI:3055649 NCBI chr19:23,330,917...23,340,486
Ensembl chr19:23,334,164...23,339,589 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19903
    cellular process 18297
      signal transduction 7129
        cell surface receptor signaling pathway 2867
          enzyme-linked receptor protein signaling pathway 1043
            transmembrane receptor protein serine/threonine kinase signaling pathway 423
              activin receptor signaling pathway 46
                activin receptor signaling pathway involved in heart jogging 0
                negative regulation of activin receptor signaling pathway + 13
                nodal signaling pathway + 17
                positive regulation of activin receptor signaling pathway + 10
                regulation of activin receptor signaling pathway + 28
Path 2
Term Annotations click to browse term
  biological_process 19903
    biological regulation 13542
      regulation of biological process 13094
        signaling 7651
          signal transduction 7129
            cell surface receptor signaling pathway 2867
              enzyme-linked receptor protein signaling pathway 1043
                transmembrane receptor protein serine/threonine kinase signaling pathway 423
                  activin receptor signaling pathway 46
                    activin receptor signaling pathway involved in heart jogging 0
                    negative regulation of activin receptor signaling pathway + 13
                    nodal signaling pathway + 17
                    positive regulation of activin receptor signaling pathway + 10
                    regulation of activin receptor signaling pathway + 28
paths to the root