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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of natural killer cell activation
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Accession:GO:0032814 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of natural killer cell activation.
Synonyms:exact_synonym: regulation of NK cell activation



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regulation of natural killer cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dcaf15 DDB1 and CUL4 associated factor 15 involved_in ISO (PMID:31452512) RGD PMID:31452512 NCBI chr19:24,053,925...24,061,277
Ensembl chr19:24,053,925...24,061,277
JBrowse link
G Lep leptin involved_in ISO
ISS
(PMID:12504075)
GO_REF:0000024
RGD
UniProt
PMID:12504075 GO_REF:0000024 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Sh2d1b2 SH2 domain containing 1B2 acts_upstream_of_or_within ISO MGI:1922595 (MGI:3836377|PMID:19151721) RGD PMID:19151721 MGI:3836377 NCBI chr13:82,416,362...82,461,511
Ensembl chr13:82,437,428...82,461,509
JBrowse link
G Slamf7 SLAM family member 7 acts_upstream_of_or_within ISO MGI:3622649 (MGI:3836377|PMID:19151721) RGD PMID:19151721 MGI:3836377 NCBI chr13:84,135,656...84,154,528
Ensembl chr13:84,136,899...84,154,105
JBrowse link
negative regulation of natural killer cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clnk cytokine-dependent hematopoietic cell linker involved_in ISO (MGI:3047506|PMID:15199160), (MGI:3774350|PMID:16439675) RGD PMID:15199160 PMID:16439675 MGI:3047506 MGI:3774350 NCBI chr14:71,923,894...72,101,180
Ensembl chr14:71,873,105...72,101,208
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase involved_in ISO (MGI:3774350|PMID:16439675) RGD PMID:16439675 MGI:3774350 NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326
JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (MGI:5705210|PMID:25337993) RGD PMID:25337993 MGI:5705210 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137
JBrowse link
G Lgals9 galectin 9 involved_in ISO (MGI:5491117|PMID:23408620) RGD PMID:23408620 MGI:5491117 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Mill1 MHC I like leukocyte 1 involved_in ISO (PMID:20068167) RGD PMID:20068167 NCBI chr 1:78,372,138...78,398,932
Ensembl chr 1:78,372,802...78,398,930
JBrowse link
G Pibf1 progesterone immunomodulatory binding factor 1 involved_in ISO (PMID:12516630) RGD PMID:12516630 NCBI chr15:75,850,389...76,019,711
Ensembl chr15:75,850,624...76,019,712
JBrowse link
G Rhbdd3 rhomboid domain containing 3 acts_upstream_of_or_within ISO MGI:5516031 (MGI:5492204|PMID:23610400) RGD PMID:23610400 MGI:5492204 NCBI chr14:79,994,111...80,000,294
Ensembl chr14:79,994,158...80,000,175
JBrowse link
negative regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 involved_in ISO (MGI:5491117|PMID:23408620) RGD PMID:23408620 MGI:5491117 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G RT1-CE5 RT1 class I, locus CE5 involved_in ISO (PMID:24018270) RGD PMID:24018270 NCBI chr20:3,403,418...3,479,476 JBrowse link
negative regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pglyrp1 peptidoglycan recognition protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2670590 (MGI:5297102|PMID:20709292)
Ensembl
RGD
PMID:20709292 GO_REF:0000107 MGI:5297102 NCBI chr 1:78,531,815...78,537,001
Ensembl chr 1:78,531,815...78,537,001
JBrowse link
G Pglyrp2 peptidoglycan recognition protein 2 acts_upstream_of_or_within ISO MGI:5297105 (MGI:5297102|PMID:20709292) RGD PMID:20709292 MGI:5297102 NCBI chr 7:11,418,674...11,432,162
Ensembl chr 7:11,418,880...11,427,773
JBrowse link
G Pglyrp3 peptidoglycan recognition protein 3 acts_upstream_of_or_within ISO MGI:5297106 (MGI:5297102|PMID:20709292) RGD PMID:20709292 MGI:5297102 NCBI chr 2:177,479,693...177,490,867
Ensembl chr 2:176,855,732...176,874,162
Ensembl chr 2:176,855,732...176,874,162
JBrowse link
G Pglyrp4 peptidoglycan recognition protein 4 acts_upstream_of_or_within ISO MGI:5297107 (MGI:5297102|PMID:20709292) RGD PMID:20709292 MGI:5297102 NCBI chr 2:176,202,654...176,322,859
Ensembl chr 2:176,218,519...176,242,251
JBrowse link
positive regulation of natural killer cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bloc1s3 biogenesis of lysosomal organelles complex-1, subunit 3 acts_upstream_of_or_within ISO MGI:1857021 (MGI:55273|PMID:7089489) RGD PMID:7089489 MGI:55273 NCBI chr 1:79,155,914...79,158,326
Ensembl chr 1:79,155,693...79,158,505
JBrowse link
G Bloc1s6 biogenesis of lysosomal organelles complex 1 subunit 6 acts_upstream_of_or_within ISO MGI:1856982 (MGI:55273|PMID:7089489) RGD PMID:7089489 MGI:55273 NCBI chr 3:109,816,397...109,826,528
Ensembl chr 3:109,816,366...109,828,308
JBrowse link
G Hps1 HPS1, biogenesis of lysosomal organelles complex 3 subunit 1 acts_upstream_of_or_within ISO MGI:1856712 (MGI:55273|PMID:7089489) RGD PMID:7089489 MGI:55273 NCBI chr 1:241,551,180...241,577,292
Ensembl chr 1:241,551,175...241,577,268
JBrowse link
G Il12a interleukin 12A involved_in ISO
IEA
(PMID:1674604)
GO_REF:0000107
RGD
Ensembl
PMID:1674604 GO_REF:0000107 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B involved_in ISO (PMID:1674604) RGD PMID:1674604 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Lyst lysosomal trafficking regulator acts_upstream_of_or_within ISO MGI:1855968 (MGI:55273|PMID:7089489) RGD PMID:7089489 MGI:55273 NCBI chr17:86,241,384...86,443,501 JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 involved_in ISO (MGI:5302428|PMID:21957144) RGD PMID:21957144 MGI:5302428 NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056
JBrowse link
G Ticam1 toll-like receptor adaptor molecule 1 acts_upstream_of_or_within ISO MGI:3701472 (MGI:5293306|PMID:21059856) RGD PMID:21059856 MGI:5293306 NCBI chr 9:1,102,559...1,115,573 JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp involved_in IBA
ISO
PMID:21873635
(MGI:1276991|PMID:9647200)
RGD PMID:9647200 PMID:21873635 MGI:1276991, RGD:13792537 NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848
JBrowse link
G Ulbp1 UL16 binding protein 1 acts_upstream_of_or_within ISO (MGI:2450811|PMID:12645935) RGD PMID:12645935 MGI:2450811 NCBI chr 1:1,694,255...1,716,160 JBrowse link
positive regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 involved_in ISO (PMID:23632890) RGD PMID:23632890 NCBI chr19:37,744,666...37,831,131
Ensembl chr19:37,744,633...37,829,167
JBrowse link
G Cd160 CD160 molecule involved_in ISO (PMID:19109136) RGD PMID:19109136 NCBI chr 2:184,340,820...184,383,421
Ensembl chr 2:184,340,599...184,375,834
JBrowse link
G Klrc2 killer cell lectin like receptor C2 involved_in ISO (PMID:21825173) RGD PMID:21825173 NCBI chr 4:163,122,700...163,133,843
Ensembl chr 4:163,122,704...163,133,843
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 involved_in ISO (PMID:23632890) RGD PMID:23632890 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
JBrowse link
G RT1-CE5 RT1 class I, locus CE5 involved_in ISO (PMID:27455421) RGD PMID:27455421 NCBI chr20:3,403,418...3,479,476 JBrowse link
positive regulation of natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axl Axl receptor tyrosine kinase involved_in ISO (PMID:18840707) RGD PMID:18840707 NCBI chr 1:81,265,656...81,296,278
Ensembl chr 1:81,265,088...81,296,265
JBrowse link
G Flt3lg Fms related receptor tyrosine kinase 3 ligand acts_upstream_of_or_within ISO MGI:2158499 (MGI:3701546|PMID:14607906) RGD PMID:14607906 MGI:3701546 NCBI chr 1:95,615,056...95,620,463 JBrowse link
G Gas6 growth arrest specific 6 involved_in ISS
ISO
GO_REF:0000024
(PMID:18840707)
UniProt
RGD
PMID:18840707 GO_REF:0000024 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
JBrowse link
G Il15 interleukin 15 acts_upstream_of_or_within ISO MGI:1931086|MGI:2136897 (MGI:3701546|PMID:14607906), (MGI:3703651|PMID:17318811) RGD PMID:14607906 PMID:17318811 MGI:3701546 MGI:3703651 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il15ra interleukin 15 receptor subunit alpha acts_upstream_of_or_within ISO MGI:1934016 (MGI:3701546|PMID:14607906) RGD PMID:14607906 MGI:3701546 NCBI chr17:66,802,300...66,831,973
Ensembl chr17:66,802,334...66,832,278
JBrowse link
G Il21 interleukin 21 acts_upstream_of_or_within ISO (MGI:3028812|PMID:14764669) RGD PMID:14764669 MGI:3028812 NCBI chr 2:120,119,598...120,126,941
Ensembl chr 2:120,119,444...120,126,996
JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 involved_in ISO (MGI:5302428|PMID:21957144) RGD PMID:21957144 MGI:5302428 NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056
JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO MGI:1857249 (MGI:3655409|PMID:9841920) RGD PMID:9841920 MGI:3655409 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
JBrowse link
G Stat5b signal transducer and activator of transcription 5B involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2181592 (MGI:3655409|PMID:9841920)
Ensembl
RGD
PMID:9841920 GO_REF:0000107 MGI:3655409 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
JBrowse link
G Tox thymocyte selection-associated high mobility group box acts_upstream_of_or_within ISO MGI:3773716 (MGI:4834966|PMID:20818394) RGD PMID:20818394 MGI:4834966 NCBI chr 5:19,874,994...20,171,272
Ensembl chr 5:19,874,467...20,171,272
JBrowse link
G Zbtb1 zinc finger and BTB domain containing 1 involved_in ISO (MGI:5446979|PMID:22753936) RGD PMID:22753936 MGI:5446979 NCBI chr 6:95,096,838...95,125,811
Ensembl chr 6:95,096,387...95,118,996
JBrowse link
positive regulation of natural killer cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd244 CD244 molecule involved_in ISO (MGI:3773416|PMID:15905190) RGD PMID:15905190 MGI:3773416 NCBI chr13:84,018,887...84,036,612
Ensembl chr13:84,020,095...84,036,100
JBrowse link
G Flt3lg Fms related receptor tyrosine kinase 3 ligand IDA RGD PMID:16528542 RGD:11049499 NCBI chr 1:95,615,056...95,620,463 JBrowse link
G Il12b interleukin 12B involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il15 interleukin 15 acts_upstream_of_or_within ISO (MGI:3701546|PMID:14607906) RGD PMID:14607906 MGI:3701546 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il18 interleukin 18 involved_in ISO
IEA
(PMID:19088061)
GO_REF:0000107
RGD
Ensembl
PMID:19088061 GO_REF:0000107 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 involved_in ISO (PMID:30134159) RGD PMID:30134159 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G Stat5b signal transducer and activator of transcription 5B involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2181592 (MGI:3655409|PMID:9841920)
Ensembl
RGD
PMID:9841920 GO_REF:0000107 MGI:3655409 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
JBrowse link
regulation of natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 involved_in ISO (MGI:5491117|PMID:23408620) RGD PMID:23408620 MGI:5491117 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Prdm1 PR/SET domain 1 involved_in ISO (MGI:5779429|PMID:27102484) RGD PMID:27102484 MGI:5779429 NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
JBrowse link
G Zfp683 zinc finger protein 683 involved_in ISO (MGI:5779429|PMID:27102484) RGD PMID:27102484 MGI:5779429 NCBI chr 5:146,277,972...146,285,856 JBrowse link
regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zfp683 zinc finger protein 683 involved_in ISO (MGI:5437828|PMID:22885984) RGD PMID:22885984 MGI:5437828 NCBI chr 5:146,277,972...146,285,856 JBrowse link
regulation of natural killer cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lep leptin involved_in ISO
ISS
(PMID:12504075)
GO_REF:0000024
RGD
UniProt
PMID:12504075 GO_REF:0000024 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in ISS
ISO
GO_REF:0000024
(PMID:20522204)
BHF-UCL
RGD
PMID:20522204 GO_REF:0000024 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19390
    immune system process 2787
      leukocyte activation 1066
        regulation of leukocyte activation 700
          regulation of lymphocyte activation 586
            regulation of natural killer cell activation 47
              negative regulation of natural killer cell activation + 12
              positive regulation of natural killer cell activation + 29
              regulation of natural killer cell degranulation + 6
              regulation of natural killer cell differentiation + 18
              regulation of natural killer cell proliferation + 10
Path 2
Term Annotations click to browse term
  biological_process 19390
    biological regulation 13476
      regulation of biological process 12735
        regulation of cellular process 12196
          regulation of cell activation 748
            regulation of leukocyte activation 700
              regulation of lymphocyte activation 586
                regulation of natural killer cell activation 47
                  negative regulation of natural killer cell activation + 12
                  positive regulation of natural killer cell activation + 29
                  regulation of natural killer cell degranulation + 6
                  regulation of natural killer cell differentiation + 18
                  regulation of natural killer cell proliferation + 10
paths to the root