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ONTOLOGY REPORT - ANNOTATIONS

Term:low-density lipoprotein particle receptor catabolic process
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Accession:GO:0032802 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of a low-density lipoprotein particle receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
Synonyms:exact_synonym: LDL receptor breakdown;   LDL receptor catabolic process;   LDL receptor degradation;   low-density lipoprotein receptor breakdown;   low-density lipoprotein receptor catabolic process;   low-density lipoprotein receptor catabolism;   low-density lipoprotein receptor degradation
 related_synonym: LDL receptor catabolism


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low-density lipoprotein particle receptor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PCSK9 proprotein convertase subtilisin/kexin type 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:157,388,370...157,409,620
Ensembl chr 6:157,388,372...157,409,551 		JBrowse link
negative regulation of low-density lipoprotein particle receptor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA2 annexin A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:111,588,721...111,635,064
Ensembl chr 1:111,588,306...111,635,059 		JBrowse link
G FURIN furin, paired basic amino acid cleaving enzyme involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:53,455,634...53,472,791
Ensembl chr 7:53,460,017...53,472,787 		JBrowse link
positive regulation of low-density lipoprotein particle receptor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:21810484) ARUK-UCL
Ensembl		 PMID:21810484 GO_REF:0000107
G APOE apolipoprotein E involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,292...51,375,330 		JBrowse link
G PCSK9 proprotein convertase subtilisin/kexin type 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:157,388,370...157,409,620
Ensembl chr 6:157,388,372...157,409,551 		JBrowse link
regulation of low-density lipoprotein particle receptor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYLIP myosin regulatory light chain interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:12,117,240...12,137,934
Ensembl chr 7:12,117,240...12,137,925 		JBrowse link
G PCSK9 proprotein convertase subtilisin/kexin type 9 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15741654)
(PMID:15805190)		 Ensembl
MGI		 PMID:15741654 PMID:15805190 GO_REF:0000107 NCBI chr 6:157,388,370...157,409,620
Ensembl chr 6:157,388,372...157,409,551 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17799
    metabolic process 10358
      cellular metabolic process 8632
        cellular catabolic process 1037
          receptor catabolic process 31
            low-density lipoprotein particle receptor catabolic process 6
              negative regulation of low-density lipoprotein particle receptor catabolic process 2
              positive regulation of low-density lipoprotein particle receptor catabolic process 3
              regulation of low-density lipoprotein particle receptor catabolic process + 6
Path 2
Term Annotations click to browse term
  biological_process 17799
    metabolic process 10358
      organic substance metabolic process 9930
        macromolecule metabolic process 8387
          macromolecule catabolic process 1459
            protein catabolic process 1011
              low-density lipoprotein particle receptor catabolic process 6
                negative regulation of low-density lipoprotein particle receptor catabolic process 2
                positive regulation of low-density lipoprotein particle receptor catabolic process 3
                regulation of low-density lipoprotein particle receptor catabolic process + 6
paths to the root