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ONTOLOGY REPORT - ANNOTATIONS

Term:low-density lipoprotein particle receptor catabolic process
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Accession:GO:0032802 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of a low-density lipoprotein particle receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
Synonyms:exact_synonym: LDL receptor breakdown;   LDL receptor catabolic process;   LDL receptor degradation;   low-density lipoprotein receptor breakdown;   low-density lipoprotein receptor catabolic process;   low-density lipoprotein receptor catabolism;   low-density lipoprotein receptor degradation
 related_synonym: LDL receptor catabolism


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low-density lipoprotein particle receptor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PCSK9 proprotein convertase subtilisin/kexin type 9 involved_in IDA (PMID:16912035), (PMID:18197702) HGNC-UCL PMID:16912035 PMID:18197702 NCBI chr 1:55,039,548...55,064,852
Ensembl chr 1:55,039,447...55,064,852 		JBrowse link
negative regulation of low-density lipoprotein particle receptor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA2 annexin A2 involved_in IDA
IEA		 (PMID:22848640) BHF-UCL
Ensembl		 PMID:22848640 GO_REF:0000107 NCBI chr15:60,347,151...60,397,986
Ensembl chr15:60,347,134...60,402,883 		JBrowse link
G FURIN furin, paired basic amino acid cleaving enzyme involved_in IDA (PMID:16912035) HGNC-UCL PMID:16912035 NCBI chr15:90,868,588...90,883,457
Ensembl chr15:90,868,588...90,883,564 		JBrowse link
positive regulation of low-density lipoprotein particle receptor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of IDA (PMID:21810484) ARUK-UCL PMID:21810484 NCBI chr 9:137,007,234...137,028,922
Ensembl chr 9:137,007,234...137,028,915 		JBrowse link
G APOE apolipoprotein E involved_in IDA (PMID:15950758) BHF-UCL PMID:15950758 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393 		JBrowse link
G PCSK9 proprotein convertase subtilisin/kexin type 9 involved_in IDA (PMID:22848640) BHF-UCL PMID:22848640 NCBI chr 1:55,039,548...55,064,852
Ensembl chr 1:55,039,447...55,064,852 		JBrowse link
regulation of low-density lipoprotein particle receptor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYLIP myosin regulatory light chain interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:16,129,086...16,163,887
Ensembl chr 6:16,129,086...16,148,248 		JBrowse link
G PCSK9 proprotein convertase subtilisin/kexin type 9 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15741654)
(PMID:15805190)		 Ensembl
MGI		 PMID:15741654 PMID:15805190 GO_REF:0000107 NCBI chr 1:55,039,548...55,064,852
Ensembl chr 1:55,039,447...55,064,852 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    metabolic process 12464
      cellular metabolic process 10651
        cellular catabolic process 1234
          receptor catabolic process 30
            low-density lipoprotein particle receptor catabolic process 6
              negative regulation of low-density lipoprotein particle receptor catabolic process 2
              positive regulation of low-density lipoprotein particle receptor catabolic process 3
              regulation of low-density lipoprotein particle receptor catabolic process + 6
Path 2
Term Annotations click to browse term
  biological_process 19669
    metabolic process 12464
      organic substance metabolic process 11967
        macromolecule metabolic process 10246
          macromolecule catabolic process 1604
            protein catabolic process 1071
              low-density lipoprotein particle receptor catabolic process 6
                negative regulation of low-density lipoprotein particle receptor catabolic process 2
                positive regulation of low-density lipoprotein particle receptor catabolic process 3
                regulation of low-density lipoprotein particle receptor catabolic process + 6
paths to the root