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ONTOLOGY REPORT - ANNOTATIONS

Term:low-density lipoprotein particle receptor catabolic process
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Accession:GO:0032802 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of a low-density lipoprotein particle receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
Synonyms:exact_synonym: LDL receptor breakdown;   LDL receptor catabolic process;   LDL receptor degradation;   low-density lipoprotein receptor breakdown;   low-density lipoprotein receptor catabolic process;   low-density lipoprotein receptor catabolism;   low-density lipoprotein receptor degradation
 related_synonym: LDL receptor catabolism


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low-density lipoprotein particle receptor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pcsk9 proprotein convertase subtilisin/kexin type 9 involved_in ISO
ISS		 (PMID:16912035), (PMID:18197702)
PMID:12552133
GO_REF:0000024		 RGD
UniProt		 PMID:16912035 PMID:18197702 PMID:12552133 GO_REF:0000024, RGD:629554 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688 		JBrowse link
negative regulation of low-density lipoprotein particle receptor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa2 annexin A2 involved_in ISO (PMID:22848640)
(MGI:5446858|PMID:22848640)		 RGD PMID:22848640 MGI:5446858 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658 		JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) involved_in ISO (PMID:16912035) RGD PMID:16912035 NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314 		JBrowse link
positive regulation of low-density lipoprotein particle receptor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:21810484)
GO_REF:0000107		 RGD
Ensembl		 PMID:21810484 GO_REF:0000107 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537 		JBrowse link
G Apoe apolipoprotein E involved_in ISO
IEA		 (PMID:15950758)
GO_REF:0000107		 RGD
Ensembl		 PMID:15950758 GO_REF:0000107 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 involved_in ISO (PMID:22848640) RGD PMID:22848640 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688 		JBrowse link
regulation of low-density lipoprotein particle receptor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mylip myosin regulatory light chain interacting protein involved_in ISO (MGI:3849777|PMID:19520913) RGD PMID:19520913 MGI:3849777 NCBI chr17:19,286,649...19,308,295
Ensembl chr17:19,286,650...19,308,295 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 acts_upstream_of_or_within ISO MGI:3577021 (MGI:3576461|PMID:15805190), (MGI:3583861|PMID:15741654) RGD PMID:15741654 PMID:15805190 MGI:3576461 MGI:3583861 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19738
    metabolic process 12010
      cellular metabolic process 7444
        cellular catabolic process 1516
          receptor catabolic process 30
            low-density lipoprotein particle receptor catabolic process 6
              negative regulation of low-density lipoprotein particle receptor catabolic process 2
              positive regulation of low-density lipoprotein particle receptor catabolic process 3
              regulation of low-density lipoprotein particle receptor catabolic process + 6
Path 2
Term Annotations click to browse term
  biological_process 19738
    metabolic process 12010
      nitrogen compound metabolic process 8214
        organonitrogen compound metabolic process 6750
          protein metabolic process 5765
            protein catabolic process 1043
              low-density lipoprotein particle receptor catabolic process 6
                negative regulation of low-density lipoprotein particle receptor catabolic process 2
                positive regulation of low-density lipoprotein particle receptor catabolic process 3
                regulation of low-density lipoprotein particle receptor catabolic process + 6
paths to the root