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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of interleukin-1 production
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Accession:GO:0032732 term browser browse the term
Definition:Any process that activates or increases the frequency, rate, or extent of interleukin-1 production.
Synonyms:exact_synonym: positive regulation of IL-1 production;   up regulation of interleukin-1 production;   upregulation of interleukin-1 production
 narrow_synonym: activation of interleukin-1 production;   positive regulation of interleukin-1 biosynthetic process;   positive regulation of interleukin-1 secretion;   stimulation of interleukin-1 production
 alt_id: GO:0045362;   GO:0050716


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positive regulation of interleukin-1 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 IMP (MGI:MGI:4839671|PMID:20937702) UniProtKB PMID:20937702 MGI:MGI:4839671 NCBI chr11:46,454,931...46,481,255
Ensembl chr11:46,454,935...46,481,255
JBrowse link
G Hdac1 histone deacetylase 1 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr 4:129,516,104...129,542,646
Ensembl chr 4:129,516,104...129,542,713
JBrowse link
G Hdac2 histone deacetylase 2 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr10:36,974,297...37,001,889
Ensembl chr10:36,974,544...37,001,889
JBrowse link
G Hmgb1 high mobility group box 1 ISO (PMID:12765338)
PMID:10952726
UniProt PMID:10952726, PMID:12765338 RGD:10054071 NCBI chr 5:149,046,702...149,053,057
Ensembl chr 5:149,046,702...149,184,489
JBrowse link
G Ighd immunoglobulin heavy constant delta ISO (PMID:8774350) UniProt PMID:8774350 NCBI chr12:113,407,535...113,416,324
Ensembl chr12:113,406,604...113,416,324
JBrowse link
G Lgals9 lectin, galactose binding, soluble 9 IMP (MGI:MGI:4839671|PMID:20937702) UniProtKB PMID:20937702 MGI:MGI:4839671 NCBI chr11:78,962,979...78,984,924
Ensembl chr11:78,962,974...78,984,946
JBrowse link
G Orm1 orosomucoid 1 ISO (PMID:8774350) UniProt PMID:8774350 NCBI chr 4:63,344,556...63,348,163
Ensembl chr 4:63,344,560...63,348,163
JBrowse link
G Orm2 orosomucoid 2 ISO (PMID:8774350) UniProt PMID:8774350 NCBI chr 4:63,362,449...63,365,877
Ensembl chr 4:63,362,449...63,365,878
JBrowse link
G Panx1 pannexin 1 IEA UniProt GO_REF:0000002, MGI:MGI:2152098 NCBI chr 9:15,005,785...15,045,478
Ensembl chr 9:15,002,128...15,045,478
JBrowse link
G Panx2 pannexin 2 IEA UniProt GO_REF:0000002, MGI:MGI:2152098 NCBI chr15:89,059,057...89,073,566
Ensembl chr15:89,059,734...89,073,567
JBrowse link
G Panx3 pannexin 3 IEA UniProt GO_REF:0000002, MGI:MGI:2152098 NCBI chr 9:37,659,902...37,669,222
Ensembl chr 9:37,659,902...37,669,235
JBrowse link
G Tlr4 toll-like receptor 4 IDA
NAS
(MGI:MGI:4456948|PMID:15356140)
(MGI:MGI:3688055|PMID:11490012)
BHF-UCL
UniProt
PMID:11490012, PMID:15356140 MGI:MGI:3688055, MGI:MGI:4456948 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284
JBrowse link
positive regulation of interleukin-1 alpha production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin/calcitonin-related polypeptide, alpha ISO (PMID:16904178) UniProtKB PMID:16904178 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Casp1 caspase 1 IMP (MGI:MGI:3796019|PMID:18490713) MGI PMID:18490713 MGI:MGI:3796019 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Ccl20 chemokine (C-C motif) ligand 20 ISO MGI GO_REF:0000096, MGI:MGI:4417868 NCBI chr 1:83,116,766...83,119,167
Ensembl chr 1:83,116,766...83,119,167
JBrowse link
G Il16 interleukin 16 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 7:83,642,819...83,746,028
Ensembl chr 7:83,642,825...83,745,726
JBrowse link
G Isl1 ISL1 transcription factor, LIM/homeodomain IDA (MGI:MGI:5437583|PMID:22727192) BHF-UCL PMID:22727192 MGI:MGI:5437583 NCBI chr13:116,298,270...116,309,688
Ensembl chr13:116,298,281...116,309,689
JBrowse link
G Nlrp10 NLR family, pyrin domain containing 10 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 7:108,921,853...108,930,158
Ensembl chr 7:108,921,852...108,930,178
JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 IMP (MGI:MGI:3796019|PMID:18490713) MGI PMID:18490713 MGI:MGI:3796019 NCBI chr 5:122,643,927...122,692,336
Ensembl chr 5:122,643,911...122,691,432
JBrowse link
G Panx1 pannexin 1 IMP (MGI:MGI:3796019|PMID:18490713) MGI PMID:18490713 MGI:MGI:3796019 NCBI chr 9:15,005,785...15,045,478
Ensembl chr 9:15,002,128...15,045,478
JBrowse link
positive regulation of interleukin-1 beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 1810058I24Rik RIKEN cDNA 1810058I24 gene IMP (MGI:MGI:6384515|PMID:31836654) UniProt PMID:31836654 MGI:MGI:6384515 NCBI chr 6:35,252,710...35,261,639
Ensembl chr 6:35,252,654...35,263,496
JBrowse link
G Ager advanced glycosylation end product-specific receptor IGI (MGI:MGI:5424311|PMID:22406537) ARUK-UCL PMID:22406537 MGI:MGI:5424311 NCBI chr17:34,597,460...34,600,937
Ensembl chr17:34,597,862...34,600,936
JBrowse link
G Aim2 absent in melanoma 2 IMP
IGI
ISO
IDA
(MGI:MGI:3839029|PMID:19158675)
(MGI:MGI:5547461|PMID:23997220)
(MGI:MGI:3839523|PMID:19158676)
UniProtKB
MGI
PMID:19158675, PMID:19158676, PMID:23997220 GO_REF:0000096, MGI:MGI:3839029, MGI:MGI:3839523, MGI:MGI:4834177, MGI:MGI:5547461 NCBI chr 1:173,349,547...173,466,040
Ensembl chr 1:173,350,879...173,466,040
JBrowse link
G App amyloid beta (A4) precursor protein ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Casp1 caspase 1 ISO
IMP
(MGI:MGI:3796019|PMID:18490713) MGI PMID:18490713 GO_REF:0000096, MGI:MGI:3796019, MGI:MGI:4417868, MGI:MGI:4834177 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp4 caspase 4, apoptosis-related cysteine peptidase IGI (MGI:MGI:5468674|PMID:22002608) MGI PMID:22002608 MGI:MGI:5468674 NCBI chr 9:5,308,849...5,336,791
Ensembl chr 9:5,308,828...5,336,783
JBrowse link
G Casp8 caspase 8 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Ccl19 chemokine (C-C motif) ligand 19 IDA (MGI:MGI:3576832|PMID:15845453) BHF-UCL PMID:15845453 MGI:MGI:3576832 NCBI chr 4:42,754,525...42,756,365
Ensembl chr 4:42,754,525...42,756,577
JBrowse link
G Ccl3 chemokine (C-C motif) ligand 3 IGI (MGI:MGI:5301204|PMID:21784977) UniProt PMID:21784977 MGI:MGI:5301204 NCBI chr11:83,647,843...83,649,378
Ensembl chr11:83,647,844...83,649,355
JBrowse link
G Ccr5 chemokine (C-C motif) receptor 5 ISO MGI GO_REF:0000096, MGI:MGI:4417868 NCBI chr 9:124,121,543...124,127,183
Ensembl chr 9:124,121,543...124,147,699
JBrowse link
G Ccr7 chemokine (C-C motif) receptor 7 IC (MGI:MGI:3576832|PMID:15845453) BHF-UCL PMID:15845453 MGI:MGI:3576832 NCBI chr11:99,144,199...99,155,077
Ensembl chr11:99,144,196...99,155,077
JBrowse link
G Clec7a C-type lectin domain family 7, member a ISO (PMID:22267217) ARUK-UCL PMID:22267217 NCBI chr 6:129,461,591...129,472,785
Ensembl chr 6:129,461,591...129,472,779
JBrowse link
G Egr1 early growth response 1 IMP (MGI:MGI:1928025|PMID:11100120) UniProt PMID:11100120 MGI:MGI:1928025 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Fzd5 frizzled class receptor 5 IGI (MGI:MGI:5291547|PMID:21857966) ARUK-UCL PMID:21857966 MGI:MGI:5291547 NCBI chr 1:64,730,558...64,737,750
Ensembl chr 1:64,730,558...64,737,751
JBrowse link
G Gsdmd gasdermin D IDA (MGI:MGI:5751630|PMID:26611636) UniProt PMID:26611636 MGI:MGI:5751630 NCBI chr15:75,862,144...75,867,408
Ensembl chr15:75,862,327...75,867,408
JBrowse link
G Hk1 hexokinase 1 IDA (MGI:MGI:5790524|PMID:27374331) CAFA PMID:27374331 MGI:MGI:5790524 NCBI chr10:62,268,855...62,379,920
Ensembl chr10:62,268,855...62,379,908
JBrowse link
G Hmgb1 high mobility group box 1 IMP (MGI:MGI:4367121|PMID:19890330) UniProt PMID:19890330 MGI:MGI:4367121 NCBI chr 5:149,046,702...149,053,057
Ensembl chr 5:149,046,702...149,184,489
JBrowse link
G Hspb1 heat shock protein 1 IDA (MGI:MGI:5050077|PMID:12385642) BHF-UCL PMID:12385642 MGI:MGI:5050077 NCBI chr 5:135,887,919...135,889,563
Ensembl chr 5:135,887,919...135,889,563
JBrowse link
G Ifi204 interferon activated gene 204 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 1:173,747,293...173,767,069
Ensembl chr 1:173,747,293...173,766,943
JBrowse link
G Ifi205 interferon activated gene 205 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 1:174,011,998...174,031,755
Ensembl chr 1:174,011,998...174,031,810
JBrowse link
G Ifi211 interferon activated gene 211 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 1:173,896,339...173,913,087
Ensembl chr 1:173,896,345...173,913,046
JBrowse link
G Ifnar1 interferon (alpha and beta) receptor 1 IMP (MGI:MGI:5547461|PMID:23997220) MGI PMID:23997220 MGI:MGI:5547461 NCBI chr16:91,485,032...91,510,523
Ensembl chr16:91,485,238...91,507,441
JBrowse link
G Ifng interferon gamma IMP
IDA
(MGI:MGI:2673020|PMID:12925700)
(MGI:MGI:5776417|PMID:26227742)
MGI
ARUK-UCL
PMID:12925700, PMID:26227742 MGI:MGI:2673020, MGI:MGI:5776417 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il17a interleukin 17A ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 1:20,730,905...20,734,496
Ensembl chr 1:20,730,905...20,734,496
JBrowse link
G Il18 interleukin 18 ISO RGD PMID:17623049 RGD:4889480 NCBI chr 9:50,554,700...50,581,841
Ensembl chr 9:50,554,827...50,581,840
JBrowse link
G Il6 interleukin 6 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Inava innate immunity activator ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 1:136,213,522...136,234,293
Ensembl chr 1:136,213,531...136,234,264
JBrowse link
G Isl1 ISL1 transcription factor, LIM/homeodomain IDA (MGI:MGI:5437583|PMID:22727192) BHF-UCL PMID:22727192 MGI:MGI:5437583 NCBI chr13:116,298,270...116,309,688
Ensembl chr13:116,298,281...116,309,689
JBrowse link
G Jak2 Janus kinase 2 ISO
IGI
(MGI:MGI:5776417|PMID:26227742) RGD
ARUK-UCL
PMID:26227742 GO_REF:0000096, MGI:MGI:4417868, MGI:MGI:5776417 NCBI chr19:29,251,803...29,313,095
Ensembl chr19:29,251,828...29,313,080
JBrowse link
G Lgals9 lectin, galactose binding, soluble 9 ISO (PMID:20209097) UniProt PMID:20209097 NCBI chr11:78,962,979...78,984,924
Ensembl chr11:78,962,974...78,984,946
JBrowse link
G Lilra5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 7:4,237,643...4,243,690
Ensembl chr 7:4,237,754...4,243,463
JBrowse link
G Lpl lipoprotein lipase IGI (MGI:MGI:6282927|PMID:22963823) ARUK-UCL PMID:22963823 MGI:MGI:6282927 NCBI chr 8:68,880,555...68,906,932
Ensembl chr 8:68,880,491...68,907,448
JBrowse link
G Malt1 MALT1 paracaspase ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr18:65,430,939...65,478,888
Ensembl chr18:65,430,938...65,479,067
JBrowse link
G Mndal myeloid nuclear differentiation antigen like IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 1:173,857,215...173,880,382
Ensembl chr 1:173,849,126...173,880,881
JBrowse link
G Naip5 NLR family, apoptosis inhibitory protein 5 IDA (MGI:MGI:6120354|PMID:29182158) UniProtKB PMID:29182158 MGI:MGI:6120354 NCBI chr13:100,211,735...100,250,930
Ensembl chr13:100,211,739...100,246,323
JBrowse link
G Nlrc4 NLR family, CARD domain containing 4 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr17:74,426,255...74,459,144
Ensembl chr17:74,425,438...74,459,142
JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A IDA (MGI:MGI:4943384|PMID:18511561) BHF-UCL PMID:18511561 MGI:MGI:4943384 NCBI chr11:71,091,197...71,144,969
Ensembl chr11:71,092,236...71,144,704
JBrowse link
G Nlrp2 NLR family, pyrin domain containing 2 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 7:5,298,547...5,351,035
Ensembl chr 7:5,298,547...5,351,035
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 IGI
IDA
ISO
IMP
(MGI:MGI:5547461|PMID:23997220)
(MGI:MGI:6095076|PMID:28847925)
(MGI:MGI:5468674|PMID:22002608)
(MGI:MGI:5790524|PMID:27374331)
MGI
UniProt
CAFA
PMID:22002608, PMID:23997220, PMID:27374331, PMID:28847925 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:5468674, MGI:MGI:5547461, MGI:MGI:5790524, MGI:MGI:6095076 NCBI chr11:59,541,569...59,566,955
Ensembl chr11:59,541,568...59,566,956
JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr 6:54,923,942...54,972,674
Ensembl chr 6:54,923,949...54,972,612
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO
IDA
(MGI:MGI:4943384|PMID:18511561) MGI
BHF-UCL
PMID:18511561 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:4943384 NCBI chr 8:88,647,315...88,688,474
Ensembl chr 8:88,647,315...88,688,474
JBrowse link
G Orm1 orosomucoid 1 ISO (PMID:8774350) UniProt PMID:8774350 NCBI chr 4:63,344,556...63,348,163
Ensembl chr 4:63,344,560...63,348,163
JBrowse link
G Orm2 orosomucoid 2 ISO (PMID:8774350) UniProt PMID:8774350 NCBI chr 4:63,362,449...63,365,877
Ensembl chr 4:63,362,449...63,365,878
JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 IMP
ISO
(MGI:MGI:1929334|PMID:11016935)
(MGI:MGI:3796019|PMID:18490713)
(MGI:MGI:3580953|PMID:15905573)
MGI PMID:11016935, PMID:15905573, PMID:18490713 GO_REF:0000096, MGI:MGI:1929334, MGI:MGI:3580953, MGI:MGI:3796019, MGI:MGI:4834177 NCBI chr 5:122,643,927...122,692,336
Ensembl chr 5:122,643,911...122,691,432
JBrowse link
G Panx1 pannexin 1 ISO
IMP
(MGI:MGI:3796019|PMID:18490713) MGI PMID:18490713 GO_REF:0000096, MGI:MGI:3796019, MGI:MGI:4834177 NCBI chr 9:15,005,785...15,045,478
Ensembl chr 9:15,002,128...15,045,478
JBrowse link
G Pycard PYD and CARD domain containing ISO
IGI
IMP
(MGI:MGI:5468674|PMID:22002608)
(MGI:MGI:5547461|PMID:23997220)
(MGI:MGI:3839029|PMID:19158675)
MGI
UniProt
PMID:19158675, PMID:22002608, PMID:23997220 GO_REF:0000096, MGI:MGI:3839029, MGI:MGI:4834177, MGI:MGI:5468674, MGI:MGI:5547461 NCBI chr 7:127,991,373...127,993,867
Ensembl chr 7:127,989,708...127,993,867
JBrowse link
G Ripk2 receptor (TNFRSF)-interacting serine-threonine kinase 2 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 4:16,122,732...16,163,678
Ensembl chr 4:16,122,733...16,163,647
JBrowse link
G Smad3 SMAD family member 3 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr 9:63,646,766...63,757,994
Ensembl chr 9:63,646,767...63,757,994
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr11:100,886,806...100,939,594
Ensembl chr11:100,885,098...100,939,540
JBrowse link
G Tlr2 toll-like receptor 2 IGI (MGI:MGI:5307186|PMID:22198949) ARUK-UCL PMID:22198949 MGI:MGI:5307186 NCBI chr 3:83,836,272...83,841,824
Ensembl chr 3:83,836,272...83,841,767
JBrowse link
G Tlr4 toll-like receptor 4 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284
JBrowse link
G Tlr8 toll-like receptor 8 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr  X:167,241,123...167,264,329
Ensembl chr  X:167,242,696...167,264,329
JBrowse link
G Tnf tumor necrosis factor ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trim16 tripartite motif-containing 16 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr11:62,820,198...62,842,948
Ensembl chr11:62,820,231...62,850,808
JBrowse link
G Tyrobp TYRO protein tyrosine kinase binding protein IMP (MGI:MGI:5638298|PMID:25690660) ARUK-UCL PMID:25690660 MGI:MGI:5638298 NCBI chr 7:30,413,782...30,417,582
Ensembl chr 7:30,413,760...30,417,585
JBrowse link
G Usp50 ubiquitin specific peptidase 50 IMP
ISO
(MGI:MGI:5888801|PMID:28094437) MGI PMID:28094437 MGI:MGI:5888801 NCBI chr 2:126,761,050...126,783,460
Ensembl chr 2:126,709,096...126,783,470
JBrowse link
G Wnt5a wingless-type MMTV integration site family, member 5A IMP
ISO
IDA
IGI
(MGI:MGI:5291547|PMID:21857966)
(MGI:MGI:5009385|PMID:18174455)
ARUK-UCL
MGI
BHF-UCL
PMID:18174455, PMID:21857966 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:5009385, MGI:MGI:5291547 NCBI chr14:28,504,543...28,527,448
Ensembl chr14:28,504,750...28,527,448
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23392
    multicellular organismal process 8879
      cytokine production 761
        interleukin-1 production 108
          positive regulation of interleukin-1 production 67
            positive regulation of interleukin-1 alpha production 8
            positive regulation of interleukin-1 beta production 57
Path 2
Term Annotations click to browse term
  biological_process 23392
    biological regulation 13113
      regulation of biological process 12479
        positive regulation of biological process 6538
          positive regulation of metabolic process 3872
            positive regulation of macromolecule metabolic process 3572
              positive regulation of gene expression 2388
                positive regulation of cytokine production 468
                  positive regulation of interleukin-1 production 67
                    positive regulation of interleukin-1 alpha production 8
                    positive regulation of interleukin-1 beta production 57
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.