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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of interleukin-6 production
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Accession:GO:0032715 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.
Synonyms:exact_synonym: down regulation of interleukin-6 production;   downregulation of interleukin-6 production;   negative regulation of IL-6 production
 narrow_synonym: inhibition of interleukin-6 production;   negative regulation of interleukin-6 biosynthetic process;   negative regulation of interleukin-6 secretion
 alt_id: GO:0045409;   GO:1900165


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negative regulation of interleukin-6 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 ISO RGD PMID:11096136 RGD:8548521 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Aqp4 aquaporin 4 IMP RGD PMID:22449442 RGD:8695996 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Arrb1 arrestin, beta 1 involved_in ISO (PMID:16378096) RGD PMID:16378096 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061 		JBrowse link
G Arrb2 arrestin, beta 2 involved_in ISO
IEA		 (MGI:3662828|PMID:16378096)
GO_REF:0000107		 RGD
Ensembl		 PMID:16378096 GO_REF:0000107 MGI:3662828 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Bank1 B-cell scaffold protein with ankyrin repeats 1 acts_upstream_of_or_within ISO MGI:3686872 (MGI:5554491|PMID:24227780) RGD PMID:24227780 MGI:5554491 NCBI chr 2:224,530,475...224,800,420
Ensembl chr 2:224,530,475...224,800,405 		JBrowse link
G Bpi bactericidal/permeability-increasing protein involved_in IBA
ISO		 PMID:21873635
(PMID:8409400)		 RGD PMID:8409400 PMID:21873635 RGD:13792537 NCBI chr 3:146,909,626...146,936,487
Ensembl chr 3:146,909,629...146,936,221 		JBrowse link
G C1qtnf3 C1q and TNF related 3 involved_in ISO (PMID:16213490) RGD PMID:16213490 NCBI chr 2:59,917,099...59,939,519
Ensembl chr 2:59,917,188...59,939,433 		JBrowse link
G C5ar2 complement C5a receptor 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:16204243)		 UniProt
RGD		 PMID:16204243 GO_REF:0000024 NCBI chr 1:76,930,381...76,945,432
Ensembl chr 1:76,930,383...76,959,517 		JBrowse link
G Cd200 Cd200 molecule involved_in IGI PMID:18164423 ARUK-UCL PMID:18164423 RGD:13792521 NCBI chr11:55,410,166...55,437,527
Ensembl chr11:55,410,196...55,501,648 		JBrowse link
G Cd200r1 CD200 receptor 1 involved_in IGI PMID:18164423 ARUK-UCL PMID:18164423 RGD:13792521 NCBI chr11:55,886,937...55,921,217
Ensembl chr11:55,887,717...55,921,285 		JBrowse link
G Cd24 CD24 molecule involved_in ISO (MGI:5913663|PMID:19264983) RGD PMID:19264983 MGI:5913663 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662 		JBrowse link
G Cd84 CD84 molecule involved_in ISO
IBA		 (MGI:5700297|PMID:20628063)
PMID:21873635		 RGD PMID:20628063 PMID:21873635 MGI:5700297, RGD:13792537 NCBI chr13:84,327,580...84,367,153
Ensembl chr13:84,327,553...84,362,076 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1888407 (MGI:3040787|PMID:12508119)		 Ensembl
RGD		 PMID:12508119 GO_REF:0000107 MGI:3040787 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Csk C-terminal Src kinase IDA RGD PMID:10411542 RGD:5134371 NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292 		JBrowse link
G Elf4 E74 like ETS transcription factor 4 involved_in ISO (PMID:34326534)
(MGI:6740250|PMID:34326534)		 RGD PMID:34326534 MGI:6740250 NCBI chr  X:127,587,401...127,639,063
Ensembl chr  X:127,590,650...127,630,200 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 acts_upstream_of_or_within ISO MGI:3628823 (MGI:4452060|PMID:20457904) RGD PMID:20457904 MGI:4452060 NCBI chr12:7,623,930...7,699,474
Ensembl chr12:7,623,930...7,699,474 		JBrowse link
G Foxj1 forkhead box J1 involved_in ISO
IEA		 (MGI:3589323|PMID:16002694)
GO_REF:0000107		 RGD
Ensembl		 PMID:16002694 GO_REF:0000107 MGI:3589323 NCBI chr10:101,566,299...101,570,370
Ensembl chr10:101,566,304...101,570,237 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:3696705 (MGI:3695768|PMID:16275384) RGD PMID:16275384 MGI:3695768 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Gas6 growth arrest specific 6 involved_in ISO
ISS		 (PMID:19657094), (PMID:20103767)
GO_REF:0000024		 RGD
UniProt		 PMID:19657094 PMID:20103767 GO_REF:0000024 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904 		JBrowse link
G Gba1 glucosylceramidase beta 1 involved_in ISO (PMID:19279008) RGD PMID:19279008 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide involved_in ISO
ISS		 (PMID:15232612)
GO_REF:0000024		 RGD
UniProt		 PMID:15232612 GO_REF:0000024 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621 		JBrowse link
G Ghsr growth hormone secretagogue receptor involved_in ISO
ISS		 (PMID:15232612)
GO_REF:0000024		 RGD
UniProt		 PMID:15232612 GO_REF:0000024 NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865 		JBrowse link
G H19 H19 imprinted maternally expressed transcript IMP RGD PMID:27796346 RGD:156430325 NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (MGI:5437532|PMID:22842346) RGD PMID:22842346 MGI:5437532 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137 		JBrowse link
G Hgf hepatocyte growth factor acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:4849876|PMID:21072211)
GO_REF:0000107		 RGD
Ensembl		 PMID:21072211 GO_REF:0000107 MGI:4849876 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Il10 interleukin 10 involved_in ISS
ISO		 GO_REF:0000024
(PMID:10443688)		 UniProt
RGD		 PMID:10443688 GO_REF:0000024 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il27ra interleukin 27 receptor subunit alpha involved_in ISO UniProtKB:P35951 (MGI:5581894|PMID:22927332) RGD PMID:22927332 MGI:5581894 NCBI chr19:24,109,963...24,121,977
Ensembl chr19:24,109,972...24,121,938 		JBrowse link
G Il36rn interleukin 36 receptor antagonist acts_upstream_of_or_within ISO MGI:1859324|MGI:1916927|MGI:2449929 (MGI:5300146|PMID:21860022) RGD PMID:21860022 MGI:5300146 NCBI chr 3:7,044,419...7,051,016
Ensembl chr 3:7,044,406...7,051,016 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2386884 (MGI:2386137|PMID:12161749)		 Ensembl
RGD		 PMID:12161749 GO_REF:0000107 MGI:2386137 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 involved_in ISO (PMID:18156187)
(MGI:2183694|PMID:12150927)		 RGD PMID:12150927 PMID:18156187 MGI:2183694 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121 		JBrowse link
G Klf2 KLF transcription factor 2 IMP RGD PMID:19192484 RGD:2316542 NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944 		JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:19380766) RGD PMID:19380766 NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660 		JBrowse link
G Mir101-2 microRNA 101-2 acts_upstream_of ISO (PMID:26022377) RGD PMID:26022377 NCBI chr 1:226,860,371...226,860,467
Ensembl chr 1:226,860,371...226,860,467 		JBrowse link
G Mir101a microRNA 101a acts_upstream_of ISO (PMID:26022377) RGD PMID:26022377 NCBI chr 5:115,966,332...115,966,406
Ensembl chr 5:115,966,328...115,966,410 		JBrowse link
G Mir105 microRNA 105 acts_upstream_of ISO (PMID:19509287) RGD PMID:19509287 NCBI chr  X:150,438,529...150,438,601
Ensembl chr  X:150,438,529...150,438,601 		JBrowse link
G Mir125a microRNA 125a IDA RGD PMID:29700287 RGD:26884455 NCBI chr 1:58,677,626...58,677,710
Ensembl chr 1:58,677,626...58,677,710 		JBrowse link
G Mir140 microRNA 140 acts_upstream_of ISO
IMP		 (PMID:30321456) RGD PMID:30321456 PMID:31376096 PMID:32519270 RGD:329337378, RGD:329347827 NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675 		JBrowse link
G Mir146a microRNA 146a involved_in
acts_upstream_of		 ISO (PMID:28433754), (PMID:29896267), (PMID:31086599)
(PMID:21329689), (PMID:29896267)		 RGD PMID:21329689 PMID:28433754 PMID:29896267 PMID:31086599 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mir154 microRNA 154 IMP RGD PMID:31746418 RGD:152995474 NCBI chr 6:128,752,947...128,753,030
Ensembl chr 6:128,752,947...128,753,030 		JBrowse link
G Mir181a2 microRNA 181a-2 involved_in ISO (PMID:23516523) RGD PMID:23516523 NCBI chr 3:22,615,845...22,615,961
Ensembl chr 3:22,615,845...22,615,961 		JBrowse link
G Mir19a microRNA 19a acts_upstream_of ISO UniProtKB:O60603 (PMID:22105995), (PMID:28078022) RGD PMID:22105995 PMID:28078022 NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993 		JBrowse link
G Mir19b1 microRNA 19b-1 acts_upstream_of ISO (PMID:22105995) RGD PMID:22105995 NCBI chr15:92,181,214...92,181,300
Ensembl chr15:92,181,214...92,181,300 		JBrowse link
G Mir19b2 microRNA 19b-2 acts_upstream_of ISO (PMID:22105995) RGD PMID:22105995 NCBI chr  X:132,422,072...132,422,167
Ensembl chr  X:132,422,072...132,422,167 		JBrowse link
G Mir204 microRNA 204 acts_upstream_of ISO (PMID:29441883) RGD PMID:29441883 NCBI chr 1:220,316,931...220,317,040
Ensembl chr 1:220,316,931...220,317,040 		JBrowse link
G Mir206 microRNA 206 involved_in ISO (PMID:31507089) RGD PMID:31507089 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332 		JBrowse link
G Mir217 microRNA 217 involved_in ISO (PMID:28642131) RGD PMID:28642131 NCBI chr14:102,531,505...102,531,609
Ensembl chr14:102,531,505...102,531,609 		JBrowse link
G Mir26a microRNA 26a acts_upstream_of
involved_in		 ISO (PMID:27252421)
(PMID:27252421), (PMID:30542439)		 RGD PMID:27252421 PMID:30542439 NCBI chr 8:118,755,289...118,755,378
Ensembl chr 8:118,755,289...118,755,378 		JBrowse link
G Mir365b microRNA 365b involved_in ISO (PMID:30233734) RGD PMID:30233734 NCBI chr10:64,686,255...64,686,340
Ensembl chr10:64,686,252...64,686,351 		JBrowse link
G Mir494 microRNA 494 IDA RGD PMID:30783439 RGD:150527846 NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793 		JBrowse link
G Mir708 microRNA 708 acts_upstream_of ISO (PMID:31599428) RGD PMID:31599428 NCBI chr 1:150,599,876...150,599,963
Ensembl chr 1:150,599,876...150,599,963 		JBrowse link
G Mir98 microRNA 98 involved_in ISO (PMID:31886314) RGD PMID:31886314 NCBI chr  X:20,981,235...20,981,342
Ensembl chr  X:20,981,235...20,981,342 		JBrowse link
G Muc16 mucin 16, cell surface associated acts_upstream_of_or_within ISO MGI:3840843 (MGI:5754666|PMID:24812549) RGD PMID:24812549 MGI:5754666 NCBI chr 8:16,164,531...16,323,126 JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISS
ISO		 GO_REF:0000024
(MGI:3818191|PMID:19015308)		 UniProt
RGD		 PMID:19015308 GO_REF:0000024 MGI:3818191 NCBI chr 7:134,577,470...134,622,928
Ensembl chr 7:134,577,482...134,622,934 		JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 involved_in ISO (PMID:22863753)
(MGI:5437524|PMID:22863753), (MGI:5568884|PMID:24560620)		 RGD PMID:22863753 PMID:24560620 MGI:5437524 MGI:5568884 NCBI chr10:11,551,378...11,585,027
Ensembl chr10:11,551,356...11,584,398 		JBrowse link
G Nlrp12 NLR family, pyrin domain containing 12 involved_in ISO (PMID:16203735) RGD PMID:16203735 NCBI chr 1:65,932,610...65,969,873
Ensembl chr 1:65,932,595...65,960,934 		JBrowse link
G Nlrx1 NLR family member X1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:5141085 (MGI:5050761|PMID:21703540)		 Ensembl
RGD		 PMID:21703540 GO_REF:0000107 MGI:5050761 NCBI chr 8:44,588,476...44,606,678
Ensembl chr 8:44,590,048...44,606,484 		JBrowse link
G Nmb neuromedin B involved_in ISO (MGI:6435299|PMID:31601264) RGD PMID:31601264 MGI:6435299 NCBI chr 1:134,869,446...134,875,507
Ensembl chr 1:134,869,446...134,872,190 		JBrowse link
G Nmbr neuromedin B receptor involved_in ISS
ISO		 GO_REF:0000024
(PMID:31601264)
(MGI:6435299|PMID:31601264)		 UniProt
RGD		 PMID:31601264 GO_REF:0000024 MGI:6435299 NCBI chr 1:9,115,033...9,146,081
Ensembl chr 1:9,134,889...9,145,462 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 involved_in ISO
IEA		 (MGI:5708041|PMID:21242261)
GO_REF:0000107		 RGD
Ensembl		 PMID:21242261 GO_REF:0000107 MGI:5708041 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Orm1 orosomucoid 1 involved_in ISO (PMID:23973664) RGD PMID:23973664 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G Prg4 proteoglycan 4 acts_upstream_of_or_within ISO MGI:3513195 (MGI:5294851|PMID:21939632) RGD PMID:21939632 MGI:5294851 NCBI chr13:62,487,257...62,504,657
Ensembl chr13:62,487,257...62,504,119 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in ISO (PMID:23991106)
(MGI:5640942|PMID:23991106)		 RGD PMID:23991106 MGI:5640942 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:P97797 (MGI:3760575|PMID:17954568)		 Ensembl
RGD		 PMID:17954568 GO_REF:0000107 MGI:3760575 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO MGI:3051384 (MGI:3620385|PMID:16533754) RGD PMID:16533754 MGI:3620385 NCBI chr12:26,459,190...26,503,790
Ensembl chr12:26,460,175...26,503,744 		JBrowse link
G Selenos selenoprotein S involved_in IEA
ISO		 GO_REF:0000107
(MGI:3773781|PMID:16227999)		 Ensembl
RGD		 PMID:16227999 GO_REF:0000107 MGI:3773781 NCBI chr 1:119,659,779...119,669,546
Ensembl chr 1:119,659,751...119,669,833 		JBrowse link
G Sirpa signal-regulatory protein alpha involved_in ISO (MGI:3760575|PMID:17954568) RGD PMID:17954568 MGI:3760575 NCBI chr 3:116,819,730...116,858,099
Ensembl chr 3:116,819,726...116,858,098 		JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 involved_in ISO (PMID:16317102) RGD PMID:16317102 NCBI chr13:84,270,316...84,305,497
Ensembl chr13:84,270,316...84,305,497 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (MGI:5659826|PMID:24255059) RGD PMID:24255059 MGI:5659826 NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834 		JBrowse link
G Syt11 synaptotagmin 11 involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:5468041|PMID:23303671), (MGI:5780534|PMID:25063865), (MGI:5913303|PMID:28686317)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:23303671 PMID:25063865 PMID:28686317 GO_REF:0000024 GO_REF:0000107 MGI:5468041 MGI:5780534 MGI:5913303 NCBI chr 2:174,206,032...174,232,540
Ensembl chr 2:174,206,191...174,231,964 		JBrowse link
G Tlr4 toll-like receptor 4 involved_in IEA
ISO		 GO_REF:0000107
(MGI:3773594|PMID:18203139), (MGI:4421230|PMID:20051628)		 Ensembl
RGD		 PMID:18203139 PMID:20051628 GO_REF:0000107 MGI:3773594 MGI:4421230 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:10443688) RGD PMID:10443688 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 involved_in ISO (MGI:3763997|PMID:18006655), (MGI:3777503|PMID:18342009), (MGI:4946158|PMID:21088135) RGD PMID:18006655 PMID:18342009 PMID:21088135 MGI:3763997 MGI:3777503 MGI:4946158 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A IDA RGD PMID:20501675 RGD:5130988 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A involved_in ISO
ISS		 (PMID:18178554)
GO_REF:0000024
(MGI:5142149|PMID:21616078)		 RGD
UniProt		 PMID:18178554 PMID:21616078 GO_REF:0000024 MGI:5142149 NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19574
    multicellular organismal process 9171
      negative regulation of multicellular organismal process 1373
        negative regulation of cytokine production 387
          negative regulation of interleukin-6 production 74
Path 2
Term Annotations click to browse term
  biological_process 19574
    biological regulation 13203
      regulation of biological process 12829
        regulation of metabolic process 6385
          regulation of biosynthetic process 5263
            regulation of cellular biosynthetic process 5218
              regulation of macromolecule biosynthetic process 5072
                regulation of gene expression 4958
                  regulation of cytokine production 898
                    negative regulation of cytokine production 387
                      negative regulation of interleukin-6 production 74
paths to the root