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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of interleukin-2 production
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Accession:GO:0032703 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.
Synonyms:exact_synonym: down regulation of interleukin-2 production;   downregulation of interleukin-2 production;   negative regulation of IL-2 production
 narrow_synonym: inhibition of interleukin-2 production;   negative regulation of interleukin-2 biosynthetic process;   negative regulation of interleukin-2 secretion
 alt_id: GO:0045085;   GO:1900041


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negative regulation of interleukin-2 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd276 CD276 antigen acts_upstream_of_or_within IDA (PMID:12925852) MGI PMID:12925852 NCBI chr 9:58,431,581...58,463,437
Ensembl chr 9:58,431,581...58,462,720 		JBrowse link
G Cd34 CD34 antigen involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:194,621,239...194,643,587
Ensembl chr 1:194,621,127...194,643,587 		JBrowse link
G Ezr ezrin involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr17:7,005,530...7,050,179
Ensembl chr17:7,005,440...7,050,183 		JBrowse link
G Foxp3 forkhead box P3 involved_in
acts_upstream_of_or_within		 IMP
IDA
ISO		 (MGI:3795336|PMID:18368049)
(MGI:3710039|PMID:17377532)
(PMID:16769892), (PMID:17028180)		 UniProt
MGI		 PMID:16769892 PMID:17028180 PMID:17377532 PMID:18368049 GO_REF:0000119 MGI:3710039 MGI:3795336 MGI:4834177 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G Gata3 GATA binding protein 3 acts_upstream_of_or_within IDA (PMID:18792410) MGI PMID:18792410 NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845 		JBrowse link
G Gbp2b guanylate binding protein 2b involved_in ISO (PMID:24337748) UniProt PMID:24337748 NCBI chr 3:142,300,577...142,324,940
Ensembl chr 3:142,300,608...142,324,940 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in IMP
ISO		 (MGI:2679123|PMID:14556006) UniProt
MGI		 PMID:14556006 GO_REF:0000119 MGI:2679123 MGI:4834177 NCBI chr11:46,345,758...46,372,082
Ensembl chr11:46,345,762...46,372,082 		JBrowse link
G Hdac7 histone deacetylase 7 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr15:97,690,542...97,742,383
Ensembl chr15:97,690,545...97,742,383 		JBrowse link
G Homer2 homer scaffolding protein 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:81,250,229...81,356,673
Ensembl chr 7:81,250,229...81,357,275 		JBrowse link
G Homer3 homer scaffolding protein 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 8:70,735,529...70,747,011
Ensembl chr 8:70,735,477...70,747,011 		JBrowse link
G Il20rb interleukin 20 receptor beta acts_upstream_of_or_within IMP (PMID:19124723) MGI PMID:19124723 NCBI chr 9:100,339,772...100,368,526
Ensembl chr 9:100,339,772...100,368,841 		JBrowse link
G Kat5 K(lysine) acetyltransferase 5 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr19:5,653,042...5,661,584
Ensembl chr19:5,653,042...5,660,265 		JBrowse link
G Lag3 lymphocyte-activation gene 3 acts_upstream_of_or_within IDA (PMID:12421911) MGI PMID:12421911 NCBI chr 6:124,881,322...124,888,668
Ensembl chr 6:124,881,324...124,888,668 		JBrowse link
G Laptm5 lysosomal-associated protein transmembrane 5 involved_in IMP (MGI:3803048|PMID:18619870) ARUK-UCL PMID:18619870 MGI:3803048 NCBI chr 4:130,640,627...130,663,459
Ensembl chr 4:130,640,436...130,663,452 		JBrowse link
G Lilrb4a leukocyte immunoglobulin-like receptor, subfamily B, member 4A involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:51,366,999...51,372,709
Ensembl chr10:51,367,052...51,372,707 		JBrowse link
G Lilrb4b leukocyte immunoglobulin-like receptor, subfamily B, member 4B involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:51,356,757...51,362,417
Ensembl chr10:51,356,728...51,362,799 		JBrowse link
G Mir181c microRNA 181c acts_upstream_of ISO (PMID:21112091) ARUK-UCL PMID:21112091 NCBI chr 8:84,905,502...84,905,590
Ensembl chr 8:84,905,502...84,905,590 		JBrowse link
G Nav3 neuron navigator 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:109,517,121...110,292,148
Ensembl chr10:109,517,120...110,292,065 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 acts_upstream_of_or_within IMP (PMID:19139201) MGI PMID:19139201 NCBI chr 8:89,373,943...89,415,103
Ensembl chr 8:89,373,943...89,415,102 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 involved_in IMP (MGI:5707586|PMID:18972444) UniProt PMID:18972444 MGI:5707586 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
G Prnp prion protein involved_in IMP (MGI:4943618|PMID:20145049) BHF-UCL PMID:20145049 MGI:4943618 NCBI chr 2:131,751,848...131,780,356
Ensembl chr 2:131,751,848...131,780,349 		JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C involved_in IGI (MGI:3530407|PMID:15661907) ARUK-UCL PMID:15661907 MGI:3530407 NCBI chr 1:137,990,601...138,103,491
Ensembl chr 1:137,990,599...138,103,446 		JBrowse link
G Sftpd surfactant associated protein D involved_in ISO RGD
MGI		 PMID:9794387 GO_REF:0000096 MGI:4417868 RGD:4144057 NCBI chr14:40,894,169...40,907,155
Ensembl chr14:40,894,171...40,907,106 		JBrowse link
G Tbx21 T-box 21 involved_in IMP (MGI:5543347|PMID:23616576) UniProt PMID:23616576 MGI:5543347 NCBI chr11:96,988,833...97,006,157
Ensembl chr11:96,988,897...97,006,157 		JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405 		JBrowse link
G Trim27 tripartite motif-containing 27 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:21,363,570...21,378,893
Ensembl chr13:21,363,615...21,378,894 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 involved_in
acts_upstream_of_or_within		 IBA
IDA		 (PMID:17016562) GO_Central
MGI		 PMID:17016562 GO_REF:0000033 NCBI chr  X:95,290,807...95,337,044
Ensembl chr  X:95,290,809...95,337,044 		JBrowse link
G Xcl1 chemokine (C motif) ligand 1 involved_in ISO (PMID:10887101) BHF-UCL PMID:10887101 NCBI chr 1:164,759,216...164,763,094
Ensembl chr 1:164,759,213...164,763,096 		JBrowse link
G Zfp36 zinc finger protein 36 involved_in IMP (MGI:5795825|PMID:15634918) UniProt PMID:15634918 MGI:5795825 NCBI chr 7:28,076,208...28,078,680
Ensembl chr 7:28,076,209...28,079,678 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    multicellular organismal process 8901
      negative regulation of multicellular organismal process 1438
        negative regulation of cytokine production 419
          negative regulation of interleukin-2 production 29
Path 2
Term Annotations click to browse term
  biological_process 28573
    biological regulation 13112
      regulation of biological process 12722
        regulation of metabolic process 6601
          regulation of biosynthetic process 5423
            regulation of cellular biosynthetic process 5370
              regulation of macromolecule biosynthetic process 5216
                regulation of gene expression 5095
                  regulation of cytokine production 976
                    negative regulation of cytokine production 419
                      negative regulation of interleukin-2 production 29
paths to the root