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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of interleukin-2 production
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Accession:GO:0032663 term browser browse the term
Definition:Any process that modulates the frequency, rate, or extent of interleukin-2 production.
Synonyms:exact_synonym: regulation of IL-2 production
 narrow_synonym: regulation of interleukin-2 biosynthetic process;   regulation of interleukin-2 secretion
 alt_id: GO:0045076;   GO:1900040


show annotations for term's descendants           Sort by:
 
regulation of interleukin-2 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Card9 caspase recruitment domain family, member 9 acts_upstream_of_or_within ISO MGI:3663486 (MGI:3654747|PMID:16862125) RGD PMID:16862125 MGI:3654747 NCBI chr 3:9,171,814...9,180,310
Ensembl chr 3:9,171,815...9,180,237 		JBrowse link
G Clec2dl1 C-type lectin domain family 2 member D-like 1 acts_upstream_of_or_within ISO (MGI:3622591|PMID:16143319) RGD PMID:16143319 MGI:3622591 NCBI chr 4:162,263,578...162,274,882
Ensembl chr 4:162,263,639...162,274,880 		JBrowse link
G Il17f interleukin 17F involved_in ISO
IEA		 (PMID:11591732)
GO_REF:0000107		 RGD
Ensembl		 PMID:11591732 GO_REF:0000107 NCBI chr 9:23,190,094...23,201,482
Ensembl chr 9:23,190,100...23,201,482 		JBrowse link
negative regulation of interleukin-2 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd276 Cd276 molecule acts_upstream_of_or_within ISO (MGI:2671029|PMID:12925852) RGD PMID:12925852 MGI:2671029 NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380 		JBrowse link
G Cd34 CD34 molecule involved_in ISS
ISO		 GO_REF:0000024
(PMID:9815891)		 UniProt
RGD		 PMID:9815891 GO_REF:0000024 NCBI chr13:106,480,074...106,499,462
Ensembl chr13:106,480,043...106,499,832 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 acts_upstream_of_or_within ISO MGI:2448686|MGI:3693674 (MGI:3693042|PMID:17081782) RGD PMID:17081782 MGI:3693042 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Ezr ezrin involved_in ISO (PMID:17911601) RGD PMID:17911601 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505 		JBrowse link
G Foxp3 forkhead box P3 involved_in
acts_upstream_of_or_within		 ISO (PMID:15466453), (PMID:16873067), (PMID:17360565), (PMID:17377532), (PMID:23169781)
(MGI:3693968|PMID:16769892), (MGI:3697020|PMID:17028180)
(MGI:3710039|PMID:17377532), (MGI:3795336|PMID:18368049)		 RGD PMID:15466453 PMID:16769892 PMID:16873067 PMID:17028180 PMID:17360565 More... MGI:3693968 MGI:3697020 MGI:3710039 MGI:3795336 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Gata3 GATA binding protein 3 acts_upstream_of_or_within ISO (MGI:3817792|PMID:18792410) RGD PMID:18792410 MGI:3817792 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Gbp1 guanylate binding protein 1 involved_in ISO (PMID:24337748) RGD PMID:24337748 NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:26492563)
(MGI:2679123|PMID:14556006)		 RGD PMID:14556006 PMID:26492563 MGI:2679123 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137 		JBrowse link
G Hdac7 histone deacetylase 7 involved_in ISO (PMID:17360565) RGD PMID:17360565 NCBI chr 7:128,923,918...128,962,025
Ensembl chr 7:128,923,920...128,962,072 		JBrowse link
G Homer2 homer scaffold protein 2 involved_in ISO
ISS		 (PMID:18218901)
GO_REF:0000024		 RGD
UniProt		 PMID:18218901 GO_REF:0000024 NCBI chr 1:135,558,977...135,659,780
Ensembl chr 1:135,567,414...135,659,772 		JBrowse link
G Homer3 homer scaffold protein 3 involved_in ISO
ISS		 (PMID:18218901)
GO_REF:0000024		 RGD
UniProt		 PMID:18218901 GO_REF:0000024 NCBI chr16:19,132,177...19,142,739
Ensembl chr16:19,132,162...19,142,680 		JBrowse link
G Il20rb interleukin 20 receptor subunit beta acts_upstream_of_or_within ISO MGI:3830304 (MGI:3827040|PMID:19124723) RGD PMID:19124723 MGI:3827040 NCBI chr 8:100,979,085...101,010,829
Ensembl chr 8:100,980,383...101,009,942 		JBrowse link
G Kat5 lysine acetyltransferase 5 involved_in ISO (PMID:17360565) RGD PMID:17360565 NCBI chr 1:202,895,751...202,903,178
Ensembl chr 1:202,895,751...202,903,458 		JBrowse link
G Lag3 lymphocyte activating 3 acts_upstream_of_or_within ISO (MGI:2429474|PMID:12421911) RGD PMID:12421911 MGI:2429474 NCBI chr 4:157,712,665...157,722,229
Ensembl chr 4:157,712,667...157,720,404 		JBrowse link
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (MGI:3803048|PMID:18619870) RGD PMID:18619870 MGI:3803048 NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807 		JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:18420485) RGD PMID:18420485 NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660 		JBrowse link
G Mir181c microRNA 181c acts_upstream_of ISO (PMID:21112091) RGD PMID:21112091 NCBI chr19:23,983,523...23,983,628
Ensembl chr19:23,983,523...23,983,628 		JBrowse link
G Nav3 neuron navigator 3 involved_in ISO (PMID:16166283) RGD PMID:16166283 NCBI chr 7:45,052,206...45,840,471
Ensembl chr 7:45,054,296...45,840,698 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 acts_upstream_of_or_within ISO MGI:3529594 (MGI:3839525|PMID:19139201) RGD PMID:19139201 MGI:3839525 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 involved_in ISO
IEA		 (MGI:5707586|PMID:18972444)
GO_REF:0000107		 RGD
Ensembl		 PMID:18972444 GO_REF:0000107 MGI:5707586 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Prnp prion protein involved_in ISO (MGI:4943618|PMID:20145049) RGD PMID:20145049 MGI:4943618 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C involved_in ISO UniProtKB:P06240 (MGI:3530407|PMID:15661907) RGD PMID:15661907 MGI:3530407 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Sftpd surfactant protein D IDA RGD PMID:9794387 RGD:4144057 NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:5543347|PMID:23616576) RGD PMID:23616576 MGI:5543347 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 involved_in ISO (PMID:18223652) RGD PMID:18223652 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Trim27 tripartite motif-containing 27 involved_in ISO (PMID:22128329) RGD PMID:22128329 NCBI chr17:43,538,282...43,550,633
Ensembl chr17:43,538,285...43,550,643 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:3689239|PMID:17016562)		 RGD PMID:17016562 PMID:21873635 MGI:3689239, RGD:13792537 NCBI chr  X:61,144,926...61,170,212
Ensembl chr  X:61,144,928...61,170,212 		JBrowse link
G Xcl1 X-C motif chemokine ligand 1 involved_in ISO (PMID:10887101) RGD PMID:10887101 NCBI chr13:77,248,865...77,252,308
Ensembl chr13:77,248,717...77,252,329 		JBrowse link
G Zfp36 zinc finger protein 36 involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:5795825|PMID:15634918)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:15634918 GO_REF:0000024 GO_REF:0000107 MGI:5795825 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564 		JBrowse link
positive regulation of interleukin-2 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:87860 (MGI:4399009|PMID:18025176) RGD PMID:18025176 MGI:4399009 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:87859 (MGI:4399009|PMID:18025176) RGD PMID:18025176 MGI:4399009 NCBI chr13:68,673,702...68,839,742
Ensembl chr13:68,673,722...68,839,742 		JBrowse link
G Anxa1 annexin A1 involved_in ISS
ISO
IBA		 GO_REF:0000024
(PMID:17008549)
PMID:21873635		 UniProt
RGD		 PMID:17008549 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Btnl2 butyrophilin-like 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:3775536|PMID:16751379)		 Ensembl
RGD		 PMID:16751379 GO_REF:0000107 MGI:3775536 NCBI chr20:4,490,904...4,502,557
Ensembl chr20:4,489,517...4,503,341 		JBrowse link
G Card11 caspase recruitment domain family, member 11 involved_in
acts_upstream_of_or_within		 ISO (PMID:12154360)
MGI:3039682 (MGI:3039643|PMID:12867038)		 RGD PMID:12154360 PMID:12867038 MGI:3039643 NCBI chr12:13,620,979...13,758,115
Ensembl chr12:13,621,087...13,758,112 		JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 acts_upstream_of_or_within ISO MGI:4462559|MGI:5547539 (MGI:5544842|PMID:24097820) RGD PMID:24097820 MGI:5544842 NCBI chr19:33,571,255...33,586,783
Ensembl chr19:33,574,257...33,586,965 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3699670|PMID:14662900)		 BHF-UCL
RGD		 PMID:14662900 GO_REF:0000024 MGI:3699670 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Cd1d1 CD1d1 molecule acts_upstream_of_or_within ISO (MGI:2180705|PMID:10201995), (MGI:2679144|PMID:14557411), (MGI:3041278|PMID:11754812), (MGI:72888|PMID:7538697) RGD PMID:7538697 PMID:10201995 PMID:11754812 PMID:14557411 MGI:2180705 MGI:2679144 MGI:3041278 MGI:72888 NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089 		JBrowse link
G Cd276 Cd276 molecule acts_upstream_of_or_within ISO (MGI:3775536|PMID:16751379) RGD PMID:16751379 MGI:3775536 NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380 		JBrowse link
G Cd28 Cd28 molecule involved_in
acts_upstream_of_or_within		 ISO
ISS		 (PMID:3875683)
MGI:1857150 (MGI:62368|PMID:7688139)
GO_REF:0000024		 RGD
UniProt		 PMID:3875683 PMID:7688139 GO_REF:0000024 MGI:62368 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685 		JBrowse link
G Cd3e CD3 epsilon subunit of T-cell receptor complex acts_upstream_of_or_within ISO (MGI:3822044|PMID:12874832) RGD PMID:12874832 MGI:3822044 NCBI chr 8:45,303,848...45,315,297
Ensembl chr 8:45,303,852...45,315,022 		JBrowse link
G Cd83 CD83 molecule acts_upstream_of_or_within ISO MGI:3055293 (MGI:3054335|PMID:15322158) RGD PMID:15322158 MGI:3054335 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083 		JBrowse link
G Clec7a C-type lectin domain containing 7A involved_in ISO (PMID:19358895) RGD PMID:19358895 NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897 		JBrowse link
G Defb25 defensin beta 25 involved_in ISO (PMID:24955228) RGD PMID:24955228 NCBI chr 3:141,098,856...141,099,696
Ensembl chr 3:141,098,856...141,099,696 		JBrowse link
G Glmn glomulin, FKBP associated protein involved_in
acts_upstream_of_or_within		 ISO (PMID:12604780) RGD PMID:12604780 NCBI chr14:2,187,144...2,231,295
Ensembl chr14:2,187,642...2,230,420 		JBrowse link
G Il1a interleukin 1 alpha involved_in
acts_upstream_of_or_within		 ISO
IEA
IMP		 (PMID:2989698)
GO_REF:0000107
(MGI:5468848|PMID:23395675)
PMID:31172560		 RGD
Ensembl		 PMID:2989698 PMID:23395675 PMID:31172560 GO_REF:0000107 MGI:5468848, RGD:15023467 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta involved_in ISO (PMID:2989698) RGD PMID:2989698 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Irf4 interferon regulatory factor 4 involved_in ISO (PMID:12374808) RGD PMID:12374808 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070 		JBrowse link
G Malt1 MALT1 paracaspase involved_in ISO (PMID:15125833) RGD PMID:15125833 NCBI chr18:58,942,282...58,996,318
Ensembl chr18:58,942,299...58,994,260 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 involved_in ISO (PMID:15125833) RGD PMID:15125833 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Pde4b phosphodiesterase 4B involved_in ISO (PMID:17404263) RGD PMID:17404263 NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696 		JBrowse link
G Pde4d phosphodiesterase 4D involved_in ISO (PMID:17404263) RGD PMID:17404263 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884 		JBrowse link
G Plcg2 phospholipase C, gamma 2 involved_in ISO
IEA		 (MGI:3844414|PMID:19136564)
GO_REF:0000107		 RGD
Ensembl		 PMID:19136564 GO_REF:0000107 MGI:3844414 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930 		JBrowse link
G Pnp purine nucleoside phosphorylase involved_in ISO (PMID:16930574) RGD PMID:16930574 NCBI chr15:24,170,456...24,178,274
Ensembl chr15:24,170,602...24,203,986 		JBrowse link
G Prkcq protein kinase C, theta involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2664379 (MGI:3039643|PMID:12867038)		 Ensembl
RGD		 PMID:12867038 GO_REF:0000107 MGI:3039643 NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704 		JBrowse link
G Prkd2 protein kinase D2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4849903|PMID:20819079)		 UniProt
RGD		 PMID:20819079 GO_REF:0000024 MGI:4849903 NCBI chr 1:77,513,625...77,542,386
Ensembl chr 1:77,513,986...77,542,376 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C involved_in ISO UniProtKB:P05480 (MGI:3530407|PMID:15661907) RGD PMID:15661907 MGI:3530407 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within ISO MGI:2660793 (MGI:2176422|PMID:11894098) RGD PMID:11894098 MGI:2176422 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G Rps3 ribosomal protein S3 involved_in ISO (PMID:18045535) RGD PMID:18045535 NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680 		JBrowse link
G Runx1 RUNX family transcription factor 1 involved_in ISO
IEA		 (PMID:17377532)
(MGI:3710039|PMID:17377532)
GO_REF:0000107		 RGD
Ensembl		 PMID:17377532 GO_REF:0000107 MGI:3710039 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542 		JBrowse link
G Sash3 SAM and SH3 domain containing 3 acts_upstream_of_or_within ISO MGI:3716944 (MGI:3607020|PMID:16227612) RGD PMID:16227612 MGI:3607020 NCBI chr  X:127,326,815...127,341,521
Ensembl chr  X:127,326,859...127,341,519 		JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 involved_in ISO (PMID:24337748) RGD PMID:24337748 NCBI chr14:103,842,684...104,008,507
Ensembl chr14:103,842,684...104,008,507 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO MGI:103035 (MGI:1332382|PMID:10072077) RGD PMID:10072077 MGI:1332382 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:103036 (MGI:1332382|PMID:10072077)		 Ensembl
RGD		 PMID:10072077 GO_REF:0000107 MGI:1332382 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Stoml2 stomatin like 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5438519|PMID:23028053)		 UniProt
RGD		 PMID:23028053 GO_REF:0000024 MGI:5438519 NCBI chr 5:57,256,227...57,259,824
Ensembl chr 5:57,256,220...57,259,920 		JBrowse link
G Tnfsf4 TNF superfamily member 4 IDA RGD PMID:9790919 RGD:634509 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 involved_in ISO (PMID:15125833) RGD PMID:15125833 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
G Traf6 TNF receptor associated factor 6 involved_in ISO (PMID:15125833) RGD PMID:15125833 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Vtcn1 V-set domain containing T cell activation inhibitor 1 acts_upstream_of_or_within ISO (MGI:3775536|PMID:16751379) RGD PMID:16751379 MGI:3775536 NCBI chr 2:188,253,594...188,321,658
Ensembl chr 2:188,253,594...188,321,658 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20094
    regulation of biological process 13157
      regulation of multicellular organismal process 3161
        regulation of cytokine production 857
          regulation of interleukin-2 production 69
            negative regulation of interleukin-2 production 29
            positive regulation of interleukin-2 production 39
Path 2
Term Annotations click to browse term
  biological_process 20094
    metabolic process 12347
      organic substance metabolic process 11867
        macromolecule metabolic process 10212
          gene expression 6699
            cytokine production 864
              regulation of cytokine production 857
                regulation of interleukin-2 production 69
                  negative regulation of interleukin-2 production 29
                  positive regulation of interleukin-2 production 39
paths to the root