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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of interleukin-12 production
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Accession:GO:0032655 term browser browse the term
Definition:Any process that modulates the frequency, rate, or extent of interleukin-12 production.
Synonyms:exact_synonym: regulation of IL-12 production
 narrow_synonym: regulation of interleukin-12 biosynthetic process;   regulation of interleukin-12 secretion
 related_synonym: regulation of CLMF production;   regulation of NKSF production
 alt_id: GO:0045075;   GO:2001182


show annotations for term's descendants           Sort by:
regulation of interleukin-12 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd47 Cd47 molecule involved_in ISO (PMID:11509594) RGD PMID:11509594 NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425 		JBrowse link
G Foxp1 forkhead box P1 involved_in ISO (PMID:18799727) RGD PMID:18799727 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258 		JBrowse link
G Mast2 microtubule associated serine/threonine kinase 2 involved_in ISO (MGI:3029081|PMID:14764729)
(PMID:14764729)		 RGD PMID:14764729 MGI:3029081 NCBI chr 5:129,776,293...129,915,502
Ensembl chr 5:129,775,676...129,915,606 		JBrowse link
negative regulation of interleukin-12 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2180086 (PMID:11168643)		 Ensembl
RGD		 PMID:11168643 GO_REF:0000107 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Arrb2 arrestin, beta 2 involved_in ISO
IEA		 (MGI:3662828|PMID:16378096)
GO_REF:0000107
(PMID:16378096)		 RGD
Ensembl		 PMID:16378096 GO_REF:0000107 MGI:3662828 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G C1qbp complement C1q binding protein involved_in ISO
ISS
IEA		 (PMID:16177118), (PMID:17881511)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:16177118 PMID:17881511 GO_REF:0000024 GO_REF:0000107 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 acts_upstream_of ISO (MGI:4441559|PMID:20176793)
(PMID:20176793)		 RGD PMID:20176793 MGI:4441559 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309 		JBrowse link
G Cmklr1 chemerin chemokine-like receptor 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5009414|PMID:15753205)		 UniProt
RGD		 PMID:15753205 GO_REF:0000024 MGI:5009414 NCBI chr12:42,974,462...43,027,321
Ensembl chr12:42,974,410...43,028,129 		JBrowse link
G Il10 interleukin 10 acts_upstream_of_or_within ISO MGI:1857199 (PMID:15240714) RGD PMID:15240714 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 involved_in ISO
IBA		 (PMID:18156187)
(PMID:12150927)
GO_REF:0000033
(MGI:2183694|PMID:12150927)		 RGD
GO_Central		 PMID:12150927 PMID:18156187 GO_REF:0000033 MGI:2183694 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:16020505)
(MGI:3719947|PMID:16020505)		 BHF-UCL
RGD		 PMID:16020505 GO_REF:0000024 MGI:3719947 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Lilra5 leukocyte immunoglobulin like receptor A5 involved_in ISO (PMID:19009525) RGD PMID:19009525 NCBI chr 1:69,973,292...69,978,750
Ensembl chr 1:69,973,292...70,001,718 		JBrowse link
G Mefv MEFV innate immunity regulator, pyrin involved_in ISO (PMID:20041150) RGD PMID:20041150 NCBI chr10:11,786,948...11,796,977
Ensembl chr10:11,787,422...11,796,973 		JBrowse link
G Mir21 microRNA 21 acts_upstream_of
involved_in		 ISO (PMID:30106099)
(PMID:27571873), (PMID:30106099)		 RGD PMID:27571873 PMID:30106099 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:14568984)		 Ensembl
RGD		 PMID:14568984 GO_REF:0000107 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 involved_in ISO (MGI:5437524|PMID:22863753) RGD PMID:22863753 MGI:5437524 NCBI chr10:11,551,378...11,585,027
Ensembl chr10:11,551,356...11,584,398 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 acts_upstream_of_or_within ISO MGI:2680581 (PMID:15220916), (PMID:16949315) RGD PMID:15220916 PMID:16949315 NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177 		JBrowse link
G Pibf1 progesterone immunomodulatory binding factor 1 involved_in ISO (PMID:14634107) RGD PMID:14634107 NCBI chr15:75,850,389...76,019,711
Ensembl chr15:75,850,624...76,019,712 		JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 involved_in ISO (PMID:16317102) RGD PMID:16317102 NCBI chr13:84,270,316...84,305,497
Ensembl chr13:84,270,316...84,305,497 		JBrowse link
G Thbs1 thrombospondin 1 involved_in ISO (PMID:14568985), (PMID:16882710) RGD PMID:14568985 PMID:16882710 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Tigit T cell immunoreceptor with Ig and ITIM domains involved_in ISO
IBA		 (PMID:19011627)
GO_REF:0000033		 RGD
GO_Central		 PMID:19011627 GO_REF:0000033 NCBI chr11:57,029,024...57,046,627
Ensembl chr11:57,029,118...57,045,994 		JBrowse link
G Tlr2 toll-like receptor 2 acts_upstream_of_or_within ISO (PMID:16949315) RGD PMID:16949315 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr8 toll-like receptor 8 involved_in ISO (PMID:24942581) RGD PMID:24942581 NCBI chr  X:27,091,780...27,116,092
Ensembl chr  X:27,091,778...27,116,549 		JBrowse link
positive regulation of interleukin-12 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor involved_in ISO
IEA		 (PMID:15944249)
GO_REF:0000107		 RGD
Ensembl		 PMID:15944249 GO_REF:0000107 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 acts_upstream_of ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 involved_in ISO (MGI:3576832|PMID:15845453)
(PMID:15845453)		 RGD PMID:15845453 MGI:3576832 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309 		JBrowse link
G Cd36 CD36 molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2447190 (PMID:16061696)		 Ensembl
RGD		 PMID:16061696 GO_REF:0000107 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cd40 CD40 molecule acts_upstream_of_or_within ISO (PMID:15240714) RGD PMID:15240714 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd40lg CD40 ligand involved_in IDA
ISO
IEA		 (PMID:9922218)
GO_REF:0000107		 RGD
Ensembl		 PMID:9922218 PMID:18384807 GO_REF:0000107, RGD:2313415 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Clec7a C-type lectin domain containing 7A involved_in ISO (PMID:19358895) RGD PMID:19358895 NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897 		JBrowse link
G Defb25 defensin beta 25 involved_in ISO (PMID:24955228) RGD PMID:24955228 NCBI chr 3:141,098,813...141,099,752
Ensembl chr 3:141,098,856...141,099,696 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 acts_upstream_of_or_within ISO MGI:3628823 (PMID:20457904) RGD PMID:20457904 NCBI chr12:7,623,930...7,699,474
Ensembl chr12:7,623,930...7,699,474 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:15944249) RGD PMID:15944249 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 involved_in ISO (PMID:17164250) RGD PMID:17164250 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3505776 (PMID:19234212)		 Ensembl
RGD		 PMID:19234212 GO_REF:0000107 NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730 		JBrowse link
G Ifng interferon gamma involved_in
acts_upstream_of_or_within		 ISO (PMID:7605994), (PMID:8557999)
(PMID:14568984), (PMID:9348310)		 RGD PMID:7605994 PMID:8557999 PMID:9348310 PMID:14568984 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il12b interleukin 12B involved_in ISO (PMID:20027291) RGD PMID:20027291 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il16 interleukin 16 involved_in ISO (PMID:30634164) RGD PMID:30634164 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130 		JBrowse link
G Il17a interleukin 17A acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:29734196)
GO_REF:0000107		 RGD
Ensembl		 PMID:29734196 GO_REF:0000107 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO (PMID:20027291) RGD PMID:20027291 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il23r interleukin 23 receptor involved_in ISO (PMID:20027291) RGD PMID:20027291 NCBI chr 4:96,580,568...96,672,540
Ensembl chr 4:96,580,714...96,674,021 		JBrowse link
G Irf1 interferon regulatory factor 1 acts_upstream_of_or_within ISO MGI:1857205 (PMID:14568984) RGD PMID:14568984 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Irf8 interferon regulatory factor 8 acts_upstream_of_or_within ISO MGI:1926332 (PMID:9348310) RGD PMID:9348310 NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829 		JBrowse link
G Isl1 ISL LIM homeobox 1 involved_in ISO
IEA		 (MGI:5437583|PMID:22727192)
GO_REF:0000107
(PMID:22727192)		 RGD
Ensembl		 PMID:22727192 GO_REF:0000107 MGI:5437583 NCBI chr 2:48,079,412...48,090,704
Ensembl chr 2:48,080,522...48,095,584 		JBrowse link
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (MGI:6391873|PMID:22733818)
(PMID:22733818)		 RGD PMID:22733818 MGI:6391873 NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807 		JBrowse link
G Lep leptin involved_in ISS
ISO		 GO_REF:0000024
(MGI:3690675|PMID:9438411)
(PMID:9438411)		 UniProt
RGD		 PMID:9438411 GO_REF:0000024 MGI:3690675 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:16116184), (PMID:25754930) RGD PMID:16116184 PMID:25754930 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G Ltb lymphotoxin beta involved_in ISO (MGI:3773766|PMID:17982081)
(PMID:17982081)		 RGD PMID:17982081 MGI:3773766 NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 involved_in ISO (PMID:25754930) RGD PMID:25754930 NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 involved_in ISO
IEA		 (PMID:25754930)
GO_REF:0000107		 RGD
Ensembl		 PMID:25754930 GO_REF:0000107 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mdk midkine involved_in ISO
ISS
IEA		 (PMID:22323540)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:22323540 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 acts_upstream_of_or_within ISO MGI:2680581|MGI:3529594 (PMID:14560001), (PMID:15220916), (PMID:15692051) RGD PMID:14560001 PMID:15220916 PMID:15692051 NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177 		JBrowse link
G Plcb1 phospholipase C beta 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:4943671|PMID:9444325)		 BHF-UCL
Ensembl
RGD		 PMID:9444325 GO_REF:0000024 GO_REF:0000107 MGI:4943671 NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869 		JBrowse link
G Plcg2 phospholipase C, gamma 2 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5300086|PMID:22041900)		 Ensembl
RGD		 PMID:22041900 GO_REF:0000107 MGI:5300086 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930 		JBrowse link
G Rel REL proto-oncogene, NF-kB subunit acts_upstream_of_or_within ISO (PMID:14568984) RGD PMID:14568984 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit acts_upstream_of_or_within ISO (PMID:14568984) RGD PMID:14568984 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 involved_in ISO (PMID:20702625) RGD PMID:20702625 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G Scimp SLP adaptor and CSK interacting membrane protein involved_in ISO (MGI:5913054|PMID:28098138) RGD PMID:28098138 MGI:5913054 NCBI chr10:55,507,646...55,527,764
Ensembl chr10:55,507,519...55,528,171 		JBrowse link
G Syk spleen associated tyrosine kinase involved_in ISO
IEA		 (PMID:19358895)
GO_REF:0000107		 RGD
Ensembl		 PMID:19358895 GO_REF:0000107 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
G Tirap TIR domain containing adaptor protein involved_in ISO (MGI:3531416|PMID:12447442)
(PMID:12447442)		 RGD PMID:12447442 MGI:3531416 NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432 		JBrowse link
G Tlr2 toll-like receptor 2 involved_in ISO (MGI:4456948|PMID:15356140) RGD PMID:15356140 MGI:4456948 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr3 toll-like receptor 3 involved_in ISO (MGI:4456948|PMID:15356140)
(PMID:15356140)		 RGD PMID:15356140 MGI:4456948 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545 		JBrowse link
G Tlr4 toll-like receptor 4 involved_in IEA
ISO		 GO_REF:0000107
(PMID:15027902)
(MGI:4456948|PMID:15356140), (MGI:5913054|PMID:28098138)		 Ensembl
RGD		 PMID:15027902 PMID:15356140 PMID:28098138 GO_REF:0000107 MGI:4456948 MGI:5913054 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr9 toll-like receptor 9 involved_in ISO (MGI:4456948|PMID:15356140)
(PMID:15356140)		 RGD PMID:15356140 MGI:4456948 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Tnfsf18 TNF superfamily member 18 NOT|involved_in ISO (MGI:5551556|PMID:24107315) RGD PMID:24107315 MGI:5551556 NCBI chr13:73,833,478...73,907,249
Ensembl chr13:73,831,252...73,843,169 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4835591|PMID:20844189) RGD PMID:20844189 MGI:4835591 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
G Tnfsf9 TNF superfamily member 9 IDA RGD PMID:18687212 RGD:2317345 NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345 		JBrowse link
G Traf6 TNF receptor associated factor 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2678775 (PMID:14499111)		 Ensembl
RGD		 PMID:14499111 GO_REF:0000107 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Unc93b1 unc-93 homolog B1, TLR signaling regulator acts_upstream_of_or_within ISO MGI:3619211 (PMID:20457904) RGD PMID:20457904 NCBI chr 1:201,167,388...201,178,343
Ensembl chr 1:201,152,693...201,178,338 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20134
    multicellular organismal process 8877
      cytokine production 916
        regulation of cytokine production 909
          regulation of interleukin-12 production 66
            negative regulation of interleukin-12 production 20
            positive regulation of interleukin-12 production 46
Path 2
Term Annotations click to browse term
  biological_process 20134
    biological regulation 13566
      regulation of biological process 13139
        regulation of cellular process 12763
          regulation of metabolic process 6825
            regulation of cellular metabolic process 5473
              regulation of cellular biosynthetic process 5389
                regulation of macromolecule biosynthetic process 5288
                  regulation of gene expression 5169
                    regulation of cytokine production 909
                      regulation of interleukin-12 production 66
                        negative regulation of interleukin-12 production 20
                        positive regulation of interleukin-12 production 46
paths to the root