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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of interleukin-12 production
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Accession:GO:0032655 term browser browse the term
Definition:Any process that modulates the frequency, rate, or extent of interleukin-12 production.
Synonyms:exact_synonym: regulation of IL-12 production
 narrow_synonym: regulation of interleukin-12 biosynthetic process;   regulation of interleukin-12 secretion
 related_synonym: regulation of CLMF production;   regulation of NKSF production
 alt_id: GO:0045075;   GO:2001182



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regulation of interleukin-12 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd47 Cd47 molecule involved_in ISO (PMID:11509594) RGD PMID:11509594 NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
JBrowse link
G Foxp1 forkhead box P1 involved_in ISO (PMID:18799727) RGD PMID:18799727 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258
JBrowse link
G Mast2 microtubule associated serine/threonine kinase 2 involved_in ISO (MGI:3029081|PMID:14764729) RGD PMID:14764729 MGI:3029081 NCBI chr 5:129,776,293...129,915,502
Ensembl chr 5:129,775,676...129,915,606
JBrowse link
G RT1-A1 RT1 class Ia, locus A1 involved_in ISO (PMID:20008523) RGD PMID:20008523 NCBI chr20:4,905,309...4,914,593 JBrowse link
negative regulation of interleukin-12 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant acts_upstream_of_or_within ISO MGI:2180086 (MGI:1930064|PMID:11168643) RGD PMID:11168643 MGI:1930064 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Arrb2 arrestin, beta 2 involved_in ISO (MGI:3662828|PMID:16378096) RGD PMID:16378096 MGI:3662828 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G C1qbp complement C1q binding protein involved_in ISO
ISS
(PMID:16177118), (PMID:17881511)
GO_REF:0000024
RGD
UniProt
PMID:16177118 PMID:17881511 GO_REF:0000024 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 acts_upstream_of ISO (MGI:4441559|PMID:20176793) RGD PMID:20176793 MGI:4441559 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
JBrowse link
G Cmklr1 chemerin chemokine-like receptor 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5009414|PMID:15753205)
UniProt
RGD
PMID:15753205 GO_REF:0000024 MGI:5009414 NCBI chr12:42,974,462...43,027,321
Ensembl chr12:42,974,410...43,028,129
JBrowse link
G Il10 interleukin 10 acts_upstream_of_or_within ISO MGI:1857199 (MGI:3051177|PMID:15240714) RGD PMID:15240714 MGI:3051177 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 involved_in ISO
IBA
(PMID:18156187)
PMID:21873635
(MGI:2183694|PMID:12150927)
RGD PMID:12150927 PMID:18156187 PMID:21873635 MGI:2183694, RGD:13792537 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121
JBrowse link
G Jak3 Janus kinase 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:3719947|PMID:16020505)
BHF-UCL
RGD
PMID:16020505 GO_REF:0000024 MGI:3719947 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
JBrowse link
G Lilra5 leukocyte immunoglobulin like receptor A5 involved_in ISO (PMID:19009525) RGD PMID:19009525 NCBI chr 1:69,973,292...69,978,750
Ensembl chr 1:69,973,292...70,001,718
JBrowse link
G Mefv MEFV innate immuity regulator, pyrin involved_in ISO (PMID:20041150) RGD PMID:20041150 NCBI chr10:11,786,948...11,796,977
Ensembl chr10:11,787,422...11,796,973
JBrowse link
G Mir21 microRNA 21 acts_upstream_of
involved_in
ISO (PMID:30106099)
(PMID:27571873), (PMID:30106099)
RGD PMID:27571873 PMID:30106099 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 acts_upstream_of_or_within ISO (MGI:2679145|PMID:14568984) RGD PMID:14568984 MGI:2679145 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 involved_in ISO (MGI:5437524|PMID:22863753) RGD PMID:22863753 MGI:5437524 NCBI chr10:11,551,378...11,585,027
Ensembl chr10:11,551,356...11,584,398
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 acts_upstream_of_or_within ISO MGI:2680581 (MGI:3050756|PMID:15220916), (MGI:3686795|PMID:16949315) RGD PMID:15220916 PMID:16949315 MGI:3050756 MGI:3686795 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Pibf1 progesterone immunomodulatory binding factor 1 involved_in ISO (PMID:14634107) RGD PMID:14634107 NCBI chr15:75,850,389...76,019,711
Ensembl chr15:75,850,624...76,019,712
JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 involved_in ISO (PMID:16317102) RGD PMID:16317102 NCBI chr13:84,270,316...84,305,497
Ensembl chr13:84,270,316...84,305,497
JBrowse link
G Thbs1 thrombospondin 1 involved_in ISO (PMID:16882710) RGD PMID:16882710 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Tigit T cell immunoreceptor with Ig and ITIM domains involved_in ISO
IBA
(PMID:19011627)
PMID:21873635
RGD PMID:19011627 PMID:21873635 RGD:13792537 NCBI chr11:57,029,024...57,046,627
Ensembl chr11:57,029,118...57,045,994
JBrowse link
G Tlr2 toll-like receptor 2 acts_upstream_of_or_within ISO (MGI:3686795|PMID:16949315) RGD PMID:16949315 MGI:3686795 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr8 toll-like receptor 8 involved_in ISO (PMID:24942581) RGD PMID:24942581 NCBI chr  X:27,091,780...27,116,092
Ensembl chr  X:27,091,778...27,116,549
JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 acts_upstream_of_or_within ISO (MGI:3807131|PMID:18640726) RGD PMID:18640726 MGI:3807131 NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000
JBrowse link
positive regulation of interleukin-12 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor involved_in ISO (PMID:15944249) RGD PMID:15944249 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in
acts_upstream_of
ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 involved_in ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
JBrowse link
G Cd36 CD36 molecule acts_upstream_of_or_within
involved_in
ISO
IEA
MGI:2447190 (MGI:3587138|PMID:16061696)
GO_REF:0000107
RGD
Ensembl
PMID:16061696 GO_REF:0000107 MGI:3587138 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cd36-ps1 CD36 molecule, pseudogene 1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 4:17,487,837...17,514,900 JBrowse link
G Cd40 CD40 molecule involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:3051177|PMID:15240714)
RGD PMID:15240714 PMID:21873635 MGI:3051177, RGD:13792537 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd40lg CD40 ligand involved_in IDA
ISO
IEA
(PMID:9922218)
GO_REF:0000107
RGD
Ensembl
PMID:9922218 PMID:18384807 GO_REF:0000107, RGD:2313415 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Clec7a C-type lectin domain containing 7A involved_in ISO (PMID:19358895) RGD PMID:19358895 NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897
JBrowse link
G Defb25 defensin beta 25 involved_in ISO (PMID:24955228) RGD PMID:24955228 NCBI chr 3:141,098,856...141,099,696
Ensembl chr 3:141,098,856...141,099,696
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 acts_upstream_of_or_within ISO MGI:3628823 (MGI:4452060|PMID:20457904) RGD PMID:20457904 MGI:4452060 NCBI chr12:7,623,658...7,699,474
Ensembl chr12:7,623,930...7,699,474
JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:15944249) RGD PMID:15944249 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 involved_in ISO (PMID:17164250) RGD PMID:17164250 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 acts_upstream_of_or_within ISO MGI:3505776 (MGI:3837074|PMID:19234212) RGD PMID:19234212 MGI:3837074 NCBI chr16:67,430,684...67,442,459
Ensembl chr16:67,430,578...67,442,730
JBrowse link
G Ifng interferon gamma involved_in
acts_upstream_of_or_within
ISO (PMID:7605994), (PMID:8557999)
(MGI:2679145|PMID:14568984), (MGI:3653161|PMID:9348310)
RGD PMID:7605994 PMID:8557999 PMID:9348310 PMID:14568984 MGI:2679145 MGI:3653161 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il12b interleukin 12B involved_in ISO (PMID:20027291) RGD PMID:20027291 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il16 interleukin 16 involved_in ISO (PMID:30634164) RGD PMID:30634164 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130
JBrowse link
G Il17a interleukin 17A acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:29734196)
GO_REF:0000107
RGD
Ensembl
PMID:29734196 GO_REF:0000107 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO (PMID:20027291) RGD PMID:20027291 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il23r interleukin 23 receptor involved_in ISO (PMID:20027291) RGD PMID:20027291 NCBI chr 4:96,580,568...96,672,540
Ensembl chr 4:96,580,714...96,674,021
JBrowse link
G Irf1 interferon regulatory factor 1 acts_upstream_of_or_within ISO MGI:1857205 (MGI:2679145|PMID:14568984) RGD PMID:14568984 MGI:2679145 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Irf8 interferon regulatory factor 8 acts_upstream_of_or_within ISO MGI:1926332 (MGI:3653161|PMID:9348310) RGD PMID:9348310 MGI:3653161 NCBI chr19:48,790,483...48,812,363
Ensembl chr19:48,790,588...48,811,829
JBrowse link
G Isl1 ISL LIM homeobox 1 involved_in ISO (MGI:5437583|PMID:22727192) RGD PMID:22727192 MGI:5437583 NCBI chr 2:48,079,412...48,090,704
Ensembl chr 2:48,080,522...48,095,584
JBrowse link
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (MGI:6391873|PMID:22733818) RGD PMID:22733818 MGI:6391873 NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807
JBrowse link
G Lep leptin involved_in ISS
ISO
GO_REF:0000024
(MGI:3690675|PMID:9438411)
UniProt
RGD
PMID:9438411 GO_REF:0000024 MGI:3690675 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:16116184), (PMID:25754930) RGD PMID:16116184 PMID:25754930 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Ltb lymphotoxin beta involved_in ISO (MGI:3773766|PMID:17982081) RGD PMID:17982081 MGI:3773766 NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381
JBrowse link
G Mapk11 mitogen-activated protein kinase 11 involved_in ISO (PMID:25754930) RGD PMID:25754930 NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395
JBrowse link
G Mapk14 mitogen activated protein kinase 14 involved_in ISO
IEA
(PMID:25754930)
GO_REF:0000107
RGD
Ensembl
PMID:25754930 GO_REF:0000107 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mdk midkine involved_in ISO
ISS
(PMID:22323540)
GO_REF:0000024
RGD
UniProt
PMID:22323540 GO_REF:0000024 NCBI chr 3:77,901,156...77,903,997
Ensembl chr 3:77,901,158...77,903,130
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 acts_upstream_of_or_within ISO MGI:2680581|MGI:3529594 (MGI:2679172|PMID:14560001), (MGI:3050756|PMID:15220916), (MGI:3528786|PMID:15692051) RGD PMID:14560001 PMID:15220916 PMID:15692051 MGI:2679172 MGI:3050756 MGI:3528786 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Plcb1 phospholipase C beta 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:4943671|PMID:9444325)
BHF-UCL
Ensembl
RGD
PMID:9444325 GO_REF:0000024 GO_REF:0000107 MGI:4943671 NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
G Plcg2 phospholipase C, gamma 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:5300086|PMID:22041900)
Ensembl
RGD
PMID:22041900 GO_REF:0000107 MGI:5300086 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit acts_upstream_of_or_within ISO (MGI:2679145|PMID:14568984) RGD PMID:14568984 MGI:2679145 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit acts_upstream_of_or_within ISO (MGI:2679145|PMID:14568984) RGD PMID:14568984 MGI:2679145 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G RGD1565355 similar to fatty acid translocase/CD36 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 4:17,424,749...17,465,808
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 involved_in ISO (PMID:20702625) RGD PMID:20702625 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
JBrowse link
G Scimp SLP adaptor and CSK interacting membrane protein involved_in ISO (MGI:5913054|PMID:28098138) RGD PMID:28098138 MGI:5913054 NCBI chr10:55,507,593...55,528,288
Ensembl chr10:55,507,519...55,528,171
JBrowse link
G Syk spleen associated tyrosine kinase involved_in ISO
IEA
(PMID:19358895)
GO_REF:0000107
RGD
Ensembl
PMID:19358895 GO_REF:0000107 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
JBrowse link
G Tirap TIR domain containing adaptor protein involved_in ISO (MGI:3531416|PMID:12447442) RGD PMID:12447442 MGI:3531416 NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432
JBrowse link
G Tlr2 toll-like receptor 2 involved_in ISO (MGI:4456948|PMID:15356140) RGD PMID:15356140 MGI:4456948 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr3 toll-like receptor 3 involved_in ISO (MGI:4456948|PMID:15356140) RGD PMID:15356140 MGI:4456948 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
JBrowse link
G Tlr4 toll-like receptor 4 involved_in IEA
ISO
GO_REF:0000107
(PMID:15027902)
(MGI:4456948|PMID:15356140), (MGI:5913054|PMID:28098138)
Ensembl
RGD
PMID:15027902 PMID:15356140 PMID:28098138 GO_REF:0000107 MGI:4456948 MGI:5913054 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr9 toll-like receptor 9 involved_in ISO (MGI:4456948|PMID:15356140) RGD PMID:15356140 MGI:4456948 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
JBrowse link
G Tnfsf18 TNF superfamily member 18 NOT|involved_in ISO (MGI:5551556|PMID:24107315) RGD PMID:24107315 MGI:5551556 NCBI chr13:73,833,478...73,907,249
Ensembl chr13:73,831,252...73,843,169
JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4835591|PMID:20844189) RGD PMID:20844189 MGI:4835591 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788
JBrowse link
G Tnfsf9 TNF superfamily member 9 IDA RGD PMID:18687212 RGD:2317345 NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345
JBrowse link
G Traf6 TNF receptor associated factor 6 acts_upstream_of_or_within ISO MGI:2678775 (MGI:2677080|PMID:14499111) RGD PMID:14499111 MGI:2677080 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
G Unc93b1 unc-93 homolog B1, TLR signaling regulator acts_upstream_of_or_within ISO MGI:3619211 (MGI:4452060|PMID:20457904) RGD PMID:20457904 MGI:4452060 NCBI chr 1:201,167,388...201,178,343
Ensembl chr 1:201,152,693...201,178,338
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20094
    regulation of biological process 13157
      regulation of multicellular organismal process 3161
        regulation of cytokine production 857
          regulation of interleukin-12 production 70
            negative regulation of interleukin-12 production 21
            positive regulation of interleukin-12 production 48
Path 2
Term Annotations click to browse term
  biological_process 20094
    metabolic process 12347
      organic substance metabolic process 11867
        macromolecule metabolic process 10212
          gene expression 6699
            cytokine production 864
              regulation of cytokine production 857
                regulation of interleukin-12 production 70
                  negative regulation of interleukin-12 production 21
                  positive regulation of interleukin-12 production 48
paths to the root