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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of interleukin-10 production
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Accession:GO:0032653 term browser browse the term
Definition:Any process that modulates the frequency, rate, or extent of interleukin-10 production.
Synonyms:exact_synonym: regulation of IL-10 production
 narrow_synonym: regulation of interleukin-10 biosynthetic process;   regulation of interleukin-10 secretion
 alt_id: GO:0045074;   GO:2001179



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regulation of interleukin-10 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd47 Cd47 molecule involved_in ISO (PMID:11509594) RGD PMID:11509594 NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 involved_in ISO (PMID:20543955) RGD PMID:20543955 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
negative regulation of interleukin-10 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor involved_in ISO (PMID:22473704) RGD PMID:22473704 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Btk Bruton tyrosine kinase IMP RGD PMID:28352114 RGD:151665126 NCBI chr  X:97,722,796...97,762,315
Ensembl chr  X:97,722,802...97,761,853
JBrowse link
G Cd274 CD274 molecule involved_in ISO (PMID:12538684), (PMID:24187568) RGD PMID:12538684 PMID:24187568 NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450
JBrowse link
G Cd84 CD84 molecule involved_in ISO (MGI:5700297|PMID:20628063) RGD PMID:20628063 MGI:5700297 NCBI chr13:84,327,580...84,367,153
Ensembl chr13:84,327,553...84,362,076
JBrowse link
G Dll1 delta like canonical Notch ligand 1 involved_in ISO
IEA
(PMID:23086448)
GO_REF:0000107
RGD
Ensembl
PMID:23086448 GO_REF:0000107 NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179
JBrowse link
G Epx eosinophil peroxidase acts_upstream_of_or_within ISO MGI:2182952 (MGI:3656344|PMID:16926417) RGD PMID:16926417 MGI:3656344 NCBI chr10:72,666,865...72,677,952
Ensembl chr10:72,666,865...72,677,952
JBrowse link
G Fcgr2b Fc gamma receptor 2B acts_upstream_of_or_within ISO MGI:1857166 (MGI:3608295|PMID:12385742) RGD PMID:12385742 MGI:3608295 NCBI chr13:83,191,253...83,207,776
Ensembl chr13:83,193,163...83,207,778
JBrowse link
G Foxp3 forkhead box P3 involved_in
acts_upstream_of_or_within
ISO (PMID:15466453)
MGI:3696705 (MGI:3695768|PMID:16275384)
RGD PMID:15466453 PMID:16275384 MGI:3695768 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 acts_upstream_of_or_within ISO MGI:3505776 (MGI:3837074|PMID:19234212) RGD PMID:19234212 MGI:3837074 NCBI chr16:67,430,684...67,442,459
Ensembl chr16:67,430,578...67,442,730
JBrowse link
G Il12b interleukin 12B involved_in ISO (PMID:16751425) RGD PMID:16751425 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO (PMID:16751425) RGD PMID:16751425 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il23r interleukin 23 receptor involved_in ISO (PMID:16751425) RGD PMID:16751425 NCBI chr 4:96,580,568...96,672,540
Ensembl chr 4:96,580,714...96,674,021
JBrowse link
G Jak3 Janus kinase 3 involved_in ISO
ISS
(MGI:3719947|PMID:16020505)
GO_REF:0000024
RGD
BHF-UCL
PMID:16020505 GO_REF:0000024 MGI:3719947 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:18420485) RGD PMID:18420485 NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660
JBrowse link
G Mir106a microRNA 106a acts_upstream_of
involved_in
ISO (PMID:19307576) RGD PMID:19307576 NCBI chr  X:132,422,584...132,422,661
Ensembl chr  X:132,422,584...132,422,661
JBrowse link
G Mir194-1 microRNA 194-1 involved_in
acts_upstream_of
ISO (PMID:26147452) RGD PMID:26147452 NCBI chr13:96,851,166...96,851,248
Ensembl chr13:96,851,166...96,851,248
JBrowse link
G Mir194-2 microRNA 194-2 acts_upstream_of
involved_in
ISO (PMID:26147452) RGD PMID:26147452 NCBI chr 1:203,564,761...203,564,845
Ensembl chr 1:203,564,761...203,564,845
JBrowse link
G Mir98 microRNA 98 acts_upstream_of_or_within
involved_in
ISO (MGI:5013871|PMID:21609717)
(PMID:29702181)
(PMID:29702181), (PMID:31886314)
RGD PMID:21609717 PMID:29702181 PMID:31886314 MGI:5013871 NCBI chr  X:20,981,235...20,981,342
Ensembl chr  X:20,981,235...20,981,342
JBrowse link
G Mirlet7c1 microRNA let-7c-1 acts_upstream_of
involved_in
ISO (PMID:22835429) RGD PMID:22835429 NCBI chr11:16,201,163...16,201,256
Ensembl chr11:16,201,158...16,201,265
JBrowse link
G Mmp8 matrix metallopeptidase 8 involved_in IEA
ISO
GO_REF:0000107
(MGI:6201889|PMID:25049354)
Ensembl
RGD
PMID:25049354 GO_REF:0000107 MGI:6201889 NCBI chr 8:4,724,009...4,732,956
Ensembl chr 8:4,724,029...4,733,520
JBrowse link
G Pdcd1lg2 programmed cell death 1 ligand 2 involved_in ISO (PMID:12538684) RGD PMID:12538684 NCBI chr 1:227,158,941...227,223,938
Ensembl chr 1:227,158,941...227,223,938
JBrowse link
G Prg2 proteoglycan 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3027719 (MGI:3656344|PMID:16926417)
Ensembl
RGD
PMID:16926417 GO_REF:0000107 MGI:3656344 NCBI chr 3:70,062,535...70,066,102
Ensembl chr 3:70,062,535...70,066,101
JBrowse link
G Tnfrsf21 TNF receptor superfamily member 21 involved_in ISS
ISO
GO_REF:0000024
(MGI:2137821|PMID:11485735)
UniProt
RGD
PMID:11485735 GO_REF:0000024 MGI:2137821 NCBI chr 9:17,879,156...17,954,085
Ensembl chr 9:17,879,156...17,954,085
JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 acts_upstream_of_or_within ISO (MGI:3807131|PMID:18640726) RGD PMID:18640726 MGI:3807131 NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000
JBrowse link
G Trib2 tribbles pseudokinase 2 involved_in ISO (PMID:18643775) RGD PMID:18643775 NCBI chr 6:38,545,971...38,570,349
Ensembl chr 6:38,545,975...38,569,370
JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp involved_in ISO (MGI:5638298|PMID:25690660) RGD PMID:25690660 MGI:5638298 NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848
JBrowse link
G Vsir V-set immunoregulatory receptor involved_in ISO (PMID:24691993) RGD PMID:24691993 NCBI chr20:28,281,582...28,307,262
Ensembl chr20:28,281,596...28,303,878
JBrowse link
positive regulation of interleukin-10 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl3 BCL3, transcription coactivator acts_upstream_of_or_within ISO (MGI:3522403|PMID:15465827) RGD PMID:15465827 MGI:3522403 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
JBrowse link
G Cd274 CD274 molecule involved_in ISO (PMID:10581077) RGD PMID:10581077 NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450
JBrowse link
G Cd28 Cd28 molecule involved_in ISS
ISO
GO_REF:0000024
(PMID:8617933)
UniProt
RGD
PMID:8617933 GO_REF:0000024 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
JBrowse link
G Cd34 CD34 molecule involved_in ISS
ISO
GO_REF:0000024
(PMID:17505307)
UniProt
RGD
PMID:17505307 GO_REF:0000024 NCBI chr13:106,480,074...106,499,462
Ensembl chr13:106,480,043...106,499,832
JBrowse link
G Cd40lg CD40 ligand involved_in IDA
ISO
IEA
(PMID:8617933)
GO_REF:0000107
RGD
Ensembl
PMID:8617933 PMID:18262271 GO_REF:0000107, RGD:2313421 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Cd46 CD46 molecule involved_in ISO (PMID:12540904), (PMID:23086448) RGD PMID:12540904 PMID:23086448 NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445
JBrowse link
G Cd83 CD83 molecule acts_upstream_of_or_within ISO MGI:3055293 (MGI:3054335|PMID:15322158) RGD PMID:15322158 MGI:3054335 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
JBrowse link
G Clec7a C-type lectin domain containing 7A involved_in ISO (PMID:19358895) RGD PMID:19358895 NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897
JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO
ISS
(PMID:18453611)
GO_REF:0000024
RGD
UniProt
PMID:18453611 GO_REF:0000024 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
JBrowse link
G Fcer1g Fc epsilon receptor Ig acts_upstream_of_or_within ISO MGI:2384004 (MGI:2664488|PMID:11911824) RGD PMID:11911824 MGI:2664488 NCBI chr13:83,649,447...83,654,215
Ensembl chr13:83,649,449...83,671,443
JBrowse link
G Hgf hepatocyte growth factor acts_upstream_of_or_within ISO (MGI:4849876|PMID:21072211) RGD PMID:21072211 MGI:4849876 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:22473704) RGD PMID:22473704 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 involved_in ISO (PMID:16148103) RGD PMID:16148103 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Il12b interleukin 12B involved_in ISO (PMID:15265908) RGD PMID:15265908 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il13 interleukin 13 involved_in ISO UniProtKB:P05112 (PMID:30634164) RGD PMID:30634164 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il20rb interleukin 20 receptor subunit beta acts_upstream_of_or_within ISO MGI:3830304 (MGI:3827040|PMID:19124723) RGD PMID:19124723 MGI:3827040 NCBI chr 8:100,979,085...101,010,829
Ensembl chr 8:100,980,383...101,009,942
JBrowse link
G Il21 interleukin 21 acts_upstream_of_or_within ISO (MGI:3028812|PMID:14764669) RGD PMID:14764669 MGI:3028812 NCBI chr 2:120,119,598...120,126,941
Ensembl chr 2:120,119,444...120,126,996
JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO (PMID:15265908) RGD PMID:15265908 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il4 interleukin 4 involved_in IDA
IBA
ISO
PMID:21873635
UniProtKB:P35225 (PMID:30634164)
RGD PMID:30634164 PMID:17125592 PMID:21873635 RGD:2317299, RGD:13792537 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 acts_upstream_of_or_within
involved_in
ISO RNAcentral:URS00004E0808_9606 (PMID:31886314) RGD PMID:31886314 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Inava innate immunity activator involved_in ISO (PMID:28436939) RGD PMID:28436939 NCBI chr13:47,666,446...47,687,383
Ensembl chr13:47,666,447...47,686,729
JBrowse link
G Irf4 interferon regulatory factor 4 involved_in ISO (PMID:12374808) RGD PMID:12374808 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier involved_in ISO (PMID:29100055) RGD PMID:29100055 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:16116184), (PMID:20209097)
(MGI:5688819|PMID:25065622)
RGD PMID:16116184 PMID:20209097 PMID:25065622 MGI:5688819 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Lilra5 leukocyte immunoglobulin like receptor A5 involved_in ISO (PMID:19009525) RGD PMID:19009525 NCBI chr 1:69,973,292...69,978,750
Ensembl chr 1:69,973,292...70,001,718
JBrowse link
G Mir145 microRNA 145 acts_upstream_of ISO (PMID:30634164) RGD PMID:30634164 NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 involved_in ISO (MGI:4946442|PMID:21156799) RGD PMID:21156799 MGI:4946442 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Pibf1 progesterone immunomodulatory binding factor 1 involved_in ISO (PMID:14634107) RGD PMID:14634107 NCBI chr15:75,850,389...76,019,711
Ensembl chr15:75,850,624...76,019,712
JBrowse link
G Plcg2 phospholipase C, gamma 2 involved_in ISO
IEA
(MGI:3844414|PMID:19136564), (MGI:5300086|PMID:22041900)
GO_REF:0000107
RGD
Ensembl
PMID:19136564 PMID:22041900 GO_REF:0000107 MGI:3844414 MGI:5300086 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
JBrowse link
G Prkcz protein kinase C, zeta involved_in ISS
ISO
GO_REF:0000024
(MGI:3584076|PMID:15987782)
UniProt
RGD
PMID:15987782 GO_REF:0000024 MGI:3584076 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:15560120 RGD:10043380 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (PMID:16982856) RGD PMID:16982856 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Sash3 SAM and SH3 domain containing 3 acts_upstream_of_or_within ISO MGI:3716944 (MGI:3607020|PMID:16227612) RGD PMID:16227612 MGI:3607020 NCBI chr  X:127,326,815...127,341,521
Ensembl chr  X:127,326,859...127,341,519
JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in
acts_upstream_of
ISO RNAcentral:URS00004E0808_9606|UniProtKB:P05231 (PMID:31886314) RGD PMID:31886314 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Syk spleen associated tyrosine kinase involved_in ISO
IEA
(PMID:19358895)
GO_REF:0000107
RGD
Ensembl
PMID:19358895 GO_REF:0000107 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
JBrowse link
G Tigit T cell immunoreceptor with Ig and ITIM domains involved_in ISO
IBA
(PMID:19011627)
PMID:21873635
RGD PMID:19011627 PMID:21873635 RGD:13792537 NCBI chr11:57,029,024...57,046,627
Ensembl chr11:57,029,118...57,045,994
JBrowse link
G Tlr2 toll-like receptor 2 IDA RGD PMID:22653369 RGD:7241093 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:5013871|PMID:21609717)
(MGI:4456948|PMID:15356140)
Ensembl
RGD
PMID:15356140 PMID:21609717 GO_REF:0000107 MGI:4456948 MGI:5013871 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr9 toll-like receptor 9 involved_in ISO (MGI:4456948|PMID:15356140) RGD PMID:15356140 MGI:4456948 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
JBrowse link
G Tnfsf18 TNF superfamily member 18 NOT|involved_in ISO (MGI:5551556|PMID:24107315) RGD PMID:24107315 MGI:5551556 NCBI chr13:73,833,478...73,907,249
Ensembl chr13:73,831,252...73,843,169
JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4835591|PMID:20844189) RGD PMID:20844189 MGI:4835591 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6294162|PMID:28592261) RGD PMID:28592261 MGI:6294162 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
G Tslp thymic stromal lymphopoietin involved_in ISO (PMID:17242164) RGD PMID:17242164 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
JBrowse link
G Tusc2 tumor suppressor 2, mitochondrial calcium regulator acts_upstream_of_or_within ISO MGI:3706236 (MGI:5518492|PMID:24042119) RGD PMID:24042119 MGI:5518492 NCBI chr 8:108,236,838...108,240,056
Ensembl chr 8:108,236,838...108,240,056
JBrowse link
G Xcl1 X-C motif chemokine ligand 1 involved_in ISO (PMID:18832695) RGD PMID:18832695 NCBI chr13:77,248,865...77,252,308
Ensembl chr13:77,248,717...77,252,329
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20099
    regulation of biological process 13160
      regulation of multicellular organismal process 3162
        regulation of cytokine production 857
          regulation of interleukin-10 production 71
            negative regulation of interleukin-10 production 27
            positive regulation of interleukin-10 production 45
Path 2
Term Annotations click to browse term
  biological_process 20099
    metabolic process 12353
      organic substance metabolic process 11873
        macromolecule metabolic process 10218
          gene expression 6704
            cytokine production 864
              regulation of cytokine production 857
                regulation of interleukin-10 production 71
                  negative regulation of interleukin-10 production 27
                  positive regulation of interleukin-10 production 45
paths to the root