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ONTOLOGY REPORT - ANNOTATIONS

Term:interleukin-2 production
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Accession:GO:0032623 term browser browse the term
Definition:The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms:exact_synonym: IL-2 production
 narrow_synonym: interleukin-2 biosynthetic process;   interleukin-2 secretion
 alt_id: GO:0042094;   GO:0070970


show annotations for term's descendants           Sort by:
negative regulation of interleukin-2 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd276 CD276 antigen acts_upstream_of_or_within IDA (PMID:12925852) MGI PMID:12925852 NCBI chr 9:58,431,581...58,463,437
Ensembl chr 9:58,431,581...58,462,720 		JBrowse link
G Cd34 CD34 antigen involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:194,621,239...194,643,587
Ensembl chr 1:194,621,127...194,643,587 		JBrowse link
G Ezr ezrin involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr17:7,005,530...7,050,179
Ensembl chr17:7,005,440...7,050,183 		JBrowse link
G Foxp3 forkhead box P3 involved_in
acts_upstream_of_or_within		 IMP
IDA
ISO		 (MGI:3795336|PMID:18368049)
(PMID:16769892), (PMID:17028180)
(MGI:3710039|PMID:17377532)		 UniProt
MGI		 PMID:16769892 PMID:17028180 PMID:17377532 PMID:18368049 GO_REF:0000119 MGI:3710039 MGI:3795336 MGI:4834177 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G Gata3 GATA binding protein 3 acts_upstream_of_or_within IDA (PMID:18792410) MGI PMID:18792410 NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845 		JBrowse link
G Gbp2b guanylate binding protein 2b involved_in ISO (PMID:24337748) UniProt PMID:24337748 NCBI chr 3:142,300,577...142,324,940
Ensembl chr 3:142,300,608...142,324,940 		JBrowse link
G Gpr174 G protein-coupled receptor 174 involved_in ISO (PMID:29457279) UniProt PMID:29457279 NCBI chr  X:106,299,484...106,340,377
Ensembl chr  X:106,299,484...106,340,375 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in IMP
ISO		 (MGI:2679123|PMID:14556006) UniProt
MGI		 PMID:14556006 GO_REF:0000119 MGI:2679123 MGI:4834177 NCBI chr11:46,345,758...46,372,082
Ensembl chr11:46,345,762...46,372,082 		JBrowse link
G Hdac7 histone deacetylase 7 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr15:97,690,542...97,742,383
Ensembl chr15:97,690,545...97,742,383 		JBrowse link
G Homer2 homer scaffolding protein 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:81,250,229...81,356,673
Ensembl chr 7:81,250,229...81,357,275 		JBrowse link
G Homer3 homer scaffolding protein 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 8:70,735,529...70,747,011
Ensembl chr 8:70,735,477...70,747,011 		JBrowse link
G Il20rb interleukin 20 receptor beta acts_upstream_of_or_within IMP (PMID:19124723) MGI PMID:19124723 NCBI chr 9:100,339,772...100,368,526
Ensembl chr 9:100,339,772...100,368,841 		JBrowse link
G Kat5 K(lysine) acetyltransferase 5 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr19:5,653,042...5,661,584
Ensembl chr19:5,653,042...5,660,265 		JBrowse link
G Lag3 lymphocyte-activation gene 3 acts_upstream_of_or_within IDA (PMID:12421911) MGI PMID:12421911 NCBI chr 6:124,881,322...124,888,668
Ensembl chr 6:124,881,324...124,888,668 		JBrowse link
G Laptm5 lysosomal-associated protein transmembrane 5 involved_in IMP (MGI:3803048|PMID:18619870) ARUK-UCL PMID:18619870 MGI:3803048 NCBI chr 4:130,640,627...130,663,459
Ensembl chr 4:130,640,436...130,663,452 		JBrowse link
G Lilrb4a leukocyte immunoglobulin-like receptor, subfamily B, member 4A involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:51,366,999...51,372,709
Ensembl chr10:51,367,052...51,372,707 		JBrowse link
G Lilrb4b leukocyte immunoglobulin-like receptor, subfamily B, member 4B involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:51,356,757...51,362,417
Ensembl chr10:51,356,728...51,362,799 		JBrowse link
G Mir181c microRNA 181c acts_upstream_of ISO (PMID:21112091) ARUK-UCL PMID:21112091 NCBI chr 8:84,905,502...84,905,590
Ensembl chr 8:84,905,502...84,905,590 		JBrowse link
G Nav3 neuron navigator 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:109,517,121...110,292,148
Ensembl chr10:109,517,120...110,292,065 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 acts_upstream_of_or_within IMP (PMID:19139201) MGI PMID:19139201 NCBI chr 8:89,373,943...89,415,103
Ensembl chr 8:89,373,943...89,415,102 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 involved_in IMP (MGI:5707586|PMID:18972444) UniProt PMID:18972444 MGI:5707586 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
G Prnp prion protein involved_in IMP (MGI:4943618|PMID:20145049) BHF-UCL PMID:20145049 MGI:4943618 NCBI chr 2:131,751,848...131,780,356
Ensembl chr 2:131,751,848...131,780,349 		JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C involved_in IGI (MGI:3530407|PMID:15661907) ARUK-UCL PMID:15661907 MGI:3530407 NCBI chr 1:137,990,601...138,103,491
Ensembl chr 1:137,990,599...138,103,446 		JBrowse link
G Sftpd surfactant associated protein D involved_in ISO RGD
MGI		 PMID:9794387 GO_REF:0000096 MGI:4417868 RGD:4144057 NCBI chr14:40,894,169...40,907,155
Ensembl chr14:40,894,171...40,907,106 		JBrowse link
G Tbx21 T-box 21 involved_in IMP (MGI:5543347|PMID:23616576) UniProt PMID:23616576 MGI:5543347 NCBI chr11:96,988,833...97,006,157
Ensembl chr11:96,988,897...97,006,157 		JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405 		JBrowse link
G Trim27 tripartite motif-containing 27 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:21,363,570...21,378,893
Ensembl chr13:21,363,615...21,378,894 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 involved_in
acts_upstream_of_or_within		 IBA
IDA		 (PMID:17016562) GO_Central
MGI		 PMID:17016562 GO_REF:0000033 NCBI chr  X:95,290,807...95,337,044
Ensembl chr  X:95,290,809...95,337,044 		JBrowse link
G Xcl1 chemokine (C motif) ligand 1 involved_in ISO (PMID:10887101) BHF-UCL PMID:10887101 NCBI chr 1:164,759,216...164,763,094
Ensembl chr 1:164,759,213...164,763,096 		JBrowse link
G Zfp36 zinc finger protein 36 involved_in IMP (MGI:5795825|PMID:15634918) UniProt PMID:15634918 MGI:5795825 NCBI chr 7:28,076,208...28,078,680
Ensembl chr 7:28,076,209...28,079,678 		JBrowse link
positive regulation of interleukin-2 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 c-abl oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within IGI (PMID:18025176) MGI PMID:18025176 NCBI chr 2:31,578,256...31,697,105
Ensembl chr 2:31,578,388...31,694,239 		JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase acts_upstream_of_or_within IGI (PMID:18025176) MGI PMID:18025176 NCBI chr 1:156,386,160...156,477,189
Ensembl chr 1:156,386,356...156,477,138 		JBrowse link
G Anxa1 annexin A1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308 		JBrowse link
G Btnl2 butyrophilin-like 2 acts_upstream_of_or_within IMP (PMID:16751379) MGI PMID:16751379 NCBI chr17:34,573,763...34,588,466
Ensembl chr17:34,573,796...34,588,469 		JBrowse link
G Card11 caspase recruitment domain family, member 11 involved_in
acts_upstream_of_or_within		 ISO
IMP		 (PMID:12867038) MGI PMID:12867038 GO_REF:0000119 MGI:4834177 NCBI chr 5:140,858,109...140,986,398
Ensembl chr 5:140,858,745...140,986,337 		JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 acts_upstream_of_or_within IMP (PMID:24097820) MGI PMID:24097820 NCBI chr 8:106,412,642...106,424,827
Ensembl chr 8:106,412,906...106,424,819 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 involved_in IMP (MGI:3699670|PMID:14662900) BHF-UCL PMID:14662900 MGI:3699670 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594 		JBrowse link
G Cd1d1 CD1d1 antigen acts_upstream_of_or_within IDA (PMID:10201995), (PMID:11754812), (PMID:14557411), (PMID:7538697) MGI PMID:7538697 PMID:10201995 PMID:11754812 PMID:14557411 NCBI chr 3:86,903,141...86,919,665
Ensembl chr 3:86,903,141...86,906,748 		JBrowse link
G Cd1d2 CD1d2 antigen acts_upstream_of_or_within IDA (PMID:10201995) MGI PMID:10201995 NCBI chr 3:86,893,875...86,896,843
Ensembl chr 3:86,893,858...86,897,087 		JBrowse link
G Cd276 CD276 antigen acts_upstream_of_or_within IMP (PMID:16751379) MGI PMID:16751379 NCBI chr 9:58,431,581...58,463,437
Ensembl chr 9:58,431,581...58,462,720 		JBrowse link
G Cd28 CD28 antigen involved_in
acts_upstream_of_or_within		 ISO
IMP		 (PMID:7688139) MGI PMID:7688139 GO_REF:0000119 MGI:4834177 NCBI chr 1:60,785,547...60,812,521
Ensembl chr 1:60,755,959...60,812,518 		JBrowse link
G Cd3e CD3 antigen, epsilon polypeptide acts_upstream_of_or_within IDA (PMID:12874832) MGI PMID:12874832 NCBI chr 9:44,910,033...44,920,961
Ensembl chr 9:44,910,038...44,920,925 		JBrowse link
G Cd83 CD83 antigen acts_upstream_of_or_within IMP (PMID:15322158) MGI PMID:15322158 NCBI chr13:43,938,661...43,956,608
Ensembl chr13:43,938,251...43,956,608 		JBrowse link
G Clec7a C-type lectin domain family 7, member a involved_in IMP
ISO		 (MGI:3844414|PMID:19136564) ARUK-UCL
MGI		 PMID:19136564 GO_REF:0000119 MGI:3844414 MGI:4834177 NCBI chr 6:129,438,554...129,449,748
Ensembl chr 6:129,438,554...129,449,742 		JBrowse link
G Defb25 defensin beta 25 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:152,464,274...152,465,002
Ensembl chr 2:152,464,276...152,464,973 		JBrowse link
G Glmn glomulin, FKBP associated protein involved_in
acts_upstream_of_or_within		 ISO (PMID:12604780) MGI
MGI		 PMID:12604780 GO_REF:0000008 NCBI chr 5:107,696,828...107,745,754
Ensembl chr 5:107,696,833...107,745,754 		JBrowse link
G Il1a interleukin 1 alpha acts_upstream_of
involved_in		 ISO MGI GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Irf4 interferon regulatory factor 4 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:30,933,191...30,950,965
Ensembl chr13:30,933,209...30,950,959 		JBrowse link
G Malt1 MALT1 paracaspase involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr18:65,564,010...65,612,138
Ensembl chr18:65,564,009...65,612,138 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467 		JBrowse link
G Pde4b phosphodiesterase 4B, cAMP specific involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:101,944,529...102,464,459
Ensembl chr 4:101,944,740...102,464,456 		JBrowse link
G Pde4d phosphodiesterase 4D, cAMP specific involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:108,790,711...110,092,503
Ensembl chr13:108,586,482...110,089,995 		JBrowse link
G Plcg2 phospholipase C, gamma 2 involved_in IMP (MGI:3844414|PMID:19136564) ARUK-UCL PMID:19136564 MGI:3844414 NCBI chr 8:118,225,014...118,361,881
Ensembl chr 8:118,225,030...118,361,881 		JBrowse link
G Pnp purine-nucleoside phosphorylase involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr14:51,181,760...51,190,869
Ensembl chr14:51,168,539...51,190,869 		JBrowse link
G Pnp2 purine-nucleoside phosphorylase 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr14:51,193,598...51,202,206
Ensembl chr14:51,193,449...51,202,206 		JBrowse link
G Prkcq protein kinase C, theta acts_upstream_of_or_within IMP (PMID:12867038) MGI PMID:12867038 NCBI chr 2:11,176,922...11,306,033
Ensembl chr 2:11,176,919...11,306,033 		JBrowse link
G Prkd2 protein kinase D2 involved_in IMP (MGI:4849903|PMID:20819079) UniProt PMID:20819079 MGI:4849903 NCBI chr 7:16,576,827...16,604,386
Ensembl chr 7:16,576,827...16,604,389 		JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C involved_in IGI (MGI:3530407|PMID:15661907) ARUK-UCL PMID:15661907 MGI:3530407 NCBI chr 1:137,990,601...138,103,491
Ensembl chr 1:137,990,599...138,103,446 		JBrowse link
G Ripk2 receptor (TNFRSF)-interacting serine-threonine kinase 2 acts_upstream_of_or_within IMP (PMID:11894098) MGI PMID:11894098 NCBI chr 4:16,122,740...16,163,674
Ensembl chr 4:16,122,733...16,163,647 		JBrowse link
G Rps3 ribosomal protein S3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:99,127,103...99,132,916
Ensembl chr 7:99,127,103...99,132,945 		JBrowse link
G Runx1 runt related transcription factor 1 involved_in IMP
ISO		 (MGI:3710039|PMID:17377532) UniProt
MGI		 PMID:17377532 GO_REF:0000119 MGI:3710039 MGI:4834177 NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037 		JBrowse link
G Sash3 SAM and SH3 domain containing 3 acts_upstream_of_or_within IMP (PMID:16227612) MGI PMID:16227612 NCBI chr  X:47,235,313...47,250,442
Ensembl chr  X:47,235,313...47,250,442 		JBrowse link
G Sptbn1 spectrin beta, non-erythrocytic 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:30,049,395...30,218,384
Ensembl chr11:30,049,395...30,218,175 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within IGI (PMID:10072077) MGI PMID:10072077 NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B acts_upstream_of_or_within IGI (PMID:10072077) MGI PMID:10072077 NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550 		JBrowse link
G Stoml2 stomatin (Epb7.2)-like 2 involved_in IMP (MGI:5438519|PMID:23028053) UniProt PMID:23028053 MGI:5438519 NCBI chr 4:43,027,690...43,031,402
Ensembl chr 4:43,027,690...43,031,710 		JBrowse link
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 involved_in ISO RGD
MGI		 PMID:9790919 GO_REF:0000096 MGI:4417868 RGD:634509 NCBI chr 1:161,223,009...161,245,777
Ensembl chr 1:161,222,980...161,245,981 		JBrowse link
G Traf2 TNF receptor-associated factor 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:25,407,994...25,436,952
Ensembl chr 2:25,407,994...25,436,952 		JBrowse link
G Traf6 TNF receptor-associated factor 6 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014 		JBrowse link
G Vtcn1 V-set domain containing T cell activation inhibitor 1 acts_upstream_of_or_within IMP (PMID:16751379) MGI PMID:16751379 NCBI chr 3:100,732,775...100,805,555
Ensembl chr 3:100,732,775...100,804,238 		JBrowse link
regulation of interleukin-2 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Card9 caspase recruitment domain family, member 9 acts_upstream_of_or_within IMP (PMID:16862125) MGI PMID:16862125 NCBI chr 2:26,242,199...26,250,957
Ensembl chr 2:26,242,188...26,250,930 		JBrowse link
G Clec2i C-type lectin domain family 2, member i acts_upstream_of_or_within IMP (PMID:16143319) MGI PMID:16143319 NCBI chr 6:128,864,550...128,875,131
Ensembl chr 6:128,864,551...128,875,130 		JBrowse link
G Il17f interleukin 17F involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:20,847,370...20,855,498
Ensembl chr 1:20,847,370...20,860,841 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    multicellular organismal process 8908
      cytokine production 985
        interleukin-2 production 72
          negative regulation of interleukin-2 production 30
          positive regulation of interleukin-2 production 41
          regulation of interleukin-2 production + 72
Path 2
Term Annotations click to browse term
  biological_process 28573
    metabolic process 11001
      organic substance metabolic process 10573
        macromolecule metabolic process 8853
          macromolecule biosynthetic process 6879
            gene expression 6461
              cytokine production 985
                interleukin-2 production 72
                  negative regulation of interleukin-2 production 30
                  positive regulation of interleukin-2 production 41
                  regulation of interleukin-2 production + 72
paths to the root