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ONTOLOGY REPORT - ANNOTATIONS

Term:interleukin-2 production
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Accession:GO:0032623 term browser browse the term
Definition:The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms:exact_synonym: IL-2 production
 narrow_synonym: interleukin-2 biosynthetic process;   interleukin-2 secretion
 alt_id: GO:0042094;   GO:0070970

show annotations for term's descendants           Sort by:
 
negative regulation of interleukin-2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd276 Cd276 molecule ISO (MGI:2671029|PMID:12925852) RGD PMID:12925852 MGI:2671029 NCBI chr 8:63,312,060...63,350,411
Ensembl chr 8:63,318,019...63,350,269 		JBrowse link
G Cd34 CD34 molecule ISO
ISS		 (PMID:9815891)
GO_REF:0000024		 RGD
UniProt		 PMID:9815891 GO_REF:0000024 NCBI chr13:113,691,842...113,711,259
Ensembl chr13:113,691,932...113,711,647 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 ISO MGI:2448686|MGI:3693674 (MGI:3693042|PMID:17081782) RGD PMID:17081782 MGI:3693042 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345 		JBrowse link
G Ezr ezrin ISO (PMID:17911601) RGD PMID:17911601 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412 		JBrowse link
G Foxp3 forkhead box P3 ISO (PMID:15466453), (PMID:16873067), (PMID:17360565), (PMID:17377532), (PMID:23169781)
(MGI:3693968|PMID:16769892), (MGI:3697020|PMID:17028180), (MGI:3710039|PMID:17377532), (MGI:3795336|PMID:18368049)		 RGD PMID:15466453 PMID:16769892 PMID:16873067 PMID:17028180 PMID:17360565 PMID:17377532 PMID:18368049 PMID:23169781 MGI:3693968 MGI:3697020 MGI:3710039 MGI:3795336 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522 		JBrowse link
G Gata3 GATA binding protein 3 ISO (MGI:3817792|PMID:18792410) RGD PMID:18792410 MGI:3817792 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681 		JBrowse link
G Gbp1 guanylate binding protein 1 ISO (PMID:24337748) RGD PMID:24337748 NCBI chr 2:248,343,334...248,423,402
Ensembl chr 2:248,398,917...248,409,570 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 ISO (PMID:26492563)
(MGI:2679123|PMID:14556006)		 RGD PMID:14556006 PMID:26492563 MGI:2679123 NCBI chr10:31,561,838...31,590,624
Ensembl chr10:31,561,895...31,588,943 		JBrowse link
G Hdac7 histone deacetylase 7 ISO (PMID:17360565) RGD PMID:17360565 NCBI chr 7:139,280,396...139,319,108
Ensembl chr 7:139,281,187...139,318,455 		JBrowse link
G Homer2 homer scaffold protein 2 ISS
ISO		 GO_REF:0000024
(PMID:18218901)		 UniProt
RGD		 PMID:18218901 GO_REF:0000024 NCBI chr 1:143,443,300...143,535,579
Ensembl chr 1:143,443,300...143,535,583 		JBrowse link
G Homer3 homer scaffold protein 3 ISS
ISO		 GO_REF:0000024
(PMID:18218901)		 UniProt
RGD		 PMID:18218901 GO_REF:0000024 NCBI chr16:20,880,447...20,890,968
Ensembl chr16:20,881,518...20,890,949 		JBrowse link
G Il20rb interleukin 20 receptor subunit beta ISO MGI:3830304 (MGI:3827040|PMID:19124723) RGD PMID:19124723 MGI:3827040 NCBI chr 8:108,745,906...108,778,561
Ensembl chr 8:108,747,204...108,777,717 		JBrowse link
G Kat5 lysine acetyltransferase 5 ISO
IEA		 (PMID:17360565)
GO_REF:0000107		 RGD
Ensembl		 PMID:17360565 GO_REF:0000107 NCBI chr 1:220,967,795...220,974,596
Ensembl chr 1:220,967,796...220,974,597 		JBrowse link
G Lag3 lymphocyte activating 3 ISO (MGI:2429474|PMID:12421911) RGD PMID:12421911 MGI:2429474 NCBI chr 4:157,425,644...157,433,700
Ensembl chr 4:157,425,644...157,433,467 		JBrowse link
G Laptm5 lysosomal protein transmembrane 5 ISO (MGI:3803048|PMID:18619870) RGD PMID:18619870 MGI:3803048 NCBI chr 5:149,015,793...149,069,719
Ensembl chr 5:149,047,681...149,069,719 		JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 ISO (PMID:18420485) RGD PMID:18420485 NCBI chr 1:73,393,854...73,399,448
Ensembl chr 1:73,393,850...73,399,579 		JBrowse link
G Nav3 neuron navigator 3 ISO (PMID:16166283) RGD PMID:16166283 NCBI chr 7:52,164,805...52,508,145
Ensembl chr 7:52,165,233...52,404,774 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO MGI:3529594 (MGI:3839525|PMID:19139201) RGD PMID:19139201 MGI:3839525 NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 IEA
ISO		 GO_REF:0000107
(MGI:5707586|PMID:18972444)		 Ensembl
RGD		 PMID:18972444 GO_REF:0000107 MGI:5707586 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056 		JBrowse link
G Prnp prion protein ISO (MGI:4943618|PMID:20145049) RGD PMID:20145049 MGI:4943618 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C ISO UniProtKB:P06240 (MGI:3530407|PMID:15661907) RGD PMID:15661907 MGI:3530407 NCBI chr13:55,061,561...55,174,150
Ensembl chr13:55,061,562...55,173,692 		JBrowse link
G Sftpd surfactant protein D IDA RGD PMID:9794387 RGD:4144057 NCBI chr16:18,753,535...18,766,100
Ensembl chr16:18,745,458...18,766,174 		JBrowse link
G Tbx21 T-box transcription factor 21 ISO (MGI:5543347|PMID:23616576) RGD PMID:23616576 MGI:5543347 NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 ISO (PMID:18223652) RGD PMID:18223652 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807 		JBrowse link
G Trim27 tripartite motif-containing 27 ISO (PMID:22128329) RGD PMID:22128329 NCBI chr17:45,613,863...45,626,212
Ensembl chr17:45,613,864...45,626,212 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 ISO
IBA		 (MGI:3689239|PMID:17016562)
PMID:21873635		 RGD PMID:17016562, PMID:21873635 MGI:3689239, RGD:13792537 NCBI chr  X:65,370,851...65,400,298
Ensembl chr  X:65,370,851...65,400,298 		JBrowse link
G Xcl1 X-C motif chemokine ligand 1 ISO (PMID:10887101) RGD PMID:10887101 NCBI chr13:83,199,402...83,202,845
Ensembl chr13:83,199,264...83,202,864 		JBrowse link
G Zfp36 zinc finger protein 36 ISS
ISO
IEA		 GO_REF:0000024
(MGI:5795825|PMID:15634918)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:15634918 GO_REF:0000024 GO_REF:0000107 MGI:5795825 NCBI chr 1:85,380,088...85,382,565
Ensembl chr 1:85,380,088...85,382,569 		JBrowse link
positive regulation of interleukin-2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase ISO MGI:87860 (MGI:4399009|PMID:18025176) RGD PMID:18025176 MGI:4399009 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388 		JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase ISO MGI:87859 (MGI:4399009|PMID:18025176) RGD PMID:18025176 MGI:4399009 NCBI chr13:74,154,533...74,333,244
Ensembl chr13:74,154,835...74,333,244 		JBrowse link
G Anxa1 annexin A1 ISO
IBA
ISS		 (PMID:17008549)
PMID:21873635
GO_REF:0000024		 RGD
UniProt		 PMID:17008549, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012 		JBrowse link
G Btnl2 butyrophilin-like 2 IEA
ISO		 GO_REF:0000107
(MGI:3775536|PMID:16751379)		 Ensembl
RGD		 PMID:16751379 GO_REF:0000107 MGI:3775536 NCBI chr20:4,140,184...4,156,365
Ensembl chr20:4,141,878...4,154,978 		JBrowse link
G Card11 caspase recruitment domain family, member 11 ISO (PMID:12154360)
MGI:3039682 (MGI:3039643|PMID:12867038)		 RGD PMID:12154360 PMID:12867038 MGI:3039643 NCBI chr12:15,700,600...15,844,512
Ensembl chr12:15,700,825...15,844,512 		JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 ISO MGI:4462559|MGI:5547539 (MGI:5544842|PMID:24097820) RGD PMID:24097820 MGI:5544842 NCBI chr19:37,652,383...37,665,333
Ensembl chr19:37,652,969...37,668,019 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISS
ISO		 GO_REF:0000024
(MGI:3699670|PMID:14662900)		 BHF-UCL
RGD		 PMID:14662900 GO_REF:0000024 MGI:3699670
G Cd1d1 CD1d1 molecule ISO (MGI:2180705|PMID:10201995), (MGI:2679144|PMID:14557411), (MGI:3041278|PMID:11754812), (MGI:72888|PMID:7538697) RGD PMID:7538697 PMID:10201995 PMID:11754812 PMID:14557411 MGI:2180705 MGI:2679144 MGI:3041278 MGI:72888 NCBI chr 2:186,330,298...186,333,805
Ensembl chr 2:186,330,298...186,333,805 		JBrowse link
G Cd276 Cd276 molecule ISO (MGI:3775536|PMID:16751379) RGD PMID:16751379 MGI:3775536 NCBI chr 8:63,312,060...63,350,411
Ensembl chr 8:63,318,019...63,350,269 		JBrowse link
G Cd28 Cd28 molecule ISO
IEA
ISS		 (PMID:3875683)
GO_REF:0000107
MGI:1857150 (MGI:62368|PMID:7688139)
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:3875683 PMID:7688139 GO_REF:0000024 GO_REF:0000107 MGI:62368 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871 		JBrowse link
G Cd3e CD3e molecule ISO (MGI:3822044|PMID:12874832) RGD PMID:12874832 MGI:3822044 NCBI chr 8:49,297,604...49,309,370
Ensembl chr 8:49,297,608...49,308,806 		JBrowse link
G Cd83 CD83 molecule ISO MGI:3055293 (MGI:3054335|PMID:15322158) RGD PMID:15322158 MGI:3054335 NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790 		JBrowse link
G Clec7a C-type lectin domain containing 7A ISO (PMID:19358895) RGD PMID:19358895 NCBI chr 4:163,216,152...163,227,367
Ensembl chr 4:163,216,163...163,227,334 		JBrowse link
G Defb25 defensin beta 25 ISO (PMID:24955228) RGD PMID:24955228 NCBI chr 3:148,103,643...148,104,483
Ensembl chr 3:148,103,643...148,104,483 		JBrowse link
G Glmn glomulin, FKBP associated protein ISO (PMID:12604780) RGD PMID:12604780 NCBI chr14:3,204,390...3,247,703
Ensembl chr14:3,204,390...3,247,695 		JBrowse link
G Il1a interleukin 1 alpha ISO
IEA
IMP		 (PMID:2989698)
(MGI:5468848|PMID:23395675)
GO_REF:0000107
PMID:31172560		 RGD
Ensembl		 PMID:2989698 PMID:23395675, PMID:31172560 GO_REF:0000107 MGI:5468848, RGD:15023467 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il1b interleukin 1 beta ISO
IEA		 (PMID:2989698)
GO_REF:0000107		 RGD
Ensembl		 PMID:2989698 GO_REF:0000107 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Irf4 interferon regulatory factor 4 ISO (PMID:12374808) RGD PMID:12374808 NCBI chr17:34,886,746...34,905,191
Ensembl chr17:34,886,739...34,905,117 		JBrowse link
G Malt1 MALT1 paracaspase ISO (PMID:15125833) RGD PMID:15125833 NCBI chr18:61,108,712...61,162,446
Ensembl chr18:61,109,069...61,162,445 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISO (PMID:15125833) RGD PMID:15125833 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416 		JBrowse link
G Pde4b phosphodiesterase 4B ISO
IEA		 (PMID:17404263)
GO_REF:0000107		 RGD
Ensembl		 PMID:17404263 GO_REF:0000107 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814 		JBrowse link
G Pde4d phosphodiesterase 4D ISO
IEA		 (PMID:17404263)
GO_REF:0000107		 RGD
Ensembl		 PMID:17404263 GO_REF:0000107 NCBI chr 2:40,219,999...41,468,551
Ensembl chr 2:40,554,146...41,464,264 		JBrowse link
G Prkcq protein kinase C, theta IEA
ISO		 GO_REF:0000107
MGI:2664379 (MGI:3039643|PMID:12867038)		 Ensembl
RGD		 PMID:12867038 GO_REF:0000107 MGI:3039643 NCBI chr17:70,971,915...71,105,286
Ensembl chr17:70,971,915...71,105,286 		JBrowse link
G Prkd2 protein kinase D2 ISS
ISO		 GO_REF:0000024
(MGI:4849903|PMID:20819079)		 UniProt
RGD		 PMID:20819079 GO_REF:0000024 MGI:4849903 NCBI chr 1:78,767,911...78,796,223
Ensembl chr 1:78,767,911...78,796,231 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C ISO UniProtKB:P05480 (MGI:3530407|PMID:15661907) RGD PMID:15661907 MGI:3530407 NCBI chr13:55,061,561...55,174,150
Ensembl chr13:55,061,562...55,173,692 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 ISO MGI:2660793 (MGI:2176422|PMID:11894098) RGD PMID:11894098 MGI:2176422 NCBI chr 5:29,838,713...29,870,390
Ensembl chr 5:29,838,747...29,870,735 		JBrowse link
G Rps3 ribosomal protein S3 ISO (PMID:18045535) RGD PMID:18045535 NCBI chr 1:164,435,868...164,441,167
Ensembl chr 1:164,435,878...164,441,167 		JBrowse link
G Runx1 RUNX family transcription factor 1 IEA
ISO		 GO_REF:0000107
(MGI:3710039|PMID:17377532)
(PMID:17377532)		 Ensembl
RGD		 PMID:17377532 GO_REF:0000107 MGI:3710039 NCBI chr11:32,765,147...33,003,061
Ensembl chr11:32,769,165...33,003,021 		JBrowse link
G Sash3 SAM and SH3 domain containing 3 ISO MGI:3716944 (MGI:3607020|PMID:16227612) RGD PMID:16227612 MGI:3607020 NCBI chr  X:134,979,637...134,994,351
Ensembl chr  X:134,979,646...134,994,349 		JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 ISO (PMID:24337748) RGD PMID:24337748 NCBI chr14:114,517,839...114,700,199
Ensembl chr14:114,518,816...114,692,764 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A ISO MGI:103035 (MGI:1332382|PMID:10072077) RGD PMID:10072077 MGI:1332382 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B IEA
ISO		 GO_REF:0000107
MGI:103036 (MGI:1332382|PMID:10072077)		 Ensembl
RGD		 PMID:10072077 GO_REF:0000107 MGI:1332382 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829 		JBrowse link
G Tnfsf4 TNF superfamily member 4 IDA RGD PMID:9790919 RGD:634509 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 ISO (PMID:15125833) RGD PMID:15125833 NCBI chr 3:2,746,061...2,770,690
Ensembl chr 3:2,746,075...2,770,620 		JBrowse link
G Traf6 TNF receptor associated factor 6 ISO (PMID:15125833) RGD PMID:15125833 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607 		JBrowse link
G Vtcn1 V-set domain containing T cell activation inhibitor 1 ISO (MGI:3775536|PMID:16751379) RGD PMID:16751379 MGI:3775536 NCBI chr 2:203,200,435...203,274,264
Ensembl chr 2:203,200,427...203,276,142 		JBrowse link
regulation of interleukin-2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Card9 caspase recruitment domain family, member 9 ISO MGI:3663486 (MGI:3654747|PMID:16862125) RGD PMID:16862125 MGI:3654747 NCBI chr 3:3,798,346...3,806,841
Ensembl chr 3:3,798,347...3,806,713 		JBrowse link
G Il17f interleukin 17F ISO
IEA		 (PMID:11591732)
GO_REF:0000107		 RGD
Ensembl		 PMID:11591732 GO_REF:0000107 NCBI chr 9:26,885,702...26,897,219
Ensembl chr 9:26,885,708...26,897,219 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20044
    multicellular organismal process 9040
      cytokine production 740
        interleukin-2 production 64
          negative regulation of interleukin-2 production 28
          positive regulation of interleukin-2 production 36
          regulation of interleukin-2 production + 64
Path 2
Term Annotations click to browse term
  biological_process 20044
    metabolic process 12101
      organic substance metabolic process 11622
        macromolecule metabolic process 10033
          gene expression 6358
            cytokine production 740
              interleukin-2 production 64
                negative regulation of interleukin-2 production 28
                positive regulation of interleukin-2 production 36
                regulation of interleukin-2 production + 64
paths to the root