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ONTOLOGY REPORT - ANNOTATIONS

Term:interleukin-10 production
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Accession:GO:0032613 term browser browse the term
Definition:The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms:exact_synonym: IL-10 production
 narrow_synonym: interleukin-10 biosynthetic process;   interleukin-10 secretion
 alt_id: GO:0042091;   GO:0072608

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negative regulation of interleukin-10 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor IEA
ISO		 GO_REF:0000107
(PMID:22473704)		 Ensembl
RGD		 PMID:22473704 GO_REF:0000107 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079 		JBrowse link
G Cd274 CD274 molecule ISO (PMID:12538684), (PMID:24187568) RGD PMID:12538684 PMID:24187568 NCBI chr 1:247,519,890...247,539,659
Ensembl chr 1:247,519,939...247,537,943 		JBrowse link
G Cd84 CD84 molecule ISO (MGI:5700297|PMID:20628063) RGD PMID:20628063 MGI:5700297 NCBI chr13:90,241,369...90,283,625
Ensembl chr13:90,244,681...90,277,865 		JBrowse link
G Dll1 delta like canonical Notch ligand 1 IEA
ISO		 GO_REF:0000107
(PMID:23086448)		 Ensembl
RGD		 PMID:23086448 GO_REF:0000107 NCBI chr 1:57,318,621...57,326,732
Ensembl chr 1:57,318,708...57,327,379 		JBrowse link
G Epx eosinophil peroxidase ISO MGI:2182952 (MGI:3656344|PMID:16926417) RGD PMID:16926417 MGI:3656344 NCBI chr10:75,160,690...75,171,774
Ensembl chr10:75,160,690...75,171,774 		JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb ISO MGI:1857166 (MGI:3608295|PMID:12385742) RGD PMID:12385742 MGI:3608295 NCBI chr13:89,329,298...89,343,916
Ensembl chr13:89,327,794...89,433,815 		JBrowse link
G Foxp3 forkhead box P3 ISO (PMID:15466453)
MGI:3696705 (MGI:3695768|PMID:16275384)		 RGD PMID:15466453 PMID:16275384 MGI:3695768 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 IEA
ISO		 GO_REF:0000107
MGI:3505776 (MGI:3837074|PMID:19234212)		 Ensembl
RGD		 PMID:19234212 GO_REF:0000107 MGI:3837074 NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098 		JBrowse link
G Il12b interleukin 12B ISO (PMID:16751425) RGD PMID:16751425 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085 		JBrowse link
G Il23a interleukin 23 subunit alpha ISO (PMID:16751425) RGD PMID:16751425 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723 		JBrowse link
G Il23r interleukin 23 receptor ISO (PMID:16751425) RGD PMID:16751425 NCBI chr 4:98,203,788...98,306,729
Ensembl chr 4:98,203,958...98,305,173 		JBrowse link
G Jak3 Janus kinase 3 ISS
ISO		 GO_REF:0000024
(MGI:3719947|PMID:16020505)		 BHF-UCL
RGD		 PMID:16020505 GO_REF:0000024 MGI:3719947 NCBI chr16:20,107,471...20,120,678
Ensembl chr16:20,109,200...20,120,668 		JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 ISO (PMID:18420485) RGD PMID:18420485 NCBI chr 1:73,393,854...73,399,448
Ensembl chr 1:73,393,850...73,399,579 		JBrowse link
G Mir98 microRNA 98 ISO (MGI:5013871|PMID:21609717) RGD PMID:21609717 MGI:5013871 NCBI chr  X:21,583,875...21,583,982
Ensembl chr  X:21,583,875...21,583,982 		JBrowse link
G Mmp8 matrix metallopeptidase 8 IEA
ISO		 GO_REF:0000107
(MGI:6201889|PMID:25049354)		 Ensembl
RGD		 PMID:25049354 GO_REF:0000107 MGI:6201889 NCBI chr 8:5,768,808...5,777,741
Ensembl chr 8:5,768,811...5,778,702 		JBrowse link
G Pdcd1lg2 programmed cell death 1 ligand 2 ISO (PMID:12538684) RGD PMID:12538684 NCBI chr 1:247,562,202...247,629,279
Ensembl chr 1:247,562,202...247,627,193 		JBrowse link
G Prg2 proteoglycan 2 IEA
ISO		 GO_REF:0000107
MGI:3027719 (MGI:3656344|PMID:16926417)		 Ensembl
RGD		 PMID:16926417 GO_REF:0000107 MGI:3656344 NCBI chr 3:72,385,678...72,389,245
Ensembl chr 3:72,385,666...72,389,276 		JBrowse link
G Tnfrsf21 TNF receptor superfamily member 21 ISS
ISO		 GO_REF:0000024
(MGI:2137821|PMID:11485735)		 UniProt
RGD		 PMID:11485735 GO_REF:0000024 MGI:2137821 NCBI chr 9:20,546,159...20,621,051
Ensembl chr 9:20,546,159...20,621,051 		JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 ISO (MGI:3807131|PMID:18640726) RGD PMID:18640726 MGI:3807131 NCBI chr 5:168,009,245...168,035,813
Ensembl chr 5:168,009,393...168,035,810 		JBrowse link
G Trib2 tribbles pseudokinase 2 ISO (PMID:18643775) RGD PMID:18643775 NCBI chr 6:41,016,722...41,040,972
Ensembl chr 6:41,016,730...41,039,437 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp ISO (MGI:5638298|PMID:25690660) RGD PMID:25690660 MGI:5638298 NCBI chr 1:88,875,370...88,879,305
Ensembl chr 1:88,875,375...88,879,303 		JBrowse link
G Vsir V-set immunoregulatory receptor ISO (PMID:24691993) RGD PMID:24691993 NCBI chr20:29,897,543...29,923,381
Ensembl chr20:29,897,594...29,919,998 		JBrowse link
positive regulation of interleukin-10 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl3 BCL3, transcription coactivator ISO (MGI:3522403|PMID:15465827) RGD PMID:15465827 MGI:3522403 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831 		JBrowse link
G Cd274 CD274 molecule ISO (PMID:10581077) RGD PMID:10581077 NCBI chr 1:247,519,890...247,539,659
Ensembl chr 1:247,519,939...247,537,943 		JBrowse link
G Cd28 Cd28 molecule ISO
IEA
ISS		 (PMID:8617933)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:8617933 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871 		JBrowse link
G Cd34 CD34 molecule ISO
ISS		 (PMID:17505307)
GO_REF:0000024		 RGD
UniProt		 PMID:17505307 GO_REF:0000024 NCBI chr13:113,691,842...113,711,259
Ensembl chr13:113,691,932...113,711,647 		JBrowse link
G Cd40lg CD40 ligand IDA
ISO
IEA		 (PMID:8617933)
GO_REF:0000107		 RGD
Ensembl		 PMID:8617933, PMID:18262271 GO_REF:0000107, RGD:2313421 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562 		JBrowse link
G Cd46 CD46 molecule ISO (PMID:12540904) RGD PMID:12540904 NCBI chr13:113,786,525...113,818,741
Ensembl chr13:113,787,349...113,817,995 		JBrowse link
G Cd83 CD83 molecule ISO MGI:3055293 (MGI:3054335|PMID:15322158) RGD PMID:15322158 MGI:3054335 NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790 		JBrowse link
G Clec7a C-type lectin domain containing 7A ISO (PMID:19358895) RGD PMID:19358895 NCBI chr 4:163,216,152...163,227,367
Ensembl chr 4:163,216,163...163,227,334 		JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig ISO MGI:2384004 (MGI:2664488|PMID:11911824) RGD PMID:11911824 MGI:2664488 NCBI chr13:89,601,894...89,606,326
Ensembl chr13:89,601,896...89,606,326 		JBrowse link
G Hgf hepatocyte growth factor ISO (MGI:4849876|PMID:21072211) RGD PMID:21072211 MGI:4849876 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362 		JBrowse link
G Hmgb1 high mobility group box 1 ISO (PMID:22473704) RGD PMID:22473704 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 ISO (PMID:16148103) RGD PMID:16148103 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956 		JBrowse link
G Il12b interleukin 12B ISO (PMID:15265908) RGD PMID:15265908 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085 		JBrowse link
G Il13 interleukin 13 ISO UniProtKB:P05112 (PMID:30634164) RGD PMID:30634164 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466 		JBrowse link
G Il20rb interleukin 20 receptor subunit beta ISO MGI:3830304 (MGI:3827040|PMID:19124723) RGD PMID:19124723 MGI:3827040 NCBI chr 8:108,745,906...108,778,561
Ensembl chr 8:108,747,204...108,777,717 		JBrowse link
G Il21 interleukin 21 ISO (MGI:3028812|PMID:14764669) RGD PMID:14764669 MGI:3028812 NCBI chr 2:123,965,021...123,972,356
Ensembl chr 2:123,965,021...123,972,356 		JBrowse link
G Il23a interleukin 23 subunit alpha ISO (PMID:15265908) RGD PMID:15265908 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723 		JBrowse link
G Il4 interleukin 4 IDA
IBA
ISO		 PMID:21873635
UniProtKB:P35225 (PMID:30634164)		 RGD PMID:30634164, PMID:17125592, PMID:21873635 RGD:2317299, RGD:13792537 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Il6 interleukin 6 ISO RNAcentral:URS00004E0808_9606 (PMID:31886314) RGD PMID:31886314 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Inava innate immunity activator ISO (PMID:28436939) RGD PMID:28436939 NCBI chr13:53,088,438...53,108,713
Ensembl chr13:53,088,439...53,108,713 		JBrowse link
G Irf4 interferon regulatory factor 4 ISO (PMID:12374808) RGD PMID:12374808 NCBI chr17:34,886,746...34,905,191
Ensembl chr17:34,886,739...34,905,117 		JBrowse link
G Lgals9 galectin 9 ISO (PMID:16116184), (PMID:20209097)
(MGI:5688819|PMID:25065622)		 RGD PMID:16116184 PMID:20209097 PMID:25065622 MGI:5688819 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201 		JBrowse link
G Lilra5 leukocyte immunoglobulin like receptor A5 ISO (PMID:19009525) RGD PMID:19009525 NCBI chr 1:73,655,767...73,682,232
Ensembl chr 1:73,656,028...73,682,247 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO (MGI:4946442|PMID:21156799) RGD PMID:21156799 MGI:4946442 NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492 		JBrowse link
G Pibf1 progesterone immunomodulatory binding factor 1 ISO (PMID:14634107) RGD PMID:14634107 NCBI chr15:83,494,110...83,663,202
Ensembl chr15:83,495,377...83,663,143 		JBrowse link
G Prkcz protein kinase C, zeta ISS
ISO		 GO_REF:0000024
(MGI:3584076|PMID:15987782)		 UniProt
RGD		 PMID:15987782 GO_REF:0000024 MGI:3584076 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421 		JBrowse link
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:15560120 RGD:10043380 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448 		JBrowse link
G Pycard PYD and CARD domain containing ISO (PMID:16982856) RGD PMID:16982856 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210 		JBrowse link
G Sash3 SAM and SH3 domain containing 3 ISO MGI:3716944 (MGI:3607020|PMID:16227612) RGD PMID:16227612 MGI:3607020 NCBI chr  X:134,979,637...134,994,351
Ensembl chr  X:134,979,646...134,994,349 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO RNAcentral:URS00004E0808_9606|UniProtKB:P05231 (PMID:31886314) RGD PMID:31886314 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Syk spleen associated tyrosine kinase ISO
IEA		 (PMID:19358895)
GO_REF:0000107		 RGD
Ensembl		 PMID:19358895 GO_REF:0000107 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573 		JBrowse link
G Tigit T cell immunoreceptor with Ig and ITIM domains ISO
IBA		 (PMID:19011627)
PMID:21873635		 RGD PMID:19011627, PMID:21873635 RGD:13792537 NCBI chr11:61,966,780...61,987,749
Ensembl chr11:61,970,976...61,987,760 		JBrowse link
G Tlr2 toll-like receptor 2 IDA RGD PMID:22653369 RGD:7241093 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061 		JBrowse link
G Tlr4 toll-like receptor 4 IEA
ISO		 GO_REF:0000107
(MGI:4456948|PMID:15356140), (MGI:5013871|PMID:21609717)		 Ensembl
RGD		 PMID:15356140 PMID:21609717 GO_REF:0000107 MGI:4456948 MGI:5013871 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Tlr9 toll-like receptor 9 ISO (MGI:4456948|PMID:15356140) RGD PMID:15356140 MGI:4456948 NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171 		JBrowse link
G Tnfsf4 TNF superfamily member 4 ISO (MGI:4835591|PMID:20844189) RGD PMID:20844189 MGI:4835591 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 ISO (MGI:6294162|PMID:28592261) RGD PMID:28592261 MGI:6294162 NCBI chr 9:14,611,541...14,618,076
Ensembl chr 9:14,611,561...14,618,013 		JBrowse link
G Tslp thymic stromal lymphopoietin ISO (PMID:17242164) RGD PMID:17242164 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361 		JBrowse link
G Tusc2 tumor suppressor 2, mitochondrial calcium regulator ISO MGI:3706236 (MGI:5518492|PMID:24042119) RGD PMID:24042119 MGI:5518492 NCBI chr 8:116,318,963...116,322,181
Ensembl chr 8:116,318,963...116,322,181 		JBrowse link
G Xcl1 X-C motif chemokine ligand 1 ISO (PMID:18832695) RGD PMID:18832695 NCBI chr13:83,199,402...83,202,845
Ensembl chr13:83,199,264...83,202,864 		JBrowse link
regulation of interleukin-10 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd47 Cd47 molecule ISO (PMID:11509594) RGD PMID:11509594 NCBI chr11:53,511,485...53,575,754
Ensembl chr11:53,514,595...53,575,175 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 ISO (PMID:20543955) RGD PMID:20543955 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20045
    multicellular organismal process 9042
      cytokine production 740
        interleukin-10 production 61
          negative regulation of interleukin-10 production 22
          positive regulation of interleukin-10 production 40
          regulation of interleukin-10 production + 61
Path 2
Term Annotations click to browse term
  biological_process 20045
    metabolic process 12102
      organic substance metabolic process 11623
        macromolecule metabolic process 10034
          gene expression 6359
            cytokine production 740
              interleukin-10 production 61
                negative regulation of interleukin-10 production 22
                positive regulation of interleukin-10 production 40
                regulation of interleukin-10 production + 61
paths to the root