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ONTOLOGY REPORT - ANNOTATIONS

Term:interferon-beta production
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Accession:GO:0032608 term browser browse the term
Definition:The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Comment:Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
Synonyms:exact_synonym: IFN-beta production;   IFNB production
 narrow_synonym: interferon-beta biosynthetic process;   interferon-beta secretion
 alt_id: GO:0035546;   GO:0045350


show annotations for term's descendants           Sort by:
negative regulation of interferon-beta production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg9a autophagy related 9A acts_upstream_of_or_within ISO (PMID:24670807) RGD PMID:24670807 NCBI chr 9:76,677,403...76,688,050
Ensembl chr 9:76,677,404...76,687,986 		JBrowse link
G Cactin cactin, spliceosome C complex subunit involved_in ISO (PMID:20829348) RGD PMID:20829348 NCBI chr 7:8,391,396...8,397,219
Ensembl chr 7:8,391,397...8,396,829 		JBrowse link
G Crebbp CREB binding protein involved_in ISO (MGI:2151262|PMID:11583620) RGD PMID:11583620 MGI:2151262 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Mir26b microRNA 26b acts_upstream_of ISO (PMID:26222045) RGD PMID:26222045 NCBI chr 9:75,976,596...75,976,680
Ensembl chr 9:75,976,596...75,976,680 		JBrowse link
G Morc3 MORC family CW-type zinc finger 3 involved_in ISO (PMID:34759314) RGD PMID:34759314 NCBI chr11:33,151,906...33,194,650
Ensembl chr11:33,152,025...33,194,646 		JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 involved_in ISO (MGI:5568884|PMID:24560620) RGD PMID:24560620 MGI:5568884 NCBI chr10:11,551,378...11,585,027
Ensembl chr10:11,551,356...11,584,398 		JBrowse link
G Nlrx1 NLR family member X1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:5141085 (PMID:21703540)		 Ensembl
RGD		 PMID:21703540 GO_REF:0000107 NCBI chr 8:44,588,476...44,606,678
Ensembl chr 8:44,590,048...44,606,484 		JBrowse link
G Nmi N-myc (and STAT) interactor acts_upstream_of_or_within ISO (PMID:23956435) RGD PMID:23956435 NCBI chr 3:36,415,607...36,439,716
Ensembl chr 3:36,415,607...36,439,498 		JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:22750291)		 UniProt
Ensembl
RGD		 PMID:22750291 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:9,646,695...9,707,471
Ensembl chr 6:9,655,765...9,707,974 		JBrowse link
G Ptprs protein tyrosine phosphatase, receptor type, S involved_in ISO
IEA		 (PMID:26231120)
GO_REF:0000107		 RGD
Ensembl		 PMID:26231120 GO_REF:0000107 NCBI chr 9:1,245,408...1,307,015
Ensembl chr 9:1,245,410...1,306,947 		JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (PMID:19158675) RGD PMID:19158675 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rel REL proto-oncogene, NF-kB subunit involved_in ISO (PMID:22065573) RGD PMID:22065573 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit involved_in ISO (PMID:22065573) RGD PMID:22065573 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507 		JBrowse link
G Sirpa signal-regulatory protein alpha involved_in ISO (MGI:3760575|PMID:17954568) RGD PMID:17954568 MGI:3760575 NCBI chr 3:116,819,730...116,858,099
Ensembl chr 3:116,819,726...116,858,098 		JBrowse link
G Traf3ip1 TRAF3 interacting protein 1 acts_upstream_of_or_within ISO (PMID:22079989) RGD PMID:22079989 NCBI chr 9:92,073,622...92,110,427
Ensembl chr 9:92,073,640...92,108,977 		JBrowse link
G Traip TRAF-interacting protein involved_in ISO (MGI:5619447|PMID:22945920) RGD PMID:22945920 MGI:5619447 NCBI chr 8:108,641,860...108,661,640
Ensembl chr 8:108,641,852...108,661,638 		JBrowse link
G Yy1 YY1 transcription factor involved_in ISO (PMID:16260628) RGD PMID:16260628 NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747 		JBrowse link
positive regulation of interferon-beta production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrdc4 arrestin domain containing 4 involved_in ISO (PMID:28594402) RGD PMID:28594402 NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:122,369,360...122,383,290 		JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked involved_in ISO (PMID:27980081), (PMID:31575075) RGD PMID:27980081 PMID:31575075 NCBI chr  X:9,479,532...9,493,169
Ensembl chr  X:9,479,532...9,493,168 		JBrowse link
G Dhx9 DExH-box helicase 9 involved_in ISO (PMID:21957149) RGD PMID:21957149 NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069 		JBrowse link
G Flot1 flotillin 1 involved_in ISO (PMID:25204797) RGD PMID:25204797 NCBI chr20:2,917,864...2,927,993
Ensembl chr20:2,917,137...2,927,978 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (MGI:4367121|PMID:19890330) RGD PMID:19890330 MGI:4367121 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmgb2 high mobility group box 2 involved_in ISO (MGI:4367121|PMID:19890330) RGD PMID:19890330 MGI:4367121 NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 involved_in ISO
ISS		 (PMID:20628368)
GO_REF:0000024		 RGD
UniProt		 PMID:20628368 GO_REF:0000024 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Ifih1 interferon induced with helicase C domain 1 involved_in ISO (PMID:17600090), (PMID:19656871), (PMID:21957149), (PMID:33727702) RGD PMID:17600090 PMID:19656871 PMID:21957149 PMID:33727702 NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456 		JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 involved_in ISO (MGI:5619426|PMID:24598055) RGD PMID:24598055 MGI:5619426 NCBI chr11:30,725,774...30,752,227
Ensembl chr11:30,725,790...30,749,979 		JBrowse link
G Irf1 interferon regulatory factor 1 involved_in ISO
ISS
IEA		 (PMID:21389130)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:21389130 GO_REF:0000024 GO_REF:0000107 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Irf3 interferon regulatory factor 3 involved_in ISO (MGI:4365354|PMID:18562536) RGD PMID:18562536 MGI:4365354 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935 		JBrowse link
G Irf7 interferon regulatory factor 7 involved_in ISO (PMID:22065573) RGD PMID:22065573 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier involved_in ISO (PMID:33727702) RGD PMID:33727702 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435 		JBrowse link
G Mavs mitochondrial antiviral signaling protein involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
(PMID:16127453), (PMID:19609254), (PMID:19631370), (PMID:20628368), (PMID:21957149)
MGI:6430641 (PMID:31390091)		 UniProt
RGD		 PMID:16127453 PMID:19609254 PMID:19631370 PMID:20628368 PMID:21957149 More... GO_REF:0000024 NCBI chr 3:118,451,650...118,466,094
Ensembl chr 3:118,451,743...118,466,094 		JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A involved_in ISO (PMID:30822544) RGD PMID:30822544 NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517 		JBrowse link
G Oas2 2'-5' oligoadenylate synthetase 2 involved_in ISO
IEA		 (PMID:30822544)
GO_REF:0000107		 RGD
Ensembl		 PMID:30822544 GO_REF:0000107 NCBI chr12:35,802,824...35,830,778
Ensembl chr12:35,806,759...35,829,371 		JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 involved_in ISO
IEA		 (PMID:30822544)
GO_REF:0000107		 RGD
Ensembl		 PMID:30822544 GO_REF:0000107 NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781 		JBrowse link
G Polr3a RNA polymerase III subunit A involved_in ISO (PMID:19609254) RGD PMID:19609254 NCBI chr16:49,178...88,178
Ensembl chr16:49,521...88,172 		JBrowse link
G Polr3b RNA polymerase III subunit B involved_in ISO (PMID:19609254) RGD PMID:19609254 NCBI chr 7:19,039,179...19,142,450
Ensembl chr 7:19,038,552...19,142,598 		JBrowse link
G Polr3c RNA polymerase III subunit C involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:19609254)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:19609254 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:184,246,201...184,262,150
Ensembl chr 2:184,246,204...184,262,208 		JBrowse link
G Polr3d RNA polymerase III subunit D involved_in ISO (PMID:19631370) RGD PMID:19631370 NCBI chr15:45,511,587...45,516,256
Ensembl chr15:45,511,589...45,516,353 		JBrowse link
G Polr3f RNA polymerase III subunit F involved_in ISO (PMID:19631370) RGD PMID:19631370 NCBI chr 3:131,908,466...131,924,838
Ensembl chr 3:131,908,466...131,924,837 		JBrowse link
G Polr3g RNA polymerase III subunit G involved_in ISO (PMID:19609254), (PMID:19631370) RGD PMID:19609254 PMID:19631370 NCBI chr 2:11,945,215...11,986,125
Ensembl chr 2:11,945,217...11,986,125 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 involved_in ISO
IEA		 (MGI:3760575|PMID:17954568)
GO_REF:0000107		 RGD
Ensembl		 PMID:17954568 GO_REF:0000107 MGI:3760575 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in ISO (MGI:5562517|PMID:23871208) RGD PMID:23871208 MGI:5562517 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779 		JBrowse link
G Rig1 RNA sensor RIG-1 involved_in ISO (MGI:5318026|PMID:17942531)
(PMID:17079289), (PMID:19609254), (PMID:19631370), (PMID:21957149)		 RGD PMID:17079289 PMID:17942531 PMID:19609254 PMID:19631370 PMID:21957149 MGI:5318026 NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819 		JBrowse link
G Riok3 RIO kinase 3 involved_in ISO (PMID:24807708) RGD PMID:24807708 NCBI chr18:3,327,776...3,353,350
Ensembl chr18:3,327,776...3,353,343 		JBrowse link
G Rnf135 ring finger protein 135 involved_in ISS
ISO		 GO_REF:0000024
(PMID:19017631)		 UniProt
RGD		 PMID:19017631 GO_REF:0000024 NCBI chr10:65,170,560...65,189,791
Ensembl chr10:65,170,560...65,262,804 		JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:19433799), (PMID:21074459), (PMID:25254379)
(MGI:3849536|PMID:19433799), (MGI:4365649|PMID:19776740)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:19433799 PMID:19776740 PMID:21074459 PMID:25254379 GO_REF:0000024 GO_REF:0000107 MGI:3849536 MGI:4365649 NCBI chr18:27,332,119...27,338,371
Ensembl chr18:27,332,119...27,338,335 		JBrowse link
G Tbk1 TANK-binding kinase 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:16127453)
MGI:3046789 (PMID:15661922)		 RGD PMID:15661922 PMID:16127453 NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892 		JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 acts_upstream_of_or_within ISO MGI:2679794|MGI:3029019 (PMID:12855817), (PMID:12872135) RGD PMID:12855817 PMID:12872135 NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147 		JBrowse link
G Tlr2 toll-like receptor 2 involved_in ISO (MGI:4456948|PMID:15356140) RGD PMID:15356140 MGI:4456948 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr3 toll-like receptor 3 involved_in ISO (PMID:12054664), (PMID:16286015)
(MGI:4456948|PMID:15356140)		 RGD PMID:12054664 PMID:15356140 PMID:16286015 MGI:4456948 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545 		JBrowse link
G Tlr4 toll-like receptor 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:4456948|PMID:15356140)
MGI:1860885 (PMID:15661922)		 Ensembl
RGD		 PMID:15356140 PMID:15661922 GO_REF:0000107 MGI:4456948 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr7 toll-like receptor 7 involved_in ISO (PMID:16286015) RGD PMID:16286015 NCBI chr  X:27,027,380...27,054,309
Ensembl chr  X:27,027,425...27,054,754 		JBrowse link
G Tlr8 toll-like receptor 8 involved_in ISO (PMID:16286015) RGD PMID:16286015 NCBI chr  X:27,091,780...27,116,092
Ensembl chr  X:27,091,778...27,116,549 		JBrowse link
G Tlr9 toll-like receptor 9 involved_in ISO (PMID:16286015)
(MGI:4456948|PMID:15356140)		 RGD PMID:15356140 PMID:16286015 MGI:4456948 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Tomm70 translocase of outer mitochondrial membrane 70 involved_in ISO
IEA
ISS		 (PMID:20628368)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:20628368 GO_REF:0000024 GO_REF:0000107 NCBI chr11:43,378,719...43,417,166
Ensembl chr11:43,377,216...43,417,202 		JBrowse link
G Traf3ip3 TRAF3 interacting protein 3 acts_upstream_of_or_within ISO MGI:5795738 (PMID:31390091) RGD PMID:31390091 NCBI chr13:104,694,802...104,719,655
Ensembl chr13:104,694,805...104,719,673 		JBrowse link
G Trim56 tripartite motif containing 56 involved_in ISO (MGI:4849871|PMID:21074459) RGD PMID:21074459 MGI:4849871 NCBI chr12:19,544,913...19,567,324
Ensembl chr12:19,551,521...19,567,462 		JBrowse link
G Trim65 tripartite motif-containing 65 involved_in
acts_upstream_of_or_within		 ISO (PMID:28594402)
MGI:6356825|MGI:6356826|MGI:6356827 (PMID:28031478)		 RGD PMID:28031478 PMID:28594402 NCBI chr10:101,357,937...101,364,036
Ensembl chr10:101,357,937...101,364,971 		JBrowse link
G Zbtb20 zinc finger and BTB domain containing 20 involved_in ISO (MGI:5619432|PMID:23776228) RGD PMID:23776228 MGI:5619432 NCBI chr11:57,052,129...57,791,214
Ensembl chr11:57,072,880...57,510,210 		JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 involved_in ISO (PMID:21102435) RGD PMID:21102435 NCBI chr 4:67,012,129...67,062,428
Ensembl chr 4:67,012,185...67,062,428 		JBrowse link
regulation of interferon-beta production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rnf216 ring finger protein 216 involved_in ISO (PMID:19893624) RGD PMID:19893624 NCBI chr12:11,454,752...11,576,305
Ensembl chr12:11,454,797...11,576,304 		JBrowse link
G Tirap TIR domain containing adaptor protein involved_in ISO (MGI:4942245|PMID:14630816) RGD PMID:14630816 MGI:4942245 NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432 		JBrowse link
G Traf3 Tnf receptor-associated factor 3 involved_in ISO (MGI:4839450|PMID:16306937) RGD PMID:16306937 MGI:4839450 NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481 		JBrowse link
G Trim38 tripartite motif containing 38 acts_upstream_of_or_within ISO (PMID:22539786) RGD PMID:22539786 NCBI chr17:41,351,857...41,365,021 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20292
    multicellular organismal process 8887
      cytokine production 913
        type I interferon production 127
          interferon-beta production 64
            negative regulation of interferon-beta production 17
            positive regulation of interferon-beta production 43
            regulation of interferon-beta production + 64
Path 2
Term Annotations click to browse term
  biological_process 20292
    metabolic process 11720
      organic substance metabolic process 11221
        macromolecule metabolic process 9473
          macromolecule biosynthetic process 7370
            gene expression 6922
              cytokine production 913
                type I interferon production 127
                  interferon-beta production 64
                    negative regulation of interferon-beta production 17
                    positive regulation of interferon-beta production 43
                    regulation of interferon-beta production + 64
paths to the root