Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:DNA duplex unwinding
go back to main search page
Accession:GO:0032508 term browser browse the term
Definition:The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
Comment:Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'.
Synonyms:exact_synonym: DNA unwinding;   duplex DNA melting


show annotations for term's descendants           Sort by:
DNA duplex unwinding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 involved_in ISO
IBA		 (PMID:21873635) RGD
GO_Central		 PMID:20655937 PMID:21873635 RGD:7421590 NCBI chr 1:226,414,200...226,431,963
Ensembl chr 1:226,414,306...226,432,279 		JBrowse link
G ASCC3 activating signal cointegrator 1 complex subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:67,331,939...67,657,080
Ensembl chr 1:67,331,948...67,657,085 		JBrowse link
G BLM BLM RecQ like helicase involved_in IEA GOC
Ensembl		 GO_REF:0000107 GO_REF:0000108 NCBI chr 7:53,317,515...53,412,649
Ensembl chr 7:53,317,540...53,412,645 		JBrowse link
G BRIP1 BRCA1 interacting helicase 1 involved_in IEA GOC GO_REF:0000108 NCBI chr12:36,498,138...36,639,847
Ensembl chr12:36,498,205...36,635,973 		JBrowse link
G CHD1L chromodomain helicase DNA binding protein 1 like involved_in IEA GOC GO_REF:0000108 NCBI chr 4:100,264,963...100,425,728
Ensembl chr 4:100,264,968...100,425,692 		JBrowse link
G CHD8 chromodomain helicase DNA binding protein 8 involved_in IEA GOC GO_REF:0000108 NCBI chr 7:77,719,476...77,780,148
Ensembl chr 7:77,719,582...77,780,146 		JBrowse link
G CHTF18 chromosome transmission fidelity factor 18 involved_in IEA GOC GO_REF:0000108 NCBI chr 3:41,000,688...41,009,588
Ensembl chr 3:41,000,690...41,009,589 		JBrowse link
G DDX1 DEAD-box helicase 1 involved_in ISO (PMID:18710941) UniProt PMID:18710941 NCBI chr 3:121,818,400...121,856,667
Ensembl chr 3:121,818,406...121,856,604 		JBrowse link
G DDX11 DEAD/H-box helicase 11 involved_in IBA
IEA		 (PMID:21873635) GO_Central
GOC		 PMID:21873635 GO_REF:0000108 NCBI chr 5:67,359,399...67,395,739
Ensembl chr 5:67,364,877...67,395,730 		JBrowse link
G DDX3X DEAD-box helicase 3 X-linked involved_in IEA GOC GO_REF:0000108 NCBI chr  X:36,988,031...37,005,496
Ensembl chr  X:36,988,031...37,018,202 		JBrowse link
G DHX36 DEAH-box helicase 36 involved_in IEA GOC GO_REF:0000108 NCBI chr13:94,298,790...94,350,333
Ensembl chr13:94,298,794...94,350,308 		JBrowse link
G DHX9 DExH-box helicase 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:124,141,929...124,183,838
Ensembl chr 9:124,141,967...124,185,349 		JBrowse link
G DNA2 DNA replication helicase/nuclease 2 involved_in IEA GOC GO_REF:0000108 NCBI chr14:71,550,405...71,607,067
Ensembl chr14:71,552,121...71,610,740 		JBrowse link
G DSCC1 DNA replication and sister chromatid cohesion 1 involved_in IEA GOC GO_REF:0000108 NCBI chr 4:19,161,063...19,180,002
Ensembl chr 4:19,161,226...19,178,568 		JBrowse link
G DTD1 D-aminoacyl-tRNA deacylase 1 involved_in ISO (PMID:17264083) DisProt PMID:17264083 NCBI chr17:26,811,139...26,946,651
Ensembl chr17:26,811,173...26,947,435 		JBrowse link
G ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit involved_in IEA GOC GO_REF:0000108 NCBI chr 6:51,734,318...51,757,508
Ensembl chr 6:51,734,320...51,757,553 		JBrowse link
G ERCC3 ERCC excision repair 3, TFIIH core complex helicase subunit involved_in IEA GOC GO_REF:0000108 NCBI chr15:25,189,644...25,224,381
Ensembl chr15:25,189,663...25,228,066 		JBrowse link
G FANCM FA complementation group M involved_in IEA GOC GO_REF:0000108 NCBI chr 1:175,333,965...175,402,065
Ensembl chr 1:175,334,141...175,400,685 		JBrowse link
G FBH1 F-box DNA helicase 1 involved_in IEA GOC GO_REF:0000108 NCBI chr10:65,060,714...65,108,975
Ensembl chr10:65,060,312...65,108,379 		JBrowse link
G G3BP1 G3BP stress granule assembly factor 1 involved_in IEA GOC GO_REF:0000108 NCBI chr16:71,236,025...71,276,111
Ensembl chr16:71,236,339...71,276,078 		JBrowse link
G HELB DNA helicase B involved_in IEA GOC GO_REF:0000108 NCBI chr 5:30,645,378...30,696,488
Ensembl chr 5:30,645,656...30,697,232 		JBrowse link
G HELQ helicase, POLQ like involved_in IEA GOC GO_REF:0000108 NCBI chr 8:135,026,117...135,061,051
Ensembl chr 8:135,026,315...135,061,043 		JBrowse link
G IGHMBP2 immunoglobulin mu DNA binding protein 2 involved_in ISO (PMID:19158098), (PMID:30218034) UniProt PMID:19158098 PMID:30218034 NCBI chr 2:4,169,510...4,194,699
Ensembl chr 2:4,171,344...4,194,525 		JBrowse link
G LOC100512195 activated RNA polymerase II transcriptional coactivator p15 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:17,576,852...17,578,161 JBrowse link
G MCM2 minichromosome maintenance complex component 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr13:72,630,378...72,651,270
Ensembl chr13:72,630,380...72,657,786 		JBrowse link
G MCM3 minichromosome maintenance complex component 3 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr 7:46,084,648...46,104,425
Ensembl chr 7:46,084,662...46,104,375 		JBrowse link
G MCM4 minichromosome maintenance complex component 4 involved_in IEA InterPro GO_REF:0000002 NCBI chr 4:79,674,737...79,686,964
Ensembl chr 4:79,674,739...79,686,685 		JBrowse link
G MCM5 minichromosome maintenance complex component 5 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104
G MCM6 minichromosome maintenance complex component 6 involved_in IEA InterPro GO_REF:0000002 NCBI chr15:15,923,638...15,978,587
Ensembl chr15:15,923,681...15,985,405 		JBrowse link
G MCM7 minichromosome maintenance complex component 7 involved_in IEA InterPro GO_REF:0000002 NCBI chr 3:8,005,890...8,014,047
Ensembl chr 3:8,005,900...8,014,053 		JBrowse link
G MCM8 minichromosome maintenance 8 homologous recombination repair factor involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr17:14,790,398...14,837,420
Ensembl chr17:14,790,396...14,837,416 		JBrowse link
G MCM9 minichromosome maintenance 9 homologous recombination repair factor involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:43,171,906...43,268,533 JBrowse link
G MCMDC2 minichromosome maintenance domain containing 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr 4:67,850,585...67,892,438
Ensembl chr 4:67,847,817...67,895,867 		JBrowse link
G MRE11 MRE11 homolog, double strand break repair nuclease involved_in ISO (PMID:15790808) BHF-UCL PMID:15790808 NCBI chr 9:26,572,352...26,634,596
Ensembl chr 9:26,572,361...26,634,567 		JBrowse link
G NBN nibrin involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:46,787,664...46,854,331
Ensembl chr 4:46,787,691...46,874,603 		JBrowse link
G PIF1 PIF1 5'-to-3' DNA helicase involved_in IEA GOC GO_REF:0000108 NCBI chr 1:107,218,580...107,227,171
Ensembl chr 1:107,218,657...107,227,168 		JBrowse link
G POT1 protection of telomeres 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:22,885,704...22,981,893
Ensembl chr18:22,885,749...22,981,890 		JBrowse link
G RAD50 RAD50 double strand break repair protein involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr 2:134,844,460...134,939,188
Ensembl chr 2:134,700,817...134,939,189 		JBrowse link
G RECQL RecQ like helicase involved_in IEA GOC GO_REF:0000108 NCBI chr 5:51,953,460...51,995,619
Ensembl chr 5:51,953,451...52,003,740 		JBrowse link
G RECQL4 RecQ like helicase 4 involved_in ISO (PMID:19177149) UniProt PMID:19177149 NCBI chr 4:287,206...293,629
Ensembl chr 4:287,214...293,913 		JBrowse link
G RECQL5 RecQ like helicase 5 involved_in IEA GOC GO_REF:0000108 NCBI chr12:5,732,336...5,770,136
Ensembl chr12:5,732,348...5,770,133 		JBrowse link
G RFC2 replication factor C subunit 2 involved_in IEA GOC GO_REF:0000108 NCBI chr 3:11,373,489...11,392,690
Ensembl chr 3:11,373,492...11,392,695 		JBrowse link
G RFC3 replication factor C subunit 3 involved_in IEA GOC GO_REF:0000108 NCBI chr11:10,145,927...10,524,472
Ensembl chr11:10,146,531...10,165,172 		JBrowse link
G RFC4 replication factor C subunit 4 involved_in IEA GOC GO_REF:0000108 NCBI chr13:124,589,292...124,604,421
Ensembl chr13:124,589,295...124,604,426 		JBrowse link
G RTEL1 regulator of telomere elongation helicase 1 involved_in IEA GOC
Ensembl		 GO_REF:0000107 GO_REF:0000108 NCBI chr17:62,611,844...62,636,628
Ensembl chr17:62,611,909...62,634,690 		JBrowse link
G RUVBL1 RuvB like AAA ATPase 1 involved_in IEA GOC GO_REF:0000108 NCBI chr13:72,196,219...72,246,514
Ensembl chr13:72,200,511...72,248,582 		JBrowse link
G RUVBL2 RuvB like AAA ATPase 2 involved_in IEA GOC GO_REF:0000108 NCBI chr 6:54,250,494...54,263,492
Ensembl chr 6:54,250,515...54,266,893 		JBrowse link
G SLC25A16 solute carrier family 25 member 16 involved_in IEA GOC GO_REF:0000108 NCBI chr14:71,612,273...71,651,341
Ensembl chr14:71,610,475...71,651,102 		JBrowse link
G SUB1 SUB1 regulator of transcription involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:18,758,886...18,779,421
Ensembl chr16:18,758,962...18,779,419 		JBrowse link
G SUPV3L1 Suv3 like RNA helicase involved_in ISO (PMID:12466530) UniProt PMID:12466530 NCBI chr14:72,245,526...72,272,948
Ensembl chr14:72,245,600...72,273,688 		JBrowse link
G TMEM169 transmembrane protein 169 involved_in IEA GOC GO_REF:0000108 NCBI chr15:118,335,915...118,352,713
Ensembl chr15:118,346,943...118,352,707 		JBrowse link
G TREX1 three prime repair exonuclease 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5637600|PMID:25848017) MGI
Ensembl		 PMID:25848017 GO_REF:0000107 MGI:5637600 NCBI chr13:31,177,604...31,180,764
Ensembl chr13:31,179,291...31,180,747 		JBrowse link
G TWNK twinkle mtDNA helicase acts_upstream_of_or_within ISO (MGI:2136707|PMID:11431692) GOC PMID:11431692 MGI:2136707 NCBI chr14:112,068,463...112,076,169
Ensembl chr14:112,069,925...112,075,792 		JBrowse link
G UPF1 UPF1 RNA helicase and ATPase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:58,975,013...59,013,546
Ensembl chr 2:58,975,023...59,013,495 		JBrowse link
G WRN WRN RecQ like helicase involved_in IEA Ensembl
GOC		 GO_REF:0000107 GO_REF:0000108 NCBI chr15:53,966,968...54,094,855
Ensembl chr15:53,966,986...54,094,587 		JBrowse link
G WRNIP1 WRN helicase interacting protein 1 involved_in IEA GOC GO_REF:0000108 NCBI chr 7:1,656,952...1,667,885
Ensembl chr 7:1,656,984...1,667,879 		JBrowse link
G XRCC5 X-ray repair cross complementing 5 involved_in IEA GOC GO_REF:0000108 NCBI chr15:118,354,943...118,451,974
Ensembl chr15:118,354,796...118,451,960 		JBrowse link
G XRCC6 X-ray repair cross complementing 6 involved_in IEA GOC GO_REF:0000108 NCBI chr 5:6,903,496...6,929,162
Ensembl chr 5:6,903,495...6,929,052 		JBrowse link
DNA unwinding involved in DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BLM BLM RecQ like helicase involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:53,317,515...53,412,649
Ensembl chr 7:53,317,540...53,412,645 		JBrowse link
G CDC45 cell division cycle 45 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:51,133,111...51,158,604
Ensembl chr14:51,133,408...51,158,606 		JBrowse link
G GINS1 GINS complex subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:31,060,540...31,076,807
Ensembl chr17:31,060,650...31,080,314 		JBrowse link
G GINS2 GINS complex subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:3,218,655...3,252,740
Ensembl chr 6:3,218,702...3,243,899 		JBrowse link
G GINS3 GINS complex subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:20,162,264...20,170,385
Ensembl chr 6:20,162,636...20,170,258 		JBrowse link
G GINS4 GINS complex subunit 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:10,656,869...10,668,664
Ensembl chr17:10,656,884...10,668,664 		JBrowse link
G MCM2 minichromosome maintenance complex component 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2156014|PMID:10531422) MGI
Ensembl		 PMID:10531422 GO_REF:0000107 MGI:2156014 NCBI chr13:72,630,378...72,651,270
Ensembl chr13:72,630,380...72,657,786 		JBrowse link
G MCM3 minichromosome maintenance complex component 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:46,084,648...46,104,425
Ensembl chr 7:46,084,662...46,104,375 		JBrowse link
G MCM4 minichromosome maintenance complex component 4 acts_upstream_of_or_within
involved_in		 ISO
IBA
IEA		 (MGI:3582148|PMID:15917436)
(PMID:21873635)		 MGI
GO_Central
Ensembl		 PMID:15917436 PMID:21873635 GO_REF:0000107 MGI:3582148 NCBI chr 4:79,674,737...79,686,964
Ensembl chr 4:79,674,739...79,686,685 		JBrowse link
G MCM5 minichromosome maintenance complex component 5 involved_in IEA Ensembl GO_REF:0000107
G MCM6 minichromosome maintenance complex component 6 acts_upstream_of_or_within
involved_in		 ISO
IBA
IEA		 (MGI:3582148|PMID:15917436)
(PMID:21873635)		 MGI
GO_Central
Ensembl		 PMID:15917436 PMID:21873635 GO_REF:0000107 MGI:3582148 NCBI chr15:15,923,638...15,978,587
Ensembl chr15:15,923,681...15,985,405 		JBrowse link
G MCM7 minichromosome maintenance complex component 7 acts_upstream_of_or_within
involved_in		 ISO
IBA
IEA		 (MGI:3582148|PMID:15917436)
(PMID:21873635)		 MGI
GO_Central
Ensembl		 PMID:15917436 PMID:21873635 GO_REF:0000107 MGI:3582148 NCBI chr 3:8,005,890...8,014,047
Ensembl chr 3:8,005,900...8,014,053 		JBrowse link
G PURA purine rich element binding protein A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:141,877,775...141,899,259
Ensembl chr 2:141,884,155...141,886,330 		JBrowse link
G RAD51 RAD51 recombinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:130,592,414...130,640,326
Ensembl chr 1:130,586,665...130,640,136 		JBrowse link
G SSBP1 single stranded DNA binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:8,084,292...8,167,983
Ensembl chr18:8,151,029...8,167,983 		JBrowse link
G TWNK twinkle mtDNA helicase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2136707|PMID:11431692) MGI
Ensembl		 PMID:11431692 GO_REF:0000107 MGI:2136707 NCBI chr14:112,068,463...112,076,169
Ensembl chr14:112,069,925...112,075,792 		JBrowse link
G WRN WRN RecQ like helicase involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:53,966,968...54,094,855
Ensembl chr15:53,966,986...54,094,587 		JBrowse link
negative regulation of DNA duplex unwinding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100512195 activated RNA polymerase II transcriptional coactivator p15 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:17,576,852...17,578,161 JBrowse link
G SUB1 SUB1 regulator of transcription involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:18,758,886...18,779,421
Ensembl chr16:18,758,962...18,779,419 		JBrowse link
G TOP2A DNA topoisomerase II alpha involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:22,001,300...22,028,452
Ensembl chr12:22,001,282...22,028,450 		JBrowse link
negative regulation of DNA helicase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MCM2 minichromosome maintenance complex component 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr13:72,630,378...72,651,270
Ensembl chr13:72,630,380...72,657,786 		JBrowse link
G MNAT1 MNAT1 component of CDK activating kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:189,690,343...189,908,144
Ensembl chr 1:189,690,354...189,910,589 		JBrowse link
nucleotide-excision repair, DNA duplex unwinding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERCC3 ERCC excision repair 3, TFIIH core complex helicase subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:25,189,644...25,224,381
Ensembl chr15:25,189,663...25,228,066 		JBrowse link
positive regulation of DNA helicase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POT1 protection of telomeres 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:22,885,704...22,981,893
Ensembl chr18:22,885,749...22,981,890 		JBrowse link
G SSBP1 single stranded DNA binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:8,084,292...8,167,983
Ensembl chr18:8,151,029...8,167,983 		JBrowse link
regulation of DNA helicase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POT1 protection of telomeres 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:22,885,704...22,981,893
Ensembl chr18:22,885,749...22,981,890 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17167
    cellular process 15303
      cellular component organization or biogenesis 6385
        cellular component organization 6191
          organelle organization 3421
            chromosome organization 538
              DNA conformation change 80
                DNA geometric change 73
                  DNA duplex unwinding 68
                    DNA unwinding involved in DNA replication + 17
                    negative regulation of DNA duplex unwinding + 5
                    nucleotide-excision repair, DNA duplex unwinding 1
                    positive regulation of DNA duplex unwinding + 2
                    regulation of DNA duplex unwinding + 7
paths to the root