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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA duplex unwinding
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Accession:GO:0032508 term browser browse the term
Definition:The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
Comment:Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'.
Synonyms:exact_synonym: DNA unwinding;   duplex DNA melting


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DNA duplex unwinding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 ISO RGD PMID:20655937 RGD:7421590 NCBI chr 1:84,744,159...84,763,011
Ensembl chr 1:84,744,163...84,763,011 		JBrowse link
G ASCC3 activating signal cointegrator 1 complex subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:58,590,888...58,932,677
Ensembl chr12:58,592,025...58,932,615 		JBrowse link
G BLM BLM RecQ like helicase involved_in IEA Ensembl
GOC		 GO_REF:0000107 GO_REF:0000108 NCBI chr 3:53,408,120...53,506,728
Ensembl chr 3:53,408,217...53,473,146 		JBrowse link
G BRIP1 BRCA1 interacting helicase 1 involved_in IEA GOC GO_REF:0000108 NCBI chr 9:34,804,285...34,984,640
Ensembl chr 9:34,806,535...34,983,788 		JBrowse link
G CHD1L chromodomain helicase DNA binding protein 1 like involved_in IEA GOC GO_REF:0000108 NCBI chr17:57,725,823...57,806,065
Ensembl chr17:57,725,640...57,806,048 		JBrowse link
G CHD8 chromodomain helicase DNA binding protein 8 involved_in IEA GOC GO_REF:0000108 NCBI chr15:18,430,601...18,492,564
Ensembl chr15:18,431,019...18,491,920 		JBrowse link
G CHTF18 chromosome transmission fidelity factor 18 involved_in IEA GOC GO_REF:0000108 NCBI chr 6:39,806,924...39,815,145
Ensembl chr 6:39,806,673...39,815,333 		JBrowse link
G CRLS1 cardiolipin synthase 1 involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr24:15,814,111...15,837,485
Ensembl chr24:15,814,770...15,893,458 		JBrowse link
G DDX1 DEAD-box helicase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:11,432,060...11,467,000
Ensembl chr17:11,432,136...11,466,990 		JBrowse link
G DDX11 DEAD/H-box helicase 11 involved_in IEA GOC GO_REF:0000108 NCBI chr27:42,067,845...42,102,699
Ensembl chr27:42,067,898...42,105,870 		JBrowse link
G DDX3X DEAD-box helicase 3 X-linked involved_in IEA GOC GO_REF:0000108 NCBI chr  X:35,759,367...35,789,759
Ensembl chr  X:35,759,416...35,789,774 		JBrowse link
G DHX36 DEAH-box helicase 36 involved_in IEA GOC GO_REF:0000108 NCBI chr23:48,404,351...48,456,360
Ensembl chr23:48,407,316...48,456,654 		JBrowse link
G DHX9 DExH-box helicase 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:16,233,763...16,292,576
Ensembl chr 7:16,233,814...16,292,618 		JBrowse link
G DNA2 DNA replication helicase/nuclease 2 involved_in IEA GOC GO_REF:0000108 NCBI chr 4:19,626,001...19,683,819
Ensembl chr 4:19,626,977...19,684,660 		JBrowse link
G DSCC1 DNA replication and sister chromatid cohesion 1 involved_in IEA GOC GO_REF:0000108 NCBI chr13:18,825,522...18,841,905
Ensembl chr13:18,825,844...18,841,873 		JBrowse link
G DTD1 D-aminoacyl-tRNA deacylase 1 involved_in ISO (PMID:17264083) DisProt PMID:17264083 NCBI chr24:4,452,053...4,637,186 JBrowse link
G ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit involved_in IEA GOC GO_REF:0000108 NCBI chr 1:110,173,781...110,191,612
Ensembl chr 1:110,173,715...110,190,125 		JBrowse link
G ERCC3 ERCC excision repair 3, TFIIH core complex helicase subunit involved_in IEA GOC GO_REF:0000108 NCBI chr19:23,310,911...23,344,083
Ensembl chr19:23,310,986...23,337,683 		JBrowse link
G FANCM FA complementation group M involved_in IEA GOC GO_REF:0000108 NCBI chr 8:22,561,862...22,625,077
Ensembl chr 8:22,562,147...22,623,994 		JBrowse link
G FBH1 F-box DNA helicase 1 involved_in IEA GOC GO_REF:0000108 NCBI chr 2:30,047,994...30,095,761
Ensembl chr 2:30,048,567...30,095,696 		JBrowse link
G G3BP1 G3BP stress granule assembly factor 1 involved_in IEA GOC GO_REF:0000108 NCBI chr 4:57,541,627...57,585,375
Ensembl chr 4:57,481,908...57,585,241 		JBrowse link
G HELB DNA helicase B involved_in IEA GOC GO_REF:0000108 NCBI chr10:8,766,023...8,797,055
Ensembl chr10:8,765,617...8,798,092 		JBrowse link
G IGHMBP2 immunoglobulin mu DNA binding protein 2 involved_in ISO (PMID:19158098), (PMID:30218034) UniProt PMID:19158098 PMID:30218034 NCBI chr18:49,063,748...49,090,625
Ensembl chr18:49,064,609...49,091,453 		JBrowse link
G LOC119864252 DNA-binding protein SMUBP-2-like involved_in IEA Ensembl GO_REF:0000107
G MCM2 minichromosome maintenance complex component 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr20:1,682,928...1,702,689
Ensembl chr20:1,682,886...1,702,366 		JBrowse link
G MCM3 minichromosome maintenance complex component 3 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr12:19,924,017...19,945,576
Ensembl chr12:19,920,210...19,945,605 		JBrowse link
G MCM4 minichromosome maintenance complex component 4 involved_in IEA InterPro GO_REF:0000002 NCBI chr29:244,634...261,154
Ensembl chr29:244,656...260,991 		JBrowse link
G MCM5 minichromosome maintenance complex component 5 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr10:28,721,421...28,738,457
Ensembl chr10:28,721,660...28,738,390 		JBrowse link
G MCM6 minichromosome maintenance complex component 6 involved_in IEA InterPro GO_REF:0000002 NCBI chr19:38,627,154...38,660,312
Ensembl chr19:38,627,183...38,660,280 		JBrowse link
G MCM7 minichromosome maintenance complex component 7 involved_in IEA InterPro GO_REF:0000002 NCBI chr 6:9,492,654...9,499,846
Ensembl chr 6:9,492,573...9,499,855 		JBrowse link
G MCM8 minichromosome maintenance 8 homologous recombination repair factor involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr24:15,850,602...15,893,452
Ensembl chr24:15,814,770...15,893,458 		JBrowse link
G MCM9 minichromosome maintenance 9 homologous recombination repair factor involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 1:58,746,637...58,862,550
Ensembl chr 1:58,767,159...58,859,282 		JBrowse link
G MCMDC2 minichromosome maintenance domain containing 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr29:16,424,088...16,462,094
Ensembl chr29:16,426,318...16,460,599 		JBrowse link
G MRE11 MRE11 homolog, double strand break repair nuclease involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:6,448,909...6,528,185
Ensembl chr21:6,449,822...6,527,119 		JBrowse link
G NAV2 neuron navigator 2 involved_in IEA GOC GO_REF:0000108 NCBI chr21:41,458,280...42,181,227
Ensembl chr21:41,458,984...42,177,813 		JBrowse link
G NBN nibrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr29:35,416,093...35,477,569
Ensembl chr29:35,416,093...35,477,563 		JBrowse link
G PIF1 PIF1 5'-to-3' DNA helicase involved_in IEA GOC GO_REF:0000108 NCBI chr30:29,223,507...29,232,584
Ensembl chr30:29,157,119...29,232,043 		JBrowse link
G POLQ DNA polymerase theta involved_in IEA GOC GO_REF:0000108 NCBI chr33:24,713,174...24,837,113
Ensembl chr33:24,714,086...24,837,402 		JBrowse link
G POT1 protection of telomeres 1 involved_in ISO (PMID:16030011) BHF-UCL PMID:16030011 NCBI chr14:10,987,385...11,067,473
Ensembl chr14:10,987,494...11,066,956 		JBrowse link
G RAD50 RAD50 double strand break repair protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:20,836,863...20,928,930
Ensembl chr11:20,836,879...20,928,819 		JBrowse link
G RBPMS2 RNA binding protein, mRNA processing factor 2 involved_in IEA GOC GO_REF:0000108 NCBI chr30:29,160,879...29,187,231
Ensembl chr30:29,157,119...29,232,043 		JBrowse link
G RECQL4 RecQ like helicase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:37,930,906...37,936,653
Ensembl chr13:37,930,621...37,936,753 		JBrowse link
G RECQL5 RecQ like helicase 5 involved_in IEA GOC GO_REF:0000108 NCBI chr 9:4,902,753...4,940,442
Ensembl chr 9:4,903,477...4,940,436 		JBrowse link
G RFC2 replication factor C subunit 2 involved_in IEA GOC GO_REF:0000108 NCBI chr 6:6,119,203...6,159,293
Ensembl chr 6:6,119,164...6,160,886 		JBrowse link
G RFC3 replication factor C subunit 3 involved_in IEA GOC GO_REF:0000108 NCBI chr25:6,469,865...6,486,935
Ensembl chr25:6,469,867...6,486,849 		JBrowse link
G RFC4 replication factor C subunit 4 involved_in IEA GOC GO_REF:0000108 NCBI chr34:19,361,024...19,377,289
Ensembl chr34:19,361,044...19,377,294 		JBrowse link
G RFC5 replication factor C subunit 5 involved_in IEA GOC GO_REF:0000108 NCBI chr26:14,428,661...14,439,641
Ensembl chr26:14,428,695...14,438,986 		JBrowse link
G RTEL1 regulator of telomere elongation helicase 1 involved_in IEA GOC GO_REF:0000108 NCBI chr24:47,219,977...47,248,791 JBrowse link
G RUVBL1 RuvB like AAA ATPase 1 involved_in IEA GOC GO_REF:0000108 NCBI chr20:2,095,807...2,137,528
Ensembl chr20:2,095,786...2,137,579 		JBrowse link
G RUVBL2 RuvB like AAA ATPase 2 involved_in IEA GOC GO_REF:0000108 NCBI chr 1:107,384,328...107,400,849
Ensembl chr 1:107,384,342...107,400,505 		JBrowse link
G SUB1 SUB1 regulator of transcription involved_in ISO (PMID:16605275) CAFA PMID:16605275 NCBI chr 4:74,931,105...74,951,707
Ensembl chr 4:74,933,620...74,951,573 		JBrowse link
G SUPV3L1 Suv3 like RNA helicase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:20,313,902...20,342,375
Ensembl chr 4:20,313,814...20,340,882 		JBrowse link
G TREX1 three prime repair exonuclease 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5637600|PMID:25848017) MGI
Ensembl		 PMID:25848017 GO_REF:0000107 MGI:5637600 NCBI chr20:40,624,845...40,626,840
Ensembl chr20:40,624,891...40,626,906 		JBrowse link
G TWNK twinkle mtDNA helicase acts_upstream_of_or_within ISO (MGI:2136707|PMID:11431692) GOC PMID:11431692 MGI:2136707 NCBI chr28:13,672,772...13,680,732
Ensembl chr28:13,676,304...13,680,044 		JBrowse link
G UPF1 UPF1 RNA helicase and ATPase involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:44,234,411...44,271,129
Ensembl chr20:44,236,264...44,270,916 		JBrowse link
G WRN WRN RecQ like helicase involved_in IEA GOC
Ensembl		 GO_REF:0000107 GO_REF:0000108 NCBI chr16:33,164,662...33,304,466
Ensembl chr16:33,167,364...33,304,625 		JBrowse link
G XRCC5 X-ray repair cross complementing 5 involved_in IEA GOC GO_REF:0000108 NCBI chr37:23,095,769...23,185,680
Ensembl chr37:23,095,754...23,185,586 		JBrowse link
G XRCC6 X-ray repair cross complementing 6 involved_in IEA GOC GO_REF:0000108 NCBI chr10:23,637,905...23,661,618
Ensembl chr10:23,638,237...23,661,480 		JBrowse link
DNA unwinding involved in DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC45 cell division cycle 45 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:29,707,523...29,738,599
Ensembl chr26:29,707,564...29,739,252 		JBrowse link
G GINS1 GINS complex subunit 1 involved_in ISO (PMID:22474384) ComplexPortal PMID:22474384 NCBI chr23:1,567,723...1,598,910
Ensembl chr23:1,567,825...1,590,464 		JBrowse link
G GINS2 GINS complex subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:66,982,033...66,997,115
Ensembl chr 5:66,982,137...67,000,338 		JBrowse link
G GINS3 GINS complex subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:58,233,425...58,244,429
Ensembl chr 2:58,234,321...58,245,219 		JBrowse link
G GINS4 GINS complex subunit 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:24,055,720...24,068,469
Ensembl chr16:24,056,963...24,069,052 		JBrowse link
G MCM2 minichromosome maintenance complex component 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2156014|PMID:10531422) MGI
Ensembl		 PMID:10531422 GO_REF:0000107 MGI:2156014 NCBI chr20:1,682,928...1,702,689
Ensembl chr20:1,682,886...1,702,366 		JBrowse link
G MCM3 minichromosome maintenance complex component 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:19,924,017...19,945,576
Ensembl chr12:19,920,210...19,945,605 		JBrowse link
G MCM4 minichromosome maintenance complex component 4 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3582148|PMID:15917436) MGI
Ensembl		 PMID:15917436 GO_REF:0000107 MGI:3582148 NCBI chr29:244,634...261,154
Ensembl chr29:244,656...260,991 		JBrowse link
G MCM5 minichromosome maintenance complex component 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:28,721,421...28,738,457
Ensembl chr10:28,721,660...28,738,390 		JBrowse link
G MCM6 minichromosome maintenance complex component 6 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3582148|PMID:15917436) MGI
Ensembl		 PMID:15917436 GO_REF:0000107 MGI:3582148 NCBI chr19:38,627,154...38,660,312
Ensembl chr19:38,627,183...38,660,280 		JBrowse link
G MCM7 minichromosome maintenance complex component 7 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3582148|PMID:15917436) MGI
Ensembl		 PMID:15917436 GO_REF:0000107 MGI:3582148 NCBI chr 6:9,492,654...9,499,846
Ensembl chr 6:9,492,573...9,499,855 		JBrowse link
G PURA purine rich element binding protein A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:35,325,630...35,345,366
Ensembl chr 2:35,330,902...35,332,835 		JBrowse link
G RAD51 RAD51 recombinase involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr30:7,842,540...7,877,128
Ensembl chr30:7,842,540...7,877,606 		JBrowse link
G SSBP1 single stranded DNA binding protein 1 involved_in ISO (PMID:26446790) FlyBase PMID:26446790 NCBI chr16:7,445,351...7,461,513
Ensembl chr16:7,451,444...7,461,464 		JBrowse link
G TWNK twinkle mtDNA helicase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2136707|PMID:11431692) MGI
Ensembl		 PMID:11431692 GO_REF:0000107 MGI:2136707 NCBI chr28:13,672,772...13,680,732
Ensembl chr28:13,676,304...13,680,044 		JBrowse link
negative regulation of DNA duplex unwinding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SUB1 SUB1 regulator of transcription involved_in ISO (PMID:16605275) DisProt PMID:16605275 NCBI chr 4:74,931,105...74,951,707
Ensembl chr 4:74,933,620...74,951,573 		JBrowse link
G TOP2A DNA topoisomerase II alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:22,207,501...22,237,497
Ensembl chr 9:22,207,638...22,237,496 		JBrowse link
negative regulation of DNA helicase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MCM2 minichromosome maintenance complex component 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr20:1,682,928...1,702,689
Ensembl chr20:1,682,886...1,702,366 		JBrowse link
G MNAT1 MNAT1 component of CDK activating kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:35,747,883...35,946,353
Ensembl chr 8:35,756,933...35,946,353 		JBrowse link
nucleotide-excision repair, DNA duplex unwinding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERCC3 ERCC excision repair 3, TFIIH core complex helicase subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:23,310,911...23,344,083
Ensembl chr19:23,310,986...23,337,683 		JBrowse link
positive regulation of DNA helicase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POT1 protection of telomeres 1 involved_in ISO (PMID:19734539) BHF-UCL PMID:19734539 NCBI chr14:10,987,385...11,067,473
Ensembl chr14:10,987,494...11,066,956 		JBrowse link
G SSBP1 single stranded DNA binding protein 1 involved_in ISO (PMID:15167897) FlyBase PMID:15167897 NCBI chr16:7,445,351...7,461,513
Ensembl chr16:7,451,444...7,461,464 		JBrowse link
regulation of DNA helicase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POT1 protection of telomeres 1 involved_in ISO (PMID:19734539) BHF-UCL PMID:19734539 NCBI chr14:10,987,385...11,067,473
Ensembl chr14:10,987,494...11,066,956 		JBrowse link
Term paths to the root
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  biological_process 16545
    cellular process 14656
      cellular component organization or biogenesis 6123
        cellular component organization 5938
          organelle organization 3215
            chromosome organization 517
              DNA conformation change 80
                DNA geometric change 73
                  DNA duplex unwinding 68
                    DNA unwinding involved in DNA replication + 15
                    negative regulation of DNA duplex unwinding + 4
                    nucleotide-excision repair, DNA duplex unwinding 1
                    positive regulation of DNA duplex unwinding + 2
                    regulation of DNA duplex unwinding + 6
paths to the root