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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA duplex unwinding
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Accession:GO:0032508 term browser browse the term
Definition:The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
Comment:Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'.
Synonyms:exact_synonym: DNA unwinding;   duplex DNA melting

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DNA duplex unwinding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 ISO RGD PMID:20655937 RGD:7421590 NCBI chrNW_004955512:5,686,508...5,703,645 JBrowse link
G Ascc3 activating signal cointegrator 1 complex subunit 3 involved_in ISO (PMID:22055184) UniProt PMID:22055184 NCBI chrNW_004955411:26,305,103...26,599,375
Ensembl chrNW_004955411:26,302,597...26,598,824 		JBrowse link
G Blm BLM RecQ like helicase involved_in ISO (PMID:11735402), (PMID:24816114), (PMID:25901030) BHF-UCL PMID:11735402 PMID:24816114 PMID:25901030 NCBI chrNW_004955416:14,814,753...14,899,865
Ensembl chrNW_004955416:14,842,033...14,899,687 		JBrowse link
G Ddx1 DEAD-box helicase 1 involved_in ISO (PMID:18710941) UniProt PMID:18710941 NCBI chrNW_004955487:9,085,950...9,117,599
Ensembl chrNW_004955487:9,085,918...9,119,979 		JBrowse link
G Ddx11 DEAD/H-box helicase 11 involved_in ISO (PMID:10648783), (PMID:18499658), (PMID:26503245) UniProt PMID:10648783 PMID:18499658 PMID:26503245 NCBI chrNW_004955524:1,932,988...1,957,231
Ensembl chrNW_004955524:1,932,729...1,957,231 		JBrowse link
G Dhx9 DExH-box helicase 9 involved_in ISO (PMID:12711669)
(PMID:21561811), (PMID:9111062)		 UniProt PMID:9111062 PMID:12711669 PMID:21561811 NCBI chrNW_004955406:21,697,813...21,743,551
Ensembl chrNW_004955406:21,697,813...21,745,011 		JBrowse link
G Dtd1 D-aminoacyl-tRNA deacylase 1 involved_in ISO (PMID:17264083) DisProt PMID:17264083 NCBI chrNW_004955415:27,089,117...27,195,034
Ensembl chrNW_004955415:27,089,044...27,195,040 		JBrowse link
G Ighmbp2 immunoglobulin mu DNA binding protein 2 involved_in ISO (PMID:19158098), (PMID:30218034) UniProt PMID:19158098 PMID:30218034 NCBI chrNW_004955422:17,017,855...17,047,724
Ensembl chrNW_004955422:17,017,358...17,048,650 		JBrowse link
G Mcm8 minichromosome maintenance 8 homologous recombination repair factor involved_in ISO (PMID:26300262) ComplexPortal PMID:26300262 NCBI chrNW_004955415:16,345,472...16,379,922
Ensembl chrNW_004955415:16,346,253...16,379,021 		JBrowse link
G Mcm9 minichromosome maintenance 9 homologous recombination repair factor involved_in ISO (PMID:26300262) UniProt PMID:26300262 NCBI chrNW_004955436:1,642,337...1,661,362 JBrowse link
G Nbn nibrin involved_in ISO (PMID:15790808) BHF-UCL PMID:15790808 NCBI chrNW_004955417:6,840,916...6,880,479
Ensembl chrNW_004955417:6,839,312...6,880,133 		JBrowse link
G Pot1 protection of telomeres 1 involved_in ISO (PMID:16030011) BHF-UCL PMID:16030011 NCBI chrNW_004955479:6,140,599...6,230,512
Ensembl chrNW_004955479:6,140,501...6,209,031 		JBrowse link
G Rad50 RAD50 double strand break repair protein involved_in ISO (PMID:15790808) BHF-UCL PMID:15790808 NCBI chrNW_004955408:3,953,801...4,035,494
Ensembl chrNW_004955408:3,953,800...4,035,494 		JBrowse link
G Recql4 RecQ like helicase 4 involved_in ISO (PMID:19177149) UniProt PMID:19177149 NCBI chrNW_004955454:3,136,097...3,142,525
Ensembl chrNW_004955454:3,136,216...3,142,422 		JBrowse link
G Rtel1 regulator of telomere elongation helicase 1 involved_in ISO (MGI:5522574|PMID:24115439) BHF-UCL PMID:24115439 MGI:5522574 NCBI chrNW_004955528:531,680...578,003
Ensembl chrNW_004955528:532,385...572,398 		JBrowse link
G Sub1 SUB1 regulator of transcription involved_in ISO (PMID:16605275) CAFA PMID:16605275 NCBI chrNW_004955426:18,380,680...18,394,627
Ensembl chrNW_004955426:18,380,117...18,394,627 		JBrowse link
G Supv3l1 Suv3 like RNA helicase involved_in ISO (PMID:12466530) UniProt PMID:12466530 NCBI chrNW_004955437:21,880,778...21,905,540
Ensembl chrNW_004955437:21,877,666...21,906,362 		JBrowse link
G Trex1 three prime repair exonuclease 1 acts_upstream_of_or_within ISO (MGI:5637600|PMID:25848017) MGI PMID:25848017 MGI:5637600 NCBI chrNW_004955532:533,877...535,767
Ensembl chrNW_004955532:533,877...535,767 		JBrowse link
G Twnk twinkle mtDNA helicase acts_upstream_of_or_within ISO (MGI:2136707|PMID:11431692) GOC PMID:11431692 MGI:2136707 NCBI chrNW_004955485:9,193,838...9,198,697
Ensembl chrNW_004955485:9,191,919...9,198,697 		JBrowse link
G Upf1 UPF1 RNA helicase and ATPase involved_in ISO (PMID:30218034) UniProt PMID:30218034 NCBI chrNW_004955524:2,798,336...2,814,063
Ensembl chrNW_004955524:2,798,336...2,913,176 		JBrowse link
G Wrn WRN RecQ like helicase involved_in ISO (PMID:11735402), (PMID:26420422) BHF-UCL PMID:11735402 PMID:26420422 NCBI chrNW_004955463:7,495,243...7,633,532
Ensembl chrNW_004955463:7,525,100...7,633,596 		JBrowse link
DNA unwinding involved in DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc45 cell division cycle 45 involved_in ISO (PMID:22474384) ComplexPortal PMID:22474384 NCBI chrNW_004955442:18,513,398...18,548,317
Ensembl chrNW_004955442:18,514,731...18,547,805 		JBrowse link
G Gins1 GINS complex subunit 1 involved_in ISO (PMID:22474384) ComplexPortal PMID:22474384 NCBI chrNW_004955415:31,341,021...31,363,069
Ensembl chrNW_004955415:31,341,021...31,367,135 		JBrowse link
G Gins2 GINS complex subunit 2 involved_in ISO (PMID:22474384) ComplexPortal PMID:22474384 NCBI chrNW_004955541:809,079...816,807
Ensembl chrNW_004955541:809,079...816,807 		JBrowse link
G Gins3 GINS complex subunit 3 involved_in ISO (PMID:22474384) ComplexPortal PMID:22474384 NCBI chrNW_004955433:15,843,025...15,864,942
Ensembl chrNW_004955433:15,842,991...15,863,677 		JBrowse link
G Gins4 GINS complex subunit 4 involved_in ISO (PMID:22474384) ComplexPortal PMID:22474384 NCBI chrNW_004955536:1,360,811...1,375,691
Ensembl chrNW_004955536:1,360,811...1,375,712 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 acts_upstream_of_or_within
involved_in		 ISO (MGI:2156014|PMID:10531422)
(PMID:22474384)		 MGI
ComplexPortal		 PMID:10531422 PMID:22474384 MGI:2156014 NCBI chrNW_004955429:16,012,345...16,027,151
Ensembl chrNW_004955429:16,012,173...16,027,277 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 involved_in ISO (PMID:22474384) ComplexPortal PMID:22474384 NCBI chrNW_004955411:5,800,800...5,832,713
Ensembl chrNW_004955411:5,814,041...5,832,796 		JBrowse link
G Mcm4 minichromosome maintenance complex component 4 acts_upstream_of_or_within
involved_in		 ISO (MGI:3582148|PMID:15917436)
(PMID:22474384)		 MGI
ComplexPortal		 PMID:15917436 PMID:22474384 MGI:3582148 NCBI chrNW_004955454:7,891,646...7,908,240
Ensembl chrNW_004955454:7,891,456...7,908,462 		JBrowse link
G Mcm5 minichromosome maintenance complex component 5 involved_in ISO (PMID:22474384) ComplexPortal PMID:22474384 NCBI chrNW_004955405:43,132,815...43,145,699
Ensembl chrNW_004955405:43,132,204...43,145,699 		JBrowse link
G Mcm6 minichromosome maintenance complex component 6 acts_upstream_of_or_within
involved_in		 ISO (MGI:3582148|PMID:15917436)
(PMID:22474384)		 MGI
ComplexPortal		 PMID:15917436 PMID:22474384 MGI:3582148 NCBI chrNW_004955440:3,200,803...3,234,437
Ensembl chrNW_004955440:3,200,803...3,234,437 		JBrowse link
G Mcm7 minichromosome maintenance complex component 7 acts_upstream_of_or_within
involved_in		 ISO (MGI:3582148|PMID:15917436)
(PMID:22474384)		 MGI
ComplexPortal		 PMID:15917436 PMID:22474384 MGI:3582148 NCBI chrNW_004955573:763,358...770,782
Ensembl chrNW_004955573:763,358...775,489 		JBrowse link
G Pura purine rich element binding protein A involved_in ISO (PMID:15777841) UniProt PMID:15777841 NCBI chrNW_004955418:538,883...548,605 JBrowse link
G Rad51 RAD51 recombinase involved_in ISO (PMID:7988572) UniProt PMID:7988572 NCBI chrNW_004955416:7,566,715...7,590,628
Ensembl chrNW_004955416:7,566,686...7,590,628 		JBrowse link
G Ssbp1 single stranded DNA binding protein 1 involved_in ISO (PMID:26446790) FlyBase PMID:26446790 NCBI chrNW_004955494:1,807,885...1,826,375
Ensembl chrNW_004955494:1,814,106...1,826,375 		JBrowse link
G Twnk twinkle mtDNA helicase involved_in
acts_upstream_of_or_within		 ISO (PMID:15167897)
(MGI:2136707|PMID:11431692)		 FlyBase
MGI		 PMID:11431692 PMID:15167897 MGI:2136707 NCBI chrNW_004955485:9,193,838...9,198,697
Ensembl chrNW_004955485:9,191,919...9,198,697 		JBrowse link
negative regulation of DNA duplex unwinding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sub1 SUB1 regulator of transcription involved_in ISO (PMID:16605275) DisProt PMID:16605275 NCBI chrNW_004955426:18,380,680...18,394,627
Ensembl chrNW_004955426:18,380,117...18,394,627 		JBrowse link
G Top2a DNA topoisomerase II alpha involved_in ISO (PMID:12711669) UniProt PMID:12711669 NCBI chrNW_004955451:14,928,273...14,964,855
Ensembl chrNW_004955451:14,929,136...14,964,723 		JBrowse link
negative regulation of DNA helicase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mnat1 MNAT1 component of CDK activating kinase involved_in ISO (PMID:11445587) UniProt PMID:11445587 NCBI chrNW_004955466:8,690,960...8,895,021
Ensembl chrNW_004955466:8,690,960...8,895,021 		JBrowse link
nucleotide-excision repair, DNA duplex unwinding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit involved_in ISO (PMID:17466626) UniProt PMID:17466626 NCBI chrNW_004955459:3,210,936...3,238,401
Ensembl chrNW_004955459:3,210,479...3,242,576 		JBrowse link
positive regulation of DNA helicase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pot1 protection of telomeres 1 involved_in ISO (PMID:19734539) BHF-UCL PMID:19734539 NCBI chrNW_004955479:6,140,599...6,230,512
Ensembl chrNW_004955479:6,140,501...6,209,031 		JBrowse link
G Ssbp1 single stranded DNA binding protein 1 involved_in ISO (PMID:15167897) FlyBase PMID:15167897 NCBI chrNW_004955494:1,807,885...1,826,375
Ensembl chrNW_004955494:1,814,106...1,826,375 		JBrowse link
regulation of DNA helicase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pot1 protection of telomeres 1 involved_in ISO (PMID:19734539) BHF-UCL PMID:19734539 NCBI chrNW_004955479:6,140,599...6,230,512
Ensembl chrNW_004955479:6,140,501...6,209,031 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12334
    cellular process 10997
      cellular component organization or biogenesis 5239
        cellular component organization 5114
          organelle organization 2843
            chromosome organization 447
              DNA conformation change 49
                DNA geometric change 43
                  DNA duplex unwinding 38
                    DNA unwinding involved in DNA replication + 15
                    negative regulation of DNA duplex unwinding + 3
                    nucleotide-excision repair, DNA duplex unwinding 1
                    positive regulation of DNA duplex unwinding + 2
                    regulation of DNA duplex unwinding + 5
paths to the root